Mettl8 (methyltransferase 8, tRNA N3-cytidine)

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Gene: Mettl8 (methyltransferase 8, tRNA N3-cytidine) Rattus norvegicus

Analyze

Symbol:

Mettl8

Name:

methyltransferase 8, tRNA N3-cytidine (Ensembl:methyltransferase 8, methylcytidine)

RGD ID:

1561059

Description:

Predicted to enable histone acetyltransferase activity; mRNA methyltransferase activity; and tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in RNA modification and positive regulation of mitochondrial translation. Predicted to act upstream of or within chromatin remodeling; fat cell differentiation; and skeletal muscle tissue development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. Orthologous to human METTL8 (methyltransferase 8, tRNA N3-cytidine); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; copper atom.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AABR07052486.1; LOC502633; methyltransferase 8, methylcytidine; methyltransferase like 8; methyltransferase-like protein 8; mRNA N(3)-methylcytidine methyltransferase METTL8; RGD1561059; similar to BC004636 protein; tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	55,731,453 - 55,863,652 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	55,770,167 - 55,863,676 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	59,167,776 - 59,261,627 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	67,751,350 - 67,845,196 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	65,514,225 - 65,607,442 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	57,257,394 - 57,642,096 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	57,257,394 - 57,646,610 (-)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	64,067,269 - 64,142,322 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	3	63,739,467 - 63,753,417 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	53,215,940 - 53,310,137 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	55,318,933 - 55,411,758 (-)	NCBI		Celera
Cytogenetic Map	3	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

split hand-foot malformation 5 (ISO)

Woodhouse-Sakati syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

calcitriol (ISO)

calcium silicate (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

formaldehyde (ISO)

gallic acid (ISO)

methamphetamine (ISO)

methapyrilene (ISO)

methimazole (EXP)

methoxychlor (EXP)

methylmercury chloride (ISO)

ozone (ISO)

paracetamol (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

SB 431542 (ISO)

sulfadimethoxine (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA,ISO)

fat cell differentiation (ISO)

mitochondrial tRNA modification (ISO)

mRNA methylation (ISO)

positive regulation of mitochondrial translation (ISO)

skeletal muscle tissue development (ISO)

tRNA C3-cytosine methylation (ISO)

Cellular Component

cytoplasm (ISO)

mitochondrion (ISO)

nucleus (ISO)

Molecular Function

histone acetyltransferase activity (ISO)

mRNA methyltransferase activity (ISO)

tRNA (cytidine-3-)-methyltransferase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15992539	PMID:28655767

Genomics

Comparative Map Data

Mettl8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	55,731,453 - 55,863,652 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	55,770,167 - 55,863,676 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	59,167,776 - 59,261,627 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	67,751,350 - 67,845,196 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	65,514,225 - 65,607,442 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	57,257,394 - 57,642,096 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	57,257,394 - 57,646,610 (-)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	64,067,269 - 64,142,322 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	3	63,739,467 - 63,753,417 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	53,215,940 - 53,310,137 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	55,318,933 - 55,411,758 (-)	NCBI		Celera
Cytogenetic Map	3	q22	NCBI

METTL8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	171,315,746 - 171,434,772 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	171,315,746 - 171,434,802 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	172,172,256 - 172,291,282 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	171,888,007 - 171,998,865 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	165,790,476 - 165,907,900 (-)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	164,059,509 - 164,176,804 (-)	NCBI		HuRef
CHM1_1	2	172,180,433 - 172,298,093 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	171,792,877 - 171,911,912 (-)	NCBI		T2T-CHM13v2.0

Mettl8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	70,794,902 - 70,886,729 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	70,794,905 - 70,885,927 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	70,964,561 - 71,056,388 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	70,964,561 - 71,055,583 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	70,802,618 - 70,893,663 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	70,765,400 - 70,856,366 (-)	NCBI		MGSCv36	mm8
Celera	2	72,632,432 - 72,724,286 (-)	NCBI		Celera
Cytogenetic Map	2	C2	NCBI
cM Map	2	42.34	NCBI

Mettl8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	3,490,568 - 3,533,584 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	3,458,683 - 3,534,377 (+)	NCBI	ChiLan1.0	ChiLan1.0

METTL8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2B	74,008,563 - 74,128,842 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	58,605,042 - 58,725,999 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	176,070,609 - 176,183,862 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	176,070,609 - 176,183,862 (-)	Ensembl	panpan1.1		panPan2

METTL8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	15,816,518 - 15,906,019 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	15,819,138 - 15,905,064 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	15,826,849 - 15,916,386 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	15,939,707 - 16,029,316 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	15,942,170 - 16,028,784 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	16,025,454 - 16,115,010 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	16,025,261 - 16,114,815 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	16,127,954 - 16,217,507 (-)	NCBI		UU_Cfam_GSD_1.0

Mettl8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	133,037,469 - 133,124,784 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	1,591,348 - 1,652,673 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	1,590,583 - 1,678,680 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METTL8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	77,477,231 - 77,525,714 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	77,477,229 - 77,564,492 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	86,863,793 - 86,948,404 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

METTL8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	56,851,898 - 56,951,920 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	56,852,279 - 56,950,983 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	142,594,431 - 142,738,373 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mettl8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	8,780,172 - 8,829,699 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	8,784,206 - 8,857,834 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mettl8
933 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	88
Count of miRNA genes:	73
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000058524
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	16954708	61954708	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
2302055	Pia30	Pristane induced arthritis QTL 30	3.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	3	27936919	72936919	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	28249687	73249687	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	28249687	73249687	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	28249687	73249687	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	28249687	73249687	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	28249687	73249687	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	28468571	73468571	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	28468571	73468571	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
11565451	Bw177	Body weight QTL 177		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	3	31426403	70668733	Rat
11565452	Kidm57	Kidney mass QTL 57		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	31426403	70668733	Rat
12879866	Cm94	Cardiac mass QTL 94		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	31426403	70668733	Rat
12879867	Cm95	Cardiac mass QTL 95		0.047	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	31426403	70668733	Rat
12879868	Am6	Aortic mass QTL 6		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	31426403	70668733	Rat
2301400	Cm68	Cardiac mass QTL 68		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	31426403	70668733	Rat
1300169	Bp177	Blood pressure QTL 177	2.96		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	3	33703347	61017857	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
2302276	Bw82	Body weight QTL 82	4.32		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	62951183	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582249	Bw77	Body weight QTL 77	3.2	0.0025	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	64655484	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat

Markers in Region

RH134988

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	55,786,554 - 55,786,763 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	57,570,128 - 57,570,337	NCBI	Rnor6.0
Celera	3	55,334,662 - 55,334,871	UniSTS
Cytogenetic Map	3	q21	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399514	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001060093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006224480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106365	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106366	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005502190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005502191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000058524 ⟹ ENSRNOP00000055322

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	55,770,171 - 55,859,065 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000075860 ⟹ ENSRNOP00000067958

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	55,770,167 - 55,863,676 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000076202 ⟹ ENSRNOP00000068431

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	55,771,977 - 55,863,554 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093222 ⟹ ENSRNOP00000076118

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	55,786,419 - 55,863,554 (-)	Ensembl

RefSeq Acc Id:

NM_001399513 ⟹ NP_001386442

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	55,770,171 - 55,863,639 (-)	NCBI

RefSeq Acc Id:

NM_001399514 ⟹ NP_001386443

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	55,770,171 - 55,863,639 (-)	NCBI

RefSeq Acc Id:

XM_008761954 ⟹ XP_008760176

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	55,770,167 - 55,860,682 (-)	NCBI
Rnor_6.0	3	57,257,394 - 57,642,096 (-)	NCBI

Sequence:

show sequence

ATTGGGAAGGTTGAGGACCACTGAGCTAGAGAGTACTCAGTGTTACACGTAATCATTATTGGTT
GAAAACACAGATTTCTTAGGTAATAGAAATAAAGCTGGGAGCCCCACTTTAGCCGGAGTGGTCA
GAGAAGGCCCCTCTAAAAGAGGAGCTTTCAACAGTCTCAGGAAAGAGAGGGCATTGTGACTCAT
GCTTGGAATCCCAGCACTCAAGAGGTTGAGGCACAAGAGCCCGTGTGAGTTTAAGGCTACCCTG
GCTTAGAGAATGGCGCCGTGAGACCTGTCTCAAACAAAAGCAAGCACCCAGGCAAAGCGATGAT
CAATTACGGGATTCTTAAGGTCCTGTTTGGGATGAATGTGATTTGGAGAAATTGCATTTGCCGT
CTGAGGCAAGGGAAGGTGCCACACAGATGTCAGAGCGGTGTCCACCCGGTGGCCCCTCTGGGGT
CAAGGATTTTAACTGACCCCACCAAAGTTTTCGAACACAACATGTGGGATCACATGCAGTGGTC
CAAAGAGGAAGAAGACGAAGCTAGAAAAAAAGTAGAGGAAAACTCAGCCACACGAGTCGCCCCA
GAAGAGCAAGTTAAGTTTGAAAATGCTGCTAACAAATACTGGGACACTTTTTACCAAACCCATA
AGAATAAGTTTTTCAAGAATCGTAATTGGCTGTTGAGGGAATTTCCTGAAATTCTTCCCGTTGA
TCAGAACACTAAAGAGAAACTGGGAGAATCATCCTGGGACCCAGCCAGAAGCAGCATCTCAAGA
ACGCAAGGAACAGAAACCCACCGACAAGAGACTTTTGTCTCATCAGAACCTGGGAGCAGAGAAA
GGTCTGCTTCTAACCCTGACTTGGAAGAATACAGCAGAGGACCCAGGAAGGCAGAGCAGTTTCC
TGGTAGCAAGGCTACTTTTCGAATACTAGAGGTTGGCTGTGGTGCTGGAAATAGCGTGTTTCCA
ATCCTGAACACCTTGCAGAACATCCCAGGATCCTTTCTTTACTGCTGTGACTTCGCCCCTGAAG
CAGTGGAGCTCGTAAAGTCACATGAGGCCTACAGCGAGGCCCACTGTTCTGCCTTTATTCATGA
CGTGTGTGACGACGGCTTGGCCTACCCTTTTCCAGACGGGACCCTGGACGTCATTCTCCTTGTC
TTTGTGCTCTCTTCTATTCACCCTGACAGGATGCAAGCTGTCATCCACCGGCTGTCCAGGTTGC
TGAAGCCCGGAGGAATGCTATTGTTTCGGGATCATGGAAGATACGACAATGCTCAGCTTCGCTT
TAAAAAAGGGCGTTGTTTATCTGAAAATTTTTACGTCCGAGGGGATGGTACCAGAGCCTATTTC
TTTACAAAAGGGGAGATCCACCGTATGTTCTGCGAGGCCGGATTACATGAAAAGCAAAATCTGG
TTGATCATCGCTTGCAAGTTAATAGGAAAAAGCAAATACAAATGCACCGAGTGTGGGTTCAAGG
GAAATTCCAGAAACCATCGTGCTGGACTCCACGGAGTGCAGATGAGCACGCTCTCCCTTCTCCA
GACTGAACTGTTAAAGTAGGAAACCAGGGCATGGTACCGTTCAAAGGCTTACGAGCAGGAGAGC
ATCTGCAGCTCTGCTGGCCTGCTATCAGTGCTCTTGGGACATTTTAAGAACACAGACGTGACTT
GAAAGAGTGTCCTACCCTCTGGGTTTTCAGAACTTGAAAAATGTTTGGTTTTGTTTCATCTAAC
CACGTTCCCTTGAATGGTATGACTTTGAATTAAGTAGCTGATATAAGGCATATAGTTTTGCAAC
CCATCCATGTTTTAGAAGTGGAAATATTATCTACTTTATTATTGGGTGTGGTAAAGCAGTCAGA
CTGTCCTCAGCTGCCAGCCAGTAGCAGAGGCACAGTGTGCCTTGTTCTTAGGGGATGGGATGTT
CTTAGGATGAAGGGATGCTGTGTTTTGTTTTGTTCTCATCTATTTTCTCTTAACCCCTTACCCC
CACACACTAGTGTCTGAAATGCAACTTCTGTTTCCCTTCCTTTGCAAATAATGGGGAAGTAAGG
CCTTGTCACCACCCCTCCAGGGCTGTTCTCAGCTACACAGATCATCTGAGAGACGCTGTCATGC
CGTGGTGGCTAGTTTCATTTGTCAACTTGACACACTCTAGAATCACTGTGGAAGAGTCTCAGGT
TGTCAGTTGTCTGTGAAAGTTTGTCTTAATTGTGTTAATCGATGTGGGAAGACCTGTCTACTGG
GGGCAGTACCATTCCCTGGGGTTTGGACCCTGAACCAAGTGTGGGAAAAGTGAGCTGAGCCCTG
ACCCACTTGCATTCTTCGTTCTCACTCTGCTCTTGACTGCTCTTGACCAGCTGCTTCAAGTTCC
TGCCTCCCTGACTTACTGCTGCAACTGGGTGGACTGTAACTTGGAGTTGTGATCCGAAATAAAC
CTTTTCTGCCCTAA

hide sequence

RefSeq Acc Id:

XM_039106364 ⟹ XP_038962292

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	55,731,453 - 55,860,694 (-)	NCBI

RefSeq Acc Id:

XM_039106365 ⟹ XP_038962293

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	55,770,167 - 55,825,055 (-)	NCBI

RefSeq Acc Id:

XM_039106366 ⟹ XP_038962294

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	55,770,167 - 55,863,652 (-)	NCBI

RefSeq Acc Id:

XR_005502190

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	55,732,752 - 55,860,694 (-)	NCBI

RefSeq Acc Id:

XR_005502191

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	55,772,614 - 55,860,691 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001386442	(Get FASTA)	NCBI Sequence Viewer
	NP_001386443	(Get FASTA)	NCBI Sequence Viewer
	XP_008760176	(Get FASTA)	NCBI Sequence Viewer
	XP_038962292	(Get FASTA)	NCBI Sequence Viewer
	XP_038962293	(Get FASTA)	NCBI Sequence Viewer
	XP_038962294	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL79087	(Get FASTA)	NCBI Sequence Viewer
	EDL79088	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000055322
	ENSRNOP00000055322.5
	ENSRNOP00000067958
	ENSRNOP00000067958.2
	ENSRNOP00000068431
	ENSRNOP00000068431.2
	ENSRNOP00000076118.2

RefSeq Acc Id:	XP_008760176 ⟸ XM_008761954
- Peptide Label:	isoform X1
- UniProtKB:	D3ZFN6 (UniProtKB/TrEMBL), A6HM36 (UniProtKB/TrEMBL)
- Sequence:	show sequence MINYGILKVLFGMNVIWRNCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPTKVFEHNMWDHMQ WSKEEEDEARKKVEENSATRVAPEEQVKFENAANKYWDTFYQTHKNKFFKNRNWLLREFPEILP VDQNTKEKLGESSWDPARSSISRTQGTETHRQETFVSSEPGSRERSASNPDLEEYSRGPRKAEQ FPGSKATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFAPEAVELVKSHEAYSEAHCSAFI HDVCDDGLAYPFPDGTLDVILLVFVLSSIHPDRMQAVIHRLSRLLKPGGMLLFRDHGRYDNAQL RFKKGRCLSENFYVRGDGTRAYFFTKGEIHRMFCEAGLHEKQNLVDHRLQVNRKKQIQMHRVWV QGKFQKPSCWTPRSADEHALPSPD hide sequence

RefSeq Acc Id:	XP_038962292 ⟸ XM_039106364
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038962294 ⟸ XM_039106366
- Peptide Label:	isoform X4
- UniProtKB:	A6HM36 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038962293 ⟸ XM_039106365
- Peptide Label:	isoform X3
- UniProtKB:	A6HM36 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000076118 ⟸ ENSRNOT00000093222

RefSeq Acc Id:

ENSRNOP00000068431 ⟸ ENSRNOT00000076202

RefSeq Acc Id:

ENSRNOP00000055322 ⟸ ENSRNOT00000058524

RefSeq Acc Id:

ENSRNOP00000067958 ⟸ ENSRNOT00000075860

RefSeq Acc Id:	NP_001386443 ⟸ NM_001399514
- Peptide Label:	isoform 2

RefSeq Acc Id:	NP_001386442 ⟸ NM_001399513
- Peptide Label:	isoform 1
- UniProtKB:	A6HM37 (UniProtKB/TrEMBL), A6HM36 (UniProtKB/TrEMBL)

Protein Domains

Methyltransferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZFN6-F1-model_v2	AlphaFold	D3ZFN6	1-209	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561059	AgrOrtholog
BioCyc Gene	G2FUF-49479	BioCyc
Ensembl Genes	ENSRNOG00000009382	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000058524	ENTREZGENE
	ENSRNOT00000058524.6	UniProtKB/TrEMBL
	ENSRNOT00000075860	ENTREZGENE
	ENSRNOT00000075860.2	UniProtKB/TrEMBL
	ENSRNOT00000076202	ENTREZGENE
	ENSRNOT00000076202.2	UniProtKB/TrEMBL
	ENSRNOT00000093222.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	Methyltransf_25	UniProtKB/TrEMBL
	MeTrfase	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
KEGG Report	rno:502633	UniProtKB/TrEMBL
NCBI Gene	502633	ENTREZGENE
PANTHER	MRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL8	UniProtKB/TrEMBL
	PTHR22809	UniProtKB/TrEMBL
Pfam	Methyltransf_25	UniProtKB/TrEMBL
PhenoGen	Mettl8	PhenoGen
PIRSF	Mettl2_prd	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009382	RatGTEx
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A096MJ18_RAT	UniProtKB/TrEMBL
	A0A096MK97_RAT	UniProtKB/TrEMBL
	A0A1W2Q633_RAT	UniProtKB/TrEMBL
	A6HM36	ENTREZGENE, UniProtKB/TrEMBL
	A6HM37	ENTREZGENE, UniProtKB/TrEMBL
	D3ZFN6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-06-09	Mettl8	methyltransferase 8, tRNA N3-cytidine	Mettl8	methyltransferase 8, methylcytidine	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2022-06-17	Mettl8	methyltransferase 8, methylcytidine	Mettl8	methyltransferase like 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2022-06-02	Mettl8	methyltransferase like 8	AABR07052486.1		Data merged from RGD:15003350	737654	PROVISIONAL
2019-11-08	AABR07052486.1				Symbol and Name status set to provisional	45752	PROVISIONAL
2008-02-28	Mettl8	methyltransferase like 8	RGD1561059_predicted	similar to BC004636 protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1561059_predicted	similar to BC004636 protein (predicted)	LOC502633	similar to BC004636 protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC502633	similar to BC004636 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar