Cby2 (chibby family member 2) - Rat Genome Database

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Pathways
Gene: Cby2 (chibby family member 2) Rattus norvegicus
Analyze
Symbol: Cby2
Name: chibby family member 2
RGD ID: 1561044
Description: Predicted to enable identical protein binding activity. Predicted to be located in cytoplasmic vesicle. Orthologous to human CBY2 (chibby family member 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC498572; similar to testis-specific leucine zipper protein nurit; spermatid associated; spermatid-associated protein; Spert
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81557,318,820 - 57,413,687 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1557,317,988 - 57,334,505 (-)EnsemblGRCr8
mRatBN7.21550,909,435 - 51,004,449 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1550,909,436 - 50,934,633 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1555,059,019 - 55,067,414 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01556,177,345 - 56,185,740 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,004,443 - 53,012,896 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01557,642,576 - 57,738,383 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1557,642,577 - 57,651,041 (-)Ensemblrn6Rnor6.0
Rnor_5.01561,353,104 - 61,361,569 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1550,539,217 - 50,547,288 (-)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12204287   PMID:27107012  


Genomics

Comparative Map Data
Cby2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81557,318,820 - 57,413,687 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1557,317,988 - 57,334,505 (-)EnsemblGRCr8
mRatBN7.21550,909,435 - 51,004,449 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1550,909,436 - 50,934,633 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1555,059,019 - 55,067,414 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01556,177,345 - 56,185,740 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,004,443 - 53,012,896 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01557,642,576 - 57,738,383 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1557,642,577 - 57,651,041 (-)Ensemblrn6Rnor6.0
Rnor_5.01561,353,104 - 61,361,569 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1550,539,217 - 50,547,288 (-)NCBICelera
Cytogenetic Map15q11NCBI
CBY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381345,702,320 - 45,714,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1345,702,320 - 45,714,559 (+)Ensemblhg38GRCh38
GRCh371346,276,455 - 46,288,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361345,174,447 - 45,186,694 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1327,331,110 - 27,343,357 (+)NCBICelera
Cytogenetic Map13q14.13NCBI
HuRef1327,073,127 - 27,085,374 (+)NCBIHuRef
CHM1_11346,245,374 - 46,257,621 (+)NCBICHM1_1
T2T-CHM13v2.01344,923,623 - 44,935,862 (+)NCBIT2T-CHM13v2.0
Cby2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391475,820,274 - 75,830,616 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1475,820,317 - 75,830,556 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381475,582,834 - 75,593,177 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1475,582,877 - 75,593,116 (-)Ensemblmm10GRCm38
MGSCv371475,982,641 - 75,992,923 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361474,317,032 - 74,326,119 (-)NCBIMGSCv36mm8
Celera1473,084,953 - 73,095,127 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1440.23NCBI
Cby2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555183,395,552 - 3,414,076 (+)Ensembl
ChiLan1.0NW_0049555183,395,464 - 3,410,616 (+)NCBIChiLan1.0ChiLan1.0
CBY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21445,676,673 - 45,689,244 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11336,730,717 - 36,743,288 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01327,317,454 - 27,329,698 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CBY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1225,440,473 - 5,543,710 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl225,405,741 - 5,614,277 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha225,429,537 - 5,532,815 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0225,558,384 - 5,661,519 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl225,558,394 - 5,569,845 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1225,340,206 - 5,443,499 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0225,403,466 - 5,506,437 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0225,408,683 - 5,512,047 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cby2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945155,849,176 - 155,863,046 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936857271,561 - 285,148 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936857271,561 - 285,148 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,612,493 - 21,622,446 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11121,612,319 - 21,719,817 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21122,057,078 - 22,067,206 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CBY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1323,763,786 - 23,776,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl323,764,157 - 23,776,100 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605720,269,201 - 20,281,384 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cby2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247489,336,027 - 9,356,066 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247489,336,140 - 9,356,021 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cby2
700 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000072138
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155720389580107161Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
AI596460  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21550,909,542 - 50,909,648 (+)MAPPERmRatBN7.2
Rnor_6.01557,642,684 - 57,642,789NCBIRnor6.0
Rnor_5.01561,353,212 - 61,353,317UniSTSRnor5.0
Celera1550,539,325 - 50,539,430UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 10 32 114 47 46 17 32 17 6 176 94 9 89 47 79 29 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000072138   ⟹   ENSRNOP00000066296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,318,821 - 57,334,505 (-)Ensembl
mRatBN7.2 Ensembl1550,909,436 - 50,917,900 (-)Ensembl
Rnor_6.0 Ensembl1557,642,577 - 57,651,041 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098900   ⟹   ENSRNOP00000083970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,317,988 - 57,327,285 (-)Ensembl
mRatBN7.2 Ensembl1550,909,445 - 50,916,739 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119540   ⟹   ENSRNOP00000078599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1550,909,436 - 50,934,633 (-)Ensembl
RefSeq Acc Id: NM_001017506   ⟹   NP_001017506
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,318,820 - 57,327,285 (-)NCBI
mRatBN7.21550,909,435 - 50,917,900 (-)NCBI
Rnor_6.01557,642,576 - 57,651,041 (-)NCBI
Rnor_5.01561,353,104 - 61,361,569 (-)NCBI
Celera1550,539,217 - 50,547,288 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252328   ⟹   XP_006252390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,318,820 - 57,326,296 (-)NCBI
mRatBN7.21550,909,435 - 50,916,925 (-)NCBI
Rnor_6.01557,642,731 - 57,650,276 (-)NCBI
Rnor_5.01561,353,104 - 61,361,569 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252329   ⟹   XP_006252391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,318,820 - 57,327,158 (-)NCBI
mRatBN7.21550,909,435 - 50,917,774 (-)NCBI
Rnor_6.01557,642,731 - 57,650,906 (-)NCBI
Rnor_5.01561,353,104 - 61,361,569 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770893   ⟹   XP_008769115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,318,820 - 57,413,687 (-)NCBI
mRatBN7.21550,909,435 - 51,004,449 (-)NCBI
Rnor_6.01557,642,731 - 57,669,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770895   ⟹   XP_008769117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,318,820 - 57,413,687 (-)NCBI
mRatBN7.21550,909,435 - 51,004,449 (-)NCBI
Rnor_6.01557,642,731 - 57,738,383 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001017506   ⟸   NM_001017506
- UniProtKB: Q6AXV6 (UniProtKB/Swiss-Prot),   A6HTT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252391   ⟸   XM_006252329
- Peptide Label: isoform X3
- UniProtKB: A6HTT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252390   ⟸   XM_006252328
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZY42 (UniProtKB/TrEMBL),   A6HTT0 (UniProtKB/TrEMBL),   A6HTT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769117   ⟸   XM_008770895
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G3C8 (UniProtKB/TrEMBL),   A6HTT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769115   ⟸   XM_008770893
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G3C8 (UniProtKB/TrEMBL),   A6HTT1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066296   ⟸   ENSRNOT00000072138
Ensembl Acc Id: ENSRNOP00000078599   ⟸   ENSRNOT00000119540
Ensembl Acc Id: ENSRNOP00000083970   ⟸   ENSRNOT00000098900

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXV6-F1-model_v2 AlphaFold Q6AXV6 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699832
Promoter ID:EPDNEW_R10355
Type:multiple initiation site
Name:Spert_1
Description:spermatid associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01557,651,058 - 57,651,118EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561044 AgrOrtholog
BioCyc Gene G2FUF-13122 BioCyc
Ensembl Genes ENSRNOG00000047413 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072138 ENTREZGENE
  ENSRNOT00000072138.2 UniProtKB/Swiss-Prot
  ENSRNOT00000098900 ENTREZGENE
IMAGE_CLONE IMAGE:7134526 IMAGE-MGC_LOAD
InterPro Chibby_fam UniProtKB/Swiss-Prot
KEGG Report rno:498572 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94437 IMAGE-MGC_LOAD
NCBI Gene 498572 ENTREZGENE
PANTHER LEUCINE-RICH PROTEIN UniProtKB/Swiss-Prot
  PTHR21533:SF13 UniProtKB/Swiss-Prot
Pfam Chibby UniProtKB/Swiss-Prot
PhenoGen Cby2 PhenoGen
RatGTEx ENSRNOG00000047413 RatGTEx
UniProt A0A8I5ZY42 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G3C8 ENTREZGENE, UniProtKB/TrEMBL
  A6HTT0 ENTREZGENE, UniProtKB/TrEMBL
  A6HTT1 ENTREZGENE, UniProtKB/TrEMBL
  Q6AXV6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Cby2  chibby family member 2  Spert  spermatid associated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Spert  spermatid associated  LOC498572  similar to testis-specific leucine zipper protein nurit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC498572  similar to testis-specific leucine zipper protein nurit      Symbol and Name status set to provisional 70820 PROVISIONAL