Hecw1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: Hecw1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) Rattus norvegicus
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Symbol: Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
RGD ID: 1561038
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination; regulation of dendrite morphogenesis; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase HECW1; E3 ubiquitin-protein ligase HECW1-like; hypothetical protein LOC291209; LOC103694104; LOC291209; RGD1561038; similar to HECT type E3 ubiquitin ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81755,366,904 - 55,780,028 (+)NCBIGRCr8
mRatBN7.21750,671,239 - 51,084,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1750,670,954 - 51,080,720 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1753,848,279 - 54,257,069 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01757,851,192 - 58,260,002 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01751,958,458 - 52,353,481 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01753,229,997 - 53,777,474 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1753,229,785 - 53,773,657 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01751,443,552 - 51,469,507 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01750,929,146 - 51,260,519 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41758,856,317 - 59,275,923 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1746,703,218 - 47,100,054 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:35699802  


Genomics

Comparative Map Data
Hecw1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81755,366,904 - 55,780,028 (+)NCBIGRCr8
mRatBN7.21750,671,239 - 51,084,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1750,670,954 - 51,080,720 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1753,848,279 - 54,257,069 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01757,851,192 - 58,260,002 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01751,958,458 - 52,353,481 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01753,229,997 - 53,777,474 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1753,229,785 - 53,773,657 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01751,443,552 - 51,469,507 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01750,929,146 - 51,260,519 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41758,856,317 - 59,275,923 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1746,703,218 - 47,100,054 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
HECW1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38743,112,647 - 43,566,001 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl743,112,629 - 43,566,001 (+)EnsemblGRCh38hg38GRCh38
GRCh37743,152,246 - 43,605,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36743,118,723 - 43,569,463 (+)NCBINCBI36Build 36hg18NCBI36
Build 34743,124,601 - 43,376,178NCBI
Celera743,142,126 - 43,592,827 (+)NCBICelera
Cytogenetic Map7p14.1-p13NCBI
HuRef743,037,592 - 43,488,098 (+)NCBIHuRef
CHM1_1743,155,739 - 43,606,212 (+)NCBICHM1_1
T2T-CHM13v2.0743,270,827 - 43,724,047 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2743,191,688 - 43,642,449 (+)NCBI
Hecw1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391314,401,023 - 14,697,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1314,401,023 - 14,697,813 (-)EnsemblGRCm39 Ensembl
GRCm381314,226,438 - 14,523,289 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1314,226,438 - 14,523,228 (-)EnsemblGRCm38mm10GRCm38
MGSCv371314,318,705 - 14,615,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361314,018,564 - 14,315,354 (-)NCBIMGSCv36mm8
Celera1314,533,374 - 14,829,609 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.29NCBI
Hecw1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955460334,762 - 746,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955460336,805 - 744,906 (-)NCBIChiLan1.0ChiLan1.0
HECW1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2644,877,606 - 45,322,987 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1793,206,139 - 93,647,727 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0740,678,651 - 41,124,073 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1740,726,334 - 41,202,832 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl740,726,603 - 41,038,005 (-)Ensemblpanpan1.1panPan2
HECW1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1186,644,102 - 7,084,159 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl186,647,658 - 7,084,567 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha186,489,372 - 6,929,914 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0186,686,934 - 7,131,935 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl186,690,496 - 7,130,777 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1186,675,044 - 7,115,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0186,643,955 - 7,084,340 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,756,878 - 7,197,119 (-)NCBIUU_Cfam_GSD_1.0
Hecw1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,026,162 - 99,429,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647818,349,596 - 18,641,572 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647818,237,254 - 18,639,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HECW1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1851,387,836 - 51,802,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11851,383,766 - 51,803,004 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21856,281,556 - 56,382,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HECW1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12115,028,385 - 15,488,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2115,025,579 - 15,485,436 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660627,006,160 - 7,461,370 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hecw1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474017,675,479 - 17,892,733 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474017,671,442 - 18,075,100 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hecw1
2748 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:119
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000021703
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat

Markers in Region
D17Mgh5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21750,909,099 - 50,909,196 (+)MAPPERmRatBN7.2
Rnor_6.01753,475,180 - 53,475,276NCBIRnor6.0
Rnor_5.01751,171,698 - 51,171,794UniSTSRnor5.0
RGSC_v3.41759,104,847 - 59,104,944RGDRGSC3.4
RGSC_v3.41759,104,848 - 59,104,944UniSTSRGSC3.4
RGSC_v3.11759,107,688 - 59,107,785RGD
Celera1746,929,911 - 46,930,007UniSTS
RH 3.4 Map17532.99UniSTS
RH 3.4 Map17532.99RGD
RH 2.0 Map17455.1RGD
SHRSP x BN Map1730.3699RGD
FHH x ACI Map1736.6499RGD
Cytogenetic Map17q12.1UniSTS
D17Mgh8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21750,909,096 - 50,909,253 (+)MAPPERmRatBN7.2
Rnor_6.01753,475,177 - 53,475,333NCBIRnor6.0
Rnor_5.01751,171,695 - 51,171,851UniSTSRnor5.0
RGSC_v3.41759,104,844 - 59,105,001RGDRGSC3.4
RGSC_v3.41759,104,845 - 59,105,001UniSTSRGSC3.4
RGSC_v3.11759,107,685 - 59,107,842RGD
Celera1746,929,908 - 46,930,064UniSTS
RH 3.4 Map17533.69UniSTS
RH 3.4 Map17533.69RGD
RH 2.0 Map17441.8RGD
SHRSP x BN Map1730.3699RGD
FHH x ACI Map1736.6499RGD
Cytogenetic Map17q12.1UniSTS
MARC_8191-8192:996688382:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21750,996,317 - 50,997,099 (+)MAPPERmRatBN7.2
Rnor_6.01753,600,085 - 53,600,866NCBIRnor6.0
Rnor_6.01753,562,290 - 53,563,071NCBIRnor6.0
Rnor_5.01751,258,808 - 51,259,589UniSTSRnor5.0
Rnor_5.01751,296,603 - 51,297,384UniSTSRnor5.0
RGSC_v3.41759,192,062 - 59,192,843UniSTSRGSC3.4
Celera1747,016,085 - 47,016,866UniSTS
Cytogenetic Map17q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64 1
Low 14 13 5 10 5 10 6 40
Below cutoff 3 23 29 23 8 23 5 5 21 8 5

Sequence


RefSeq Acc Id: ENSRNOT00000021703   ⟹   ENSRNOP00000021703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1750,672,804 - 51,080,720 (+)Ensembl
Rnor_6.0 Ensembl1753,231,343 - 53,773,657 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082040   ⟹   ENSRNOP00000073947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1750,828,501 - 50,998,861 (+)Ensembl
Rnor_6.0 Ensembl1753,229,785 - 53,600,206 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100241   ⟹   ENSRNOP00000080972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1750,671,248 - 51,080,720 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114793   ⟹   ENSRNOP00000091762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1750,670,954 - 51,080,720 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119865   ⟹   ENSRNOP00000085827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1750,829,316 - 51,080,720 (+)Ensembl
RefSeq Acc Id: NM_001106117   ⟹   NP_001099587
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81755,368,311 - 55,776,212 (+)NCBI
mRatBN7.21750,672,804 - 51,080,720 (+)NCBI
Rnor_6.01753,231,343 - 53,773,657 (+)NCBI
Rnor_5.01750,929,146 - 51,260,519 (+)NCBI
Rnor_5.01751,443,552 - 51,469,507 (+)NCBI
RGSC_v3.41758,856,317 - 59,275,923 (+)RGD
Celera1746,703,218 - 47,100,054 (+)RGD
Sequence:
RefSeq Acc Id: XM_008771697   ⟹   XP_008769919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81755,366,957 - 55,780,028 (+)NCBI
mRatBN7.21750,671,239 - 51,084,536 (+)NCBI
Rnor_6.01753,229,997 - 53,777,474 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600485   ⟹   XP_017455974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81755,366,904 - 55,780,028 (+)NCBI
mRatBN7.21750,671,239 - 51,084,536 (+)NCBI
Rnor_6.01753,230,005 - 53,777,474 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600486   ⟹   XP_017455975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81755,367,571 - 55,780,028 (+)NCBI
mRatBN7.21750,672,227 - 51,084,536 (+)NCBI
Rnor_6.01753,231,414 - 53,777,474 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600487   ⟹   XP_017455976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81755,366,904 - 55,780,028 (+)NCBI
mRatBN7.21750,671,239 - 51,084,536 (+)NCBI
Rnor_6.01753,230,005 - 53,777,474 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600488   ⟹   XP_017455977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81755,367,834 - 55,780,028 (+)NCBI
mRatBN7.21750,672,227 - 51,084,536 (+)NCBI
Rnor_6.01753,231,429 - 53,777,474 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600489   ⟹   XP_017455978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81755,366,904 - 55,780,028 (+)NCBI
mRatBN7.21750,671,239 - 51,084,536 (+)NCBI
Rnor_6.01753,230,005 - 53,777,474 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600490   ⟹   XP_017455979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81755,366,904 - 55,780,028 (+)NCBI
mRatBN7.21750,671,239 - 51,084,536 (+)NCBI
Rnor_6.01753,230,005 - 53,777,474 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001099587   ⟸   NM_001106117
- UniProtKB: F1M4Q8 (UniProtKB/TrEMBL),   A6K9C5 (UniProtKB/TrEMBL),   A0A8I6A475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769919   ⟸   XM_008771697
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQP0 (UniProtKB/TrEMBL),   A0A8I6A475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455974   ⟸   XM_017600485
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AG92 (UniProtKB/TrEMBL),   A6K9C4 (UniProtKB/TrEMBL),   A0A8I6A475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455978   ⟸   XM_017600489
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455976   ⟸   XM_017600487
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455979   ⟸   XM_017600490
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455975   ⟸   XM_017600486
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQP0 (UniProtKB/TrEMBL),   A0A8I6A475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455977   ⟸   XM_017600488
- Peptide Label: isoform X4
- UniProtKB: A6K9C6 (UniProtKB/TrEMBL),   A0A8I6A475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021703   ⟸   ENSRNOT00000021703
RefSeq Acc Id: ENSRNOP00000073947   ⟸   ENSRNOT00000082040
RefSeq Acc Id: ENSRNOP00000080972   ⟸   ENSRNOT00000100241
RefSeq Acc Id: ENSRNOP00000085827   ⟸   ENSRNOT00000119865
RefSeq Acc Id: ENSRNOP00000091762   ⟸   ENSRNOT00000114793
Protein Domains
C2   HECT   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4Q8-F1-model_v2 AlphaFold F1M4Q8 1-1594 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561038 AgrOrtholog
BioCyc Gene G2FUF-9068 BioCyc
Ensembl Genes ENSRNOG00000016046 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021703 ENTREZGENE
  ENSRNOT00000021703.6 UniProtKB/TrEMBL
  ENSRNOT00000082040.2 UniProtKB/TrEMBL
  ENSRNOT00000100241.1 UniProtKB/TrEMBL
  ENSRNOT00000114793.1 UniProtKB/TrEMBL
  ENSRNOT00000119865.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  2.60.40.2840 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2_HECW UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  HECW1_helix UniProtKB/TrEMBL
  HECW_N UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:291209 UniProtKB/TrEMBL
NCBI Gene 291209 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE HECW1 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  HECW1_helix UniProtKB/TrEMBL
  HECW_N UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Hecw1 PhenoGen
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016046 RatGTEx
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A0A0G2K6U6_RAT UniProtKB/TrEMBL
  A0A8I5ZQP0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A475 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AG92 ENTREZGENE, UniProtKB/TrEMBL
  A6K9C4 ENTREZGENE, UniProtKB/TrEMBL
  A6K9C5 ENTREZGENE, UniProtKB/TrEMBL
  A6K9C6 ENTREZGENE, UniProtKB/TrEMBL
  F1M4Q8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hecw1  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1  LOC103694104  E3 ubiquitin-protein ligase HECW1-like  Data merged from RGD:9389462 737654 PROVISIONAL
2014-08-25 LOC103694104  E3 ubiquitin-protein ligase HECW1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Hecw1  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1  RGD1561038  similar to HECT type E3 ubiquitin ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561038  similar to HECT type E3 ubiquitin ligase   RGD1561038_predicted  similar to HECT type E3 ubiquitin ligase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561038_predicted  similar to HECT type E3 ubiquitin ligase (predicted)  LOC291209  similar to HECT type E3 ubiquitin ligase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC291209  similar to HECT type E3 ubiquitin ligase      Symbol and Name status set to provisional 70820 PROVISIONAL