Slc25a6 (solute carrier family 25 member 6) - Rat Genome Database

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Gene: Slc25a6 (solute carrier family 25 member 6) Rattus norvegicus
Analyze
Symbol: Slc25a6
Name: solute carrier family 25 member 6
RGD ID: 1560896
Description: Predicted to enable ATP:ADP antiporter activity. Predicted to be involved in chromosome segregation; mitochondrial ADP transmembrane transport; and mitochondrial ATP transmembrane transport. Predicted to be located in membrane and mitochondrion. Orthologous to human SLC25A6 (solute carrier family 25 member 6); PARTICIPATES IN calcium/calcium-mediated signaling pathway; Huntington's disease pathway; Parkinson's disease pathway; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenine nucleotide translocator), member 6; ADP/ATP translocase 2-like; LOC498885; RGD1560896; similar to solute carrier family 25, member 5; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 6; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
RGD Orthologs
Human
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81870,846,358 - 70,847,597 (+)NCBIGRCr8
mRatBN7.21868,571,222 - 68,572,461 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,571,300 - 68,572,199 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01870,959,872 - 70,961,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,959,887 - 70,960,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,099,119 - 70,100,285 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,853,216 - 71,854,115 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1866,746,244 - 66,747,412 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Slc25a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81870,846,358 - 70,847,597 (+)NCBIGRCr8
mRatBN7.21868,571,222 - 68,572,461 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,571,300 - 68,572,199 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01870,959,872 - 70,961,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,959,887 - 70,960,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,099,119 - 70,100,285 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,853,216 - 71,854,115 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1866,746,244 - 66,747,412 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
SLC25A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38Y1,386,152 - 1,392,113 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38X1,386,152 - 1,392,113 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblY1,386,152 - 1,392,113 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 EnsemblX1,386,152 - 1,392,113 (-)EnsemblGRCh38hg38GRCh38
GRCh37X1,505,045 - 1,511,006 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37Y1,455,045 - 1,461,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X1,465,045 - 1,470,998 (-)NCBINCBI36Build 36hg18NCBI36
Build 36Y1,465,045 - 1,470,998 (-)NCBINCBI36Build 36hg18NCBI36
Build 34Y1,548,871 - 1,554,821NCBI
CeleraX5,786,374 - 5,792,489 (-)NCBICelera
Cytogenetic MapX;YNCBI
CHM1_1X1,535,623 - 1,541,618 (-)NCBICHM1_1
T2T-CHM13v2.0X1,229,798 - 1,235,760 (-)NCBIT2T-CHM13v2.0
T2T-CHM13v2.0Y1,249,921 - 1,256,001 (-)NCBIT2T-CHM13v2.0
LOC129395394
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X1,267,586 - 1,276,226 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1-v2Y45,668,078 - 45,674,038 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X1,271,231 - 1,277,161 (-)NCBINHGRI_mPanPan1
NHGRI_mPanPan1Y1,280,680 - 1,286,632 (-)NCBINHGRI_mPanPan1
SLC25A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X912,937 - 916,156 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX912,938 - 915,257 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX853,949 - 857,445 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X824,243 - 827,752 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX824,244 - 827,827 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X816,189 - 819,544 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X832,850 - 836,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X868,569 - 872,069 (-)NCBIUU_Cfam_GSD_1.0
Slc25a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404953581,561 - 583,317 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366443,793,434 - 3,795,182 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC25A6
(Sus scrofa - pig)
No map positions available.
SLC25A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660561,371,788 - 1,377,522 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc25a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624834653,599 - 657,556 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624834654,552 - 657,580 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc25a6
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000046606
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat

Markers in Region
D12Got44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21868,558,585 - 68,558,759 (+)MAPPERmRatBN7.2
Rnor_6.01870,947,180 - 70,947,353NCBIRnor6.0
Rnor_5.01870,086,428 - 70,086,601UniSTSRnor5.0
RGSC_v3.41871,840,508 - 71,840,682RGDRGSC3.4
RGSC_v3.41871,840,509 - 71,840,682UniSTSRGSC3.4
RGSC_v3.11871,913,710 - 71,913,883RGD
Celera1866,733,576 - 66,733,749UniSTS
RH 3.4 Map12307.12RGD
RH 3.4 Map12307.12UniSTS
Cytogenetic Map18q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 11 3 11 3 8 10 7 6
Below cutoff 2 19 17 9 7 9 4 5 30 14 18 5 4

Sequence


RefSeq Acc Id: ENSRNOT00000046606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1868,571,300 - 68,572,199 (+)Ensembl
Rnor_6.0 Ensembl1870,959,887 - 70,960,786 (+)Ensembl
RefSeq Acc Id: NM_001408903   ⟹   NP_001395832
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,846,358 - 70,847,597 (+)NCBI
mRatBN7.21868,571,222 - 68,572,461 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395832 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076563
  ENSRNOP00000076563.1
RefSeq Acc Id: NP_001395832   ⟸   NM_001408903
- UniProtKB: A0A8I5Y643 (UniProtKB/TrEMBL),   A6JMF8 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560896 AgrOrtholog
BioCyc Gene G2FUF-6996 BioCyc
Ensembl Genes ENSRNOG00000042387 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046606 ENTREZGENE
  ENSRNOT00000046606.4 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/TrEMBL
InterPro ADT_euk_type UniProtKB/TrEMBL
  Mit_carrier UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/TrEMBL
NCBI Gene 498885 ENTREZGENE
PANTHER ADP/ATP TRANSLOCASE 2 UniProtKB/TrEMBL
  PTHR45635 UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/TrEMBL
PhenoGen Slc25a6 PhenoGen
PRINTS ADPTRNSLCASE UniProtKB/TrEMBL
  MITOCARRIER UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042387 RatGTEx
Superfamily-SCOP SSF103506 UniProtKB/TrEMBL
UniProt A0A8I5Y643 ENTREZGENE, UniProtKB/TrEMBL
  A6JMF8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc25a6  solute carrier family 25 member 6  Slc25a6  solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Slc25a6  solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6  RGD1560896  similar to solute carrier family 25, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560896  similar to solute carrier family 25, member 5   RGD1560896_predicted  similar to solute carrier family 25, member 5 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560896_predicted  similar to solute carrier family 25, member 5 (predicted)  LOC498885  similar to solute carrier family 25, member 5  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498885  similar to solute carrier family 25, member 5      Symbol and Name status set to provisional 70820 PROVISIONAL