C1qtnf9 (C1q and TNF related 9) - Rat Genome Database

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Gene: C1qtnf9 (C1q and TNF related 9) Rattus norvegicus
Analyze
Symbol: C1qtnf9
Name: C1q and TNF related 9
RGD ID: 1560876
Description: Predicted to enable hormone activity and identical protein binding activity. Acts upstream of or within fatty acid oxidation and positive regulation of protein serine/threonine kinase activity. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. Orthologous to several human genes including C1QTNF9B (C1q and TNF related 9B); INTERACTS WITH (1->4)-beta-D-glucan (ortholog); 1,2-dimethylhydrazine (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adif1; adiponectin f1; C1q and tumor necrosis factor related protein 9; Ctrp9; LOC364395; RGD1560876; similar to hypothetical protein MGC48915
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,083,883 - 39,099,167 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1539,087,163 - 39,099,398 (+)EnsemblGRCr8
mRatBN7.21534,907,791 - 34,922,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1534,911,286 - 34,922,980 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1536,776,879 - 36,784,636 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01537,927,500 - 37,935,253 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01536,376,449 - 36,384,104 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,069,579 - 41,080,961 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,069,507 - 41,081,159 (+)Ensemblrn6Rnor6.0
Rnor_5.01544,882,217 - 44,893,080 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41539,860,425 - 39,868,076 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1534,616,332 - 34,623,981 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. Peterson JM, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Sep;305(5):R522-33. doi: 10.1152/ajpregu.00110.2013. Epub 2013 Jul 10.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18783346   PMID:19666007   PMID:22514273   PMID:28688765   PMID:29925877   PMID:30953351   PMID:31623508   PMID:32429302   PMID:34059748  


Genomics

Comparative Map Data
C1qtnf9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,083,883 - 39,099,167 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1539,087,163 - 39,099,398 (+)EnsemblGRCr8
mRatBN7.21534,907,791 - 34,922,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1534,911,286 - 34,922,980 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1536,776,879 - 36,784,636 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01537,927,500 - 37,935,253 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01536,376,449 - 36,384,104 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,069,579 - 41,080,961 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,069,507 - 41,081,159 (+)Ensemblrn6Rnor6.0
Rnor_5.01544,882,217 - 44,893,080 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41539,860,425 - 39,868,076 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1534,616,332 - 34,623,981 (+)NCBICelera
Cytogenetic Map15p12NCBI
C1QTNF9B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381323,891,099 - 23,897,502 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1323,891,099 - 23,897,502 (-)Ensemblhg38GRCh38
GRCh371324,465,238 - 24,471,641 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361323,363,428 - 23,369,125 (-)NCBIBuild 36Build 36hg18NCBI36
Celera135,528,082 - 5,533,781 (-)NCBICelera
Cytogenetic Map13q12.12NCBI
HuRef135,276,519 - 5,282,222 (-)NCBIHuRef
CHM1_11324,433,584 - 24,439,287 (-)NCBICHM1_1
T2T-CHM13v2.01323,097,537 - 23,108,727 (-)NCBIT2T-CHM13v2.0
C1qtnf9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391461,005,583 - 61,018,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1461,005,583 - 61,018,318 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381460,768,134 - 60,780,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1460,768,134 - 60,780,869 (+)Ensemblmm10GRCm38
MGSCv371461,386,971 - 61,399,705 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361459,722,244 - 59,734,978 (+)NCBIMGSCv36mm8
Celera1458,546,595 - 58,559,325 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1431.93NCBI
LOC609026
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12514,735,370 - 14,748,054 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2514,814,153 - 14,826,650 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02514,867,211 - 14,879,712 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2514,866,760 - 14,879,716 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12514,748,751 - 14,761,270 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02514,751,418 - 14,763,919 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02514,799,740 - 14,812,241 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100522569
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1112,791,855 - 2,803,526 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2112,145,862 - 2,156,840 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in C1qtnf9
161 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000018533
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
BE114209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21534,922,759 - 34,922,964 (+)MAPPERmRatBN7.2
Rnor_6.01541,080,740 - 41,080,944NCBIRnor6.0
Rnor_5.01544,892,855 - 44,893,059UniSTSRnor5.0
RGSC_v3.41539,867,856 - 39,868,060UniSTSRGSC3.4
Celera1534,623,761 - 34,623,965UniSTS
RH 3.4 Map15225.8UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 51 142 59 58 27 73 27 6 276 157 11 121 68 85 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000018533   ⟹   ENSRNOP00000018533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1539,087,163 - 39,099,090 (+)Ensembl
mRatBN7.2 Ensembl1534,911,286 - 34,922,980 (+)Ensembl
Rnor_6.0 Ensembl1541,069,507 - 41,081,159 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095495   ⟹   ENSRNOP00000076970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1539,091,186 - 39,099,398 (+)Ensembl
mRatBN7.2 Ensembl1534,914,986 - 34,922,980 (+)Ensembl
RefSeq Acc Id: NM_001191891   ⟹   NP_001178820
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,091,439 - 39,099,090 (+)NCBI
mRatBN7.21534,915,329 - 34,922,980 (+)NCBI
Rnor_6.01541,074,328 - 41,080,960 (+)NCBI
Rnor_5.01544,882,217 - 44,893,080 (+)NCBI
Celera1534,616,332 - 34,623,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252134   ⟹   XP_006252196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,083,883 - 39,099,167 (+)NCBI
mRatBN7.21534,907,791 - 34,922,985 (+)NCBI
Rnor_6.01541,069,579 - 41,080,961 (+)NCBI
Rnor_5.01544,882,217 - 44,893,080 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093547   ⟹   XP_038949475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,087,845 - 39,099,167 (+)NCBI
mRatBN7.21534,911,750 - 34,922,985 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178820 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252196 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949475 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018533
  ENSRNOP00000018533.7
  ENSRNOP00000076970.1
GenBank Protein SOR70290 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001178820   ⟸   NM_001191891
- Peptide Label: precursor
- UniProtKB: D3ZJ76 (UniProtKB/TrEMBL),   A0A3B0IP20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252196   ⟸   XM_006252134
- Peptide Label: isoform X1
- UniProtKB: A0A3B0IP20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018533   ⟸   ENSRNOT00000018533
RefSeq Acc Id: XP_038949475   ⟸   XM_039093547
- Peptide Label: isoform X2
- UniProtKB: D3ZJ76 (UniProtKB/TrEMBL),   A0A3B0IP20 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076970   ⟸   ENSRNOT00000095495
Protein Domains
C1q

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJ76-F1-model_v2 AlphaFold D3ZJ76 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560876 AgrOrtholog
BioCyc Gene G2FUF-13518 BioCyc
Ensembl Genes ENSRNOG00000013793 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018533 ENTREZGENE
  ENSRNOT00000018533.8 UniProtKB/TrEMBL
  ENSRNOT00000095495.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro C1q UniProtKB/TrEMBL
  Collagen UniProtKB/TrEMBL
  Collagen/C1q_domain UniProtKB/TrEMBL
  Tumour_necrosis_fac-like UniProtKB/TrEMBL
KEGG Report rno:364395 UniProtKB/TrEMBL
NCBI Gene 364395 ENTREZGENE
PANTHER COMPLEMENT C1Q AND TUMOR NECROSIS FACTOR-RELATED PROTEIN 9A UniProtKB/TrEMBL
  EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER UniProtKB/TrEMBL
Pfam C1q UniProtKB/TrEMBL
  Collagen UniProtKB/TrEMBL
PhenoGen C1qtnf9 PhenoGen
PRINTS COMPLEMNTC1Q UniProtKB/TrEMBL
PROSITE C1Q UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013793 RatGTEx
SMART C1Q UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt A0A3B0IP20 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJ76 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-09 C1qtnf9  C1q and TNF related 9  C1qtnf9  C1q and tumor necrosis factor related protein 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 C1qtnf9  C1q and tumor necrosis factor related protein 9  RGD1560876_predicted  similar to hypothetical protein MGC48915 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560876_predicted  similar to hypothetical protein MGC48915 (predicted)  LOC364395  similar to hypothetical protein MGC48915  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC364395  similar to hypothetical protein MGC48915      Symbol and Name status set to provisional 70820 PROVISIONAL