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Gene: Themis (thymocyte selection associated) Rattus norvegicus
Analyze
Symbol:
Themis
Name:
thymocyte selection associated
RGD ID:
1560849
Description:
Predicted to be involved in T cell receptor signaling pathway; negative T cell selection; and positive T cell selection. Predicted to be located in cell-cell junction; cytoplasm; and nucleus. Predicted to be part of COP9 signalosome. Used to study inflammatory bowel disease. Orthologous to human THEMIS (thymocyte selection associated); INTERACTS WITH (1->4)-beta-D-glucan (ortholog); 1,2-dichloroethane (ortholog); 2,4-dibromophenyl 2,4,5-tribromophenyl ether (ortholog).
Type:
protein-coding
RefSeq Status:
MODEL
Previously known as:
LOC498985; RGD1560849; similar to RIKEN cDNA E430004N04 gene
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Allele / Splice:
Themism1Adej
Genetic Models:
BN-Themism1Adej
Latest Assembly:
mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 1 16,433,906 - 16,623,889 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 16,432,631 - 16,664,329 (-) Ensembl mRatBN7.2 Ensembl Rnor_6.0 1 17,152,973 - 17,378,225 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 17,171,631 - 17,378,047 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 1 18,308,043 - 18,532,366 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 17,032,677 - 17,226,924 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 1 14,851,097 - 15,078,338 (-) NCBI Celera Cytogenetic Map 1 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
Imported Disease Annotations - CTD
Only show annotations with direct experimental evidence (0 objects hidden)
(1->4)-beta-D-glucan multiple interactions ISO RGD:1623011 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of THEMIS mRNA CTD PMID:36331819 1,2-dichloroethane increases expression ISO RGD:1623011 6480464 ethylene dichloride results in increased expression of THEMIS mRNA CTD PMID:28960355 2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expression ISO RGD:1603481 6480464 2 more ... CTD PMID:26705709 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:1623011 6480464 3 more ... CTD PMID:19467301 4,4'-sulfonyldiphenol decreases expression ISO RGD:1623011 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of THEMIS mRNA CTD PMID:33297965 aflatoxin B1 increases methylation ISO RGD:1603481 6480464 Aflatoxin B1 results in increased methylation of THEMIS gene CTD PMID:27153756 antirheumatic drug decreases expression ISO RGD:1603481 6480464 Antirheumatic Agents results in decreased expression of THEMIS mRNA CTD PMID:24449571 arsenous acid decreases expression ISO RGD:1603481 6480464 Arsenic Trioxide results in decreased expression of THEMIS mRNA CTD PMID:26705709 benzo[a]pyrene increases mutagenesis ISO RGD:1603481 6480464 Benzo(a)pyrene results in increased mutagenesis of THEMIS gene CTD PMID:25435355 benzo[a]pyrene increases methylation ISO RGD:1603481 6480464 Benzo(a)pyrene results in increased methylation of THEMIS 5' UTR, Benzo(a)pyrene results in increased methylation of THEMIS promoter CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1623011 6480464 Benzo(a)pyrene results in increased expression of THEMIS mRNA CTD PMID:19770486 bisphenol A decreases methylation ISO RGD:1603481 6480464 bisphenol A results in decreased methylation of THEMIS gene CTD PMID:31601247 buta-1,3-diene decreases expression ISO RGD:1623011 6480464 1, 3-butadiene results in decreased expression of THEMIS mRNA CTD PMID:29038090 diarsenic trioxide decreases expression ISO RGD:1603481 6480464 Arsenic Trioxide results in decreased expression of THEMIS mRNA CTD PMID:26705709 dibutyl phthalate increases expression ISO RGD:1623011 6480464 Dibutyl Phthalate results in increased expression of THEMIS mRNA CTD PMID:21266533 dimethylarsinic acid multiple interactions ISO RGD:1623011 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of THEMIS mRNA CTD PMID:34876320 epoxiconazole decreases expression ISO RGD:1623011 6480464 epoxiconazole results in decreased expression of THEMIS mRNA CTD PMID:35436446 inulin multiple interactions ISO RGD:1623011 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of THEMIS mRNA CTD PMID:36331819 methylarsonic acid multiple interactions ISO RGD:1623011 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of THEMIS mRNA CTD PMID:34876320 nickel atom increases expression ISO RGD:1603481 6480464 Nickel results in increased expression of THEMIS mRNA CTD PMID:24768652 , PMID:25583101 ozone multiple interactions ISO RGD:1623011 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of THEMIS mRNA CTD PMID:34911549 perfluorooctane-1-sulfonic acid increases expression ISO RGD:1623011 6480464 perfluorooctane sulfonic acid results in increased expression of THEMIS mRNA, perfluorooctane sulfonic acid results in increased expression of THEMIS protein CTD PMID:26300304 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:1623011 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of THEMIS mRNA more ... CTD PMID:36331819 perfluorooctanoic acid increases expression ISO RGD:1623011 6480464 perfluorooctanoic acid results in increased expression of THEMIS mRNA CTD PMID:30711707 potassium dichromate increases expression ISO RGD:1623011 6480464 Potassium Dichromate results in increased expression of THEMIS mRNA CTD PMID:23608068 silicon dioxide increases expression ISO RGD:1623011 6480464 Silicon Dioxide results in increased expression of THEMIS mRNA CTD PMID:29341224 sodium arsenate multiple interactions ISO RGD:1623011 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of THEMIS mRNA CTD PMID:34876320 sodium arsenite multiple interactions ISO RGD:1623011 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of THEMIS mRNA CTD PMID:34876320 tetrachloroethene increases expression ISO RGD:1623011 6480464 Tetrachloroethylene results in increased expression of THEMIS mRNA CTD PMID:28973375 triptonide increases expression ISO RGD:1623011 6480464 triptonide results in increased expression of THEMIS mRNA CTD PMID:33045310 zinc atom decreases expression ISO RGD:1603481 6480464 Zinc deficiency results in decreased expression of THEMIS mRNA CTD PMID:22171008 zinc(0) decreases expression ISO RGD:1603481 6480464 Zinc deficiency results in decreased expression of THEMIS mRNA CTD PMID:22171008
References
Additional References at PubMed
Genomics
Comparative Map Data
Themis Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 1 16,433,906 - 16,623,889 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 16,432,631 - 16,664,329 (-) Ensembl mRatBN7.2 Ensembl Rnor_6.0 1 17,152,973 - 17,378,225 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 17,171,631 - 17,378,047 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 1 18,308,043 - 18,532,366 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 17,032,677 - 17,226,924 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 1 14,851,097 - 15,078,338 (-) NCBI Celera Cytogenetic Map 1 p12 NCBI
THEMIS Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 6 127,696,628 - 127,918,595 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p13 Ensembl 6 127,708,072 - 127,918,631 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 6 128,029,339 - 128,239,740 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 6 128,071,038 - 128,281,435 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 6 128,771,575 - 128,982,019 (-) NCBI Celera Cytogenetic Map 6 q22.33 NCBI HuRef 6 125,605,605 - 125,816,711 (-) NCBI HuRef CHM1_1 6 128,293,828 - 128,504,020 (-) NCBI CHM1_1 T2T-CHM13v2.0 6 128,897,128 - 129,107,550 (-) NCBI T2T-CHM13v2.0
Themis Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 10 28,544,356 - 28,759,816 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 10 28,544,356 - 28,759,814 (+) Ensembl GRCm39 Ensembl GRCm38 10 28,668,360 - 28,883,820 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 10 28,668,360 - 28,883,818 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 10 28,388,201 - 28,602,555 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 10 28,357,811 - 28,572,165 (+) NCBI MGSCv36 mm8 Celera 10 29,586,196 - 29,816,300 (+) NCBI Celera Cytogenetic Map 10 A4 NCBI
Themis Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 NW_004955436 8,743,835 - 8,909,040 (-) NCBI ChiLan1.0 ChiLan1.0
THEMIS Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1 6 145,596,428 - 145,800,480 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 6 125,489,491 - 125,685,995 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 6 129,601,170 - 129,814,542 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 6 129,601,176 - 129,797,112 (-) Ensembl panpan1.1 panPan2
THEMIS Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 1 66,363,172 - 66,540,272 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 1 66,363,125 - 66,540,327 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 1 67,190,331 - 67,279,926 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 1 66,571,969 - 66,748,404 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 1 66,571,954 - 66,748,440 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 1 66,494,735 - 66,676,345 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 1 66,282,091 - 66,458,649 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 1 66,921,859 - 67,104,609 (-) NCBI UU_Cfam_GSD_1.0
Themis Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024404946 116,589,828 - 116,679,894 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936639 1,739,380 - 1,915,560 (+) Ensembl SpeTri2.0 SpeTri2.0 NW_004936639 1,739,380 - 1,915,545 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
THEMIS Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 1 35,333,465 - 35,519,870 (+) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 1 35,333,210 - 35,530,710 (+) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 1 38,931,867 - 38,999,233 (+) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
THEMIS Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 13 45,665,494 - 45,886,672 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 13 45,682,663 - 45,884,856 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666040 17,911,702 - 18,107,125 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Themis
QTLs in Region (mRatBN7.2)
1354647 Despr8 Despair related QTL 8 0.0000341 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 1 1 24744506 Rat 2298546 Neuinf4 Neuroinflammation QTL 4 5.1 nervous system integrity trait (VT:0010566) spinal cord RT1-B protein level (CMO:0002132) 1 1 28736750 Rat 2313053 Bss51 Bone structure and strength QTL 51 3.8 0.0001 tibia length (VT:0004357) tibia length (CMO:0000450) 1 1 32356093 Rat 2313070 Bss52 Bone structure and strength QTL 52 4.4 0.0001 body length (VT:0001256) body length (CMO:0000013) 1 1 32356093 Rat 2313090 Bmd69 Bone mineral density QTL 69 4.4 0.0001 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) 1 1 32356093 Rat 738020 Pia8 Pristane induced arthritis QTL 8 4.7 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 1 1 65833076 Rat 1578650 Bmd6 Bone mineral density QTL 6 12.2 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 1 509108 43284926 Rat 1578651 Bmd7 Bone mineral density QTL 7 14.2 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) 1 509108 43284926 Rat 1578669 Bss9 Bone structure and strength QTL 9 6.3 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) 1 509108 43284926 Rat 1554320 Bmd1 Bone mineral density QTL 1 12.2 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 1 509108 86060548 Rat 1600360 Mcs16 Mammary carcinoma susceptibility QTL 16 2.4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 1 2244390 43433040 Rat 7421626 Bp360 Blood pressure QTL 360 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 4393289 49393289 Rat 631688 Hcas2 Hepatocarcinoma susceptibility QTL 2 3 0.0001 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) 1 5925874 115540829 Rat 4889451 Eae29 Experimental allergic encephalomyelitis QTL 29 5.51 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) 1 5925877 24697545 Rat 631508 Sald1 Serum aldosterone level QTL 1 3.7 blood aldosterone amount (VT:0005346) serum aldosterone level (CMO:0000487) 1 9856001 54856001 Rat 2302038 Pia31 Pristane induced arthritis QTL 31 5.5 0.001 blood autoantibody amount (VT:0003725) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) 1 10992065 55992065 Rat 1300167 Hrtrt2 Heart rate QTL 2 4.35 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 1 11481312 75088344 Rat 2313062 Bmd73 Bone mineral density QTL 73 3.9 0.0001 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) 1 11481312 82174945 Rat 2313065 Bss67 Bone structure and strength QTL 67 3.1 0.0001 tibia area (VT:1000281) tibia total energy absorbed before break (CMO:0001736) 1 11481312 82174945 Rat 2313069 Bss68 Bone structure and strength QTL 68 2.9 0.0001 tibia size trait (VT:0100001) tibia total energy absorbed before break (CMO:0001736) 1 11481312 82174945 Rat 2313075 Bss66 Bone structure and strength QTL 66 3.4 0.0001 tibia length (VT:0004357) tibia length (CMO:0000450) 1 11481312 82174945 Rat 2313077 Bss69 Bone structure and strength QTL 69 3.5 0.0001 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) 1 11481312 82174945 Rat 2313092 Bmd72 Bone mineral density QTL 72 2.5 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 1 11481312 82174945 Rat 2313097 Bss70 Bone structure and strength QTL 70 3.5 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 1 11481312 82174945 Rat 2317755 Glom22 Glomerulus QTL 22 3.8 urine protein amount (VT:0005160) urine protein level (CMO:0000591) 1 11481482 32355910 Rat 1578756 Iddm22 Insulin dependent diabetes mellitus QTL 22 2.7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 11835181 56835181 Rat 70179 Xhs2 X-ray hypersensitivity QTL 2 3.2 intestine integrity trait (VT:0010554) post-insult time to onset of moribundity (CMO:0001896) 1 15321100 19121980 Rat 5684998 Bss101 Bone structure and strength QTL 101 3.6 tibia strength trait (VT:1000284) tibia ultimate force (CMO:0001734) 1 15431621 49361612 Rat 5684999 Bss102 Bone structure and strength QTL 102 5.5 0.00000072 tibia strength trait (VT:1000284) tibia stiffness (CMO:0001735) 1 15431621 49361612 Rat 631494 Bp95 Blood pressure QTL 95 40 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 16206210 49268520 Rat
