Naa12 (N(alpha)-acetyltransferase 12, NatA catalytic subunit) - Rat Genome Database

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Gene: Naa12 (N(alpha)-acetyltransferase 12, NatA catalytic subunit) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Naa12 (Ensembl: RGD1560212)
Name: N(alpha)-acetyltransferase 12, NatA catalytic subunit (Ensembl:similar to DNA segment, Chr 18, Wayne State University 98, expressed)
RGD ID: 1560212
Description: Predicted to enable peptide-glutamate-alpha-N-acetyltransferase activity and peptide-serine-alpha-N-acetyltransferase activity. Predicted to be part of NatA complex. Orthologous to human NAA11 (N-alpha-acetyltransferase 11, NatA catalytic subunit).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC498890; LOC498890; MGC156819; RGD1560212; similar to DNA segment, Chr 18, Wayne State University 98, expressed; uncharacterized protein LOC498890
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Naa11-ps1   Naa11-ps12   Naa11-ps14   Naa11-ps16  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81875,934,117 - 75,940,509 (+)NCBIGRCr8
mRatBN7.21873,659,139 - 73,665,531 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1873,659,107 - 73,674,893 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1875,760,830 - 75,767,235 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01876,430,178 - 76,436,583 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01874,275,565 - 74,281,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01876,725,253 - 76,731,645 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1876,725,253 - 76,731,643 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01872,076,398 - 72,082,824 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41877,105,748 - 77,112,140 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1872,321,857 - 72,328,249 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
NatA complex  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Naa12
24 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat

Markers in Region
AI599676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21873,659,498 - 73,659,653 (+)MAPPERmRatBN7.2
Rnor_6.01876,725,613 - 76,725,767NCBIRnor6.0
Rnor_5.01872,082,278 - 72,082,432UniSTSRnor5.0
RGSC_v3.41877,106,108 - 77,106,262UniSTSRGSC3.4
Celera1872,322,217 - 72,322,371UniSTS
RH 3.4 Map18783.3UniSTS
Cytogenetic Map18q12.3UniSTS
RH128510  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21873,665,158 - 73,665,353 (+)MAPPERmRatBN7.2
Rnor_6.01876,731,273 - 76,731,467NCBIRnor6.0
Rnor_5.01872,076,578 - 72,076,772UniSTSRnor5.0
RGSC_v3.41877,111,768 - 77,111,962UniSTSRGSC3.4
Celera1872,327,877 - 72,328,071UniSTS
RH 3.4 Map18790.0UniSTS
Cytogenetic Map18q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000082419   ⟹   ENSRNOP00000074289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1873,659,120 - 73,665,528 (+)Ensembl
Rnor_6.0 Ensembl1876,725,253 - 76,731,643 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089487   ⟹   ENSRNOP00000073923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1873,659,107 - 73,674,893 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117773   ⟹   ENSRNOP00000096609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1873,659,502 - 73,665,514 (+)Ensembl
RefSeq Acc Id: NM_001077676   ⟹   NP_001071144
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81875,934,117 - 75,940,509 (+)NCBI
mRatBN7.21873,659,139 - 73,665,531 (+)NCBI
Rnor_6.01876,725,253 - 76,731,645 (+)NCBI
Rnor_5.01872,076,398 - 72,082,824 (-)NCBI
RGSC_v3.41877,105,748 - 77,112,140 (+)RGD
Celera1872,321,857 - 72,328,249 (+)RGD
Sequence:
RefSeq Acc Id: NP_001071144   ⟸   NM_001077676
- UniProtKB: A0JPQ5 (UniProtKB/TrEMBL),   A6K5G8 (UniProtKB/TrEMBL),   A6K5G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074289   ⟸   ENSRNOT00000082419
RefSeq Acc Id: ENSRNOP00000073923   ⟸   ENSRNOT00000089487
RefSeq Acc Id: ENSRNOP00000096609   ⟸   ENSRNOT00000117773
Protein Domains
N-acetyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0JPQ5-F1-model_v2 AlphaFold A0JPQ5 1-220 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560212 AgrOrtholog
BioCyc Gene G2FUF-6861 BioCyc
Ensembl Genes ENSRNOG00000057774 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082419.2 UniProtKB/TrEMBL
  ENSRNOT00000117773 ENTREZGENE
  ENSRNOT00000117773.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.30 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7301991 IMAGE-MGC_LOAD
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  Ard1-like UniProtKB/TrEMBL
  Dim1 UniProtKB/TrEMBL
  GCN5-rel_AcTrfase UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report rno:498890 UniProtKB/TrEMBL
MGC_CLONE MGC:156819 IMAGE-MGC_LOAD
NCBI Gene 498890 ENTREZGENE
PANTHER N(ALPHA)-ACETYLTRANSFERASE 12, NATA CATALYTIC SUBUNIT UniProtKB/TrEMBL
  PTHR23091 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
  DIM1 UniProtKB/TrEMBL
PhenoGen Naa12 PhenoGen
PROSITE GNAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057774 RatGTEx
SMART DIM1 UniProtKB/TrEMBL
Superfamily-SCOP Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
UniProt A0A0G2K7P4_RAT UniProtKB/TrEMBL
  A0JPQ5 ENTREZGENE
  A6K5G7 ENTREZGENE, UniProtKB/TrEMBL
  A6K5G8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0JPQ5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Naa12  N(alpha)-acetyltransferase 12, NatA catalytic subunit  RGD1560212  similar to DNA segment, Chr 18, Wayne State University 98, expressed  Symbol and Name Changed 1299863 APPROVED
2015-02-10 RGD1560212  similar to DNA segment, Chr 18, Wayne State University 98, expressed  Txnl4a  thioredoxin-like 4A  Name and Symbol changed 629549 APPROVED
2013-11-22 Txnl4a  thioredoxin-like 4A  RGD1560212  similar to DNA segment, Chr 18, Wayne State University 98, expressed  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560212  similar to DNA segment, Chr 18, Wayne State University 98, expressed   RGD1560212_predicted  similar to DNA segment, Chr 18, Wayne State University 98, expressed (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560212_predicted  similar to DNA segment, Chr 18, Wayne State University 98, expressed (predicted)  LOC498890  similar to DNA segment, Chr 18, Wayne State University 98, expressed  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498890  similar to DNA segment, Chr 18, Wayne State University 98, expressed      Symbol and Name status set to provisional 70820 PROVISIONAL