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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Nxt2 | Rat | (-)-alpha-phellandrene | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | alpha phellandrene results in increased expression of NXT2 mRNA | CTD | PMID:25075043 | Nxt2 | Rat | 1,2-dichloroethane | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of NXT2 mRNA | CTD | PMID:28189721|PMID:28960355 | Nxt2 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Nxt2 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of NXT2 mRNA] | CTD | PMID:22206623 | Nxt2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of NXT2 mRNA | CTD | PMID:22206623 | Nxt2 | Rat | 17beta-estradiol | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | Estradiol results in decreased expression of NXT2 mRNA | CTD | PMID:39298647 | Nxt2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Nxt2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NXT2 mRNA | CTD | PMID:21570461 | Nxt2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NXT2 mRNA | CTD | PMID:33387578 | Nxt2 | Rat | 3-methylcholanthrene | multiple interactions | ISO | NXT2 (Homo sapiens) | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to NXT2 promoter] | CTD | PMID:20348232 | Nxt2 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of NXT2 mRNA | CTD | PMID:39298647 | Nxt2 | Rat | 5-aza-2'-deoxycytidine | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | Decitabine results in increased expression of NXT2 mRNA | CTD | PMID:19194470 | Nxt2 | Rat | 5-azacytidine | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | Azacitidine results in increased expression of NXT2 mRNA | CTD | PMID:19194470 | Nxt2 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of NXT2 mRNA | CTD | PMID:31881176 | Nxt2 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of NXT2 mRNA | CTD | PMID:28959563 | Nxt2 | Rat | acrylamide | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of NXT2 mRNA | CTD | PMID:32763439 | Nxt2 | Rat | aflatoxin B1 | decreases methylation | ISO | NXT2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of NXT2 gene | CTD | PMID:27153756 | Nxt2 | Rat | all-trans-retinoic acid | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of NXT2 mRNA | CTD | PMID:33167477 | Nxt2 | Rat | alpha-phellandrene | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | alpha phellandrene results in increased expression of NXT2 mRNA | CTD | PMID:25075043 | Nxt2 | Rat | benzo[a]pyrene | affects methylation | ISO | NXT2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of NXT2 5' UTR; Benzo(a)pyrene affects the methylation of NXT2 promoter | CTD | PMID:27901495 | Nxt2 | Rat | beta-lapachone | decreases expression | ISO | NXT2 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of NXT2 mRNA | CTD | PMID:38218311 | Nxt2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of NXT2 mRNA | CTD | PMID:25181051|PMID:30816183|PMID:34947998 | Nxt2 | Rat | bisphenol A | decreases methylation | ISO | Nxt2 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of NXT2 promoter | CTD | PMID:27312807 | Nxt2 | Rat | cadmium dichloride | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of NXT2 mRNA | CTD | PMID:38174414 | Nxt2 | Rat | cadmium sulfate | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | cadmium sulfate results in increased expression of NXT2 mRNA | CTD | PMID:21783983 | Nxt2 | Rat | CGP 52608 | multiple interactions | ISO | NXT2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to NXT2 gene] | CTD | PMID:28238834 | Nxt2 | Rat | copper atom | multiple interactions | ISO | NXT2 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of NXT2 mRNA | CTD | PMID:24690739 | Nxt2 | Rat | copper(0) | multiple interactions | ISO | NXT2 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of NXT2 mRNA | CTD | PMID:24690739 | Nxt2 | Rat | crocidolite asbestos | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | Asbestos, Crocidolite results in decreased expression of NXT2 mRNA | CTD | PMID:29279043 | Nxt2 | Rat | cyclosporin A | decreases expression | ISO | NXT2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of NXT2 mRNA | CTD | PMID:25562108 | Nxt2 | Rat | dicrotophos | decreases expression | ISO | NXT2 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of NXT2 mRNA | CTD | PMID:28302478 | Nxt2 | Rat | disulfiram | multiple interactions | ISO | NXT2 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of NXT2 mRNA | CTD | PMID:24690739 | Nxt2 | Rat | dorsomorphin | multiple interactions | ISO | NXT2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Nxt2 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of NXT2 mRNA | CTD | PMID:29391264 | Nxt2 | Rat | ethanol | affects splicing | ISO | Nxt2 (Mus musculus) | 6480464 | Ethanol affects the splicing of NXT2 mRNA | CTD | PMID:30319688 | Nxt2 | Rat | ethanol | affects expression | ISO | Nxt2 (Mus musculus) | 6480464 | Ethanol affects the expression of NXT2 mRNA | CTD | PMID:30319688 | Nxt2 | Rat | fenthion | increases expression | ISO | Nxt2 (Mus musculus) | 6480464 | Fenthion results in increased expression of NXT2 mRNA | CTD | PMID:34813904 | Nxt2 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of NXT2 mRNA | CTD | PMID:24793618 | Nxt2 | Rat | folic acid | multiple interactions | ISO | Nxt2 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of NXT2 mRNA] | CTD | PMID:22206623 | Nxt2 | Rat | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of NXT2 mRNA | CTD | PMID:24136188 | Nxt2 | Rat | GSK-J4 | decreases expression | ISO | NXT2 (Homo sapiens) | 6480464 | GSK-J4 results in decreased expression of NXT2 mRNA | CTD | PMID:29301935 | Nxt2 | Rat | hydrogen peroxide | affects expression | ISO | NXT2 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of NXT2 mRNA | CTD | PMID:21179406 | Nxt2 | Rat | isoprenaline | increases expression | ISO | Nxt2 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of NXT2 mRNA | CTD | PMID:20003209 | Nxt2 | Rat | methylisothiazolinone | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of NXT2 mRNA | CTD | PMID:31629900 | Nxt2 | Rat | methylmercury chloride | decreases expression | ISO | NXT2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of NXT2 mRNA | CTD | PMID:28001369 | Nxt2 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of NXT2 mRNA | CTD | PMID:25729387 | Nxt2 | Rat | paracetamol | affects expression | ISO | Nxt2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of NXT2 mRNA | CTD | PMID:17562736 | Nxt2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of NXT2 mRNA | CTD | PMID:33387578 | Nxt2 | Rat | phenobarbital | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of NXT2 mRNA | CTD | PMID:19482888 | Nxt2 | Rat | phenobarbital | affects expression | ISO | Nxt2 (Mus musculus) | 6480464 | Phenobarbital affects the expression of NXT2 mRNA | CTD | PMID:23091169 | Nxt2 | Rat | phenobarbital | increases expression | ISO | Nxt2 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of NXT2 mRNA | CTD | PMID:19270015 | Nxt2 | Rat | phenobarbital | multiple interactions | ISO | Nxt2 (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of NXT2 mRNA] | CTD | PMID:19482888 | Nxt2 | Rat | piroxicam | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | Piroxicam results in increased expression of NXT2 mRNA | CTD | PMID:21858171 | Nxt2 | Rat | propiconazole | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | propiconazole results in decreased expression of NXT2 mRNA | CTD | PMID:21278054 | Nxt2 | Rat | SB 431542 | multiple interactions | ISO | NXT2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Nxt2 | Rat | silver atom | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | Silver results in decreased expression of NXT2 mRNA | CTD | PMID:27131904 | Nxt2 | Rat | silver(0) | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | Silver results in decreased expression of NXT2 mRNA | CTD | PMID:27131904 | Nxt2 | Rat | sodium arsenite | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of NXT2 mRNA | CTD | PMID:38568856 | Nxt2 | Rat | tetrachloromethane | decreases expression | ISO | Nxt2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of NXT2 mRNA | CTD | PMID:27339419|PMID:31919559 | Nxt2 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of NXT2 mRNA | CTD | PMID:25729387 | Nxt2 | Rat | trichostatin A | decreases expression | ISO | NXT2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of NXT2 mRNA | CTD | PMID:24935251 | Nxt2 | Rat | trichostatin A | multiple interactions | ISO | NXT2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Nxt2 | Rat | triphenyl phosphate | affects expression | ISO | NXT2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of NXT2 mRNA | CTD | PMID:37042841 | Nxt2 | Rat | valproic acid | affects expression | ISO | NXT2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of NXT2 mRNA | CTD | PMID:25979313 | Nxt2 | Rat | versicolorin A | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | versicolorin A results in increased expression of NXT2 mRNA | CTD | PMID:32106047 | Nxt2 | Rat | vorinostat | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | vorinostat results in increased expression of NXT2 mRNA | CTD | PMID:27188386 | Nxt2 | Rat | zoledronic acid | increases expression | ISO | NXT2 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of NXT2 mRNA | CTD | PMID:20977926 | |