Ndufb4l3 (NADH:ubiquinone oxidoreductase subunit B4 like 3) - Rat Genome Database

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Gene: Ndufb4l3 (NADH:ubiquinone oxidoreductase subunit B4 like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ndufb4l3
Name: NADH:ubiquinone oxidoreductase subunit B4 like 3
RGD ID: 1560088
Description: Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH lead diacetate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC499131; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like; RGD1560088; similar to NADH:ubiquinone oxidoreductase B15 subunit
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8196,616,845 - 96,617,332 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl196,616,845 - 96,617,321 (+)EnsemblGRCr8
mRatBN7.2187,479,867 - 87,480,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl187,479,905 - 87,480,294 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx192,883,573 - 92,884,060 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01101,349,570 - 101,350,057 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0194,641,885 - 94,642,372 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0190,729,267 - 90,729,711 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0191,867,258 - 91,867,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4187,364,823 - 87,365,212 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera181,840,866 - 81,841,310 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ndufb4l3
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:86
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000047207
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
mesenchyme
nervous system
renal system
sensory system
visual system
2 2 3 4 1 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000049123   ⟹   ENSRNOP00000040779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl187,479,905 - 87,480,294 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158465   ⟹   ENSRNOP00000104148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl196,616,845 - 96,617,321 (+)Ensembl
RefSeq Acc Id: NM_001401863   ⟹   NP_001388792
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8196,616,845 - 96,617,332 (+)NCBI
mRatBN7.2187,479,867 - 87,480,354 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388792 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040779.4
  ENSRNOP00000104148
Ensembl Acc Id: ENSRNOP00000040779   ⟸   ENSRNOT00000049123
RefSeq Acc Id: NP_001388792   ⟸   NM_001401863
- UniProtKB: F1M7Z4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104148   ⟸   ENSRNOT00000158465

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7Z4-F1-model_v2 AlphaFold F1M7Z4 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560088 AgrOrtholog
BioCyc Gene G2FUF-60000 BioCyc
Ensembl Genes ENSRNOG00000062485 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000088815 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000049123.4 UniProtKB/TrEMBL
  ENSRNOT00000158465 ENTREZGENE
InterPro NADH_UbQ_OxRdtase_NDUFB4_su UniProtKB/TrEMBL
NCBI Gene 499131 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4 UniProtKB/TrEMBL
  PTHR15469 UniProtKB/TrEMBL
Pfam NDUF_B4 UniProtKB/TrEMBL
PhenoGen Ndufb4l3 PhenoGen
RatGTEx ENSRNOG00000062485 RatGTEx
  ENSRNOG00000088815 RatGTEx
UniProt F1M7Z4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Ndufb4l3  NADH:ubiquinone oxidoreductase subunit B4 like 3  RGD1560088  similar to NADH:ubiquinone oxidoreductase B15 subunit  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1560088  similar to NADH:ubiquinone oxidoreductase B15 subunit  RGD1560088  similar to NADH:ubiquinone oxidoreductase B15 subunit  Data merged from RGD:149736223 737654 PROVISIONAL
2021-08-09 RGD1560088  similar to NADH:ubiquinone oxidoreductase B15 subunit      Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1560088  similar to NADH:ubiquinone oxidoreductase B15 subunit   RGD1560088_predicted  similar to NADH:ubiquinone oxidoreductase B15 subunit (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560088_predicted  similar to NADH:ubiquinone oxidoreductase B15 subunit (predicted)  LOC499131  similar to NADH:ubiquinone oxidoreductase B15 subunit  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499131  similar to NADH:ubiquinone oxidoreductase B15 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL