Tbl1xr1 (TBL1X/Y related 1) - Rat Genome Database

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Gene: Tbl1xr1 (TBL1X/Y related 1) Rattus norvegicus
Analyze
Symbol: Tbl1xr1
Name: TBL1X/Y related 1
RGD ID: 1560053
Description: Predicted to enable several functions, including beta-catenin binding activity; histone binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of canonical Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blastocyst hatching; fat pad development; and white fat cell differentiation. Predicted to be located in mitotic spindle and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Human ortholog(s) of this gene implicated in Pierpont syndrome and autosomal dominant intellectual developmental disorder 41. Orthologous to human TBL1XR1 (TBL1X/Y related 1); PARTICIPATES IN Wnt signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box-like/WD repeat-containing protein TBL1XR1; LOC365755; RGD1560053; similar to IRA1 protein; TBL1X receptor 1; transducin (beta)-like 1 X-linked receptor 1; transducin (beta)-like 1X-linked receptor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82106,718,811 - 106,857,989 (+)NCBIGRCr8
mRatBN7.22104,788,950 - 104,929,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2104,801,721 - 104,929,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2111,389,385 - 111,516,649 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02109,510,519 - 109,637,780 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02104,376,892 - 104,504,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02107,221,913 - 107,359,229 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2107,233,054 - 107,359,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02126,957,062 - 127,093,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42107,561,415 - 107,688,872 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2100,118,058 - 100,245,338 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
melphalan  (ISO)
menadione  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:12628926   PMID:14980219   PMID:15601853   PMID:16127449   PMID:16893456   PMID:18193033   PMID:18326024   PMID:23499424   PMID:27869233  


Genomics

Comparative Map Data
Tbl1xr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82106,718,811 - 106,857,989 (+)NCBIGRCr8
mRatBN7.22104,788,950 - 104,929,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2104,801,721 - 104,929,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2111,389,385 - 111,516,649 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02109,510,519 - 109,637,780 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02104,376,892 - 104,504,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02107,221,913 - 107,359,229 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2107,233,054 - 107,359,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02126,957,062 - 127,093,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42107,561,415 - 107,688,872 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2100,118,058 - 100,245,338 (+)NCBICelera
Cytogenetic Map2q24NCBI
TBL1XR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383177,019,344 - 177,201,800 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3177,019,340 - 177,228,000 (-)EnsemblGRCh38hg38GRCh38
GRCh373176,737,132 - 176,915,270 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363178,221,867 - 178,397,734 (-)NCBINCBI36Build 36hg18NCBI36
Build 343178,221,874 - 178,397,742NCBI
Celera3175,142,709 - 175,319,560 (-)NCBICelera
Cytogenetic Map3q26.32NCBI
HuRef3174,119,553 - 174,197,428 (-)NCBIHuRef
CHM1_13176,701,477 - 176,877,938 (-)NCBICHM1_1
T2T-CHM13v2.03179,822,332 - 180,000,612 (-)NCBIT2T-CHM13v2.0
Tbl1xr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39322,130,756 - 22,270,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl322,130,816 - 22,270,758 (+)EnsemblGRCm39 Ensembl
GRCm38322,076,253 - 22,216,594 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl322,076,652 - 22,216,594 (+)EnsemblGRCm38mm10GRCm38
MGSCv37321,975,574 - 22,115,516 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36322,267,857 - 22,402,606 (+)NCBIMGSCv36mm8
Celera322,160,720 - 22,228,220 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map37.58NCBI
Tbl1xr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554206,546,529 - 6,705,487 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554206,546,529 - 6,705,481 (-)NCBIChiLan1.0ChiLan1.0
TBL1XR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22174,903,535 - 175,088,702 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13174,908,252 - 175,093,412 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03174,067,964 - 174,251,913 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13182,247,335 - 182,429,608 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3182,247,335 - 182,429,619 (-)Ensemblpanpan1.1panPan2
TBL1XR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13440,573,631 - 40,690,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3440,578,507 - 40,739,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3449,584,085 - 49,750,553 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03440,683,717 - 40,850,053 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3440,683,902 - 40,849,640 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13440,607,121 - 40,773,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03440,568,493 - 40,734,744 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03440,826,034 - 40,992,369 (-)NCBIUU_Cfam_GSD_1.0
Tbl1xr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602107,358,904 - 107,499,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365665,790,532 - 5,861,838 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365665,721,541 - 5,861,838 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBL1XR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13115,312,452 - 115,487,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113115,312,444 - 115,488,228 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213124,258,143 - 124,353,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TBL1XR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11512,223,404 - 12,406,165 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1512,224,226 - 12,402,908 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606321,144,769 - 21,334,894 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbl1xr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473054,835,624 - 54,884,835 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473054,835,624 - 55,013,474 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tbl1xr1
789 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:940
Count of miRNA genes:318
Interacting mature miRNAs:463
Transcripts:ENSRNOT00000015573
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
D2Rat28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22104,814,877 - 104,815,148 (+)MAPPERmRatBN7.2
Rnor_6.02107,083,299 - 107,083,569NCBIRnor6.0
Rnor_5.02126,824,467 - 126,824,737UniSTSRnor5.0
RGSC_v3.42107,574,469 - 107,574,826RGDRGSC3.4
RGSC_v3.42107,574,499 - 107,574,769UniSTSRGSC3.4
RGSC_v3.12107,519,431 - 107,519,788RGD
Celera2100,131,211 - 100,131,482UniSTS
RH 3.4 Map2737.7RGD
RH 3.4 Map2737.7UniSTS
SHRSP x BN Map238.7498UniSTS
SHRSP x BN Map238.7498RGD
FHH x ACI Map250.0599RGD
Cytogenetic Map2q24UniSTS
RH137630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22104,882,869 - 104,883,076 (+)MAPPERmRatBN7.2
Rnor_6.02107,313,042 - 107,313,248NCBIRnor6.0
Rnor_5.02127,047,547 - 127,047,753UniSTSRnor5.0
RGSC_v3.42107,642,649 - 107,642,855UniSTSRGSC3.4
Celera2100,199,136 - 100,199,342UniSTS
Cytogenetic Map2q24UniSTS
RH140040  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22104,924,658 - 104,924,871 (+)MAPPERmRatBN7.2
Rnor_6.02107,354,833 - 107,355,045NCBIRnor6.0
Rnor_5.02127,089,338 - 127,089,550UniSTSRnor5.0
RGSC_v3.42107,684,476 - 107,684,688UniSTSRGSC3.4
Celera2100,240,942 - 100,241,154UniSTS
RH 3.4 Map2741.0UniSTS
Cytogenetic Map2q24UniSTS
AI136905  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22104,788,975 - 104,789,172 (+)MAPPERmRatBN7.2
Rnor_6.02107,217,748 - 107,217,944NCBIRnor6.0
Rnor_5.02126,952,693 - 126,952,889UniSTSRnor5.0
RGSC_v3.42107,549,125 - 107,549,321UniSTSRGSC3.4
Celera2100,105,571 - 100,105,767UniSTS
RH 3.4 Map2739.2UniSTS
Cytogenetic Map2q24UniSTS
AW532079  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22104,928,100 - 104,928,275 (+)MAPPERmRatBN7.2
Rnor_6.02107,358,275 - 107,358,449NCBIRnor6.0
Rnor_5.02127,092,780 - 127,092,954UniSTSRnor5.0
RGSC_v3.42107,687,918 - 107,688,092UniSTSRGSC3.4
Celera2100,244,384 - 100,244,558UniSTS
RH 3.4 Map2737.7UniSTS
Cytogenetic Map2q24UniSTS
RH140689  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22104,924,179 - 104,924,393 (+)MAPPERmRatBN7.2
Rnor_6.02107,354,354 - 107,354,567NCBIRnor6.0
Rnor_5.02127,088,859 - 127,089,072UniSTSRnor5.0
RGSC_v3.42107,683,997 - 107,684,210UniSTSRGSC3.4
Celera2100,240,463 - 100,240,676UniSTS
RH 3.4 Map2739.8UniSTS
Cytogenetic Map2q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 46 30 19 30 8 8 74 35 37 11 8
Low 3 11 11 11 3 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000015573   ⟹   ENSRNOP00000015573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2104,801,721 - 104,929,055 (+)Ensembl
Rnor_6.0 Ensembl2107,233,054 - 107,359,229 (+)Ensembl
RefSeq Acc Id: NM_001108941   ⟹   NP_001102411
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82106,730,665 - 106,857,989 (+)NCBI
mRatBN7.22104,801,721 - 104,929,055 (+)NCBI
Rnor_6.02107,233,054 - 107,359,229 (+)NCBI
Rnor_5.02126,957,062 - 127,093,734 (+)NCBI
RGSC_v3.42107,561,415 - 107,688,872 (+)RGD
Celera2100,118,058 - 100,245,338 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232190   ⟹   XP_006232252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82106,719,236 - 106,856,662 (+)NCBI
mRatBN7.22104,790,291 - 104,927,728 (+)NCBI
Rnor_6.02107,221,913 - 107,357,902 (+)NCBI
Rnor_5.02126,957,062 - 127,093,734 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590990   ⟹   XP_017446479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82106,787,668 - 106,856,662 (+)NCBI
mRatBN7.22104,858,730 - 104,927,728 (+)NCBI
Rnor_6.02107,288,755 - 107,357,902 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590991   ⟹   XP_017446480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82106,774,409 - 106,856,662 (+)NCBI
mRatBN7.22104,845,473 - 104,927,728 (+)NCBI
Rnor_6.02107,275,707 - 107,357,902 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102745   ⟹   XP_038958673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82106,718,811 - 106,856,662 (+)NCBI
mRatBN7.22104,789,866 - 104,927,728 (+)NCBI
RefSeq Acc Id: XM_039102746   ⟹   XP_038958674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82106,722,048 - 106,856,662 (+)NCBI
mRatBN7.22104,793,104 - 104,927,728 (+)NCBI
RefSeq Acc Id: XM_039102747   ⟹   XP_038958675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82106,718,812 - 106,856,662 (+)NCBI
mRatBN7.22104,789,867 - 104,927,728 (+)NCBI
RefSeq Acc Id: XM_039102748   ⟹   XP_038958676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82106,719,238 - 106,856,662 (+)NCBI
mRatBN7.22104,790,293 - 104,927,728 (+)NCBI
RefSeq Acc Id: NP_001102411   ⟸   NM_001108941
- UniProtKB: D3ZNF4 (UniProtKB/TrEMBL),   A6IHE1 (UniProtKB/TrEMBL),   G3V6G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232252   ⟸   XM_006232190
- Peptide Label: isoform X1
- UniProtKB: D3ZNF4 (UniProtKB/TrEMBL),   A6IHE1 (UniProtKB/TrEMBL),   G3V6G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446480   ⟸   XM_017590991
- Peptide Label: isoform X1
- UniProtKB: D3ZNF4 (UniProtKB/TrEMBL),   A6IHE1 (UniProtKB/TrEMBL),   G3V6G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446479   ⟸   XM_017590990
- Peptide Label: isoform X1
- UniProtKB: D3ZNF4 (UniProtKB/TrEMBL),   A6IHE1 (UniProtKB/TrEMBL),   G3V6G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015573   ⟸   ENSRNOT00000015573
RefSeq Acc Id: XP_038958673   ⟸   XM_039102745
- Peptide Label: isoform X1
- UniProtKB: D3ZNF4 (UniProtKB/TrEMBL),   A6IHE1 (UniProtKB/TrEMBL),   G3V6G5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958675   ⟸   XM_039102747
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038958676   ⟸   XM_039102748
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038958674   ⟸   XM_039102746
- Peptide Label: isoform X1
- UniProtKB: D3ZNF4 (UniProtKB/TrEMBL),   A6IHE1 (UniProtKB/TrEMBL),   G3V6G5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZNF4-F1-model_v2 AlphaFold D3ZNF4 1-514 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560053 AgrOrtholog
BioCyc Gene G2FUF-53546 BioCyc
Ensembl Genes ENSRNOG00000003686 UniProtKB/TrEMBL
  ENSRNOG00000011216 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004901.8 UniProtKB/TrEMBL
  ENSRNOT00000015573.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.960.30 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro Ebi-like UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep_reg UniProtKB/TrEMBL
  LisH_dimerisation UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:365755 UniProtKB/TrEMBL
NCBI Gene 365755 ENTREZGENE
PANTHER F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1 UniProtKB/TrEMBL
  F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1Y UniProtKB/TrEMBL
  PTHR22846 UniProtKB/TrEMBL
Pfam LisH UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Tbl1xr1 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE LISH UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003686 RatGTEx
  ENSRNOG00000011216 RatGTEx
SMART LisH UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt A6IHE1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZNF4 ENTREZGENE, UniProtKB/TrEMBL
  G3V6G5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Tbl1xr1  TBL1X/Y related 1  Tbl1xr1  TBL1X receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-11-11 Tbl1xr1  TBL1X receptor 1  Tbl1xr1  transducin (beta)-like 1 X-linked receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-04-14 Tbl1xr1  transducin (beta)-like 1 X-linked receptor 1  Tbl1xr1  transducin (beta)-like 1X-linked receptor 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tbl1xr1  transducin (beta)-like 1X-linked receptor 1   Tbl1xr1_predicted  transducin (beta)-like 1X-linked receptor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tbl1xr1_predicted  transducin (beta)-like 1X-linked receptor 1 (predicted)  RGD1560053_predicted  similar to IRA1 protein (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560053_predicted  similar to IRA1 protein (predicted)  LOC365755  similar to IRA1 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365755  similar to IRA1 protein      Symbol and Name status set to provisional 70820 PROVISIONAL