Smsl1 (spermine synthase like 1) - Rat Genome Database

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Gene: Smsl1 (spermine synthase like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Smsl1
Name: spermine synthase like 1
RGD ID: 1559938
Description: Predicted to enable spermine synthase activity. Predicted to be involved in spermine biosynthetic process. Human ortholog(s) of this gene implicated in anxiety disorder and syndromic X-linked intellectual disability Snyder type. Orthologous to human SMS (spermine synthase).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC498273; RGD1559938; similar to spermine synthase; spermine synthase-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,968,275 - 84,969,961 (+)NCBIGRCr8
mRatBN7.21382,435,500 - 82,436,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1382,435,520 - 82,437,158 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01388,555,973 - 88,557,189 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01393,181,907 - 93,183,212 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,045,282 - 86,046,382 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1382,096,039 - 82,097,254 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

Genomics

Variants

.
Variants in Smsl1
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000051667
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134760142692601426Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000079363   ⟹   ENSRNOP00000077155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1382,435,520 - 82,437,158 (+)Ensembl
RefSeq Acc Id: XM_039091408   ⟹   XP_038947336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,968,275 - 84,969,961 (+)NCBI
mRatBN7.21382,435,500 - 82,436,942 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038947336 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077155
  ENSRNOP00000077155.1
RefSeq Acc Id: XP_038947336   ⟸   XM_039091408
- UniProtKB: A0A8I5YBN5 (UniProtKB/TrEMBL),   A6IPQ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077155   ⟸   ENSRNOT00000079363
Protein Domains
PABS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-17481 BioCyc
Ensembl Genes ENSRNOG00000059957 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079363 ENTREZGENE
  ENSRNOT00000079363.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.140.10 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
  Siroheme synthase, domain 2 UniProtKB/TrEMBL
InterPro PABS UniProtKB/TrEMBL
  PABS_CS UniProtKB/TrEMBL
  SAM-dependent_MTases_sf UniProtKB/TrEMBL
  Spermidine_synt_N UniProtKB/TrEMBL
  Spermidine_synt_N_sf UniProtKB/TrEMBL
  Spermine_synthase_animal UniProtKB/TrEMBL
  SpmSyn_N UniProtKB/TrEMBL
NCBI Gene 498273 ENTREZGENE
PANTHER PTHR46315 UniProtKB/TrEMBL
  SPERMINE SYNTHASE UniProtKB/TrEMBL
Pfam Spermine_synt_N UniProtKB/TrEMBL
  Spermine_synth UniProtKB/TrEMBL
  SpmSyn_N UniProtKB/TrEMBL
PhenoGen Smsl1 PhenoGen
PROSITE PABS_1 UniProtKB/TrEMBL
  PABS_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059957 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8I5YBN5 ENTREZGENE, UniProtKB/TrEMBL
  A6IPQ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Smsl1  spermine synthase like 1  RGD1559938  similar to spermine synthase  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1559938  similar to spermine synthase   RGD1559938_predicted  similar to spermine synthase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559938_predicted  similar to spermine synthase (predicted)  LOC498273  similar to spermine synthase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498273  similar to spermine synthase      Symbol and Name status set to provisional 70820 PROVISIONAL