Mettl17 (methyltransferase like 17) - Rat Genome Database

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Gene: Mettl17 (methyltransferase like 17) Rattus norvegicus
Analyze
Symbol: Mettl17
Name: methyltransferase like 17
RGD ID: 1559895
Description: Predicted to enable 4 iron, 4 sulfur cluster binding activity; S-adenosyl-L-methionine binding activity; and mitochondrial ribosome binding activity. Predicted to be involved in mitochondrial small ribosomal subunit assembly. Predicted to be located in mitochondrial matrix and nucleoplasm. Orthologous to human METTL17 (methyltransferase like 17); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC305845; methyltransferase 11 domain containing 1; methyltransferase-like protein 17, mitochondrial; Mett11d1; RGD1559895; similar to FLJ20859 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,055,851 - 27,062,530 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1527,055,897 - 27,062,522 (+)EnsemblGRCr8
mRatBN7.21524,582,296 - 24,589,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,582,406 - 24,589,026 (+)EnsemblmRatBN7.2
Rnor_6.01528,287,027 - 28,293,869 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,287,024 - 28,293,864 (+)Ensemblrn6Rnor6.0
Rnor_5.01532,100,128 - 32,106,849 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,319,503 - 27,326,113NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic Map15p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:34800366  


Genomics

Comparative Map Data
Mettl17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,055,851 - 27,062,530 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1527,055,897 - 27,062,522 (+)EnsemblGRCr8
mRatBN7.21524,582,296 - 24,589,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,582,406 - 24,589,026 (+)EnsemblmRatBN7.2
Rnor_6.01528,287,027 - 28,293,869 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,287,024 - 28,293,864 (+)Ensemblrn6Rnor6.0
Rnor_5.01532,100,128 - 32,106,849 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,319,503 - 27,326,113NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic Map15p14NCBI
METTL17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,989,980 - 20,997,035 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,989,973 - 20,997,035 (+)Ensemblhg38GRCh38
GRCh371421,458,139 - 21,465,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,527,805 - 20,535,034 (+)NCBIBuild 36Build 36hg18NCBI36
Celera141,318,833 - 1,326,059 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,579,073 - 1,586,300 (+)NCBIHuRef
CHM1_11421,460,070 - 21,467,296 (+)NCBICHM1_1
T2T-CHM13v2.01415,182,526 - 15,194,435 (+)NCBIT2T-CHM13v2.0
Mettl17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,122,375 - 52,129,325 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,122,299 - 52,130,496 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381451,884,842 - 51,891,868 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,884,842 - 51,893,039 (+)Ensemblmm10GRCm38
MGSCv371452,504,517 - 52,511,543 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361450,806,793 - 50,813,819 (+)NCBIMGSCv36mm8
Celera1448,869,755 - 48,876,779 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.71NCBI
Mettl17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,747,994 - 1,756,790 (+)Ensembl
ChiLan1.0NW_0049555501,747,234 - 1,755,136 (+)NCBIChiLan1.0ChiLan1.0
METTL17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,440,577 - 22,448,345 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,657,064 - 21,664,837 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,804,655 - 1,811,771 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,886,675 - 19,893,901 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,886,675 - 19,893,901 (+)EnsemblpanPan2panpan1.1
METTL17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,094,731 - 18,099,161 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,578,855 - 18,584,700 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01518,354,159 - 18,360,005 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,354,175 - 18,359,867 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11518,035,518 - 18,041,362 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,091,509 - 18,097,354 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,219,383 - 18,225,228 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mettl17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,290,895 - 32,298,643 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936880200,396 - 207,817 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936880200,355 - 208,394 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,138,233 - 78,145,331 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1778,138,237 - 78,145,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
METTL17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,463,422 - 21,470,502 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,463,612 - 21,470,699 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605924,965,643 - 24,972,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248256,986,318 - 6,995,369 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248256,986,277 - 6,993,324 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mettl17
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000064907
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
RH141282  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81527,062,150 - 27,062,437 (+)Marker Load Pipeline
mRatBN7.21524,588,649 - 24,588,936 (+)MAPPERmRatBN7.2
Rnor_6.01528,293,490 - 28,293,776NCBIRnor6.0
Rnor_5.01532,106,470 - 32,106,756UniSTSRnor5.0
RGSC_v3.41527,325,734 - 27,326,020UniSTSRGSC3.4
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064907   ⟹   ENSRNOP00000062157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1527,055,897 - 27,062,522 (+)Ensembl
mRatBN7.2 Ensembl1524,582,406 - 24,589,026 (+)Ensembl
Rnor_6.0 Ensembl1528,287,024 - 28,293,864 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109497   ⟹   ENSRNOP00000091879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,582,419 - 24,588,980 (+)Ensembl
RefSeq Acc Id: NM_001427254   ⟹   NP_001414183
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,055,911 - 27,062,530 (+)NCBI
RefSeq Acc Id: XR_005493934
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,055,851 - 27,060,810 (+)NCBI
mRatBN7.21524,582,299 - 24,587,313 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414183 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062157
  ENSRNOP00000062157.1
  ENSRNOP00000091879.1
Ensembl Acc Id: ENSRNOP00000062157   ⟸   ENSRNOT00000064907
Ensembl Acc Id: ENSRNOP00000091879   ⟸   ENSRNOT00000109497
RefSeq Acc Id: NP_001414183   ⟸   NM_001427254
- UniProtKB: D3Z930 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z930-F1-model_v2 AlphaFold D3Z930 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699641
Promoter ID:EPDNEW_R10154
Type:multiple initiation site
Name:Mettl17_1
Description:methyltransferase like 17
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,287,256 - 28,287,316EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559895 AgrOrtholog
BioCyc Gene G2FUF-14004 BioCyc
Ensembl Genes ENSRNOG00000025512 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064907 ENTREZGENE
  ENSRNOT00000064907.4 UniProtKB/TrEMBL
  ENSRNOT00000109497.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro Mt_RNA_Methyltransferase UniProtKB/TrEMBL
  Ribosomal_Rsm22_bac-type UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
NCBI Gene 305845 ENTREZGENE
PANTHER 37S RIBOSOMAL PROTEIN S22 UniProtKB/TrEMBL
  METHYLTRANSFERASE LIKE UniProtKB/TrEMBL
Pfam Rsm22 UniProtKB/TrEMBL
PhenoGen Mettl17 PhenoGen
RatGTEx ENSRNOG00000025512 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8I6AGH5_RAT UniProtKB/TrEMBL
  D3Z930 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Mettl17  methyltransferase like 17  Mett11d1  methyltransferase 11 domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Mett11d1  methyltransferase 11 domain containing 1  RGD1559895_predicted  similar to FLJ20859 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559895_predicted  similar to FLJ20859 protein (predicted)  LOC305845  similar to FLJ20859 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305845  similar to FLJ20859 protein      Symbol and Name status set to provisional 70820 PROVISIONAL