Ern1 (endoplasmic reticulum to nucleus signaling 1) - Rat Genome Database

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Gene: Ern1 (endoplasmic reticulum to nucleus signaling 1) Rattus norvegicus
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Symbol: Ern1
Name: endoplasmic reticulum to nucleus signaling 1
RGD ID: 1559716
Description: Enables Hsp90 protein binding activity. Involved in cellular response to glucose stimulus; cellular response to hydrogen peroxide; and cellular response to manganese ion. Predicted to be located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Predicted to be part of AIP1-IRE1 complex; IRE1-RACK1-PP2A complex; and IRE1-TRAF2-ASK1 complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer's disease pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,4-dithiothreitol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endoplasmic reticulum (ER) to nucleus signalling 1; LOC498013; RGD1559716; serine/threonine-protein kinase/endoribonuclease IRE1; similar to protein kinase/endoribonuclease(IRE1) alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,826,663 - 91,920,976 (-)NCBIGRCr8
mRatBN7.21091,326,889 - 91,421,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,330,654 - 91,421,029 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,385,286 - 96,446,643 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,848,447 - 95,909,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,259,314 - 91,320,624 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,588,555 - 94,682,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,588,555 - 94,681,914 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,336,640 - 94,429,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,794,488 - 95,855,895 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1090,003,932 - 90,064,578 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
abamectin  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
agomelatine  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-D-galactose  (EXP)
amiloride  (ISO)
amiodarone  (ISO)
amosite asbestos  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
aucubin  (ISO)
Azaspiracid  (ISO)
baicalin  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bicuculline  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calix[6]arene  (ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerulenin  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
choline  (ISO)
chrysophanol  (ISO)
cisplatin  (EXP,ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
dihydrocapsaicin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dizocilpine maleate  (EXP)
doxorubicin  (EXP)
edaravone  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
epoxomicin  (ISO)
erastin  (ISO)
ethanol  (ISO)
EUK-134  (ISO)
fentin chloride  (EXP)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
flufenoxuron  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (ISO)
gadolinium trichloride  (EXP)
galactose  (EXP)
gamma-aminobutyric acid  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
Guanabenz  (EXP)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
indometacin  (ISO)
isoliquiritigenin  (EXP)
L-1,4-dithiothreitol  (EXP,ISO)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
licoricidin  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lycopene  (EXP)
manganese(II) chloride  (EXP)
melatonin  (EXP)
metacetamol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methyltestosterone  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mithramycin  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morusin  (ISO)
muscimol  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naltrexone  (ISO)
nicotine  (ISO)
Nivalenol  (ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
orlistat  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
perhexiline  (ISO)
pirinixic acid  (EXP,ISO)
poly(guanylic acid)  (EXP)
potassium iodide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
procymidone  (ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
Salidroside  (ISO)
SCH 23390  (EXP)
sertraline  (ISO)
Shikonin  (EXP)
silicon dioxide  (EXP)
sincalide  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanillic acid  (ISO)
vemurafenib  (ISO)
vildagliptin  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
zerumbone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma. Archer KJ, etal., Mol Genet Genomics. 2010 Apr;283(4):341-9. doi: 10.1007/s00438-010-0522-y. Epub 2010 Feb 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells. Lipson KL, etal., PLoS One. 2008 Feb 20;3(2):e1648. doi: 10.1371/journal.pone.0001648.
4. Expression of XBP1s in peritoneal mesothelial cells is critical for inflammation-induced peritoneal fibrosis. Liu A, etal., Sci Rep. 2019 Dec 13;9(1):19043. doi: 10.1038/s41598-019-55557-1.
5. Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats. Liu J, etal., Int J Mol Med. 2018 Nov;42(5):2891-2902. doi: 10.3892/ijmm.2018.3858. Epub 2018 Sep 5.
6. [Over-expressed Bax inhibitor 1 (BI-1) inhibits apoptosis of hippocampal neurons via endoplasmic reticulum IRE1-JNK pathway in rats with subarachnoid hemorrhage]. Liu J, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Oct;33(10):1316-1322.
7. Dexmedetomidine attenuates H2O2-induced neonatal rat cardiomyocytes apoptosis through mitochondria- and ER-medicated oxidative stress pathways. Liu XR, etal., Mol Med Rep. 2018 May;17(5):7258-7264. doi: 10.3892/mmr.2018.8751. Epub 2018 Mar 15.
8. Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
9. Interleukin-6 production mediated by the IRE1-XBP1 pathway confers radioresistance in human papillomavirus-negative oropharyngeal carcinoma. Lyu X, etal., Cancer Sci. 2019 Aug;110(8):2471-2484. doi: 10.1111/cas.14094. Epub 2019 Jul 3.
10. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Marcu MG, etal., Mol Cell Biol. 2002 Dec;22(24):8506-13.
11. Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B. Ren F, etal., J Viral Hepat. 2016 Jan;23(1):23-31. doi: 10.1111/jvh.12438. Epub 2015 Jul 31.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
18. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Urano F, etal., Science. 2000 Jan 28;287(5453):664-6.
19. The impact of the unfolded protein response on human disease. Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.
20. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
21. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
22. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
Additional References at PubMed
PMID:9637683   PMID:9755171   PMID:10882126   PMID:11146108   PMID:11430819   PMID:11779464   PMID:11779465   PMID:11850408   PMID:12637535   PMID:15601821   PMID:16645094   PMID:16973740  
PMID:18281285   PMID:19328063   PMID:19622636   PMID:19875812   PMID:20103773   PMID:20625543   PMID:20798350   PMID:21317875   PMID:21779001   PMID:21896783   PMID:22529213   PMID:23000344  
PMID:23028046   PMID:23103912   PMID:23529610   PMID:24180212   PMID:24508390   PMID:24936061   PMID:25011481   PMID:25164867   PMID:26315405   PMID:26711306   PMID:27655546   PMID:28114319  
PMID:28436754   PMID:29198525   PMID:30763911   PMID:31467308   PMID:32199617   PMID:32272965   PMID:32950473   PMID:33179109   PMID:35085541  


Genomics

Comparative Map Data
Ern1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,826,663 - 91,920,976 (-)NCBIGRCr8
mRatBN7.21091,326,889 - 91,421,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,330,654 - 91,421,029 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,385,286 - 96,446,643 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,848,447 - 95,909,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,259,314 - 91,320,624 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,588,555 - 94,682,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,588,555 - 94,681,914 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,336,640 - 94,429,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,794,488 - 95,855,895 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1090,003,932 - 90,064,578 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
ERN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381764,039,142 - 64,130,144 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1764,039,080 - 64,130,819 (-)EnsemblGRCh38hg38GRCh38
GRCh371762,116,502 - 62,207,504 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,474,122 - 59,561,234 (-)NCBINCBI36Build 36hg18NCBI36
Celera1756,508,473 - 56,595,582 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,488,466 - 57,575,481 (-)NCBIHuRef
CHM1_11762,184,805 - 62,271,973 (-)NCBICHM1_1
T2T-CHM13v2.01764,909,877 - 65,000,874 (-)NCBIT2T-CHM13v2.0
Ern1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,285,474 - 106,378,701 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,285,476 - 106,378,678 (-)EnsemblGRCm39 Ensembl
GRCm3811106,397,620 - 106,487,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,394,650 - 106,487,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,258,934 - 106,349,110 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,213,710 - 106,303,886 (-)NCBIMGSCv36mm8
Celera11118,128,975 - 118,219,164 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1169.14NCBI
Ern1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,751,830 - 7,799,460 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,720,664 - 7,803,662 (+)NCBIChiLan1.0ChiLan1.0
ERN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,222,161 - 80,313,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11785,042,461 - 85,133,625 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,132,889 - 58,224,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,226,949 - 63,317,825 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,226,949 - 63,317,825 (-)Ensemblpanpan1.1panPan2
ERN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,930,614 - 12,006,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,934,965 - 12,006,814 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,825,652 - 12,903,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,591,579 - 13,669,839 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,591,584 - 13,669,995 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,538,344 - 12,616,358 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0914,915,804 - 14,993,944 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0914,918,080 - 14,996,082 (+)NCBIUU_Cfam_GSD_1.0
Ern1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,488,687 - 14,581,401 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,617,555 - 4,705,866 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,613,197 - 4,705,911 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,881,923 - 14,963,284 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11214,881,913 - 14,963,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21214,918,929 - 14,954,855 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,145,080 - 57,233,757 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,145,191 - 57,236,230 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607727,756,105 - 27,847,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ern1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,525,235 - 1,625,893 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,521,996 - 1,625,878 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ern1
410 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:85
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000017371
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat

Markers in Region
BI280353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,326,927 - 91,327,112 (+)MAPPERmRatBN7.2
Rnor_6.01094,588,594 - 94,588,778NCBIRnor6.0
Rnor_5.01094,336,679 - 94,336,863UniSTSRnor5.0
RGSC_v3.41095,790,762 - 95,790,946UniSTSRGSC3.4
Celera1090,000,206 - 90,000,390UniSTS
RH 3.4 Map10981.4UniSTS
Cytogenetic Map10q32.1UniSTS
AA866270  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,436,797 - 91,436,993 (+)MAPPERmRatBN7.2
Rnor_6.01094,698,131 - 94,698,326NCBIRnor6.0
Rnor_5.01094,446,111 - 94,446,306UniSTSRnor5.0
RGSC_v3.41096,001,780 - 96,001,975UniSTSRGSC3.4
Celera1090,109,459 - 90,109,654UniSTS
RH 3.4 Map10973.9UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 29 20 7 20 1 16 20 23 11
Low 1 39 28 21 12 21 8 10 58 15 18 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000017371   ⟹   ENSRNOP00000017371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,330,654 - 91,391,879 (-)Ensembl
Rnor_6.0 Ensembl1094,592,320 - 94,652,658 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085736   ⟹   ENSRNOP00000072244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,330,664 - 91,421,029 (-)Ensembl
Rnor_6.0 Ensembl1094,588,555 - 94,681,914 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107730   ⟹   ENSRNOP00000079836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,366,224 - 91,421,029 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108922   ⟹   ENSRNOP00000086547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,365,169 - 91,421,029 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116974   ⟹   ENSRNOP00000093755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,330,654 - 91,389,792 (-)Ensembl
RefSeq Acc Id: NM_001191926   ⟹   NP_001178855
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,830,428 - 91,891,648 (-)NCBI
mRatBN7.21091,330,654 - 91,391,879 (-)NCBI
Rnor_6.01094,592,320 - 94,652,658 (-)NCBI
Rnor_5.01094,336,640 - 94,429,967 (-)NCBI
Celera1090,003,932 - 90,064,578 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247634   ⟹   XP_006247696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,826,663 - 91,920,976 (-)NCBI
mRatBN7.21091,326,889 - 91,421,200 (-)NCBI
Rnor_6.01094,588,555 - 94,682,072 (-)NCBI
Rnor_5.01094,336,640 - 94,429,967 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597474   ⟹   XP_017452963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,826,663 - 91,903,527 (-)NCBI
mRatBN7.21091,326,889 - 91,421,201 (-)NCBI
Rnor_6.01094,588,555 - 94,681,971 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086647   ⟹   XP_038942575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,826,663 - 91,894,819 (-)NCBI
mRatBN7.21091,326,889 - 91,395,048 (-)NCBI
RefSeq Acc Id: XM_063269670   ⟹   XP_063125740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,826,663 - 91,866,112 (-)NCBI
RefSeq Acc Id: NP_001178855   ⟸   NM_001191926
- UniProtKB: F1LSY7 (UniProtKB/TrEMBL),   A0A8I6AJE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247696   ⟸   XM_006247634
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K2H4 (UniProtKB/TrEMBL),   A6HK45 (UniProtKB/TrEMBL),   A0A8I6AJE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452963   ⟸   XM_017597474
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AJE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017371   ⟸   ENSRNOT00000017371
RefSeq Acc Id: ENSRNOP00000072244   ⟸   ENSRNOT00000085736
RefSeq Acc Id: XP_038942575   ⟸   XM_039086647
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AJE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079836   ⟸   ENSRNOT00000107730
RefSeq Acc Id: ENSRNOP00000093755   ⟸   ENSRNOT00000116974
RefSeq Acc Id: ENSRNOP00000086547   ⟸   ENSRNOT00000108922
RefSeq Acc Id: XP_063125740   ⟸   XM_063269670
- Peptide Label: isoform X4
Protein Domains
KEN   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2H4-F1-model_v2 AlphaFold A0A0G2K2H4 1-977 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697849
Promoter ID:EPDNEW_R8370
Type:single initiation site
Name:Ern1_1
Description:endoplasmic reticulum to nucleus signaling 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,681,912 - 94,681,972EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559716 AgrOrtholog
BioCyc Gene G2FUF-22944 BioCyc
Ensembl Genes ENSRNOG00000012864 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017371 ENTREZGENE
  ENSRNOT00000017371.6 UniProtKB/TrEMBL
  ENSRNOT00000085736.2 UniProtKB/TrEMBL
  ENSRNOT00000107730.1 UniProtKB/TrEMBL
  ENSRNOT00000108922.1 UniProtKB/TrEMBL
  ENSRNOT00000116974.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.180 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IRE1/2-like UniProtKB/TrEMBL
  KEN_RNase_activator UniProtKB/TrEMBL
  KEN_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PQQ_beta_propeller_repeat UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Quinonprotein_ADH-like UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
KEGG Report rno:498013 UniProtKB/TrEMBL
NCBI Gene 498013 ENTREZGENE
PANTHER PTHR13954 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Ribonuc_2-5A UniProtKB/TrEMBL
PhenoGen Ern1 PhenoGen
PROSITE KEN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012864 RatGTEx
SMART PQQ UniProtKB/TrEMBL
  PUG UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  Quin_alc_DH_like UniProtKB/TrEMBL
UniProt A0A0G2K2H4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPE4_RAT UniProtKB/TrEMBL
  A0A8I6A2F5_RAT UniProtKB/TrEMBL
  A0A8I6AJE4 ENTREZGENE, UniProtKB/TrEMBL
  A6HK45 ENTREZGENE, UniProtKB/TrEMBL
  F1LSY7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-29 Ern1  endoplasmic reticulum to nucleus signaling 1  Ern1  endoplasmic reticulum (ER) to nucleus signalling 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Ern1  endoplasmic reticulum (ER) to nucleus signalling 1  RGD1559716_predicted  similar to protein kinase/endoribonuclease(IRE1) alpha (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559716_predicted  similar to protein kinase/endoribonuclease(IRE1) alpha (predicted)  LOC498013  similar to protein kinase/endoribonuclease(IRE1) alpha  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498013  similar to protein kinase/endoribonuclease(IRE1) alpha      Symbol and Name status set to provisional 70820 PROVISIONAL