Wwtr1 (WW domain containing transcription regulator 1) - Rat Genome Database

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Gene: Wwtr1 (WW domain containing transcription regulator 1) Rattus norvegicus
Analyze
Symbol: Wwtr1
Name: WW domain containing transcription regulator 1
RGD ID: 1559609
Description: Predicted to enable protein homodimerization activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in several processes, including intracellular signal transduction; negative regulation of canonical Wnt signaling pathway; and positive regulation of cell differentiation. Predicted to act upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; kidney development; and negative regulation of fat cell differentiation. Located in nucleus. Orthologous to human WWTR1 (WW domain containing transcription regulator 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC116096; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain-containing transcription regulator protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: Some orthologs of Taz (Gene ID: 363521) and Wwtr1 (Gene ID: 295062), such as the human and mouse orthologs, share the Taz symbol/alias in common. Taz is a widely used alternative name for WW domain-containing transcription regulator protein 1 (Wwtr1), which can be confused with the official symbol for tafazzin (Taz). [20 Dec 2019]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82143,801,181 - 143,916,941 (-)NCBIGRCr8
mRatBN7.22141,651,159 - 141,766,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2141,648,108 - 141,766,968 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2148,286,435 - 148,401,721 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02146,397,866 - 146,513,776 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02141,030,287 - 141,146,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02147,577,149 - 147,693,033 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2147,577,089 - 147,693,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02166,985,078 - 167,101,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42146,713,977 - 146,831,603 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2136,102,030 - 136,217,634 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4-phenylbutyric acid  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bucladesine  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
glycidyl methacrylate  (ISO)
inulin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Licochalcone A  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
rimonabant  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
nuclear body  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)
tight junction  (ISO)
transcription regulator complex  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Di Palma T, etal., Exp Cell Res. 2009 Jan 15;315(2):162-75. doi: 10.1016/j.yexcr.2008.10.016. Epub 2008 Oct 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11118213   PMID:14970209   PMID:16099986   PMID:16300735   PMID:16332960   PMID:17251353   PMID:17636028   PMID:18172001   PMID:18227151   PMID:18568018   PMID:20412773   PMID:21474562  
PMID:23918388   PMID:23974041   PMID:23998984   PMID:26549225   PMID:26625714   PMID:27444891   PMID:27548520   PMID:27683908   PMID:28642262   PMID:28647773   PMID:29356923   PMID:30716312  
PMID:31389578   PMID:31970784   PMID:33296068   PMID:34062912   PMID:34188130   PMID:34407229   PMID:34726504   PMID:37832483   PMID:38610069  


Genomics

Comparative Map Data
Wwtr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82143,801,181 - 143,916,941 (-)NCBIGRCr8
mRatBN7.22141,651,159 - 141,766,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2141,648,108 - 141,766,968 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2148,286,435 - 148,401,721 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02146,397,866 - 146,513,776 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02141,030,287 - 141,146,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02147,577,149 - 147,693,033 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2147,577,089 - 147,693,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02166,985,078 - 167,101,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42146,713,977 - 146,831,603 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2136,102,030 - 136,217,634 (-)NCBICelera
Cytogenetic Map2q26NCBI
WWTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383149,517,235 - 149,724,788 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3149,517,235 - 149,736,714 (-)EnsemblGRCh38hg38GRCh38
GRCh373149,235,022 - 149,442,575 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363150,720,722 - 150,858,472 (-)NCBINCBI36Build 36hg18NCBI36
Build 343150,720,730 - 150,858,480NCBI
Celera3147,646,975 - 147,833,799 (-)NCBICelera
Cytogenetic Map3q25.1NCBI
HuRef3146,607,062 - 146,793,082 (-)NCBIHuRef
CHM1_13149,197,935 - 149,382,368 (-)NCBICHM1_1
T2T-CHM13v2.03152,268,462 - 152,476,040 (-)NCBIT2T-CHM13v2.0
Wwtr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39357,363,065 - 57,483,331 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl357,363,070 - 57,483,331 (-)EnsemblGRCm39 Ensembl
GRCm38357,455,644 - 57,575,910 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl357,455,649 - 57,575,910 (-)EnsemblGRCm38mm10GRCm38
MGSCv37357,259,566 - 57,379,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36357,543,578 - 57,663,805 (-)NCBIMGSCv36mm8
Celera357,146,741 - 57,267,379 (-)NCBICelera
Cytogenetic Map3DNCBI
cM Map327.74NCBI
Wwtr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955448745,419 - 868,602 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955448745,419 - 868,313 (-)NCBIChiLan1.0ChiLan1.0
WWTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22147,407,776 - 147,548,748 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13147,412,506 - 147,555,680 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03146,536,564 - 146,678,847 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13154,114,034 - 154,254,479 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3154,114,034 - 154,254,490 (-)Ensemblpanpan1.1panPan2
WWTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12344,277,707 - 44,409,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2344,278,557 - 44,410,007 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2344,141,713 - 44,274,178 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02344,904,503 - 45,038,166 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2344,904,518 - 45,038,243 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12344,492,243 - 44,625,480 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02344,541,043 - 44,673,939 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02344,796,227 - 44,929,932 (-)NCBIUU_Cfam_GSD_1.0
Wwtr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560291,542,546 - 91,666,185 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936758101,620 - 225,525 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936758101,629 - 225,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WWTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1389,742,886 - 89,889,187 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11389,742,980 - 89,889,547 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21397,746,662 - 97,893,487 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WWTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,051,827 - 41,193,266 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1541,052,614 - 41,193,268 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604113,883,654 - 14,025,222 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wwtr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473026,813,624 - 26,967,691 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473026,813,716 - 26,967,615 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wwtr1
601 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:82
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000022507
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
12879830Bw178Body weight QTL 1780.001body mass (VT:0001259)body weight (CMO:0000012)2137219876142323610Rat
12879831Cm82Cardiac mass QTL 820.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2137219876142323610Rat
12879832Cm83Cardiac mass QTL 830.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2137219876142323610Rat
12879833Cm84Cardiac mass QTL 840.001heart right ventricle mass (VT:0007033)heart weight to body weight ratio (CMO:0000074)2137219876142323610Rat
12879834Am1Aortic mass QTL 10.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2137219876142323610Rat
12879835Kidm60Kidney mass QTL 600.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2137219876142323610Rat
1549841Bp256Blood pressure QTL 2560.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2137219876142323610Rat
7488931Bp367Blood pressure QTL 3670.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2139401804142323610Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat

Markers in Region
AU047912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22141,672,999 - 141,673,187 (+)MAPPERmRatBN7.2
Rnor_6.02147,598,989 - 147,599,176NCBIRnor6.0
Rnor_5.02167,007,030 - 167,007,217UniSTSRnor5.0
RGSC_v3.42146,735,817 - 146,736,004UniSTSRGSC3.4
Celera2136,123,869 - 136,124,056UniSTS
Cytogenetic Map2q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 42 11 2 9 2 8 11 39 35 34 11 8
Low 3 1 46 39 10 39 35 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000022507   ⟹   ENSRNOP00000022507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2141,648,108 - 141,766,968 (-)Ensembl
Rnor_6.0 Ensembl2147,577,089 - 147,693,082 (-)Ensembl
RefSeq Acc Id: NM_001024869   ⟹   NP_001020040
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82143,801,181 - 143,916,941 (-)NCBI
mRatBN7.22141,651,159 - 141,766,919 (-)NCBI
Rnor_6.02147,577,149 - 147,693,033 (-)NCBI
Rnor_5.02166,985,078 - 167,101,346 (-)NCBI
RGSC_v3.42146,713,977 - 146,831,603 (-)RGD
Celera2136,102,030 - 136,217,634 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020040 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97968 (Get FASTA)   NCBI Sequence Viewer  
  EDM14888 (Get FASTA)   NCBI Sequence Viewer  
  EDM14889 (Get FASTA)   NCBI Sequence Viewer  
  EDM14890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022507
  ENSRNOP00000022507.3
RefSeq Acc Id: NP_001020040   ⟸   NM_001024869
- UniProtKB: Q4V7E6 (UniProtKB/TrEMBL),   F7F4A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022507   ⟸   ENSRNOT00000022507
Protein Domains
WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7E6-F1-model_v2 AlphaFold Q4V7E6 1-395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691337
Promoter ID:EPDNEW_R1862
Type:initiation region
Name:Wwtr1_1
Description:WW domain containing transcription regulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02147,693,077 - 147,693,137EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559609 AgrOrtholog
BioCyc Gene G2FUF-53032 BioCyc
Ensembl Genes ENSRNOG00000016617 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022507 ENTREZGENE
  ENSRNOT00000022507.6 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  6.20.430.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7441820 IMAGE-MGC_LOAD
InterPro WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:295062 UniProtKB/TrEMBL
MGC_CLONE MGC:116096 IMAGE-MGC_LOAD
NCBI Gene 295062 ENTREZGENE
PANTHER WW DOMAIN-CONTAINING TRANSCRIPTION REGULATOR PROTEIN 1 UniProtKB/TrEMBL
  YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER UniProtKB/TrEMBL
Pfam PF00397 UniProtKB/TrEMBL
PhenoGen Wwtr1 PhenoGen
PROSITE WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016617 RatGTEx
SMART SM00456 UniProtKB/TrEMBL
Superfamily-SCOP WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt F7F4A7 ENTREZGENE, UniProtKB/TrEMBL
  Q4V7E6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Wwtr1  WW domain containing transcription regulator 1  MGC116096  transcriptional co-activator with PDZ-binding motif (TA)Z  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC116096  transcriptional co-activator with PDZ-binding motif (TA)Z      Symbol and Name status set to provisional 70820 PROVISIONAL