Med1 (mediator complex subunit 1) - Rat Genome Database

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Gene: Med1 (mediator complex subunit 1) Rattus norvegicus
Analyze
Symbol: Med1
Name: mediator complex subunit 1
RGD ID: 1559552
Description: Enables several functions, including DNA binding activity; histone acetyltransferase binding activity; and nuclear receptor binding activity. Contributes to ubiquitin protein ligase activity. Involved in cellular response to thyroid hormone stimulus; positive regulation of transcription by RNA polymerase II; and protein ubiquitination. Located in chromatin. Part of protein-DNA complex and ubiquitin ligase complex. Orthologous to human MED1 (mediator complex subunit 1); PARTICIPATES IN cortisol signaling pathway; estrogen signaling pathway; RNA polymerase II transcription pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC497991; mediator of RNA polymerase II transcription subunit 1; RGD1559552; similar to peroxisome proliferator-activated receptor binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,641,851 - 83,685,560 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1083,641,862 - 83,685,545 (-)EnsemblGRCr8
mRatBN7.21083,145,538 - 83,189,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,145,568 - 83,189,299 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,091,753 - 88,133,134 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,589,837 - 87,631,219 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,982,482 - 83,023,863 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,101,560 - 86,145,271 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,103,600 - 86,144,880 (-)Ensemblrn6Rnor6.0
Rnor_5.01085,899,172 - 85,942,182 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41086,917,525 - 86,959,080 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1081,896,663 - 81,937,929 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
10H-phenothiazine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
butamben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carmustine  (ISO)
chloroethene  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clemizole  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproterone acetate  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
Dicyclohexyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
Falecalcitriol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pentobarbital  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phthalic acid  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulconazole  (ISO)
tiratricol  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
Zoxazolamine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen biosynthetic process  (IEA,ISO,ISS)
angiogenesis  (IEA,ISO,ISS)
animal organ morphogenesis  (IEA,ISO)
animal organ regeneration  (IEA,ISO)
brain development  (IEA,ISO)
camera-type eye development  (IEA,ISO)
cell morphogenesis  (IEA,ISO,ISS)
cellular response to epidermal growth factor stimulus  (IEA,ISO,ISS)
cellular response to hepatocyte growth factor stimulus  (IEA,ISO)
cellular response to steroid hormone stimulus  (IEA,ISO)
cellular response to thyroid hormone stimulus  (IBA,IDA,IEA,ISO)
embryonic heart tube development  (IEA,ISO)
embryonic hemopoiesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic placenta development  (IEA,ISO)
enucleate erythrocyte development  (IEA,ISO)
epithelial cell proliferation involved in mammary gland duct elongation  (IEA,ISO)
erythrocyte development  (IEA,ISO,ISS)
fat cell differentiation  (IEA,ISO)
G0 to G1 transition  (IEA)
heart development  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA)
in utero embryonic development  (IEA,ISO)
keratinocyte differentiation  (IEA,ISO,ISS)
lactation  (IEA,ISO)
lens development in camera-type eye  (IEA,ISO,ISS)
liver development  (IEA,ISO)
mammary gland branching involved in pregnancy  (IEA,ISO)
mammary gland branching involved in thelarche  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
megakaryocyte development  (IEA,ISO,ISS)
monocyte differentiation  (IEA,ISO)
mRNA transcription by RNA polymerase II  (IEA,ISO,ISS)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of keratinocyte proliferation  (IEA,ISO,ISS)
negative regulation of neuron differentiation  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
nuclear receptor-mediated steroid hormone signaling pathway  (IEA,ISO,ISS)
peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of erythrocyte differentiation  (IEA,ISO)
positive regulation of G0 to G1 transition  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of hepatocyte proliferation  (IEA,ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (IEA,ISO)
positive regulation of keratinocyte differentiation  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO,ISS)
positive regulation of transcription initiation by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of type II interferon-mediated signaling pathway  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
protein ubiquitination  (IDA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of RNA biosynthetic process  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA)
regulation of vitamin D receptor signaling pathway  (IEA,ISO)
retinal pigment epithelium development  (IEA,ISO)
thyroid hormone generation  (IEA,ISO)
thyroid hormone receptor signaling pathway  (IEA,ISO,ISS)
ventricular trabecula myocardium morphogenesis  (IEA,ISO)

Cellular Component
chromatin  (IDA)
core mediator complex  (IEA,ISO)
mediator complex  (IBA,IEA,ISO,ISS)
nucleolus  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
protein-DNA complex  (IDA)
ubiquitin ligase complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, etal., Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10353-8. Epub 2002 Jul 29.
2. 1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex. Carvallo L, etal., J Cell Physiol. 2008 Mar;214(3):740-9.
3. Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription. Chia DJ and Rotwein P, Mol Endocrinol. 2010 Oct;24(10):2038-49. Epub 2010 Aug 11.
4. Dispersed Chromosomal Stat5b-binding elements mediate growth hormone-activated insulin-like growth factor-I gene transcription. Chia DJ, etal., J Biol Chem. 2010 Jun 4;285(23):17636-47. doi: 10.1074/jbc.M110.117697. Epub 2010 Apr 7.
5. Comparative distribution of the mammalian mediator subunit thyroid hormone receptor-associated protein (TRAP220) mRNA in developing and adult rodent brain. Galeeva A, etal., Eur J Neurosci. 2002 Aug;16(4):671-83.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
8. Novel glucocorticoid receptor coactivator effector mechanisms. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
9. Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice. Jia Y, etal., PLoS One. 2016 Aug 22;11(8):e0160755. doi: 10.1371/journal.pone.0160755. eCollection 2016.
10. The Mediator complex and transcription regulation. Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo. Sharma D and Fondell JD, Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7934-9. Epub 2002 May 28.
14. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11836-41.
15. Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes. Treuter E, etal., J Biol Chem. 1999 Mar 5;274(10):6667-77.
Additional References at PubMed
PMID:9325263   PMID:9653119   PMID:10198638   PMID:10235267   PMID:10478845   PMID:10747854   PMID:10882104   PMID:11724781   PMID:11867769   PMID:12037571   PMID:12093747   PMID:12218053  
PMID:12446761   PMID:14500757   PMID:14638676   PMID:15150259   PMID:15340084   PMID:15632090   PMID:15647257   PMID:15681609   PMID:15843544   PMID:16314496   PMID:16324150   PMID:16723356  
PMID:16828057   PMID:17082781   PMID:17132730   PMID:17223341   PMID:17438330   PMID:17641689   PMID:17827210   PMID:17962186   PMID:18339625   PMID:18391015   PMID:18722179   PMID:19497978  
PMID:19946888   PMID:20351249   PMID:20508642   PMID:20720539   PMID:21098667   PMID:22323595   PMID:24245781   PMID:29519872   PMID:30361391   PMID:34853629  


Genomics

Comparative Map Data
Med1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,641,851 - 83,685,560 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1083,641,862 - 83,685,545 (-)EnsemblGRCr8
mRatBN7.21083,145,538 - 83,189,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,145,568 - 83,189,299 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,091,753 - 88,133,134 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,589,837 - 87,631,219 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,982,482 - 83,023,863 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,101,560 - 86,145,271 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,103,600 - 86,144,880 (-)Ensemblrn6Rnor6.0
Rnor_5.01085,899,172 - 85,942,182 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41086,917,525 - 86,959,080 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1081,896,663 - 81,937,929 (-)NCBICelera
Cytogenetic Map10q31NCBI
MED1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,404,285 - 39,451,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,404,285 - 39,451,272 (-)Ensemblhg38GRCh38
GRCh371737,560,538 - 37,607,516 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,814,064 - 34,861,053 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341734,816,379 - 34,861,030NCBI
Celera1734,221,470 - 34,268,494 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,354,022 - 33,401,237 (-)NCBIHuRef
CHM1_11737,796,744 - 37,843,728 (-)NCBICHM1_1
T2T-CHM13v2.01740,268,198 - 40,315,170 (-)NCBIT2T-CHM13v2.0
Med1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,042,980 - 98,084,121 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,042,980 - 98,084,119 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381198,152,154 - 98,193,313 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,152,154 - 98,193,293 (-)Ensemblmm10GRCm38
MGSCv371198,013,468 - 98,054,607 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361197,968,244 - 98,009,350 (-)NCBIMGSCv36mm8
Celera11107,807,134 - 107,848,278 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
Med1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,202,744 - 14,237,797 (-)Ensembl
ChiLan1.0NW_00495545114,204,326 - 14,237,809 (-)NCBIChiLan1.0ChiLan1.0
MED1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,502,545 - 25,550,519 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,397,326 - 27,444,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,836,350 - 17,883,610 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11718,050,250 - 18,096,109 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1718,050,474 - 18,095,118 (+)EnsemblpanPan2panpan1.1
MED1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,989,257 - 23,019,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,989,301 - 23,019,349 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha922,461,097 - 22,488,309 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0923,782,837 - 23,810,295 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,782,848 - 23,813,191 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,554,940 - 22,582,360 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,816,047 - 22,843,443 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,941,470 - 22,968,890 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Med1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,411,935 - 22,448,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,625,897 - 14,657,802 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,625,201 - 14,663,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,841,205 - 22,872,409 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11222,830,405 - 22,872,420 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,283,204 - 23,325,356 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MED1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,719,393 - 66,764,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,719,423 - 66,762,896 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607737,634,868 - 37,686,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,572,266 - 3,607,126 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247953,572,025 - 3,605,675 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Med1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1956,200,355 - 56,242,534 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Med1
182 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:483
Count of miRNA genes:249
Interacting mature miRNAs:313
Transcripts:ENSRNOT00000067901
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
BI295735  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,150,885 - 83,151,070 (+)MAPPERmRatBN7.2
Rnor_6.01086,106,904 - 86,107,088NCBIRnor6.0
Rnor_5.01085,904,516 - 85,904,700UniSTSRnor5.0
RGSC_v3.41086,920,829 - 86,921,013UniSTSRGSC3.4
Celera1081,899,967 - 81,900,151UniSTS
RH 3.4 Map10850.6UniSTS
Cytogenetic Map10q31UniSTS
RH140774  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,147,270 - 83,147,424 (+)MAPPERmRatBN7.2
Rnor_6.01086,103,289 - 86,103,442NCBIRnor6.0
Rnor_5.01085,900,901 - 85,901,054UniSTSRnor5.0
RGSC_v3.41086,917,214 - 86,917,367UniSTSRGSC3.4
Celera1081,896,352 - 81,896,505UniSTS
RH 3.4 Map10850.9UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000067901   ⟹   ENSRNOP00000059848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1083,641,862 - 83,685,545 (-)Ensembl
mRatBN7.2 Ensembl1083,147,582 - 83,188,865 (-)Ensembl
Rnor_6.0 Ensembl1086,103,600 - 86,144,880 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101134   ⟹   ENSRNOP00000080764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,148,322 - 83,189,299 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105226   ⟹   ENSRNOP00000090271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1083,641,862 - 83,685,545 (-)Ensembl
mRatBN7.2 Ensembl1083,147,582 - 83,189,299 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114652   ⟹   ENSRNOP00000085900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,145,568 - 83,189,235 (-)Ensembl
RefSeq Acc Id: NM_001415766   ⟹   NP_001402695
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,641,851 - 83,685,545 (-)NCBI
mRatBN7.21083,145,538 - 83,189,237 (-)NCBI
RefSeq Acc Id: XM_006247399   ⟹   XP_006247461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,641,851 - 83,685,560 (-)NCBI
mRatBN7.21083,145,538 - 83,189,260 (-)NCBI
Rnor_6.01086,101,561 - 86,145,271 (-)NCBI
Rnor_5.01085,899,172 - 85,942,182 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247401   ⟹   XP_006247463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,641,851 - 83,685,559 (-)NCBI
mRatBN7.21083,145,538 - 83,189,260 (-)NCBI
Rnor_6.01086,101,560 - 86,145,269 (-)NCBI
Rnor_5.01085,899,172 - 85,942,182 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597471   ⟹   XP_017452960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,641,851 - 83,675,480 (-)NCBI
mRatBN7.21083,145,538 - 83,179,171 (-)NCBI
Rnor_6.01086,101,561 - 86,135,127 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086635   ⟹   XP_038942563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,647,134 - 83,685,560 (-)NCBI
mRatBN7.21083,151,228 - 83,189,260 (-)NCBI
RefSeq Acc Id: XM_039086636   ⟹   XP_038942564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,641,851 - 83,685,559 (-)NCBI
mRatBN7.21083,145,538 - 83,189,260 (-)NCBI
RefSeq Acc Id: XM_063269661   ⟹   XP_063125731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,641,851 - 83,648,135 (-)NCBI
RefSeq Acc Id: XP_006247463   ⟸   XM_006247401
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A4N6 (UniProtKB/TrEMBL),   A6HIQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247461   ⟸   XM_006247399
- Peptide Label: isoform X1
- UniProtKB: D3ZRN2 (UniProtKB/TrEMBL),   A6HIQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452960   ⟸   XM_017597471
- Peptide Label: isoform X2
- UniProtKB: D3ZRN2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059848   ⟸   ENSRNOT00000067901
RefSeq Acc Id: XP_038942564   ⟸   XM_039086636
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A4N6 (UniProtKB/TrEMBL),   A6HIQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942563   ⟸   XM_039086635
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A4N6 (UniProtKB/TrEMBL),   A6HIQ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090271   ⟸   ENSRNOT00000105226
Ensembl Acc Id: ENSRNOP00000085900   ⟸   ENSRNOT00000114652
Ensembl Acc Id: ENSRNOP00000080764   ⟸   ENSRNOT00000101134
RefSeq Acc Id: NP_001402695   ⟸   NM_001415766
- UniProtKB: D3ZRN2 (UniProtKB/TrEMBL),   A0A8I6AC46 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125731   ⟸   XM_063269661
- Peptide Label: isoform X3
Protein Domains
Mediator complex subunit Med1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRN2-F1-model_v2 AlphaFold D3ZRN2 1-1567 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559552 AgrOrtholog
BioCyc Gene G2FUF-23380 BioCyc
Ensembl Genes ENSRNOG00000005606 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067901.3 UniProtKB/TrEMBL
  ENSRNOT00000105226 ENTREZGENE
  ENSRNOT00000105226.2 UniProtKB/TrEMBL
InterPro Mediator_complex_subunit_1 UniProtKB/TrEMBL
  Mediator_Med1_met/fun UniProtKB/TrEMBL
NCBI Gene 497991 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 UniProtKB/TrEMBL
  MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 UniProtKB/TrEMBL
Pfam Med1-Trap220 UniProtKB/TrEMBL
PhenoGen Med1 PhenoGen
RatGTEx ENSRNOG00000005606 RatGTEx
UniProt A0A8I6A4N6 ENTREZGENE
  A0A8I6AC46 ENTREZGENE, UniProtKB/TrEMBL
  A6HIQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6HIQ7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRN2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Med1  mediator complex subunit 1  RGD1559552_predicted  similar to peroxisome proliferator-activated receptor binding protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559552_predicted  similar to peroxisome proliferator-activated receptor binding protein (predicted)  LOC497991  similar to peroxisome proliferator-activated receptor binding protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC497991  similar to peroxisome proliferator-activated receptor binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL