Enables several functions, including DNA binding activity; histone acetyltransferase binding activity; and nuclear receptor binding activity. Contributes to ubiquitin protein ligase activity. Involved in cellular response to thyroid hormone stimulus; positive regulation of transcription by RNA polymerase II; and protein ubiquitination. Located in chromatin. Part of protein-DNA complex and ubiquitin ligase complex. Orthologous to human MED1 (mediator complex subunit 1); PARTICIPATES IN cortisol signaling pathway; estrogen signaling pathway; RNA polymerase II transcription pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [Tetrachlorodibenzodioxin results in increased expression of MED1 mRNA]
[bisphenol S binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MED1 protein modified form] and bisphenol S promotes the reaction [ESR1 protein binds to MED1 protein]
[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MED1 protein modified form] and bisphenol A promotes the reaction [MED1 protein binds to and results in increased activity of NR1I2 protein]
[bisphenol AF binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MED1 protein modified form] and bisphenol AF inhibits the reaction [ESR1 protein binds to MED1 protein]
[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form]
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MED1 mRNA and pirinixic acid promotes the reaction [PPARA protein binds to MED1 protein]
MED1 protein promotes the reaction [pirinixic acid affects the localization of NR1I3 protein] and pirinixic acid promotes the reaction [PPARA protein binds to MED1 protein]
Rifampin promotes the reaction [MED1 protein binds to and results in increased activity of NR1I2 protein] and Rifampin promotes the reaction [MED1 protein binds to HNF4A protein]
1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex.
Comparative distribution of the mammalian mediator subunit thyroid hormone receptor-associated protein (TRAP220) mRNA in developing and adult rodent brain.
Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.
Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes.
