Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CCDC3 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | increases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of CCDC3 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of CCDC3 mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of CCDC3 mRNA | CTD | PMID:20660070 and PMID:30165855 | 4,4'-sulfonyldiphenol | increases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased expression of CCDC3 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in decreased methylation of CCDC3 gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | CCDC3 (Homo sapiens) | 6480464 | bis(4-hydroxyphenyl)sulfone results in decreased methylation of CCDC3 gene | CTD | PMID:31601247 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of CCDC3 mRNA | CTD | PMID:28973697 | 8-Br-cAMP | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CCDC3 mRNA | CTD | PMID:22079614 | acrylamide | increases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | Acrylamide results in increased expression of CCDC3 mRNA | CTD | PMID:30807115 | acrylamide | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of CCDC3 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases methylation | ISO | CCDC3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of CCDC3 intron | CTD | PMID:30157460 | aflatoxin B1 | decreases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of CCDC3 mRNA | CTD | PMID:32234424 | all-trans-retinoic acid | decreases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of CCDC3 mRNA | CTD | PMID:23724009 more ... | arsane | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of CCDC3 mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of CCDC3 mRNA | CTD | PMID:32525701 | benzo[a]pyrene | increases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CCDC3 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of CCDC3 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | CCDC3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CCDC3 exon and Benzo(a)pyrene results in increased methylation of CCDC3 promoter | CTD | PMID:27901495 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CCDC3 mRNA | CTD | PMID:25181051 and PMID:30816183 | bisphenol A | increases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of CCDC3 mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | bisphenol F results in increased expression of CCDC3 mRNA | CTD | PMID:30951980 | butanal | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of CCDC3 mRNA | CTD | PMID:26079696 | carbamazepine | affects expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of CCDC3 mRNA | CTD | PMID:25979313 | CGP 52608 | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CCDC3 gene] | CTD | PMID:28238834 | chlordecone | increases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | Chlordecone results in increased expression of CCDC3 mRNA | CTD | PMID:33711761 | choline | multiple interactions | ISO | Ccdc3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCDC3 mRNA | CTD | PMID:20938992 | cisplatin | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of CCDC3 mRNA | CTD | PMID:27392435 | cisplatin | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of CCDC3 mRNA | CTD | PMID:27392435 | cyclosporin A | decreases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CCDC3 mRNA | CTD | PMID:27989131 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of CCDC3 mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of CCDC3 mRNA | CTD | PMID:29803840 and PMID:30031762 | folic acid | multiple interactions | ISO | Ccdc3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCDC3 mRNA | CTD | PMID:20938992 | fulvestrant | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in decreased methylation of CCDC3 gene | CTD | PMID:31601247 | inulin | multiple interactions | ISO | Ccdc3 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of CCDC3 mRNA | CTD | PMID:36331819 | L-methionine | multiple interactions | ISO | Ccdc3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCDC3 mRNA | CTD | PMID:20938992 | lipopolysaccharide | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | nickel sulfate | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of CCDC3 mRNA | CTD | PMID:22714537 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of CCDC3 mRNA | CTD | PMID:32680482 | pentanal | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | pentanal results in increased expression of CCDC3 mRNA | CTD | PMID:26079696 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Ccdc3 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of CCDC3 mRNA | CTD | PMID:36331819 | progesterone | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of CCDC3 mRNA | CTD | PMID:20660070 | propanal | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of CCDC3 mRNA | CTD | PMID:26079696 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of CCDC3 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of CCDC3 mRNA | CTD | PMID:25895662 | silicon dioxide | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of CCDC3 mRNA | CTD | PMID:23806026 | sodium arsenate | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of CCDC3 mRNA | CTD | PMID:32525701 | sodium arsenite | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of CCDC3 mRNA | CTD | PMID:22714537 more ... | sulforaphane | decreases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of CCDC3 mRNA | CTD | PMID:31838189 | testosterone | multiple interactions | ISO | Ccdc3 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:33848595 | testosterone | increases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of CCDC3 mRNA | CTD | PMID:33848595 | tetrachloromethane | decreases expression | ISO | Ccdc3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of CCDC3 mRNA | CTD | PMID:17484886 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CCDC3 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CCDC3 mRNA] | CTD | PMID:31150632 | trichostatin A | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of CCDC3 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCDC3 mRNA | CTD | PMID:27188386 | valproic acid | decreases methylation | ISO | CCDC3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of CCDC3 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CCDC3 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of CCDC3 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCDC3 mRNA | CTD | PMID:27188386 | vorinostat | multiple interactions | ISO | CCDC3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCDC3 mRNA | CTD | PMID:27188386 | vorinostat | increases expression | ISO | CCDC3 (Homo sapiens) | 6480464 | vorinostat results in increased expression of CCDC3 mRNA | CTD | PMID:26272509 | | 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