Gene: Ctsb (cathepsin B) Mus musculus
Symbol: Ctsb
Name: cathepsin B
Description: This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cathepsin B1; CB
Homo sapiens (human) : CTSB (cathepsin B)  HGNC  AGR
Rattus norvegicus (Norway rat) : Ctsb (cathepsin B)  AGR
Chinchilla lanigera (long-tailed chinchilla) : Ctsb (cathepsin B)
Pan paniscus (bonobo/pygmy chimpanzee) : CTSB (cathepsin B)
Canis lupus familiaris (dog) : CTSB (cathepsin B)
more info ...
Related Pseudogenes: Gm14032  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381463,122,462 - 63,145,923 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371463,741,302 - 63,764,758 (+)NCBIGRCm37mm9NCBIm37
MGSCv361462,076,575 - 62,100,031 (+)NCBImm8
Celera1460,885,227 - 60,908,695 (+)NCBICelera
Cytogenetic Map14 D1NCBI
cM Map1433.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ctsb
AGR Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1558619
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2017-11-16
Status: ACTIVE