Setdb1 (SET domain, bifurcated 1) - Rat Genome Database

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Gene: Setdb1 (SET domain, bifurcated 1) Mus musculus
Analyze
Symbol: Setdb1
Name: SET domain, bifurcated 1
RGD ID: 1558610
MGI Page MGI
Description: Enables DNA binding activity; histone H3K9 methyltransferase activity; and promoter-specific chromatin binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin formation. Acts upstream of or within bone development; inner cell mass cell proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1-cell stage embryo; central nervous system; heart; long bone; and oocyte. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU022152; ERG-associated protein with SET domain; ESE; ESET; histone-lysine N-methyltransferase SETDB1; KMT1E; MGC90670; mKIAA0067; SET domain bifurcated 1; SET domain ERG-associated histone methyltransferase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm4349  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,230,836 - 95,264,513 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,230,836 - 95,264,513 (-)EnsemblGRCm39 Ensembl
GRCm38395,323,525 - 95,357,202 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,323,525 - 95,357,202 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,127,447 - 95,161,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,408,929 - 95,442,577 (-)NCBIMGSCv36mm8
Celera396,754,826 - 96,788,575 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. Histone methylation at H3K9: evidence for a restrictive epigenome in schizophrenia. Chase KA, etal., Schizophr Res. 2013 Sep;149(1-3):15-20. doi: 10.1016/j.schres.2013.06.021. Epub 2013 Jun 28.
3. The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1. Cukier HN, etal., Autism Res. 2012 Dec;5(6):385-97. doi: 10.1002/aur.1251. Epub 2012 Oct 10.
4. Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Jiang Y, etal., Neuropharmacology. 2011 Jun;60(7-8):1088-97. doi: 10.1016/j.neuropharm.2010.09.020. Epub 2010 Sep 30.
5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
6. High-frequency p16(INK) (4A) promoter methylation is associated with histone methyltransferase SETDB1 expression in sporadic cutaneous melanoma. Kostaki M, etal., Exp Dermatol. 2014 May;23(5):332-8. doi: 10.1111/exd.12398.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis. Rodriguez-Paredes M, etal., Oncogene. 2014 May 22;33(21):2807-13. doi: 10.1038/onc.2013.239. Epub 2013 Jun 17.
15. ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Ryu H, etal., Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19176-81. Epub 2006 Dec 1.
16. Role of histone lysine methyltransferases SUV39H1 and SETDB1 in gliomagenesis: modulation of cell proliferation, migration, and colony formation. Spyropoulou A, etal., Neuromolecular Med. 2014 Mar;16(1):70-82. doi: 10.1007/s12017-013-8254-x. Epub 2013 Aug 13.
17. Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion. Sun Y, etal., Asian J Androl. 2014 Mar-Apr;16(2):319-24. doi: 10.4103/1008-682X.122812.
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11791185   PMID:12398767   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12652657   PMID:14522075  
PMID:14536086   PMID:14610273   PMID:14611647   PMID:14681479   PMID:14993285   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16682412   PMID:17296600  
PMID:18022353   PMID:18319327   PMID:18799693   PMID:19010785   PMID:19498464   PMID:19884255   PMID:19884257   PMID:20014010   PMID:20164836   PMID:20505083   PMID:21267068   PMID:21402781  
PMID:21624812   PMID:21677750   PMID:21873635   PMID:21921037   PMID:22079090   PMID:22110129   PMID:22495301   PMID:22504302   PMID:22876197   PMID:22939622   PMID:22991445   PMID:23293284  
PMID:23333759   PMID:23539621   PMID:23652029   PMID:23748610   PMID:23782009   PMID:24025402   PMID:24056368   PMID:24097435   PMID:24188826   PMID:24757056   PMID:24763053   PMID:25228647  
PMID:25611934   PMID:26100872   PMID:26160163   PMID:26365490   PMID:26471002   PMID:26496610   PMID:27013243   PMID:27070551   PMID:27112447   PMID:27151458   PMID:27195021   PMID:27237050  
PMID:27301860   PMID:27317807   PMID:27349785   PMID:27511731   PMID:27890611   PMID:28115466   PMID:28190767   PMID:28671686   PMID:28890329   PMID:28963472   PMID:28981838   PMID:29084956  
PMID:29272473   PMID:29282851   PMID:29351814   PMID:29703894   PMID:29728365   PMID:30094782   PMID:30393076   PMID:30403691   PMID:30446626   PMID:30606806   PMID:30692626   PMID:30737147  
PMID:30973865   PMID:31086817   PMID:31088968   PMID:31557926   PMID:31858687   PMID:31914391   PMID:32296174   PMID:32325033   PMID:32360551   PMID:32503845   PMID:33054052   PMID:33406415  
PMID:33658714   PMID:33971063   PMID:33998651   PMID:34026436   PMID:34216590   PMID:34521010   PMID:34671158   PMID:34709266   PMID:34857746   PMID:35081363   PMID:35151207   PMID:35301318  
PMID:35445296   PMID:35546351   PMID:35776115   PMID:36123357   PMID:36335068   PMID:36443288   PMID:36580757   PMID:37419179   PMID:37661095   PMID:37812443   PMID:38167730   PMID:38216701  
PMID:38355793   PMID:38848717   PMID:38875772   PMID:38961490   PMID:39096901  


Genomics

Comparative Map Data
Setdb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,230,836 - 95,264,513 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,230,836 - 95,264,513 (-)EnsemblGRCm39 Ensembl
GRCm38395,323,525 - 95,357,202 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,323,525 - 95,357,202 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,127,447 - 95,161,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,408,929 - 95,442,577 (-)NCBIMGSCv36mm8
Celera396,754,826 - 96,788,575 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
SETDB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,926,263 - 150,964,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,926,263 - 150,964,744 (+)EnsemblGRCh38hg38GRCh38
GRCh371150,898,739 - 150,937,213 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,165,512 - 149,203,837 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,711,960 - 147,750,284NCBI
Celera1124,014,522 - 124,052,915 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,275,918 - 122,314,348 (+)NCBIHuRef
CHM1_11152,294,142 - 152,332,540 (+)NCBICHM1_1
T2T-CHM13v2.01150,049,948 - 150,088,436 (+)NCBIT2T-CHM13v2.0
Setdb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,587,722 - 185,619,084 (-)NCBIGRCr8
mRatBN7.22182,898,738 - 182,930,283 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,898,738 - 182,930,506 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,563,824 - 190,594,782 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,359,310 - 188,390,238 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,196,321 - 183,227,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,495,867 - 196,527,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,495,867 - 196,527,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02215,994,295 - 216,025,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,232,228 - 190,264,309 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,195,015 - 190,227,043 (-)NCBI
Celera2175,432,236 - 175,463,195 (-)NCBICelera
Cytogenetic Map2q34NCBI
Setdb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955588290,168 - 338,426 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955588290,497 - 338,438 (+)NCBIChiLan1.0ChiLan1.0
SETDB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,868,713 - 98,907,047 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,622,938 - 98,661,286 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,275,719 - 126,314,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11129,925,009 - 129,962,442 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,925,009 - 129,962,442 (+)Ensemblpanpan1.1panPan2
SETDB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,035,819 - 60,069,721 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,037,379 - 60,069,551 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,481,019 - 59,513,690 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01761,052,838 - 61,085,686 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1761,052,909 - 61,085,961 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,881,637 - 59,914,607 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,966,210 - 59,999,560 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,694,148 - 60,726,997 (+)NCBIUU_Cfam_GSD_1.0
Setdb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505822,115,903 - 22,162,583 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,146,277 - 1,192,842 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,146,286 - 1,192,842 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SETDB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,260,375 - 98,293,097 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,259,801 - 98,293,238 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,514,914 - 107,547,700 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SETDB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,316,851 - 12,357,421 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Setdb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,855,332 - 18,894,226 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,855,405 - 18,894,285 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1722
Count of miRNA genes:489
Interacting mature miRNAs:570
Transcripts:ENSMUST00000015841, ENSMUST00000107170, ENSMUST00000107171, ENSMUST00000124638, ENSMUST00000132468, ENSMUST00000152260
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse

Markers in Region
AU022152  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,323,553 - 95,323,784UniSTSGRCm38
MGSCv37395,127,475 - 95,127,706UniSTSGRCm37
Celera396,754,854 - 96,755,085UniSTS
Cytogenetic Map3F2UniSTS
Whitehead/MRC_RH31081.54UniSTS
UniSTS:234764  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,323,347 - 95,323,517UniSTSGRCm38
MGSCv37395,127,269 - 95,127,439UniSTSGRCm37
Celera396,754,648 - 96,754,818UniSTS
Cytogenetic Map3F2UniSTS
UniSTS:234765  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,332,685 - 95,332,796UniSTSGRCm38
MGSCv37395,136,607 - 95,136,718UniSTSGRCm37
Celera396,764,058 - 96,764,169UniSTS
Cytogenetic Map3F2UniSTS
RH126094  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,328,143 - 95,328,343UniSTSGRCm38
MGSCv37395,132,065 - 95,132,265UniSTSGRCm37
Celera396,759,444 - 96,759,644UniSTS
Cytogenetic Map3F2UniSTS
Whitehead/MRC_RH3927.59UniSTS
PMC355869P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,328,696 - 95,328,959UniSTSGRCm38
MGSCv37395,132,618 - 95,132,881UniSTSGRCm37
Celera396,759,997 - 96,760,260UniSTS
Cytogenetic Map3F2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001163641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001163642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC092202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF091628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY091600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY226577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY074856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN461297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000015841   ⟹   ENSMUSP00000015841
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,230,836 - 95,264,511 (-)Ensembl
GRCm38.p6 Ensembl395,323,525 - 95,357,200 (-)Ensembl
Ensembl Acc Id: ENSMUST00000107170   ⟹   ENSMUSP00000102788
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,230,836 - 95,264,513 (-)Ensembl
GRCm38.p6 Ensembl395,323,525 - 95,357,202 (-)Ensembl
Ensembl Acc Id: ENSMUST00000107171   ⟹   ENSMUSP00000102789
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,230,836 - 95,264,467 (-)Ensembl
GRCm38.p6 Ensembl395,323,525 - 95,357,156 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124638
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,230,836 - 95,264,466 (-)Ensembl
GRCm38.p6 Ensembl395,323,525 - 95,357,155 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132468
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,246,456 - 95,264,467 (-)Ensembl
GRCm38.p6 Ensembl395,339,145 - 95,357,156 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152260
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,262,894 - 95,264,400 (-)Ensembl
GRCm38.p6 Ensembl395,355,583 - 95,357,089 (-)Ensembl
RefSeq Acc Id: NM_001163641   ⟹   NP_001157113
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,230,836 - 95,264,513 (-)NCBI
GRCm38395,323,525 - 95,357,202 (-)ENTREZGENE
MGSCv37395,127,447 - 95,161,124 (-)RGD
Celera396,754,826 - 96,788,575 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001163642   ⟹   NP_001157114
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,230,836 - 95,264,513 (-)NCBI
GRCm38395,323,525 - 95,357,202 (-)ENTREZGENE
MGSCv37395,127,447 - 95,161,124 (-)RGD
Celera396,754,826 - 96,788,575 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_018877   ⟹   NP_061365
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,230,836 - 95,264,513 (-)NCBI
GRCm38395,323,525 - 95,357,202 (-)ENTREZGENE
MGSCv37395,127,447 - 95,161,124 (-)RGD
Celera396,754,826 - 96,788,575 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036163425   ⟹   XP_036019318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,230,836 - 95,264,484 (-)NCBI
Sequence:
RefSeq Acc Id: NP_061365   ⟸   NM_018877
- Peptide Label: isoform a
- UniProtKB: Q922K1 (UniProtKB/Swiss-Prot),   Q8CIX7 (UniProtKB/Swiss-Prot),   Q8BTV6 (UniProtKB/Swiss-Prot),   Q80U84 (UniProtKB/Swiss-Prot),   Q78N65 (UniProtKB/Swiss-Prot),   Q78N64 (UniProtKB/Swiss-Prot),   Q6AXH8 (UniProtKB/Swiss-Prot),   O88974 (UniProtKB/Swiss-Prot),   D3YYC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157113   ⟸   NM_001163641
- Peptide Label: isoform a
- UniProtKB: Q922K1 (UniProtKB/Swiss-Prot),   Q8CIX7 (UniProtKB/Swiss-Prot),   Q8BTV6 (UniProtKB/Swiss-Prot),   Q80U84 (UniProtKB/Swiss-Prot),   Q78N65 (UniProtKB/Swiss-Prot),   Q78N64 (UniProtKB/Swiss-Prot),   Q6AXH8 (UniProtKB/Swiss-Prot),   O88974 (UniProtKB/Swiss-Prot),   D3YYC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157114   ⟸   NM_001163642
- Peptide Label: isoform b
- UniProtKB: Q922K1 (UniProtKB/Swiss-Prot),   Q8CIX7 (UniProtKB/Swiss-Prot),   Q8BTV6 (UniProtKB/Swiss-Prot),   Q80U84 (UniProtKB/Swiss-Prot),   Q78N65 (UniProtKB/Swiss-Prot),   Q78N64 (UniProtKB/Swiss-Prot),   Q6AXH8 (UniProtKB/Swiss-Prot),   O88974 (UniProtKB/Swiss-Prot),   G5E8N3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000015841   ⟸   ENSMUST00000015841
Ensembl Acc Id: ENSMUSP00000102788   ⟸   ENSMUST00000107170
Ensembl Acc Id: ENSMUSP00000102789   ⟸   ENSMUST00000107171
RefSeq Acc Id: XP_036019318   ⟸   XM_036163425
- Peptide Label: isoform X1
- UniProtKB: Q922K1 (UniProtKB/Swiss-Prot),   Q8CIX7 (UniProtKB/Swiss-Prot),   Q8BTV6 (UniProtKB/Swiss-Prot),   Q80U84 (UniProtKB/Swiss-Prot),   Q78N65 (UniProtKB/Swiss-Prot),   Q78N64 (UniProtKB/Swiss-Prot),   Q6AXH8 (UniProtKB/Swiss-Prot),   O88974 (UniProtKB/Swiss-Prot),   G5E8N3 (UniProtKB/TrEMBL)
Protein Domains
MBD   Post-SET   Pre-SET   SET   Tudor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88974-F1-model_v2 AlphaFold O88974 1-1307 view protein structure

Promoters
RGD ID:6834437
Promoter ID:MM_KWN:35296
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   ES_Cell,   Liver,   Lung
Transcripts:ENSMUST00000015841,   ENSMUST00000107170,   OTTMUST00000041441,   OTTMUST00000041442,   OTTMUST00000041446,   UC008QJO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,160,821 - 95,161,321 (-)MPROMDB
RGD ID:6881610
Promoter ID:EPDNEW_M4243
Type:initiation region
Name:Setdb1_1
Description:Mus musculus SET domain, bifurcated 1 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38395,357,173 - 95,357,233EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1934229 AgrOrtholog
Ensembl Genes ENSMUSG00000015697 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015841 ENTREZGENE
  ENSMUST00000015841.12 UniProtKB/TrEMBL
  ENSMUST00000107170 ENTREZGENE
  ENSMUST00000107170.3 UniProtKB/TrEMBL
  ENSMUST00000107171 ENTREZGENE
  ENSMUST00000107171.10 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5604 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hist-Lys_N-MeTrfase_SETDB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyl_CpG_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pre-SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SETDB1/2-like_MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SETDB_methyltransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUDOR_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:84505 UniProtKB/TrEMBL
MGD MGI:1934229 ENTREZGENE
NCBI Gene 84505 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF5604 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pre-SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUDOR_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Setdb1 PhenoGen
PROSITE MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POST_SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRE_SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_MT43_SUVAR39_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PreSET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUDOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54171 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82199 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YYC3 ENTREZGENE, UniProtKB/TrEMBL
  G5E8N3 ENTREZGENE, UniProtKB/TrEMBL
  O88974 ENTREZGENE
  Q6AXH8 ENTREZGENE
  Q78N64 ENTREZGENE
  Q78N65 ENTREZGENE
  Q80U84 ENTREZGENE
  Q8BTV6 ENTREZGENE
  Q8CIX7 ENTREZGENE
  Q922K1 ENTREZGENE
  SETB1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6AXH8 UniProtKB/Swiss-Prot
  Q78N64 UniProtKB/Swiss-Prot
  Q78N65 UniProtKB/Swiss-Prot
  Q80U84 UniProtKB/Swiss-Prot
  Q8BTV6 UniProtKB/Swiss-Prot
  Q8CIX7 UniProtKB/Swiss-Prot
  Q922K1 UniProtKB/Swiss-Prot