Cbl (Casitas B-lineage lymphoma) - Rat Genome Database

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Gene: Cbl (Casitas B-lineage lymphoma) Mus musculus
Analyze
Symbol: Cbl
Name: Casitas B-lineage lymphoma
RGD ID: 1558608
MGI Page MGI
Description: Enables SH3 domain binding activity; ephrin receptor binding activity; and ubiquitin protein ligase activity. Involved in several processes, including regulation of signal transduction; ubiquitin-dependent endocytosis; and ubiquitin-dependent protein catabolic process. Acts upstream of or within regulation of Rap protein signal transduction. Located in Golgi apparatus and cilium. Part of flotillin complex. Is active in plasma membrane. Is expressed in male reproductive system and urinary system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4732447J05Rik; c-Cb; c-Cbl; casitas B-lineage lymphoma proto-oncogene; Cbl-; Cbl-2; E3 ubiquitin-protein ligase CBL; proto-oncogene c-CBL; RING-type E3 ubiquitin transferase CBL; signal transduction protein CBL
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Cbl-ps1   Gm18333   Gm6695   Gm7326  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,054,273 - 44,145,556 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,054,273 - 44,145,346 (-)EnsemblGRCm39 Ensembl
GRCm38944,142,976 - 44,234,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,142,976 - 44,234,049 (-)EnsemblGRCm38mm10GRCm38
MGSCv37943,957,345 - 44,042,129 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36943,900,257 - 43,985,041 (-)NCBIMGSCv36mm8
Celera941,406,821 - 41,486,735 (-)NCBICelera
Cytogenetic Map9A5.1- A5.2NCBI
cM Map924.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-lymphoblastic leukemia/lymphoma with hyperdiploidy  (ISO)
Carotid Artery Injuries  (ISO)
CD3epsilon deficiency  (ISO)
Chromosome 11, Partial Trisomy 11q  (ISO)
colorectal cancer  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ij  (ISO)
congenital myasthenic syndrome 13  (ISO)
congenital myopathy 1A  (ISO)
congestive heart failure  (ISO)
cryptorchidism  (ISO)
Developmental Disabilities  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Dwarfism  (ISO)
Elliptocytosis 2  (ISO)
Experimental Arthritis  (ISO)
Experimental Leukemia  (IMP)
genetic disease  (ISO)
Growth Disorders  (ISO)
Hematologic Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
hyperglycemia  (ISO)
immunodeficiency 17  (ISO)
immunodeficiency 18  (ISO)
immunodeficiency 19  (ISO)
inflammatory bowel disease 28  (ISO)
isolated microphthalmia 5  (ISO)
juvenile myelomonocytic leukemia  (ISO)
long QT syndrome 10  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphopenia  (IMP)
male infertility  (ISO)
malignant ovarian germ cell neoplasm  (ISO)
microcephaly  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (IMP,ISO)
Myocardial Reperfusion Injury  (IMP)
Neurodevelopmental Disorders  (ISO)
Noonan Like Syndrome  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia  (ISO)
osteosarcoma  (ISO)
ovarian germ cell cancer  (ISO)
Peripheral Nerve Injuries  (ISO)
RASopathy  (ISO)
rhabdomyosarcoma  (ISO)
schizophrenia  (ISO)
Stroke  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
vasculitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
2-naphthylamine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fipronil  (ISO)
flutamide  (EXP,ISO)
geldanamycin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
mercury dichloride  (EXP,ISO)
methylmercury chloride  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (EXP)
phosphane  (ISO)
resveratrol  (ISO)
retinyl acetate  (EXP)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
torcetrapib  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (EXP)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal double-negative T cell morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal fat cell morphology  (IAGP)
abnormal food intake  (IAGP)
abnormal foot pigmentation  (IAGP)
abnormal gas homeostasis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal mammary fat pad morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal myeloblast morphology/development  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal thymus development  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal thymus size  (IAGP)
darkened coat color  (IAGP)
decreased body weight  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased respiratory quotient  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased total body fat amount  (IAGP)
decreased white adipose tissue amount  (IAGP)
dermatitis  (IAGP)
dilated oviduct  (IAGP)
dilated uterus  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
improved glucose tolerance  (IAGP)
increased body temperature  (IAGP)
increased body weight  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased ear pigmentation  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased insulin sensitivity  (IAGP)
increased lean body mass  (IAGP)
increased locomotor activity  (IAGP)
increased mitochondrial size  (IAGP)
increased muscle cell glucose uptake  (IAGP)
increased oxygen consumption  (IAGP)
increased spleen red pulp amount  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased T cell proliferation  (IAGP)
increased tail pigmentation  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
myeloid hyperplasia  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
polyphagia  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
prolonged PR interval  (IEA)
spleen hyperplasia  (IAGP)
thick ventricular wall  (IEA)
thrombocytosis  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Intraarticular interferon-beta gene therapy ameliorates adjuvant arthritis in rats. Adriaansen J, etal., Hum Gene Ther. 2006 Oct;17(10):985-96.
2. CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2. Aranaz P, etal., Haematologica. 2012 Aug;97(8):1234-41. doi: 10.3324/haematol.2011.052605. Epub 2012 Feb 7.
3. SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. Borinstein SC, etal., Cell Signal 2000 Dec;12(11-12):769-79.
4. Loss of c-Cbl expression correlates with de-differentiation status and lymphatic metastasis in gastric cancer. Chen C, etal., Indian J Pathol Microbiol. 2019 Oct-Dec;62(4):549-555. doi: 10.4103/IJPM.IJPM_824_18.
5. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
6. [Expression down-regulation of c-Cbl and Cbl-b genes in peripheral blood mononuclear cells from multiple myeloma patients]. Fang S, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Aug;29(8):842-5.
7. Decreased pulmonary c-Cbl expression and tyrosine phosphorylation in the nitrofen-induced rat model of congenital diaphragmatic hernia. Friedmacher F, etal., Pediatr Surg Int. 2013 Jan;29(1):19-24. doi: 10.1007/s00383-012-3191-6.
8. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
9. Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat. Geoffrey R, etal., J Immunol. 2006 Nov 15;177(10):7275-86.
10. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Grand FH, etal., Blood. 2009 Jun 11;113(24):6182-92. doi: 10.1182/blood-2008-12-194548. Epub 2009 Apr 22.
11. Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9. Hong G, etal., Genomics 1996 Feb 1;31(3):295-300.
12. Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy. Jeong JS, etal., BMC Anesthesiol. 2018 Jul 18;18(1):87. doi: 10.1186/s12871-018-0555-z.
13. A high occurrence of acquisition and/or expansion of C-CBL mutant clones in the progression of high-risk myelodysplastic syndrome to acute myeloid leukemia. Kao HW, etal., Neoplasia. 2011 Nov;13(11):1035-42.
14. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. Kiefer KC, etal., ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28.
15. c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/β-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation. Kumaradevan S, etal., Am J Pathol. 2018 Aug;188(8):1921-1933. doi: 10.1016/j.ajpath.2018.05.007. Epub 2018 Jul 17.
16. An E3 ubiquitin ligase: c-Cbl: a new therapeutic target of lung cancer. Lo FY, etal., Cancer. 2011 Dec 1;117(23):5344-50. doi: 10.1002/cncr.26153. Epub 2011 May 23.
17. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Loh ML, etal., Blood. 2009 Aug 27;114(9):1859-63. doi: 10.1182/blood-2009-01-198416. Epub 2009 Jul 1.
18. Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. López-Avalos MD, etal., Diabetes. 2006 May;55(5):1223-31.
19. Is the c-Cbl proto-oncogene involved in chronic lymphocytic leukemia? Mankai A, etal., Ann N Y Acad Sci. 2007 Jun;1107:193-205.
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. MGD IEA MGD IEA
22. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. c-Cbl inhibition improves cardiac function and survival in response to myocardial ischemia. Rafiq K, etal., Circulation. 2014 May 20;129(20):2031-43. doi: 10.1161/CIRCULATIONAHA.113.007004. Epub 2014 Feb 28.
27. c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner. Rathinam C and Flavell RA, Proc Natl Acad Sci U S A. 2010 May 4;107(18):8316-21. doi: 10.1073/pnas.0914496107. Epub 2010 Apr 19.
28. Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling. Rathinam C, etal., Cancer Cell. 2010 Oct 19;18(4):341-52. doi: 10.1016/j.ccr.2010.09.008.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
33. Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice. Stromnes IM, etal., J Clin Invest. 2010 Oct;120(10):3722-34. doi: 10.1172/JCI41991. Epub 2010 Sep 20.
34. Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesis. Sévère N, etal., J Bone Miner Res. 2012 Oct;27(10):2108-17. doi: 10.1002/jbmr.1667.
35. CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases. Tan YH, etal., PLoS One. 2010 Jan 29;5(1):e8972. doi: 10.1371/journal.pone.0008972.
36. Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries. Tang Z, etal., Circulation. 2008 Aug 12;118(7):764-72. doi: 10.1161/CIRCULATIONAHA.107.761932. Epub 2008 Jul 28.
37. Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury. Wen XR, etal., Neuroscience. 2008 Oct 15;156(3):483-97. Epub 2008 Aug 12.
38. Peritumoral Cbl is a strong independent prognostic marker after curative resection of hepatocellular carcinoma. Zhang JB, etal., Oncotarget. 2015 Nov 24;6(37):40223-34. doi: 10.18632/oncotarget.5540.
Additional References at PubMed
PMID:1565471   PMID:1674500   PMID:1705320   PMID:1845910   PMID:2004777   PMID:2030914   PMID:2760978   PMID:2784003   PMID:7517397   PMID:7657591   PMID:8551236   PMID:8563172  
PMID:8570653   PMID:8627181   PMID:8635998   PMID:8641358   PMID:8661102   PMID:8770364   PMID:8798454   PMID:8849724   PMID:8947469   PMID:8978305   PMID:9013636   PMID:9030684  
PMID:9067577   PMID:9103201   PMID:9115297   PMID:9174058   PMID:9210408   PMID:9294143   PMID:9393882   PMID:9447983   PMID:9653117   PMID:9671496   PMID:9687507   PMID:9726248  
PMID:9861006   PMID:9890970   PMID:9989826   PMID:10095055   PMID:10199918   PMID:10349636   PMID:10358158   PMID:10391678   PMID:10393178   PMID:10441734   PMID:10633073   PMID:10646609  
PMID:10725249   PMID:10799548   PMID:10854852   PMID:10922068   PMID:10940298   PMID:11001060   PMID:11031258   PMID:11042159   PMID:11069064   PMID:11076861   PMID:11217851   PMID:11406619  
PMID:11741956   PMID:11777909   PMID:11804588   PMID:11823423   PMID:11826757   PMID:11997497   PMID:12024036   PMID:12032836   PMID:12061819   PMID:12102152   PMID:12140190   PMID:12177062  
PMID:12193575   PMID:12415267   PMID:12477932   PMID:12520002   PMID:12522270   PMID:12559036   PMID:12591907   PMID:12652654   PMID:12671687   PMID:12707333   PMID:12754251   PMID:12765336  
PMID:12794130   PMID:12842890   PMID:12881521   PMID:14499658   PMID:14610273   PMID:14629478   PMID:14657036   PMID:14681479   PMID:14691459   PMID:14739300   PMID:15001553   PMID:15031295  
PMID:15215307   PMID:15238603   PMID:15258163   PMID:15265912   PMID:15304502   PMID:15315962   PMID:15383614   PMID:15520865   PMID:15581361   PMID:15581362   PMID:15618518   PMID:15699074  
PMID:15708558   PMID:15753096   PMID:15872089   PMID:15962011   PMID:16125056   PMID:16141072   PMID:16141073   PMID:16211006   PMID:16301331   PMID:16327786   PMID:16455755   PMID:16494846  
PMID:16505234   PMID:16601135   PMID:16751776   PMID:16778019   PMID:16798838   PMID:16914641   PMID:16944949   PMID:17045823   PMID:17056522   PMID:17110436   PMID:17130487   PMID:17139251  
PMID:17202354   PMID:17353186   PMID:17372273   PMID:17420256   PMID:17493844   PMID:17620338   PMID:17675501   PMID:17702744   PMID:17875942   PMID:17884340   PMID:17904548   PMID:17938199  
PMID:17962812   PMID:17967808   PMID:18034775   PMID:18070883   PMID:18239087   PMID:18287559   PMID:18413713   PMID:18519587   PMID:18566322   PMID:18602463   PMID:18799693   PMID:18814181  
PMID:18931680   PMID:19074136   PMID:19263517   PMID:19380812   PMID:19419964   PMID:19597496   PMID:19620960   PMID:19641021   PMID:19734451   PMID:19815501   PMID:19823681   PMID:19904769  
PMID:19966856   PMID:20037154   PMID:20085752   PMID:20133944   PMID:20207996   PMID:20298671   PMID:20304029   PMID:20392263   PMID:20670954   PMID:20697350   PMID:20805496   PMID:20851882  
PMID:20852388   PMID:20886612   PMID:20951942   PMID:21118980   PMID:21242968   PMID:21267068   PMID:21490975   PMID:21703542   PMID:21712076   PMID:21725061   PMID:21768087   PMID:21799517  
PMID:21830225   PMID:21873635   PMID:21967979   PMID:22138575   PMID:22174793   PMID:22203672   PMID:22451666   PMID:22645367   PMID:22988430   PMID:22990016   PMID:23027125   PMID:23127761  
PMID:23290524   PMID:23374343   PMID:23376399   PMID:23457600   PMID:23533197   PMID:23799367   PMID:24113870   PMID:24440350   PMID:24470255   PMID:24718698   PMID:24994594   PMID:25477210  
PMID:25521828   PMID:25534201   PMID:25744063   PMID:25871390   PMID:25960397   PMID:26055326   PMID:26177294   PMID:26296084   PMID:26393915   PMID:27156691   PMID:27276677   PMID:27449297  
PMID:27474268   PMID:27503123   PMID:27609087   PMID:27693352   PMID:27693578   PMID:27884787   PMID:27926878   PMID:27930322   PMID:28082680   PMID:28100467   PMID:28209720   PMID:28611190  
PMID:29237719   PMID:29562201   PMID:29891719   PMID:30333137   PMID:30382081   PMID:30550785   PMID:31260484   PMID:31282857   PMID:31299383   PMID:31315051   PMID:31591574   PMID:31665177  
PMID:32113662   PMID:32145025   PMID:32325033   PMID:32386556   PMID:32554809   PMID:32584413   PMID:32954656   PMID:33125970   PMID:33962939   PMID:34630435   PMID:36271153   PMID:36834818  


Genomics

Comparative Map Data
Cbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,054,273 - 44,145,556 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,054,273 - 44,145,346 (-)EnsemblGRCm39 Ensembl
GRCm38944,142,976 - 44,234,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,142,976 - 44,234,049 (-)EnsemblGRCm38mm10GRCm38
MGSCv37943,957,345 - 44,042,129 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36943,900,257 - 43,985,041 (-)NCBIMGSCv36mm8
Celera941,406,821 - 41,486,735 (-)NCBICelera
Cytogenetic Map9A5.1- A5.2NCBI
cM Map924.72NCBI
CBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,206,339 - 119,308,149 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11119,206,298 - 119,313,926 (+)EnsemblGRCh38hg38GRCh38
GRCh3711119,077,049 - 119,178,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,582,200 - 118,684,069 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411118,582,199 - 118,684,068NCBI
Celera11116,236,024 - 116,339,059 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11115,017,373 - 115,119,562 (+)NCBIHuRef
CHM1_111118,963,252 - 119,065,411 (+)NCBICHM1_1
T2T-CHM13v2.011119,226,712 - 119,328,785 (+)NCBIT2T-CHM13v2.0
Cbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2844,487,824 - 44,571,620 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,489,410 - 44,571,176 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0848,481,256 - 48,564,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,489,036 - 48,564,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,105,710 - 47,183,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,135,357 - 47,211,889 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera844,074,668 - 44,158,034 (-)NCBICelera
Cytogenetic Map8q22NCBI
Cbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,307,011 - 20,388,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541220,307,011 - 20,388,539 (+)NCBIChiLan1.0ChiLan1.0
CBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan111121,015,030 - 121,119,390 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011114,044,996 - 114,149,204 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111117,973,187 - 118,076,459 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11117,973,187 - 118,074,671 (+)Ensemblpanpan1.1panPan2
CBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,600,409 - 14,676,974 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,607,013 - 14,676,956 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha514,653,516 - 14,730,936 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0514,543,644 - 14,621,193 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,549,582 - 14,620,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,681,808 - 14,759,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,585,944 - 14,663,491 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,626,100 - 14,703,693 (-)NCBIUU_Cfam_GSD_1.0
Cbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,214,875 - 101,314,342 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365424,136,511 - 4,228,288 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365424,136,389 - 4,235,746 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,416,938 - 46,512,834 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1946,416,937 - 46,512,855 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,452,262 - 51,549,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,581,049 - 110,679,284 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,581,143 - 110,674,481 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604315,352,300 - 15,453,239 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,577,515 - 14,667,575 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478414,577,582 - 14,671,816 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cbl
2539 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:921
Count of miRNA genes:470
Interacting mature miRNAs:577
Transcripts:ENSMUST00000037644
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93715336244251323Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
12738415Lfibq8_mliver fibrosis QTL 8 (mouse)94140216245343743Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
13432191Actrse4_mactivity response to saline/ethanol 4 (mouse)94370321448603195Mouse

Markers in Region
Cbl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.2UniSTS
cM Map926.0UniSTS
UniSTS:236108  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,150,922 - 44,151,174UniSTSGRCm38
GRCm38658,098,102 - 58,098,353UniSTSGRCm38
MGSCv37943,959,005 - 43,959,257UniSTSGRCm37
MGSCv37658,048,096 - 58,048,347UniSTSGRCm37
Celera941,408,481 - 41,408,733UniSTS
Celera660,252,877 - 60,253,128UniSTS
Cytogenetic Map6B3UniSTS
Cytogenetic Map9A5.2UniSTS
RH126978  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,191,734 - 44,191,949UniSTSGRCm38
MGSCv37943,999,817 - 44,000,032UniSTSGRCm37
Celera941,449,381 - 41,449,596UniSTS
Cytogenetic Map9A5.2UniSTS
cM Map926.0UniSTS
Whitehead/MRC_RH9490.11UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC148328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY902338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ551619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ552121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ558455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ561007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ563690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ565003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ566411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ685220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ686041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ687164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ690538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ695987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ714235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ716370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ722607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ722615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ723886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ725309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ727228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF442242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X57111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000037644   ⟹   ENSMUSP00000041902
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,060,559 - 44,145,293 (-)Ensembl
GRCm38.p6 Ensembl944,149,262 - 44,233,996 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205313
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,065,075 - 44,068,354 (-)Ensembl
GRCm38.p6 Ensembl944,153,778 - 44,157,057 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205755   ⟹   ENSMUSP00000145791
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,084,672 - 44,144,841 (-)Ensembl
GRCm38.p6 Ensembl944,173,375 - 44,233,544 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205968   ⟹   ENSMUSP00000146287
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,062,720 - 44,145,281 (-)Ensembl
GRCm38.p6 Ensembl944,151,423 - 44,233,984 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206125
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,064,915 - 44,065,528 (-)Ensembl
GRCm38.p6 Ensembl944,153,618 - 44,154,231 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206147   ⟹   ENSMUSP00000145827
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,054,274 - 44,145,286 (-)Ensembl
GRCm38.p6 Ensembl944,142,977 - 44,233,989 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206163
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,054,279 - 44,057,552 (-)Ensembl
GRCm38.p6 Ensembl944,142,982 - 44,146,255 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206258   ⟹   ENSMUSP00000145538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,064,356 - 44,065,555 (-)Ensembl
GRCm38.p6 Ensembl944,153,059 - 44,154,258 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206540   ⟹   ENSMUSP00000145889
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,071,577 - 44,075,426 (-)Ensembl
GRCm38.p6 Ensembl944,160,280 - 44,164,129 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206629
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,080,317 - 44,097,262 (-)Ensembl
GRCm38.p6 Ensembl944,169,020 - 44,185,965 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206720   ⟹   ENSMUSP00000146244
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,054,273 - 44,145,346 (-)Ensembl
GRCm38.p6 Ensembl944,142,976 - 44,234,049 (-)Ensembl
RefSeq Acc Id: NM_007619   ⟹   NP_031645
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,060,559 - 44,145,343 (-)NCBI
GRCm38944,149,262 - 44,234,046 (-)NCBI
MGSCv37943,957,345 - 44,042,129 (-)RGD
Celera941,406,821 - 41,486,735 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509963   ⟹   XP_006510026
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,054,273 - 44,145,556 (-)NCBI
GRCm38944,142,976 - 44,234,259 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313115   ⟹   XP_017168604
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,054,273 - 44,144,876 (-)NCBI
GRCm38944,142,976 - 44,233,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244033   ⟹   XP_030099893
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,054,273 - 44,145,312 (-)NCBI
GRCm38944,142,976 - 44,233,784 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154583   ⟹   XP_036010476
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,054,273 - 44,145,556 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031645   ⟸   NM_007619
- UniProtKB: Q8CEA1 (UniProtKB/Swiss-Prot),   P22682 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006510026   ⟸   XM_006509963
- Peptide Label: isoform X1
- UniProtKB: A0A0X1KG61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168604   ⟸   XM_017313115
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_030099893   ⟸   XM_030244033
- Peptide Label: isoform X4
RefSeq Acc Id: ENSMUSP00000145827   ⟸   ENSMUST00000206147
RefSeq Acc Id: ENSMUSP00000146244   ⟸   ENSMUST00000206720
RefSeq Acc Id: ENSMUSP00000145538   ⟸   ENSMUST00000206258
RefSeq Acc Id: ENSMUSP00000145889   ⟸   ENSMUST00000206540
RefSeq Acc Id: ENSMUSP00000145791   ⟸   ENSMUST00000205755
RefSeq Acc Id: ENSMUSP00000146287   ⟸   ENSMUST00000205968
RefSeq Acc Id: ENSMUSP00000041902   ⟸   ENSMUST00000037644
RefSeq Acc Id: XP_036010476   ⟸   XM_036154583
- Peptide Label: isoform X2
Protein Domains
Cbl-PTB   RING-type   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22682-F1-model_v2 AlphaFold P22682 1-913 view protein structure

Promoters
RGD ID:6844287
Promoter ID:MM_KWN:57094
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_007619
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36944,041,931 - 44,042,522 (-)MPROMDB
RGD ID:8669352
Promoter ID:EPDNEW_M12707
Type:initiation region
Name:Cbl_1
Description:Mus musculus Casitas B-lineage lymphoma , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38944,233,996 - 44,234,056EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88279 AgrOrtholog
Ensembl Genes ENSMUSG00000034342 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000041902 ENTREZGENE
  ENSMUSP00000041902.8 UniProtKB/TrEMBL
  ENSMUSP00000145538.2 UniProtKB/TrEMBL
  ENSMUSP00000145791.2 UniProtKB/TrEMBL
  ENSMUSP00000145827.2 UniProtKB/TrEMBL
  ENSMUSP00000145889.2 UniProtKB/TrEMBL
  ENSMUSP00000146244 ENTREZGENE
  ENSMUSP00000146244.2 UniProtKB/Swiss-Prot
  ENSMUSP00000146287.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000037644 ENTREZGENE
  ENSMUST00000037644.8 UniProtKB/TrEMBL
  ENSMUST00000205755.2 UniProtKB/TrEMBL
  ENSMUST00000205968.2 UniProtKB/TrEMBL
  ENSMUST00000206147.2 UniProtKB/TrEMBL
  ENSMUST00000206258.2 UniProtKB/TrEMBL
  ENSMUST00000206540.2 UniProtKB/TrEMBL
  ENSMUST00000206720 ENTREZGENE
  ENSMUST00000206720.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.930.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Adaptor_Cbl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_EF_hand-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_N_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_N_hlx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adaptor_Cbl_SH2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12402 UniProtKB/Swiss-Prot
MGD MGI:88279 ENTREZGENE
NCBI Gene 12402 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE CBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23007 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cbl_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl_N3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prok-RING_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cbl PhenoGen
PROSITE CBL_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47668 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNF1_MOUSE UniProtKB/TrEMBL
  A0A0U1RP17_MOUSE UniProtKB/TrEMBL
  A0A0U1RP47_MOUSE UniProtKB/TrEMBL
  A0A0U1RP95_MOUSE UniProtKB/TrEMBL
  A0A0U1RQ85_MOUSE UniProtKB/TrEMBL
  A0A0X1KG61 ENTREZGENE, UniProtKB/TrEMBL
  B1NE42_MOUSE UniProtKB/TrEMBL
  CBL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q2M4H7_MOUSE UniProtKB/TrEMBL
  Q8CEA1 ENTREZGENE
UniProt Secondary Q3U527 UniProtKB/Swiss-Prot
  Q8CEA1 UniProtKB/Swiss-Prot