Spen (spen family transcription repressor) - Rat Genome Database
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Gene: Spen (spen family transcription repressor) Mus musculus
Analyze
Symbol: Spen
Name: spen family transcription repressor
RGD ID: 1558566
Description: Exhibits DNA-binding transcription factor activity; single-stranded DNA binding activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription, DNA-templated. Localizes to nucleus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; sensory organ; and tooth. Orthologous to human SPEN (spen family transcriptional repressor); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Mi; Mint; mKIAA0929; Msx2 interacting nuclear target protein; msx2-interacting protein; SMART/HDAC1-associated repressor protein; SPEN homolog, transcriptional regulator; SPEN homolog, transcriptional regulator (Drosophila)
Orthologs:
Homo sapiens (human) : SPEN (spen family transcriptional repressor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Spen (spen family transcriptional repressor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spen (spen family transcriptional repressor)
Pan paniscus (bonobo/pygmy chimpanzee) : SPEN (spen family transcriptional repressor)
Canis lupus familiaris (dog) : SPEN (spen family transcriptional repressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spen (spen family transcriptional repressor)
Sus scrofa (pig) : SPEN (spen family transcriptional repressor)
Chlorocebus sabaeus (African green monkey) : SPEN (spen family transcriptional repressor)
Heterocephalus glaber (naked mole-rat) : Spen (spen family transcriptional repressor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,195,199 - 141,265,955 (-)NCBI
GRCm384141,467,885 - 141,538,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,467,890 - 141,538,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv374141,023,805 - 141,094,512 (-)NCBIGRCm37mm9NCBIm37
MGSCv364140,740,934 - 140,794,407 (-)NCBImm8
Celera4143,285,155 - 143,361,424 (-)NCBICelera
Cytogenetic Map4D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9119401   PMID:10349636   PMID:10451362   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11318877   PMID:12374742   PMID:12477932   PMID:12520002   PMID:12594956  
PMID:12904583   PMID:14610273   PMID:15108316   PMID:15131132   PMID:15777657   PMID:15778499   PMID:15782199   PMID:16033648   PMID:16141072   PMID:16141073   PMID:17242367   PMID:17457934  
PMID:17664272   PMID:18287559   PMID:18799693   PMID:19914235   PMID:20211142   PMID:20393883   PMID:20484411   PMID:21267068   PMID:21372128   PMID:21873635   PMID:21945074   PMID:24952961  
PMID:25915022   PMID:26190100   PMID:26190105   PMID:28640815   PMID:29880719   PMID:29977079   PMID:30457570   PMID:30673607   PMID:32025035   PMID:32325033   PMID:32986830  


Genomics

Comparative Map Data
Spen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,195,199 - 141,265,955 (-)NCBI
GRCm384141,467,885 - 141,538,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,467,890 - 141,538,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv374141,023,805 - 141,094,512 (-)NCBIGRCm37mm9NCBIm37
MGSCv364140,740,934 - 140,794,407 (-)NCBImm8
Celera4143,285,155 - 143,361,424 (-)NCBICelera
Cytogenetic Map4D3NCBI
SPEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl115,836,095 - 15,940,456 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl115,847,707 - 15,940,456 (+)EnsemblGRCh38hg38GRCh38
GRCh38115,847,707 - 15,940,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,174,359 - 16,266,951 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,046,946 - 16,139,537 (+)NCBINCBI36hg18NCBI36
Build 34115,919,664 - 16,012,256NCBI
Celera114,654,230 - 14,746,824 (+)NCBI
Cytogenetic Map1p36.21-p36.13NCBI
HuRef114,692,961 - 14,785,958 (+)NCBIHuRef
CHM1_1115,972,883 - 16,065,485 (+)NCBICHM1_1
Spen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05160,015,573 - 160,070,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,015,454 - 160,070,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,735,389 - 163,790,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,359,738 - 160,414,311 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5152,134,833 - 152,205,318 (-)NCBICelera
Cytogenetic Map5q36NCBI
Spen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,280,459 - 2,343,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,279,438 - 2,343,263 (-)NCBIChiLan1.0ChiLan1.0
SPEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,004,908 - 16,072,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,004,473 - 16,072,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0114,987,415 - 15,079,477 (+)NCBIMhudiblu_PPA_v0panPan3
SPEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,683,824 - 81,775,904 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Spen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364743,473,892 - 3,535,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,015,521 - 75,107,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,015,565 - 75,107,468 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPEN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl20116,361,008 - 116,458,064 (-)Ensembl
ChlSab1.120116,359,981 - 116,458,156 (-)NCBI
Spen
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247642,058,689 - 2,144,640 (+)NCBI

Position Markers
Spen  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384141,472,294 - 141,472,893UniSTSGRCm38
MGSCv374141,028,209 - 141,028,808UniSTSGRCm37
Celera4143,289,569 - 143,290,168UniSTS
Cytogenetic Map4E1UniSTS
cM Map4 UniSTS
SGC33756  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384141,469,123 - 141,470,324UniSTSGRCm38
MGSCv374141,025,038 - 141,026,239UniSTSGRCm37
Celera4143,286,379 - 143,287,600UniSTS
Cytogenetic Map4E1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465800000146500000Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
13208562Wght7_mweight 7 (mouse)491000000148000000Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105978113141706527Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105978113141706527Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105978113141706527Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105978113141706527Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107897771141897963Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108583899142583899Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108583899142583899Mouse
10755521Hct1_mhematocrit 1 (mouse)4108583899142583899Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111115258145115487Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111115258145115487Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112288593146288593Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112629696146629696Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112930596146930596Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116427367150427471Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117673830151673964Mouse
14746982Manh56_mmandible shape 56 (mouse)4118088606152088606Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4120137122154137225Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4120137122154137225Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120890537154890684Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120890537154890684Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4124100000144600000Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124161300141845481Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124161300142711450Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124371164142504390Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124371164150592401Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129572018151570093Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4132926037156508116Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133427367150704994Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133592276156508116Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134569994156508116Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134569994156508116Mouse
1357534Cinda3_mcytokine induced activation 3 (mouse)Not determined4137890537142562902Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137890537151570093Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137946694150592401Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138859268156508116Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1229
Count of miRNA genes:525
Interacting mature miRNAs:589
Transcripts:ENSMUST00000078886, ENSMUST00000105786, ENSMUST00000144500, ENSMUST00000147227, ENSMUST00000152081, ENSMUST00000152411
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001347235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB055980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF156529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL670285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL670446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY726481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z78160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000078886   ⟹   ENSMUSP00000077925
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4141,467,890 - 141,538,449 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105786   ⟹   ENSMUSP00000101412
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4141,467,890 - 141,538,597 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144500
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4141,495,529 - 141,516,909 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147227
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4141,468,464 - 141,471,493 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152081
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4141,521,803 - 141,538,253 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152411
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4141,484,593 - 141,488,312 (-)Ensembl
RefSeq Acc Id: NM_001347235   ⟹   NP_001334164
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,195,201 - 141,265,908 (-)NCBI
GRCm384141,467,890 - 141,538,597 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019763   ⟹   NP_062737
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,195,201 - 141,265,908 (-)NCBI
GRCm384141,467,890 - 141,538,597 (-)NCBI
MGSCv374141,023,805 - 141,094,512 (-)RGD
Celera4143,285,155 - 143,361,424 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539069   ⟹   XP_006539132
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,195,199 - 141,265,955 (-)NCBI
GRCm384141,467,885 - 141,538,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006539070   ⟹   XP_006539133
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,195,199 - 141,265,955 (-)NCBI
GRCm384141,467,899 - 141,538,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006539073   ⟹   XP_006539136
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,195,199 - 141,265,955 (-)NCBI
GRCm384141,467,885 - 141,538,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164266   ⟹   XP_036020159
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,195,199 - 141,265,955 (-)NCBI
RefSeq Acc Id: XM_036164267   ⟹   XP_036020160
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,195,199 - 141,265,955 (-)NCBI
RefSeq Acc Id: XM_036164268   ⟹   XP_036020161
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,195,199 - 141,265,934 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062737   ⟸   NM_019763
- Peptide Label: isoform 1
- UniProtKB: Q62504 (UniProtKB/Swiss-Prot),   A2ADB0 (UniProtKB/TrEMBL),   Q3UV27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539133   ⟸   XM_006539070
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006539136   ⟸   XM_006539073
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006539132   ⟸   XM_006539069
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001334164   ⟸   NM_001347235
- Peptide Label: isoform 2
- UniProtKB: A2ADB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000101412   ⟸   ENSMUST00000105786
RefSeq Acc Id: ENSMUSP00000077925   ⟸   ENSMUST00000078886
RefSeq Acc Id: XP_036020160   ⟸   XM_036164267
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036020159   ⟸   XM_036164266
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036020161   ⟸   XM_036164268
- Peptide Label: isoform X6
Protein Domains
RID   RRM   SPOC

Promoters
RGD ID:6847854
Promoter ID:MM_ACW:36324
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:SPEN.GSEP07,   SPEN.HSEP07,   SPEN.JSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,026,126 - 141,026,627 (-)MPROMDB
RGD ID:6836440
Promoter ID:MM_KWN:40486
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000024115
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,027,396 - 141,028,357 (-)MPROMDB
RGD ID:6848799
Promoter ID:MM_TRO:7153
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:MTR018985.4.2581.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,029,876 - 141,030,376 (-)MPROMDB
RGD ID:6847850
Promoter ID:MM_ACW:36325
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Kidney
Transcripts:SPEN.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,030,939 - 141,031,439 (-)MPROMDB
RGD ID:6836436
Promoter ID:MM_KWN:40487
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000024113
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,043,651 - 141,044,151 (-)MPROMDB
RGD ID:6836439
Promoter ID:MM_KWN:40488
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:UC008VOM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,050,561 - 141,051,061 (-)MPROMDB
RGD ID:6836437
Promoter ID:MM_KWN:40489
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000024116
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,072,756 - 141,073,256 (-)MPROMDB
RGD ID:6836435
Promoter ID:MM_KWN:40491
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000105786,   ENSMUST00000105787,   NM_019763,   UC008VOP.1,   UC008VOQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,094,056 - 141,095,087 (-)MPROMDB
RGD ID:6885318
Promoter ID:EPDNEW_M6110
Type:single initiation site
Name:Spen_2
Description:Mus musculus spen family transcription repressor , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6111  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384141,488,311 - 141,488,371EPDNEW
RGD ID:6885320
Promoter ID:EPDNEW_M6111
Type:initiation region
Name:Spen_1
Description:Mus musculus spen family transcription repressor , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6110  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384141,538,512 - 141,538,572EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891706 AgrOrtholog
Ensembl Genes ENSMUSG00000040761 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000077925 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000101412 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000078886 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000105786 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.40.290.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHARP_RRM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHARP_RRM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHARP_RRM3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHARP_RRM4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPOC-like_C_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPOC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPOC_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56381 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1891706 ENTREZGENE
NCBI Gene 56381 ENTREZGENE
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPOC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spen PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPOC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100939 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.299906 ENTREZGENE
UniProt A2ADB0 ENTREZGENE, UniProtKB/TrEMBL
  A2ADB1 ENTREZGENE, UniProtKB/TrEMBL
  MINT_MOUSE UniProtKB/Swiss-Prot
  Q3UV27 ENTREZGENE, UniProtKB/TrEMBL
  Q62504 ENTREZGENE
UniProt Secondary Q80TN9 UniProtKB/Swiss-Prot
  Q99PS4 UniProtKB/Swiss-Prot
  Q9QZW2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Spen  spen family transcription repressor    SPEN homolog, transcriptional regulator (Drosophila)  Symbol and/or name change 5135510 APPROVED