Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | acute lymphoblastic leukemia | | ISO | RGD:1345718 | 8554872 | ClinVar more ... | ClinVar | PMID:28492532 | chronic myelogenous leukemia, BCR-ABL1 positive | | ISO | RGD:1345718 | 8554872 | ClinVar Annotator: match by term: Chronic myelogenous leukemia, BCR-ABL1 positive | ClinVar | | common variable immunodeficiency 13 | | ISO | RGD:1345718 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency more ... | ClinVar | PMID:21548011 more ... | Diamond-Blackfan Anemia-Like | | ISO | RGD:1345718 | 8554872 | ClinVar Annotator: match by term: Diamond-Blackfan anemia-like | ClinVar | | pleomorphic xanthoastrocytoma | | ISO | RGD:1345718 | 8554872 | ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma | ClinVar | PMID:28299358 | primary immunodeficiency disease | | ISO | RGD:1345718 | 8554872 | ClinVar Annotator: match by term: Inherited Immunodeficiency Diseases | ClinVar | PMID:25741868 more ... | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
Imported Disease Annotations - OMIM
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells. | Javierre BM, etal., Mol Cancer Res. 2011 Aug;9(8):1139-51. doi: 10.1158/1541-7786.MCR-10-0515. Epub 2011 Jul 7. |
| 2. | Methylation and Gene Expression of BCAT1 and IKZF1 in Colorectal Cancer Tissues. | Jedi M, etal., Clin Med Insights Oncol. 2018 May 10;12:1179554918775064. doi: 10.1177/1179554918775064. eCollection 2018. |
| 3. | Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia. | Krentz S, etal., Leukemia. 2013 Feb;27(2):295-304. doi: 10.1038/leu.2012.155. Epub 2012 Jun 13. |
| 4. | Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing. | Li J, etal., Clin Chem. 2019 Jul;65(7):916-926. doi: 10.1373/clinchem.2019.301804. Epub 2019 Apr 22. |
| 5. | Disease risk factors identified through shared genetic architecture and electronic medical records. | Li L, etal., Sci Transl Med. 2014 Apr 30;6(234):234ra57. doi: 10.1126/scitranslmed.3007191. |
| 6. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 7. | MGD IEA | MGD IEA |
| 8. | Relationship between post-surgery detection of methylated circulating tumor DNA with risk of residual disease and recurrence-free survival. | Murray DH, etal., J Cancer Res Clin Oncol. 2018 Sep;144(9):1741-1750. doi: 10.1007/s00432-018-2701-x. Epub 2018 Jul 10. |
| 9. | Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1 to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC). | Musher BL, etal., Cancer Epidemiol Biomarkers Prev. 2020 Dec;29(12):2702-2709. doi: 10.1158/1055-9965.EPI-20-0574. Epub 2020 Sep 21. |
| 10. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 11. | A two-gene blood test for methylated DNA sensitive for colorectal cancer. | Pedersen SK, etal., PLoS One. 2015 Apr 30;10(4):e0125041. doi: 10.1371/journal.pone.0125041. eCollection 2015. |
| 12. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 13. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 14. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 15. | Evaluation of newly identified Ikaros family zinc finger 1 loci in colorectal cancer. | Sharma B, etal., J Cancer Res Ther. 2021 Jan-Mar;17(1):46-50. doi: 10.4103/jcrt.JCRT_844_20. |
| 16. | Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases. | Sun J, etal., Nat Commun. 2019 Jul 18;10(1):3190. doi: 10.1038/s41467-019-10987-3. |
| 17. | Circulating epigenetic biomarkers for detection of recurrent colorectal cancer. | Symonds EL, etal., Cancer. 2020 Apr 1;126(7):1460-1469. doi: 10.1002/cncr.32695. Epub 2020 Jan 7. |
| 18. | Circulating tumour DNA for monitoring colorectal cancer-a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection. | Symonds EL, etal., Clin Epigenetics. 2018 May 16;10:63. doi: 10.1186/s13148-018-0500-5. eCollection 2018. |
| 19. | A cross-sectional study comparing a blood test for methylated BCAT1 and IKZF1 tumor-derived DNA with CEA for detection of recurrent colorectal cancer. | Young GP, etal., Cancer Med. 2016 Oct;5(10):2763-2772. doi: 10.1002/cam4.868. Epub 2016 Oct 11. |
| 20. | Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer. | Young GP, etal., Clin Epigenetics. 2021 Jan 21;13(1):14. doi: 10.1186/s13148-020-00999-y. |
| 21. | Inhibitory effects of transcription factor Ikaros on the expression of liver cancer stem cell marker CD133 in hepatocellular carcinoma. | Zhang L, etal., Oncotarget. 2014 Nov 15;5(21):10621-35. doi: 10.18632/oncotarget.2524. |
| 22. | Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression. | Zhao W, etal., J Int Med Res. 2020 Aug;48(8):300060520945860. doi: 10.1177/0300060520945860. |
Additional References at PubMed
| PMID:1439790 | PMID:3063539 | PMID:7585946 | PMID:7923373 | PMID:7935426 | PMID:7969165 | PMID:8543809 | PMID:8889548 | PMID:8895580 | PMID:8964602 | PMID:8986714 | PMID:9133423 |
| PMID:9143685 | PMID:9155026 | PMID:9175833 | PMID:9354469 | PMID:9435248 | PMID:9560339 | PMID:9811459 | PMID:9817935 | PMID:10204489 | PMID:10204490 | PMID:10218586 | PMID:10322160 |
| PMID:10349636 | PMID:10366784 | PMID:10523602 | PMID:10544193 | PMID:10597273 | PMID:10687308 | PMID:10754285 | PMID:10956435 | PMID:11042159 | PMID:11076861 | PMID:11196687 | PMID:11217851 |
| PMID:11526101 | PMID:11799125 | PMID:11805317 | PMID:11823468 | PMID:11839096 | PMID:11869689 | PMID:11870616 | PMID:12218095 | PMID:12406904 | PMID:12431989 | PMID:12464629 | PMID:12477932 |
| PMID:12479824 | PMID:12504015 | PMID:12514733 | PMID:12565905 | PMID:12617992 | PMID:12620233 | PMID:12626565 | PMID:12707343 | PMID:12727887 | PMID:12842084 | PMID:12871645 | PMID:14596876 |
| PMID:14681479 | PMID:14960357 | PMID:14976135 | PMID:15024069 | PMID:15383578 | PMID:15580273 | PMID:15618287 | PMID:15618518 | PMID:15619624 | PMID:15713624 | PMID:15767674 | PMID:15790496 |
| PMID:15841184 | PMID:16141072 | PMID:16141073 | PMID:16272328 | PMID:16292344 | PMID:16354692 | PMID:16467156 | PMID:16518393 | PMID:16618599 | PMID:16628252 | PMID:16870249 | PMID:16889948 |
| PMID:16912230 | PMID:16940173 | PMID:16968900 | PMID:17086208 | PMID:17148585 | PMID:17307348 | PMID:17341593 | PMID:17476278 | PMID:17504264 | PMID:17625108 | PMID:17681952 | PMID:17980631 |
| PMID:18025173 | PMID:18223295 | PMID:18287091 | PMID:18287559 | PMID:18313668 | PMID:18318763 | PMID:18483254 | PMID:18505785 | PMID:18538592 | PMID:18568028 | PMID:18623087 | PMID:18799682 |
| PMID:18804520 | PMID:18818879 | PMID:18852286 | PMID:18940586 | PMID:18941217 | PMID:19030180 | PMID:19111880 | PMID:19114560 | PMID:19116116 | PMID:19124715 | PMID:19124730 | PMID:19174477 |
| PMID:19282287 | PMID:19299690 | PMID:19345118 | PMID:19386638 | PMID:19414557 | PMID:19734904 | PMID:19816952 | PMID:19818654 | PMID:19828627 | PMID:19923223 | PMID:19950118 | PMID:20059953 |
| PMID:20181579 | PMID:20194733 | PMID:20392955 | PMID:20393504 | PMID:20511547 | PMID:20566697 | PMID:20699440 | PMID:20829372 | PMID:21093322 | PMID:21245044 | PMID:21267068 | PMID:21289201 |
| PMID:21452241 | PMID:21471527 | PMID:21515796 | PMID:21572027 | PMID:21840596 | PMID:21873635 | PMID:22080921 | PMID:22142223 | PMID:22291095 | PMID:22301782 | PMID:22473956 | PMID:22611152 |
| PMID:22638570 | PMID:22778136 | PMID:22863011 | PMID:22922362 | PMID:22988430 | PMID:23071339 | PMID:23074133 | PMID:23172374 | PMID:23335373 | PMID:23382203 | PMID:23382691 | PMID:23483882 |
| PMID:23500440 | PMID:23603794 | PMID:23638021 | PMID:23732910 | PMID:23908463 | PMID:23990620 | PMID:24002445 | PMID:24013668 | PMID:24082127 | PMID:24145030 | PMID:24297995 | PMID:24509509 |
| PMID:24509510 | PMID:24643801 | PMID:24778448 | PMID:24952961 | PMID:25053428 | PMID:25085254 | PMID:25108355 | PMID:25194055 | PMID:25249461 | PMID:25629611 | PMID:25654255 | PMID:26135129 |
| PMID:26141385 | PMID:26141488 | PMID:26166575 | PMID:26314708 | PMID:26321221 | PMID:26511239 | PMID:26549758 | PMID:26713593 | PMID:26775846 | PMID:26841869 | PMID:27315244 | PMID:27354269 |
| PMID:27438771 | PMID:27588474 | PMID:27681176 | PMID:27815209 | PMID:27979924 | PMID:28190001 | PMID:28584103 | PMID:28670688 | PMID:28848064 | PMID:28914974 | PMID:28919299 | PMID:29343500 |
| PMID:29898962 | PMID:30001316 | PMID:30196744 | PMID:30635395 | PMID:31073152 | PMID:31299112 | PMID:31552487 | PMID:31591571 | PMID:32071204 | PMID:32453736 | PMID:32582141 | PMID:33446502 |
| PMID:33658297 | PMID:33770102 | PMID:33893236 | PMID:34193976 | PMID:34671097 | PMID:34871625 | PMID:35156680 | PMID:36537580 | PMID:36702234 |
Genomics
Comparative Map Data
| Ikzf1 (Mus musculus - house mouse) |
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| IKZF1 (Homo sapiens - human) |
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| Ikzf1 (Rattus norvegicus - Norway rat) |
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| Ikzf1 (Chinchilla lanigera - long-tailed chinchilla) |
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| IKZF1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| IKZF1 (Canis lupus familiaris - dog) |
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| Ikzf1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| IKZF1 (Sus scrofa - pig) |
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| IKZF1 (Chlorocebus sabaeus - green monkey) |
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| Ikzf1 (Heterocephalus glaber - naked mole-rat) |
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miRNA Target Status
Predicted Target Of
| The detailed report is available here: |  | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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QTLs in Region (GRCm39)
| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Markers in Region
| L03547 |
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| Znfn1a1 |
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| PMC156063P1 |
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| Ikzf1 |
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| Ikzf1 |
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| Znfn1a1 |
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| Ikzf1 |
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| Ikzf1 |
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| Ikzf1 |
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| Ikzf1 |
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