Clec7a (C-type lectin domain family 7, member a) - Rat Genome Database

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Gene: Clec7a (C-type lectin domain family 7, member a) Mus musculus
Analyze
Symbol: Clec7a
Name: C-type lectin domain family 7, member a
RGD ID: 1558559
MGI Page MGI
Description: Enables (1->3)-beta-D-glucan binding activity; (1->3)-beta-D-glucan immune receptor activity; and opsonin binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and response to fungus. Acts upstream of or within several processes, including phagocytosis; positive regulation of tumor necrosis factor production; and response to fungus. Located in external side of plasma membrane. Is expressed in several structures, including gut; limb; musculature; spleen; and ventral grey horn. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-; beta-glucan receptor; beta-GR; BG; BGR; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; Clecsf; Clecsf12; DC-associated C-type lectin 1; dectin; dectin-1; dendritic cell-associated C-type lectin 1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,438,554 - 129,449,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6129,438,554 - 129,449,742 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386129,461,591 - 129,472,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,461,591 - 129,472,779 (-)Ensemblmm10GRCm38
MGSCv376129,411,609 - 129,422,795 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366129,427,284 - 129,438,465 (-)NCBIMGSCv36mm8
Celera6131,183,577 - 131,194,776 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bortezomib  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
chitosan  (ISO)
chloroprene  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
D-glucose  (EXP)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diiodine  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP)
fenamidone  (EXP)
fenthion  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gardiquimod  (ISO)
glucose  (EXP)
GW 4064  (EXP)
indometacin  (ISO)
L-methionine  (EXP)
leukotriene C4  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
metam  (EXP)
methylarsonic acid  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
nickel atom  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phthalaldehyde  (EXP)
protein kinase inhibitor  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
succimer  (ISO)
tacrolimus hydrate  (EXP)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tremolite asbestos  (EXP)
Tributyltin oxide  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
vinclozolin  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antifungal innate immune response  (IDA,IMP)
apoptotic signaling pathway  (ISO)
cell activation  (IDA)
cell recognition  (ISO)
cell surface pattern recognition receptor signaling pathway  (IDA,IEA,ISO)
cell-cell adhesion  (IDA)
cellular response to molecule of fungal origin  (IDA,IEA,ISO)
detection of fungus  (IEA,ISO)
detection of molecule of fungal origin  (IDA,IEA,ISO)
detection of yeast  (IDA)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IBA,IDA,IEA)
leukocyte activation  (IEA)
leukocyte activation involved in immune response  (IDA)
phagocytosis, engulfment  (IDA)
phagocytosis, recognition  (IBA,IDA,IEA,ISO)
positive regulation of calcineurin-NFAT signaling cascade  (IMP)
positive regulation of calcium-mediated signaling  (IDA)
positive regulation of canonical NF-kappaB signal transduction  (IDA,ISO)
positive regulation of cell maturation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production involved in immune response  (IBA,IDA)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of dendritic cell cytokine production  (IDA,IMP)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (IEA,IMP,ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-2 production  (IEA,IMP,ISO)
positive regulation of interleukin-23 production  (IMP)
positive regulation of interleukin-6 production  (IEA,IMP,ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of lymphocyte activation  (ISO)
positive regulation of MAPK cascade  (IMP)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of phagocytosis  (IDA,IEA,ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of respiratory burst  (ISO)
positive regulation of stress-activated MAPK cascade  (IDA)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T-helper 17 type immune response  (IMP)
positive regulation of tumor necrosis factor production  (IDA,IEA,IMP,ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of wound healing  (ISO)
regulation of calcineurin-NFAT signaling cascade  (IMP)
regulation of canonical NF-kappaB signal transduction  (IBA,IDA)
response to molecule of fungal origin  (IDA)
response to yeast  (IDA)
stimulatory C-type lectin receptor signaling pathway  (IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses. Zhong J, etal., PLoS One. 2016 Mar 10;11(3):e0150114. doi: 10.1371/journal.pone.0150114. eCollection 2016.
Additional References at PubMed
PMID:10779524   PMID:11470510   PMID:11491532   PMID:11544516   PMID:12163569   PMID:12244185   PMID:12477932   PMID:12719478   PMID:12719479   PMID:14568930   PMID:14657220   PMID:14698225  
PMID:14707091   PMID:14726497   PMID:15213161   PMID:15304394   PMID:15489334   PMID:15729357   PMID:15731053   PMID:15845454   PMID:15956283   PMID:16407295   PMID:16517740   PMID:16622020  
PMID:16825490   PMID:17084455   PMID:17159982   PMID:17159984   PMID:17339468   PMID:17450144   PMID:17486093   PMID:17697127   PMID:17785780   PMID:17997408   PMID:18037789   PMID:18171906  
PMID:18200499   PMID:18292498   PMID:18322216   PMID:18418396   PMID:18652908   PMID:18714028   PMID:18818389   PMID:18936185   PMID:19124758   PMID:19130473   PMID:19136564   PMID:19139169  
PMID:19273561   PMID:19291703   PMID:19327548   PMID:19342673   PMID:19433551   PMID:19451235   PMID:19502385   PMID:19525229   PMID:19703985   PMID:20062524   PMID:20065023   PMID:20360401  
PMID:20451901   PMID:20493731   PMID:20562862   PMID:20617171   PMID:21059925   PMID:21242294   PMID:21246055   PMID:21257963   PMID:21267068   PMID:21282509   PMID:21357722   PMID:21400494  
PMID:21424514   PMID:21480215   PMID:21525931   PMID:21531981   PMID:21636079   PMID:21642586   PMID:21668824   PMID:21807912   PMID:21825168   PMID:21873635   PMID:21935459   PMID:22028332  
PMID:22038916   PMID:22041900   PMID:22177564   PMID:22199280   PMID:22207010   PMID:22505458   PMID:22523066   PMID:22543832   PMID:22547696   PMID:22649195   PMID:22661085   PMID:22674328  
PMID:22696442   PMID:22777843   PMID:22829762   PMID:22902620   PMID:22922409   PMID:22933634   PMID:22962686   PMID:22988015   PMID:23049859   PMID:23200858   PMID:23220005   PMID:23286586  
PMID:23386437   PMID:23518266   PMID:23533666   PMID:23609446   PMID:23637604   PMID:23684988   PMID:23770228   PMID:23825946   PMID:23926321   PMID:23950842   PMID:24072822   PMID:24362892  
PMID:24379281   PMID:24458430   PMID:24516163   PMID:24604821   PMID:24722226   PMID:24801349   PMID:24952961   PMID:25063877   PMID:25149452   PMID:25246634   PMID:25267792   PMID:25474208  
PMID:25675510   PMID:25680275   PMID:25682030   PMID:25915733   PMID:26100917   PMID:26132276   PMID:26140582   PMID:26156997   PMID:26216045   PMID:26269954   PMID:26297607   PMID:26349660  
PMID:26416276   PMID:26421959   PMID:26432261   PMID:26453753   PMID:26644324   PMID:26655905   PMID:26739065   PMID:26829985   PMID:26840954   PMID:27144456   PMID:27189427   PMID:27259855  
PMID:27288407   PMID:27294852   PMID:27391897   PMID:27428899   PMID:27492902   PMID:27559045   PMID:27568820   PMID:27852745   PMID:27872290   PMID:28282442   PMID:28295265   PMID:28394331  
PMID:28530644   PMID:28587925   PMID:28608623   PMID:28614714   PMID:28636955   PMID:28658592   PMID:28658621   PMID:28671985   PMID:28784846   PMID:28848046   PMID:29058172   PMID:29401615  
PMID:29401627   PMID:29475849   PMID:29576482   PMID:29643192   PMID:29668708   PMID:29875204   PMID:29897456   PMID:30018105   PMID:30074165   PMID:30108595   PMID:30240621   PMID:30266768  
PMID:30431070   PMID:30510167   PMID:30586706   PMID:30606613   PMID:30610060   PMID:30712258   PMID:30850233   PMID:31010852   PMID:31169521   PMID:31202927   PMID:31242262   PMID:31483778  
PMID:31754039   PMID:31811024   PMID:31875551   PMID:31978804   PMID:32234475   PMID:32296441   PMID:32358020   PMID:32376769   PMID:32459842   PMID:32466296   PMID:32485165   PMID:32511980  
PMID:32554809   PMID:32576672   PMID:32579678   PMID:32601220   PMID:32970988   PMID:33082323   PMID:33113356   PMID:33428957   PMID:33581044   PMID:33827895   PMID:34010642   PMID:34076685  
PMID:34362877   PMID:34424458   PMID:34995333   PMID:35129602   PMID:35148840   PMID:35316647   PMID:35354044   PMID:35584674   PMID:35698210   PMID:35761088   PMID:36138043   PMID:36185364  
PMID:36205788   PMID:36369287   PMID:36377664   PMID:36713833   PMID:36786193   PMID:36932082   PMID:36948194   PMID:37054997   PMID:37416769   PMID:37446240   PMID:37813169   PMID:37861312  
PMID:38007451   PMID:38055819   PMID:38170734   PMID:38215167   PMID:38385597   PMID:38459541   PMID:38671323   PMID:38953581   PMID:39478855   PMID:39570374   PMID:40117345   PMID:40121230  
PMID:40494347  


Genomics

Comparative Map Data
Clec7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,438,554 - 129,449,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6129,438,554 - 129,449,742 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386129,461,591 - 129,472,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,461,591 - 129,472,779 (-)Ensemblmm10GRCm38
MGSCv376129,411,609 - 129,422,795 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366129,427,284 - 129,438,465 (-)NCBIMGSCv36mm8
Celera6131,183,577 - 131,194,776 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.34NCBI
CLEC7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,116,777 - 10,130,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,116,777 - 10,130,258 (-)Ensemblhg38GRCh38
GRCh371210,269,376 - 10,282,798 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,160,643 - 10,174,135 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341210,171,190 - 10,174,103NCBI
Celera1215,430,059 - 15,443,548 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1210,012,523 - 10,026,010 (-)NCBIHuRef
CHM1_11210,238,652 - 10,252,134 (-)NCBICHM1_1
T2T-CHM13v2.01210,003,452 - 10,016,972 (-)NCBIT2T-CHM13v2.0
Clec7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,588,737 - 164,599,953 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4164,588,754 - 164,599,919 (-)EnsemblGRCr8
mRatBN7.24162,902,731 - 162,913,931 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4162,902,732 - 162,913,897 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4169,137,545 - 169,148,615 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04164,920,504 - 164,931,574 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,554,549 - 163,565,619 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,216,152 - 163,227,367 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,216,163 - 163,227,334 (-)Ensemblrn6Rnor6.0
Rnor_5.04211,859,714 - 211,870,889 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44166,723,515 - 166,734,681 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4151,587,575 - 151,598,651 (-)NCBICelera
Cytogenetic Map4q42NCBI
CLEC7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21015,604,637 - 15,617,580 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,599,522 - 15,614,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01210,161,780 - 10,174,943 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,410,384 - 10,425,452 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,410,384 - 10,425,452 (-)EnsemblpanPan2panpan1.1
CLEC7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12735,852,685 - 35,885,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2735,853,099 - 36,007,157 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2710,738,120 - 10,766,549 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02736,203,142 - 36,231,601 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2736,209,883 - 36,264,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,091,248 - 36,119,494 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,120,431 - 36,141,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02710,260,084 - 10,288,263 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Clec7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494597,304,630 - 97,315,165 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936902436,312 - 446,076 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936902436,224 - 446,435 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLEC7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl561,832,954 - 61,846,434 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1561,832,910 - 61,846,441 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,542,875 - 64,556,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLEC7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,989,520 - 10,007,442 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,995,203 - 10,006,746 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660892,066,063 - 2,084,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clec7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475226,871,292 - 26,891,910 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475226,871,556 - 26,885,778 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Clec7a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1618,131,910 - 18,143,037 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Clec7a
709 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:643
Count of miRNA genes:275
Interacting mature miRNAs:306
Transcripts:ENSMUST00000112076, ENSMUST00000184581, ENSMUST00000184861
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128180868149588044Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
1301084Bpq5_mblood pressure QTL 5 (mouse)Not determined6129330484149588044Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
10766452Sle23_msystematic lupus erythematosus susceptibility 23 (mouse)6128601582149588044Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
4141611Btts_mbitterness tasting (mouse)Not determined6125333609134096586Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
4141151Ath38_matherosclerosis 38 (mouse)Not determined128495857136293176Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1301686Trmq1_mT cell ratio modifier QTL 1 (mouse)Not determined6129330484149588044Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10053680Lith25_mlithogenic gene 25 (mouse)Not determined6128601582149588044Mouse
10412215Cmv3_mcytomegalovirus resistance 3 (mouse)Not determined6128811857137416927Mouse
4141974Skmw14_mskeletal muscle weight 14 (mouse)Not determined6129330484149588044Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301027Hdlq12_mHDL QTL 12 (mouse)Not determined6128601582149588044Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
10412134Cmv4_mcytomegalovirus resistance 4 (mouse)Not determined6127815180136022150Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse

Markers in Region
BE447139  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386129,461,686 - 129,461,775UniSTSGRCm38
MGSCv376129,411,704 - 129,411,793UniSTSGRCm37
Celera6131,183,672 - 131,183,761UniSTS
Cytogenetic Map6F3UniSTS
Whitehead/MRC_RH61306.88UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000112076   ⟹   ENSMUSP00000107707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6129,438,554 - 129,449,740 (-)Ensembl
GRCm38.p6 Ensembl6129,461,591 - 129,472,777 (-)Ensembl
Ensembl Acc Id: ENSMUST00000184581   ⟹   ENSMUSP00000139167
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6129,439,989 - 129,449,740 (-)Ensembl
GRCm38.p6 Ensembl6129,463,026 - 129,472,777 (-)Ensembl
Ensembl Acc Id: ENSMUST00000184861
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6129,447,503 - 129,449,742 (-)Ensembl
GRCm38.p6 Ensembl6129,470,540 - 129,472,779 (-)Ensembl
Ensembl Acc Id: ENSMUST00000195589   ⟹   ENSMUSP00000141234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6129,438,554 - 129,449,735 (-)Ensembl
GRCm38.p6 Ensembl6129,461,591 - 129,472,772 (-)Ensembl
RefSeq Acc Id: NM_001309637   ⟹   NP_001296566
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,438,554 - 129,449,748 (-)NCBI
GRCm386129,461,591 - 129,472,785 (-)NCBI
Sequence:
RefSeq Acc Id: NR_132130
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,438,554 - 129,449,742 (-)NCBI
GRCm386129,461,591 - 129,472,779 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001296566   ⟸   NM_001309637
- Peptide Label: isoform 2
- UniProtKB: Q9JI50 (UniProtKB/Swiss-Prot),   Q8K1L4 (UniProtKB/Swiss-Prot),   Q6QLQ4 (UniProtKB/Swiss-Prot),   E9QPW2 (UniProtKB/Swiss-Prot),   V9GXI5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000139167   ⟸   ENSMUST00000184581
Ensembl Acc Id: ENSMUSP00000107707   ⟸   ENSMUST00000112076
Ensembl Acc Id: ENSMUSP00000141234   ⟸   ENSMUST00000195589
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QLQ4-F1-model_v2 AlphaFold Q6QLQ4 1-244 view protein structure

Promoters
RGD ID:6839095
Promoter ID:MM_KWN:47846
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ENSMUST00000112076,   NM_020008,   UC009EFV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366129,422,546 - 129,423,046 (-)MPROMDB
RGD ID:6891204
Promoter ID:EPDNEW_M9053
Type:initiation region
Name:Clec7a_1
Description:Mus musculus C-type lectin domain family 7, member a , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386129,472,785 - 129,472,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1861431 AgrOrtholog
Ensembl Genes ENSMUSG00000079293 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000184581 ENTREZGENE
  ENSMUST00000195589 ENTREZGENE
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  CLEC7A UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  NKR-like_CTLD UniProtKB/Swiss-Prot
MGD MGI:1861431 ENTREZGENE
NCBI Gene 56644 ENTREZGENE
PANTHER C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A UniProtKB/Swiss-Prot
  PTHR47218 UniProtKB/Swiss-Prot
Pfam Lectin_C UniProtKB/Swiss-Prot
PhenoGen Clec7a PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
UniProt CLC7A_MOUSE UniProtKB/Swiss-Prot
  E9QPW2 ENTREZGENE
  Q6QLQ4 ENTREZGENE
  Q8K1L4 ENTREZGENE
  Q9JI50 ENTREZGENE
  V9GXI5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9QPW2 UniProtKB/Swiss-Prot
  Q8K1L4 UniProtKB/Swiss-Prot
  Q9JI50 UniProtKB/Swiss-Prot