Awat2 (acyl-CoA wax alcohol acyltransferase 2) - Rat Genome Database

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Gene: Awat2 (acyl-CoA wax alcohol acyltransferase 2) Mus musculus
Analyze
Symbol: Awat2
Name: acyl-CoA wax alcohol acyltransferase 2
RGD ID: 1558296
MGI Page MGI
Description: Enables retinol O-fatty-acyltransferase activity. Acts upstream of or within wax biosynthetic process. Located in endoplasmic reticulum membrane. Used to study dry eye syndrome. Orthologous to human AWAT2 (acyl-CoA wax alcohol acyltransferase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 11-cis-RE-synthase; 11-cis-specific retinyl-ester synthase; 9430062J17Rik; acyl-CoA retinol O-fatty-acyltransferase; ARAT; Dgat2; Dgat2l4; diacylglycerol O-acyltransferase 2-like 4; diacylglycerol O-acyltransferase 2-like protein 4; long-chain-alcohol O-fatty-acyltransferase 2; mWS; retinol O-fatty-acyltransferase; wax synthase 2; WS
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,445,827 - 99,537,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,445,827 - 99,486,323 (-)EnsemblGRCm39 Ensembl
GRCm38X100,402,221 - 100,494,278 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,402,221 - 100,442,717 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X97,597,560 - 97,607,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X96,604,940 - 96,615,281 (-)NCBIMGSCv36mm8
CeleraX87,327,787 - 87,338,155 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15220349   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:24200680   PMID:26714272   PMID:27899360   PMID:28096191   PMID:32851726   PMID:34113821   PMID:35665537   PMID:38355793  


Genomics

Comparative Map Data
Awat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,445,827 - 99,537,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,445,827 - 99,486,323 (-)EnsemblGRCm39 Ensembl
GRCm38X100,402,221 - 100,494,278 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,402,221 - 100,442,717 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X97,597,560 - 97,607,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X96,604,940 - 96,615,281 (-)NCBIMGSCv36mm8
CeleraX87,327,787 - 87,338,155 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.71NCBI
AWAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,040,542 - 70,049,938 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,040,542 - 70,049,938 (-)EnsemblGRCh38hg38GRCh38
GRCh37X69,260,392 - 69,269,788 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,177,117 - 69,186,513 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX69,613,775 - 69,623,166 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,081,194 - 63,090,585 (-)NCBIHuRef
CHM1_1X69,154,000 - 69,163,391 (-)NCBICHM1_1
T2T-CHM13v2.0X68,473,894 - 68,483,288 (-)NCBIT2T-CHM13v2.0
Awat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,521,778 - 69,530,664 (-)NCBIGRCr8
mRatBN7.2X65,481,676 - 65,490,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,481,929 - 65,527,625 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX66,965,672 - 66,973,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,466,062 - 70,474,322 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,026,954 - 68,035,214 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,224,761 - 70,233,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,224,654 - 70,270,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,097,874 - 71,106,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,395,929 - 88,404,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX65,843,059 - 65,851,319 (-)NCBICelera
Cytogenetic MapXq22NCBI
Awat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,592,984 - 9,634,811 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,594,157 - 9,634,596 (-)NCBIChiLan1.0ChiLan1.0
AWAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X69,717,450 - 69,727,806 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X69,722,000 - 69,731,409 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X59,308,600 - 59,318,940 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X69,372,246 - 69,381,644 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,372,246 - 69,381,644 (-)Ensemblpanpan1.1panPan2
AWAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,516,465 - 54,531,450 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX54,516,776 - 54,531,450 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX45,342,795 - 45,357,915 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X55,483,082 - 55,498,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX55,483,069 - 55,498,100 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X53,452,127 - 53,467,243 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X54,782,920 - 54,798,043 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X54,710,080 - 54,725,204 (-)NCBIUU_Cfam_GSD_1.0
Awat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,660,270 - 47,671,248 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367771,563,229 - 1,573,993 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367771,562,900 - 1,574,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AWAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,104,509 - 56,114,744 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X56,101,635 - 56,108,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,301,798 - 63,311,924 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AWAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X59,863,353 - 59,872,621 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX59,863,866 - 59,871,925 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660651,731,627 - 1,740,942 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Awat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462489141,890 - 52,628 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462489149,479 - 53,290 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Awat2
1952 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:458
Count of miRNA genes:244
Interacting mature miRNAs:273
Transcripts:ENSMUST00000033567, ENSMUST00000147103
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX76124336102062720Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_177746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011247588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011247590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011247591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011247592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017318489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK034920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY611031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY611032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY468254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000033567   ⟹   ENSMUSP00000033567
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,445,827 - 99,456,193 (-)Ensembl
GRCm38.p6 EnsemblX100,402,221 - 100,412,587 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147103   ⟹   ENSMUSP00000128516
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,445,832 - 99,486,323 (-)Ensembl
GRCm38.p6 EnsemblX100,402,226 - 100,442,717 (-)Ensembl
RefSeq Acc Id: NM_001290395   ⟹   NP_001277324
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,445,827 - 99,486,323 (-)NCBI
GRCm38X100,402,221 - 100,442,717 (-)NCBI
CeleraX87,327,787 - 87,368,746 (-)NCBI
Sequence:
RefSeq Acc Id: NM_177746   ⟹   NP_808414
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,445,827 - 99,456,193 (-)NCBI
GRCm38X100,402,221 - 100,412,587 (-)NCBI
MGSCv37X97,597,560 - 97,607,901 (-)RGD
CeleraX87,327,787 - 87,368,746 (-)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011247588   ⟹   XP_011245890
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,445,827 - 99,537,884 (-)NCBI
GRCm38X100,402,221 - 100,494,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011247590   ⟹   XP_011245892
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,445,827 - 99,472,995 (-)NCBI
GRCm38X100,402,221 - 100,430,007 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011247591   ⟹   XP_011245893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,445,827 - 99,537,884 (-)NCBI
GRCm38X100,402,221 - 100,494,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011247592   ⟹   XP_011245894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,445,827 - 99,537,885 (-)NCBI
GRCm38X100,402,221 - 100,494,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017318489   ⟹   XP_017173978
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,445,827 - 99,537,885 (-)NCBI
GRCm38X100,402,221 - 100,494,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161955   ⟹   XP_036017848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,445,827 - 99,495,259 (-)NCBI
Sequence:
RefSeq Acc Id: NP_808414   ⟸   NM_177746
- Peptide Label: isoform 1
- UniProtKB: Q8BM49 (UniProtKB/Swiss-Prot),   Q6E1M8 (UniProtKB/Swiss-Prot),   A2ADU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011245893   ⟸   XM_011247591
- Peptide Label: isoform X1
- UniProtKB: Q6E1M8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011245894   ⟸   XM_011247592
- Peptide Label: isoform X1
- UniProtKB: Q6E1M8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011245890   ⟸   XM_011247588
- Peptide Label: isoform X1
- UniProtKB: Q6E1M8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011245892   ⟸   XM_011247590
- Peptide Label: isoform X1
- UniProtKB: Q6E1M8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001277324   ⟸   NM_001290395
- Peptide Label: isoform 2
- UniProtKB: Q6E1M8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017173978   ⟸   XM_017318489
- Peptide Label: isoform X1
- UniProtKB: Q6E1M8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000128516   ⟸   ENSMUST00000147103
Ensembl Acc Id: ENSMUSP00000033567   ⟸   ENSMUST00000033567
RefSeq Acc Id: XP_036017848   ⟸   XM_036161955
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6E1M8-F1-model_v2 AlphaFold Q6E1M8 1-333 view protein structure

Promoters
RGD ID:13681024
Promoter ID:EPDNEW_M24661
Type:multiple initiation site
Name:Awat2_1
Description:Mus musculus acyl-CoA wax alcohol acyltransferase 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X100,412,597 - 100,412,657EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045345 AgrOrtholog
Ensembl Genes ENSMUSG00000031220 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033567 ENTREZGENE
  ENSMUST00000033567.15 UniProtKB/Swiss-Prot
  ENSMUST00000147103 ENTREZGENE
  ENSMUST00000147103.2 UniProtKB/Swiss-Prot
InterPro DAGAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:245532 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3045345 ENTREZGENE
NCBI Gene 245532 ENTREZGENE
PANTHER ACYL-COA WAX ALCOHOL ACYLTRANSFERASE 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIACYLGLYCEROL O-ACYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DAGAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Awat2 PhenoGen
UniProt A2ADU0 ENTREZGENE, UniProtKB/TrEMBL
  AWAT2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BM49 ENTREZGENE
UniProt Secondary Q8BM49 UniProtKB/Swiss-Prot