Iqsec2 (IQ motif and Sec7 domain 2) - Rat Genome Database

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Gene: Iqsec2 (IQ motif and Sec7 domain 2) Mus musculus
Analyze
Symbol: Iqsec2
Name: IQ motif and Sec7 domain 2
RGD ID: 1558257
MGI Page MGI
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; positive regulation of synapse assembly; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in several cellular components, including photoreceptor ribbon synapse; postsynaptic density; and presynaptic active zone cytoplasmic component. Is expressed in brain. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Brag1; IQ motif and SEC7 domain-containing protein 2; KIAA0522; mKIAA0522
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,927,179 - 151,008,233 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,927,193 - 151,008,232 (+)EnsemblGRCm39 Ensembl
GRCm38X152,144,183 - 152,225,237 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,144,268 - 152,225,236 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,578,811 - 148,659,779 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X147,519,725 - 147,565,952 (+)NCBIMGSCv36mm8
MGSCv36X129,187,494 - 129,233,721 (+)NCBIMGSCv36mm8
CeleraX132,285,132 - 132,286,052 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:15197169   PMID:15669143   PMID:16141072   PMID:16141073   PMID:17850229  
PMID:18164504   PMID:19083995   PMID:19811534   PMID:20547133   PMID:21677750   PMID:21873635   PMID:26884337   PMID:27507650   PMID:28463240   PMID:28671696   PMID:28706196   PMID:30674481  
PMID:30842726   PMID:31439632   PMID:31978606   PMID:32325033   PMID:33753721   PMID:33888678   PMID:34666607   PMID:34685703   PMID:35344748   PMID:36417873   PMID:36604605   PMID:36835332  
PMID:36902414   PMID:37142655   PMID:37787765  


Genomics

Comparative Map Data
Iqsec2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,927,179 - 151,008,233 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,927,193 - 151,008,232 (+)EnsemblGRCm39 Ensembl
GRCm38X152,144,183 - 152,225,237 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,144,268 - 152,225,236 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,578,811 - 148,659,779 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X147,519,725 - 147,565,952 (+)NCBIMGSCv36mm8
MGSCv36X129,187,494 - 129,233,721 (+)NCBIMGSCv36mm8
CeleraX132,285,132 - 132,286,052 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
IQSEC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,225,813 - 53,321,350 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,225,828 - 53,321,350 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,262,058 - 53,350,548 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,278,783 - 53,327,521 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX57,091,294 - 57,179,759 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,327,195 - 50,414,951 (-)NCBIHuRef
CHM1_1X53,252,281 - 53,340,767 (-)NCBICHM1_1
T2T-CHM13v2.0X52,512,100 - 52,607,614 (-)NCBIT2T-CHM13v2.0
Iqsec2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,734,202 - 24,816,566 (+)NCBIGRCr8
mRatBN7.2X21,254,799 - 21,337,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,254,914 - 21,336,584 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX18,720,062 - 18,802,376 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,321,193 - 21,403,511 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X21,820,482 - 21,902,802 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X22,212,137 - 22,293,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX22,212,132 - 22,294,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X64,286,343 - 64,367,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,651,275 - 41,733,435 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX21,517,185 - 21,598,702 (+)NCBICelera
Cytogenetic MapXq13NCBI
Iqsec2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955475284,168 - 369,400 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955475285,977 - 369,380 (-)NCBIChiLan1.0ChiLan1.0
IQSEC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X54,625,041 - 54,720,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X54,628,648 - 54,724,175 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X45,447,977 - 45,535,836 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X53,557,847 - 53,604,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX53,557,563 - 53,644,737 (-)Ensemblpanpan1.1panPan2
IQSEC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X44,861,813 - 44,915,011 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX44,872,888 - 44,913,704 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX36,516,736 - 36,595,958 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X45,308,027 - 45,386,860 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX45,306,847 - 45,386,965 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X44,803,229 - 44,882,038 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,252,874 - 45,331,684 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,320,205 - 45,399,024 (-)NCBIUU_Cfam_GSD_1.0
Iqsec2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X37,871,074 - 37,963,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936751210,761 - 294,399 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936751210,800 - 294,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQSEC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,011,388 - 46,094,817 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,011,386 - 46,094,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,511,372 - 51,566,645 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IQSEC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X49,363,569 - 49,452,872 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX49,364,909 - 49,387,050 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660863,317,401 - 3,407,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iqsec2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909460,626 - 565,133 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624909462,724 - 564,989 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iqsec2
1941 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:6623
Count of miRNA genes:888
Interacting mature miRNAs:1199
Transcripts:ENSMUST00000096275, ENSMUST00000112604, ENSMUST00000112605, ENSMUST00000128724, ENSMUST00000146835, ENSMUST00000153356, ENSMUST00000168786
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001114664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001405945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001405946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001405947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001405948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001405949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001405950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB275281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC083816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY451401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY153973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY154693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA491821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB236789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ260525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000096275   ⟹   ENSMUSP00000093995
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX150,961,960 - 151,008,232 (+)Ensembl
GRCm38.p6 EnsemblX152,178,964 - 152,225,236 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112604   ⟹   ENSMUSP00000108223
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX150,927,268 - 151,008,232 (+)Ensembl
GRCm38.p6 EnsemblX152,144,272 - 152,225,236 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112605   ⟹   ENSMUSP00000108224
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX150,927,268 - 151,008,232 (+)Ensembl
GRCm38.p6 EnsemblX152,144,272 - 152,225,236 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX150,961,960 - 150,977,597 (+)Ensembl
GRCm38.p6 EnsemblX152,178,964 - 152,194,601 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146835
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX150,961,960 - 150,977,597 (+)Ensembl
GRCm38.p6 EnsemblX152,178,964 - 152,194,601 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153356
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX150,961,960 - 150,987,000 (+)Ensembl
GRCm38.p6 EnsemblX152,178,964 - 152,204,004 (+)Ensembl
Ensembl Acc Id: ENSMUST00000168786   ⟹   ENSMUSP00000127249
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX150,927,193 - 151,008,232 (+)Ensembl
GRCm38.p6 EnsemblX152,144,268 - 152,225,235 (+)Ensembl
Ensembl Acc Id: ENSMUST00000249244   ⟹   ENSMUSP00000159624
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX150,927,310 - 151,008,232 (+)Ensembl
RefSeq Acc Id: NM_001005475   ⟹   NP_001005475
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,961,998 - 151,008,232 (+)NCBI
GRCm38X152,179,009 - 152,225,237 (+)NCBI
MGSCv37X148,578,811 - 148,659,779 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001114664   ⟹   NP_001108136
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,209 - 151,008,232 (+)NCBI
GRCm38X152,144,268 - 152,225,237 (+)NCBI
MGSCv37X148,578,811 - 148,659,779 (+)RGD
CeleraX132,285,141 - 132,286,052 (-)ENTREZGENE
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001405945   ⟹   NP_001392874
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,209 - 151,008,232 (+)NCBI
RefSeq Acc Id: NM_001405946   ⟹   NP_001392875
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,961,998 - 151,008,232 (+)NCBI
RefSeq Acc Id: NM_001405947   ⟹   NP_001392876
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,209 - 150,977,599 (+)NCBI
RefSeq Acc Id: NM_001405948   ⟹   NP_001392877
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,209 - 150,977,599 (+)NCBI
RefSeq Acc Id: NM_001405949   ⟹   NP_001392878
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,209 - 150,977,599 (+)NCBI
RefSeq Acc Id: NM_001405950   ⟹   NP_001392879
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,961,998 - 150,977,599 (+)NCBI
RefSeq Acc Id: XM_006528842   ⟹   XP_006528905
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,179 - 151,008,233 (+)NCBI
GRCm38X152,144,183 - 152,225,237 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006528843   ⟹   XP_006528906
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,179 - 151,007,191 (+)NCBI
GRCm38X152,144,183 - 152,225,237 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006528844   ⟹   XP_006528907
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,179 - 151,007,191 (+)NCBI
GRCm38X152,144,183 - 152,225,237 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006528845   ⟹   XP_006528908
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,469 - 151,007,191 (+)NCBI
GRCm38X152,144,183 - 152,225,237 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006528846   ⟹   XP_006528909
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,959,281 - 151,007,191 (+)NCBI
GRCm38X152,167,012 - 152,225,237 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006528847   ⟹   XP_006528910
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,959,284 - 151,007,191 (+)NCBI
GRCm38X152,167,012 - 152,225,237 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006528848   ⟹   XP_006528911
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X150,927,179 - 151,008,233 (+)NCBI
GRCm38X152,144,183 - 152,225,237 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001005475   ⟸   NM_001005475
- Peptide Label: isoform 2
- UniProtKB: D3Z6V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001108136   ⟸   NM_001114664
- Peptide Label: isoform 1
- UniProtKB: A4GZ26 (UniProtKB/TrEMBL),   A0A9L6KDT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528905   ⟸   XM_006528842
- Peptide Label: isoform X1
- UniProtKB: A0A9L6KDT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528907   ⟸   XM_006528844
- Peptide Label: isoform X3
- UniProtKB: E9QAD8 (UniProtKB/TrEMBL),   A0A9L6KDT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528906   ⟸   XM_006528843
- Peptide Label: isoform X2
- UniProtKB: A0A9L6KDT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528908   ⟸   XM_006528845
- Peptide Label: isoform X4
- UniProtKB: E9QK46 (UniProtKB/Swiss-Prot),   Q5DU25 (UniProtKB/Swiss-Prot),   A0A9L6KDT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528911   ⟸   XM_006528848
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006528909   ⟸   XM_006528846
- Peptide Label: isoform X5
- UniProtKB: A0A9L6KDT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528910   ⟸   XM_006528847
- Peptide Label: isoform X6
- UniProtKB: A0A9L6KDT1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000108223   ⟸   ENSMUST00000112604
Ensembl Acc Id: ENSMUSP00000108224   ⟸   ENSMUST00000112605
Ensembl Acc Id: ENSMUSP00000127249   ⟸   ENSMUST00000168786
Ensembl Acc Id: ENSMUSP00000093995   ⟸   ENSMUST00000096275
Ensembl Acc Id: ENSMUSP00000159624   ⟸   ENSMUST00000249244
RefSeq Acc Id: NP_001392874   ⟸   NM_001405945
- Peptide Label: isoform 3
- UniProtKB: D3Z5I6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001392876   ⟸   NM_001405947
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001392878   ⟸   NM_001405949
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001392877   ⟸   NM_001405948
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001392875   ⟸   NM_001405946
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001392879   ⟸   NM_001405950
- Peptide Label: isoform 8
- UniProtKB: A0A8V5KYN1 (UniProtKB/TrEMBL)
Protein Domains
IQ   PH   SEC7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5DU25-F1-model_v2 AlphaFold Q5DU25 1-1478 view protein structure

Promoters
RGD ID:6845861
Promoter ID:MM_KWN:62384
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000047115,   OTTMUST00000047116,   OTTMUST00000047117,   OTTMUST00000047118
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X148,613,419 - 148,613,919 (+)MPROMDB
RGD ID:13681644
Promoter ID:EPDNEW_M24971
Type:initiation region
Name:Iqsec2_2
Description:Mus musculus IQ motif and Sec7 domain 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24972  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X152,144,215 - 152,144,275EPDNEW
RGD ID:13681646
Promoter ID:EPDNEW_M24972
Type:initiation region
Name:Iqsec2_1
Description:Mus musculus IQ motif and Sec7 domain 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24971  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X152,179,002 - 152,179,062EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3528396 AgrOrtholog
Ensembl Genes ENSMUSG00000041115 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000096275 ENTREZGENE
  ENSMUST00000096275.5 UniProtKB/TrEMBL
  ENSMUST00000112604 ENTREZGENE
  ENSMUST00000112604.8 UniProtKB/TrEMBL
  ENSMUST00000112605 ENTREZGENE
  ENSMUST00000112605.8 UniProtKB/TrEMBL
  ENSMUST00000128724.8 UniProtKB/TrEMBL
  ENSMUST00000146835 ENTREZGENE
  ENSMUST00000146835.8 UniProtKB/TrEMBL
  ENSMUST00000153356.2 UniProtKB/TrEMBL
  ENSMUST00000168786 ENTREZGENE
  ENSMUST00000168786.9 UniProtKB/TrEMBL
  ENSMUST00000249244.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1000.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.220.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IQSEC_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:245666 UniProtKB/TrEMBL
MGD MGI:3528396 ENTREZGENE
NCBI Gene 245666 ENTREZGENE
PANTHER GUANYL-NUCLEOTIDE EXCHANGE FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IQ_SEC7_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Iqsec2 PhenoGen
PROSITE PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEC7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Sec7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8V5KY82_MOUSE UniProtKB/TrEMBL
  A0A8V5KYN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8V5L0N5_MOUSE UniProtKB/TrEMBL
  A0A9L6KDT1 ENTREZGENE, UniProtKB/TrEMBL
  A4GZ26 ENTREZGENE, UniProtKB/TrEMBL
  D3Z5I6 ENTREZGENE, UniProtKB/TrEMBL
  D3Z6V7 ENTREZGENE, UniProtKB/TrEMBL
  E9QAD8 ENTREZGENE, UniProtKB/TrEMBL
  E9QK46 ENTREZGENE
  IQEC2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary E9QK46 UniProtKB/Swiss-Prot