Ormdl3 (ORM1-like 3 (S. cerevisiae)) - Rat Genome Database

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Gene: Ormdl3 (ORM1-like 3 (S. cerevisiae)) Mus musculus
Analyze
Symbol: Ormdl3
Name: ORM1-like 3 (S. cerevisiae)
RGD ID: 1558251
MGI Page MGI
Description: Acts upstream of or within several processes, including negative regulation of B cell apoptotic process; negative regulation of ceramide biosynthetic process; and negative regulation of serine C-palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum. Predicted to be part of serine palmitoyltransferase complex. Is expressed in lung. Orthologous to human ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2810011N17Rik; AI315223; ORM1-like protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,472,120 - 98,478,071 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,472,082 - 98,478,194 (-)EnsemblGRCm39 Ensembl
GRCm381198,581,294 - 98,587,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,581,256 - 98,587,368 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,442,608 - 98,448,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,397,384 - 98,403,335 (-)NCBIMGSCv36mm8
Celera11108,235,703 - 108,241,654 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12093374   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21677750   PMID:21873635  
PMID:23011799   PMID:23577138   PMID:24056518   PMID:24623133   PMID:25691431   PMID:25842287   PMID:26407610   PMID:27623174   PMID:27645259   PMID:28031110   PMID:28275141   PMID:28358425  
PMID:28747345   PMID:29536159   PMID:30254094   PMID:30550785   PMID:31173170   PMID:31255288   PMID:31330218   PMID:31560728   PMID:31880535   PMID:32273303   PMID:32554809   PMID:32578458  
PMID:33643282   PMID:33679742   PMID:34560079   PMID:34954108   PMID:36680386   PMID:36753412   PMID:37124760   PMID:37316542   PMID:37594074   PMID:37877592   PMID:38081412   PMID:38715613  


Genomics

Comparative Map Data
Ormdl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,472,120 - 98,478,071 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,472,082 - 98,478,194 (-)EnsemblGRCm39 Ensembl
GRCm381198,581,294 - 98,587,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,581,256 - 98,587,368 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,442,608 - 98,448,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,397,384 - 98,403,335 (-)NCBIMGSCv36mm8
Celera11108,235,703 - 108,241,654 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.07NCBI
ORMDL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,921,041 - 39,927,601 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,921,041 - 39,927,601 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,077,294 - 38,083,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,330,822 - 35,337,380 (-)NCBINCBI36Build 36hg18NCBI36
Build 341735,330,821 - 35,337,380NCBI
Celera1734,737,556 - 34,744,114 (-)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1733,871,298 - 33,877,886 (-)NCBIHuRef
CHM1_11738,313,002 - 38,319,590 (-)NCBICHM1_1
T2T-CHM13v2.01740,784,755 - 40,791,324 (-)NCBIT2T-CHM13v2.0
Ormdl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,086,317 - 84,092,673 (-)NCBIGRCr8
mRatBN7.21083,590,052 - 83,596,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,590,071 - 83,598,620 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,535,127 - 88,542,297 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,033,204 - 88,040,374 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,425,892 - 83,433,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,545,910 - 86,554,478 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,547,339 - 86,554,478 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,341,986 - 86,350,554 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,403,919 - 87,411,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1082,339,436 - 82,346,575 (-)NCBICelera
Cytogenetic Map10q31NCBI
Ormdl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,621,399 - 14,642,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,621,565 - 14,627,556 (-)NCBIChiLan1.0ChiLan1.0
ORMDL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,027,480 - 25,034,049 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,920,795 - 26,928,871 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,361,624 - 17,368,194 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,581,001 - 17,587,741 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,581,612 - 17,587,741 (+)Ensemblpanpan1.1panPan2
ORMDL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,594,425 - 22,601,108 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,594,480 - 22,599,999 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,066,387 - 22,073,071 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,387,143 - 23,393,828 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,387,150 - 23,393,827 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,160,466 - 22,167,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,419,662 - 22,426,354 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,544,044 - 22,550,746 (+)NCBIUU_Cfam_GSD_1.0
Ormdl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,991,984 - 22,005,704 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,069,387 - 15,076,253 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,069,435 - 15,076,112 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ORMDL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,411,587 - 22,417,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,411,130 - 22,417,744 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,869,406 - 22,876,003 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ORMDL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,243,503 - 66,249,800 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,243,539 - 66,250,167 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,152,785 - 37,159,150 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ormdl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,209,605 - 3,217,539 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,210,382 - 3,216,130 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ormdl3
183 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:683
Count of miRNA genes:396
Interacting mature miRNAs:463
Transcripts:ENSMUST00000052919
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119689769399327028Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
AI315223  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,581,403 - 98,581,564UniSTSGRCm38
GRCm38457,412,411 - 57,412,580UniSTSGRCm38
MGSCv371198,442,717 - 98,442,878UniSTSGRCm37
MGSCv37457,425,283 - 57,425,452UniSTSGRCm37
Celera11108,235,812 - 108,235,973UniSTS
Celera457,323,048 - 57,323,217UniSTS
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111304.37UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000052919   ⟹   ENSMUSP00000053056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,472,082 - 98,478,194 (-)Ensembl
GRCm38.p6 Ensembl1198,581,256 - 98,587,368 (-)Ensembl
RefSeq Acc Id: NM_025661   ⟹   NP_079937
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,472,120 - 98,478,071 (-)NCBI
GRCm381198,581,294 - 98,587,245 (-)NCBI
MGSCv371198,442,608 - 98,448,559 (-)RGD
Celera11108,235,703 - 108,241,654 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_079937   ⟸   NM_025661
- UniProtKB: Q8BN65 (UniProtKB/Swiss-Prot),   A2A4X7 (UniProtKB/Swiss-Prot),   Q8R0U5 (UniProtKB/Swiss-Prot),   Q9CPZ6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000053056   ⟸   ENSMUST00000052919

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CPZ6-F1-model_v2 AlphaFold Q9CPZ6 1-153 view protein structure

Promoters
RGD ID:6821483
Promoter ID:MM_KWN:9584
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000014496
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,448,386 - 98,449,567 (-)MPROMDB
RGD ID:8676502
Promoter ID:EPDNEW_M16281
Type:initiation region
Name:Ormdl3_1
Description:Mus musculus ORM1-like 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381198,587,245 - 98,587,305EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913862 AgrOrtholog
Ensembl Genes ENSMUSG00000038150 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052919 ENTREZGENE
  ENSMUST00000052919.8 UniProtKB/Swiss-Prot
InterPro ORMDL UniProtKB/Swiss-Prot
KEGG Report mmu:66612 UniProtKB/Swiss-Prot
MGD MGI:1913862 ENTREZGENE
NCBI Gene 66612 ENTREZGENE
PANTHER PTHR12665 UniProtKB/Swiss-Prot
  PTHR12665:SF11 UniProtKB/Swiss-Prot
Pfam ORMDL UniProtKB/Swiss-Prot
PhenoGen Ormdl3 PhenoGen
PIRSF ORMDL UniProtKB/Swiss-Prot
UniProt A2A4X7 ENTREZGENE
  ORML3_MOUSE UniProtKB/Swiss-Prot
  Q8BN65 ENTREZGENE
  Q8R0U5 ENTREZGENE
  Q9CPZ6 ENTREZGENE
UniProt Secondary A2A4X7 UniProtKB/Swiss-Prot
  Q8BN65 UniProtKB/Swiss-Prot
  Q8R0U5 UniProtKB/Swiss-Prot