Mmut (methylmalonyl-Coenzyme A mutase) - Rat Genome Database

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Gene: Mmut (methylmalonyl-Coenzyme A mutase) Mus musculus
Analyze
Symbol: Mmut
Name: methylmalonyl-Coenzyme A mutase
RGD ID: 1558195
MGI Page MGI
Description: Enables methylmalonyl-CoA mutase activity. Involved in succinyl-CoA biosynthetic process. Acts upstream of or within post-embryonic development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and trophectoderm. Used to study methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency. Human ortholog(s) of this gene implicated in methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency. Orthologous to human MMUT (methylmalonyl-CoA mutase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D230010K02Rik; Mcm; methylmalonyl-CoA isomerase; methylmalonyl-CoA mutase, mitochondrial; Mut
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391741,245,576 - 41,272,880 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1741,245,576 - 41,272,879 (+)EnsemblGRCm39 Ensembl
GRCm381740,934,685 - 40,961,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1740,934,685 - 40,961,988 (+)EnsemblGRCm38mm10GRCm38
MGSCv371741,071,634 - 41,098,938 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361740,398,258 - 40,425,133 (+)NCBIMGSCv36mm8
Celera1744,347,903 - 44,375,209 (+)NCBICelera
Cytogenetic Map17B2NCBI
cM Map1719.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(+)-schisandrin B  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
adefovir  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (ISO)
aristolochic acid A  (ISO)
atazanavir sulfate  (ISO)
Benoxacor  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Brodifacoum  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (EXP)
dicrotophos  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
ethyl methanesulfonate  (ISO)
furan  (ISO)
geneticin  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ethionine  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
nefazodone  (ISO)
O-methyleugenol  (ISO)
omeprazole  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
phlorizin  (EXP)
pirinixic acid  (EXP,ISO)
propiconazole  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
tartrazine  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
mitochondrial matrix  (ISO)
mitochondrion  (HDA,IBA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood homeostasis  (IAGP)
abnormal brain morphology  (IAGP)
abnormal circulating amino acid level  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal fatty acids level  (IAGP)
abnormal hepatocyte mitochondrial morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver parenchyma morphology  (IAGP)
abnormal metabolism  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
abnormal mitochondrial matrix morphology  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal reabsorption  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal sphingolipid level  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal tricarboxylic acid cycle  (IAGP)
absent gastric milk in neonates  (IAGP)
acidemia  (IAGP)
acidosis  (IAGP)
aciduria  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating bicarbonate level  (IAGP)
decreased locomotor activity  (IAGP)
decreased renal glomerular filtration rate  (IAGP)
decreased survivor rate  (IAGP)
dehydration  (IAGP)
hepatic steatosis  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased brain weight  (IAGP)
increased circulating ammonia level  (IAGP)
increased circulating carnitine level  (IAGP)
increased circulating chloride level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating glycine level  (IAGP)
increased circulating lipocalin 2 level  (IAGP)
increased circulating methylmalonic acid level  (IAGP)
increased kidney weight  (IAGP)
increased lipocalin 2 level  (IAGP)
increased liver weight  (IAGP)
increased urine calcium level  (IAGP)
increased urine chloride ion level  (IAGP)
increased urine magnesium level  (IAGP)
increased urine potassium level  (IAGP)
increased urine sodium level  (IAGP)
lung hemorrhage  (IAGP)
metabolic acidosis  (IAGP)
methylmalonic aciduria  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
oliguria  (IAGP)
organic aciduria  (IAGP)
oxidative stress  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
respiratory distress  (IAGP)
tubulointerstitial nephritis  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Long-term rescue of a lethal murine model of methylmalonic acidemia using adeno-associated viral gene therapy. Chandler RJ and Venditti CP, Mol Ther. 2010 Jan;18(1):11-6. doi: 10.1038/mt.2009.247. Epub 2009 Oct 27.
2. Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle. Chandler RJ, etal., BMC Med Genet. 2007 Oct 15;8:64.
3. Molecular Genetic Characterization of 151 Mut-Type Methylmalonic Aciduria Patients and Identification of 41 Novel Mutations in MUT. Forny P, etal., Hum Mutat. 2016 Aug;37(8):745-54. doi: 10.1002/humu.23013. Epub 2016 May 23.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1970332   PMID:1973376   PMID:1978672   PMID:7782091   PMID:7904153   PMID:9182764   PMID:9717434   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14555645  
PMID:14610273   PMID:14651853   PMID:14681479   PMID:16141072   PMID:16141073   PMID:18614015   PMID:19088183   PMID:19372376   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22792386  
PMID:23022071   PMID:23024777   PMID:23898205   PMID:23922663   PMID:25607839   PMID:27519416   PMID:29262333   PMID:29934063   PMID:30518688   PMID:31056463   PMID:31303505   PMID:31453331  
PMID:31648943   PMID:31770620   PMID:32080200   PMID:32098917   PMID:32325033   PMID:32976669   PMID:34901307   PMID:35613279   PMID:35868241   PMID:36717752  


Genomics

Comparative Map Data
Mmut
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391741,245,576 - 41,272,880 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1741,245,576 - 41,272,879 (+)EnsemblGRCm39 Ensembl
GRCm381740,934,685 - 40,961,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1740,934,685 - 40,961,988 (+)EnsemblGRCm38mm10GRCm38
MGSCv371741,071,634 - 41,098,938 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361740,398,258 - 40,425,133 (+)NCBIMGSCv36mm8
Celera1744,347,903 - 44,375,209 (+)NCBICelera
Cytogenetic Map17B2NCBI
cM Map1719.55NCBI
MMUT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38649,430,360 - 49,463,253 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl649,430,360 - 49,463,253 (-)EnsemblGRCh38hg38GRCh38
GRCh37649,398,073 - 49,430,966 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,506,950 - 49,538,990 (-)NCBINCBI36Build 36hg18NCBI36
Build 34649,506,956 - 49,538,811NCBI
Celera650,954,278 - 50,987,247 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef649,126,994 - 49,159,962 (-)NCBIHuRef
CHM1_1649,401,109 - 49,434,080 (-)NCBICHM1_1
T2T-CHM13v2.0649,272,390 - 49,305,330 (-)NCBIT2T-CHM13v2.0
Mmut
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8927,425,935 - 27,454,202 (-)NCBIGRCr8
mRatBN7.2919,928,720 - 19,956,985 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl919,928,727 - 19,957,046 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx928,500,013 - 28,528,223 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0933,574,572 - 33,602,776 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0931,883,366 - 31,911,544 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0923,323,934 - 23,352,144 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl923,323,936 - 23,352,668 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0922,182,975 - 22,211,162 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4916,065,495 - 16,093,956 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera917,606,384 - 17,634,555 (-)NCBICelera
Cytogenetic Map9q13NCBI
Mmut
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554118,363,142 - 8,399,216 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554118,363,142 - 8,397,839 (+)NCBIChiLan1.0ChiLan1.0
MMUT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2563,921,672 - 63,954,654 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1659,786,396 - 59,819,418 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0649,007,500 - 49,040,470 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1650,269,644 - 50,302,593 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl650,269,644 - 50,302,593 (-)Ensemblpanpan1.1panPan2
MMUT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11217,306,074 - 17,339,921 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1217,307,522 - 17,339,897 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1217,207,742 - 17,239,948 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01217,803,522 - 17,836,150 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1217,791,961 - 17,836,003 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11217,323,580 - 17,355,905 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01217,428,613 - 17,461,241 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01217,558,439 - 17,590,821 (-)NCBIUU_Cfam_GSD_1.0
Mmut
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494652,718,554 - 52,751,973 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647611,208,267 - 11,241,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647611,208,251 - 11,241,648 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMUT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl743,597,246 - 43,624,671 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1743,597,313 - 43,624,603 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2750,107,559 - 50,128,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMUT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11722,922,262 - 22,957,742 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1722,922,307 - 22,957,879 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604449,420,412 - 49,455,585 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmut
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479914,404,662 - 14,433,632 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479914,404,873 - 14,433,803 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmut
1341 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:321
Count of miRNA genes:250
Interacting mature miRNAs:286
Transcripts:ENSMUST00000169611
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
1301474Hcbip2_mhexachlorobenzene induced porphyria 2 (mouse)Not determined173779305545622654Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000169611   ⟹   ENSMUSP00000130941
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1741,245,576 - 41,272,879 (+)Ensembl
GRCm38.p6 Ensembl1740,934,685 - 40,961,988 (+)Ensembl
RefSeq Acc Id: ENSMUST00000233222   ⟹   ENSMUSP00000156673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1741,266,079 - 41,269,872 (+)Ensembl
GRCm38.p6 Ensembl1740,955,188 - 40,958,981 (+)Ensembl
RefSeq Acc Id: NM_008650   ⟹   NP_032676
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391741,245,576 - 41,272,880 (+)NCBI
GRCm381740,934,685 - 40,961,989 (+)NCBI
MGSCv371741,071,634 - 41,098,938 (+)RGD
Celera1744,347,903 - 44,375,209 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017317291   ⟹   XP_017172780
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391741,249,906 - 41,272,551 (+)NCBI
GRCm381740,939,014 - 40,961,990 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032676   ⟸   NM_008650
- Peptide Label: precursor
- UniProtKB: Q3UJU1 (UniProtKB/Swiss-Prot),   P16332 (UniProtKB/Swiss-Prot),   Q8VED0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172780   ⟸   XM_017317291
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000156673   ⟸   ENSMUST00000233222
RefSeq Acc Id: ENSMUSP00000130941   ⟸   ENSMUST00000169611
Protein Domains
B12-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16332-F1-model_v2 AlphaFold P16332 1-748 view protein structure

Promoters
RGD ID:13676092
Promoter ID:EPDNEW_M22195
Type:initiation region
Name:Mut_1
Description:Mus musculus methylmalonyl-Coenzyme A mutase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381740,934,717 - 40,934,777EPDNEW
RGD ID:6828392
Promoter ID:MM_KWN:23511
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000097323
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361741,071,441 - 41,071,941 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97239 AgrOrtholog
Ensembl Genes ENSMUSG00000023921 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000169611 ENTREZGENE
  ENSMUST00000169611.4 UniProtKB/Swiss-Prot
  ENSMUST00000233222.2 UniProtKB/TrEMBL
Gene3D-CATH Cobalamin-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methylmalonyl-CoA mutase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Acid_CoA_mut_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cbl-dep_enz_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cobalamin-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cobalamin-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MeMalonylCoA_mutase_a/b_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MMCoA_mutase_a_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97239 ENTREZGENE
NCBI Gene 17850 ENTREZGENE
PANTHER METHYLMALONYL-COA MUTASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam B12-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MM_CoA_mutase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmut PhenoGen
PROSITE B12_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  METMALONYL_COA_MUTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B2WCT0_MOUSE UniProtKB/TrEMBL
  MUTA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UFU2_MOUSE UniProtKB/TrEMBL
  Q3UJU1 ENTREZGENE
  Q8BMR7_MOUSE UniProtKB/TrEMBL
  Q8VED0 ENTREZGENE, UniProtKB/TrEMBL
  Q9CSI4_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UJU1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 Mmut  methylmalonyl-Coenzyme A mutase  Mut    Symbol and/or name change 5135510 APPROVED