Tal2 (T cell acute lymphocytic leukemia 2) - Rat Genome Database

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Gene: Tal2 (T cell acute lymphocytic leukemia 2) Mus musculus
Analyze
Symbol: Tal2
Name: T cell acute lymphocytic leukemia 2
RGD ID: 1558129
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within midbrain development; post-embryonic development; and thalamus development. Is expressed in several structures, including central nervous system; future midbrain; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and adult T-cell leukemia/lymphoma. Orthologous to human TAL2 (TAL bHLH transcription factor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bHLHa; bHLHa19; MGC130117; T-cell acute lymphocytic leukemia 2; T-cell acute lymphocytic leukemia protein 2 homolog; TAL-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39453,779,701 - 53,788,712 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl453,779,705 - 53,788,712 (+)EnsemblGRCm39 Ensembl
GRCm38453,779,701 - 53,788,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl453,779,705 - 53,788,712 (+)EnsemblGRCm38mm10GRCm38
MGSCv37453,792,577 - 53,799,757 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36453,800,805 - 53,807,985 (+)NCBIMGSCv36mm8
Celera453,736,659 - 53,743,826 (+)NCBICelera
Cytogenetic Map4B2NCBI
cM Map428.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. Baer R Semin Cancer Biol 1993 Dec;4(6):341-7.
2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1763056   PMID:7774911   PMID:8889548   PMID:9482902   PMID:9520323   PMID:9931488   PMID:10349636   PMID:11042159   PMID:11071772   PMID:11076861   PMID:11747609   PMID:12477932  
PMID:16141072   PMID:16141073   PMID:18287559   PMID:18557763   PMID:18653561   PMID:19521566   PMID:20059953   PMID:20211142   PMID:21267068   PMID:21873635   PMID:22696295   PMID:22991444  
PMID:24086757   PMID:24167708   PMID:24952961   PMID:25512300   PMID:25993409   PMID:26166575   PMID:26297811   PMID:26718003   PMID:28049897   PMID:28219675   PMID:29867344   PMID:34321664  
PMID:35377797   PMID:35815619   PMID:37298722   PMID:38344749   PMID:38355793  


Genomics

Comparative Map Data
Tal2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39453,779,701 - 53,788,712 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl453,779,705 - 53,788,712 (+)EnsemblGRCm39 Ensembl
GRCm38453,779,701 - 53,788,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl453,779,705 - 53,788,712 (+)EnsemblGRCm38mm10GRCm38
MGSCv37453,792,577 - 53,799,757 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36453,800,805 - 53,807,985 (+)NCBIMGSCv36mm8
Celera453,736,659 - 53,743,826 (+)NCBICelera
Cytogenetic Map4B2NCBI
cM Map428.75NCBI
TAL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389105,662,457 - 105,663,124 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9105,662,457 - 105,663,124 (+)EnsemblGRCh38hg38GRCh38
GRCh379108,424,738 - 108,425,405 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369107,464,599 - 107,464,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 349105,504,332 - 105,504,659NCBI
Celera978,929,895 - 78,930,550 (+)NCBICelera
Cytogenetic Map9q31.2NCBI
HuRef978,026,259 - 78,026,914 (+)NCBIHuRef
CHM1_19108,571,782 - 108,572,437 (+)NCBICHM1_1
T2T-CHM13v2.09117,837,138 - 117,837,805 (+)NCBIT2T-CHM13v2.0
Tal2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8573,206,372 - 73,212,929 (+)NCBIGRCr8
mRatBN7.2568,411,012 - 68,417,569 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl568,411,012 - 68,417,569 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx570,298,984 - 70,305,554 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0572,116,021 - 72,122,597 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0572,087,805 - 72,094,377 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0570,592,871 - 70,599,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl570,592,871 - 70,599,428 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0574,768,707 - 74,775,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4571,225,719 - 71,232,276 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera567,305,181 - 67,311,736 (+)NCBICelera
Cytogenetic Map5q24NCBI
Tal2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541920,897,718 - 20,906,421 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541920,899,292 - 20,907,288 (-)NCBIChiLan1.0ChiLan1.0
TAL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21133,737,154 - 33,737,480 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1933,735,721 - 33,739,848 (-)NCBINHGRI_mPanPan1
TAL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11161,425,927 - 61,484,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1161,456,727 - 61,482,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1159,880,052 - 59,943,902 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01162,555,562 - 62,619,434 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1162,530,493 - 62,620,640 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11161,098,661 - 61,144,875 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01161,092,981 - 61,156,876 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01161,786,010 - 61,857,160 (+)NCBIUU_Cfam_GSD_1.0
TAL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1246,933,241 - 246,942,163 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11246,932,975 - 246,944,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21276,727,594 - 276,736,680 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Tal2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247585,747,765 - 5,863,612 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247585,750,458 - 5,755,861 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tal2
351 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:823
Count of miRNA genes:503
Interacting mature miRNAs:613
Transcripts:ENSMUST00000030124
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
25314308Mlh1fc1_mMLH1 foci count 1 (mouse)44850000076918237Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301213Lgth3_mbody length 3 (mouse)Not determined45010026284100408Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
1558794Agnm1_mautoimmune glomerulonephritis in MRL 1 (mouse)Not determined44633264655755867Mouse
13207572Spir2_mStreptococcus pneumoniae infection resistance 2 (mouse)45068279588510637Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44660382680603826Mouse
13432173Actrse1_mactivity response to saline/ethanol 1 (mouse)45328712856987128Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283099157Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
12879977Bod2_mbone length and organs 2 (mouse)44628353180283678Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44628353180283678Mouse
13432189Actrse2_mactivity response to saline/ethanol 2 (mouse)45298712854587128Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
1301995Lprm1_mlymphoproliferation modifier 1 (mouse)Not determined45010026284100408Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993763305Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
11532688Mh_mmodifier of hemostasis (mouse)44830477582304775Mouse

Markers in Region
D5Lev20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38453,785,813 - 53,786,120UniSTSGRCm38
MGSCv37453,798,685 - 53,798,992UniSTSGRCm37
Celera453,742,754 - 53,743,061UniSTS
Cytogenetic Map4B2UniSTS
cM Map424.7UniSTS
Tal2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4B2UniSTS
cM Map428.75UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000030124   ⟹   ENSMUSP00000030124
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl453,779,705 - 53,788,712 (+)Ensembl
GRCm38.p6 Ensembl453,779,705 - 53,788,712 (+)Ensembl
RefSeq Acc Id: NM_009317   ⟹   NP_033343
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,779,701 - 53,788,712 (+)NCBI
GRCm38453,779,701 - 53,788,712 (+)NCBI
MGSCv37453,792,577 - 53,799,757 (+)RGD
Celera453,736,659 - 53,743,826 (+)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033343 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40162 (Get FASTA)   NCBI Sequence Viewer  
  AAI10626 (Get FASTA)   NCBI Sequence Viewer  
  BAB31216 (Get FASTA)   NCBI Sequence Viewer  
  EDL02273 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030124
  ENSMUSP00000030124.4
GenBank Protein Q62282 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033343   ⟸   NM_009317
- UniProtKB: Q62282 (UniProtKB/Swiss-Prot),   Q2TB09 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000030124   ⟸   ENSMUST00000030124
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62282-F1-model_v2 AlphaFold Q62282 1-108 view protein structure

Promoters
RGD ID:6883462
Promoter ID:EPDNEW_M5182
Type:multiple initiation site
Name:Tal2_1
Description:Mus musculus T cell acute lymphocytic leukemia 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38453,779,701 - 53,779,761EPDNEW
RGD ID:6836478
Promoter ID:MM_KWN:37675
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000016194
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36453,792,279 - 53,792,779 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99540 AgrOrtholog
Ensembl Genes ENSMUSG00000028417 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030124 ENTREZGENE
  ENSMUST00000030124.4 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAL-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99540 ENTREZGENE
NCBI Gene 21350 ENTREZGENE
PANTHER PTHR13864 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tal2 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q2TB09 ENTREZGENE, UniProtKB/TrEMBL
  Q62282 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Tal2  T cell acute lymphocytic leukemia 2  Tal2  T-cell acute lymphocytic leukemia 2  Symbol and/or name change 5135510 APPROVED