Blnk (B cell linker) - Rat Genome Database

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Gene: Blnk (B cell linker) Mus musculus
Analyze
Symbol: Blnk
Name: B cell linker
RGD ID: 1558103
MGI Page MGI
Description: Predicted to enable several functions, including SH2 domain binding activity; enzyme binding activity; and molecular condensate scaffold activity. Involved in positive regulation of gene expression. Located in cytoplasm. Is expressed in several structures, including genitourinary system; gut; immune system; liver; and olfactory epithelium. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 4. Orthologous to human BLNK (B cell linker).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker protein; BA; BASH; BC; Bca; BL; cytoplasmic adapter protein; Ly-5; Ly-57; Ly5; Ly57; lymphocyte antigen 57; Lyw-57; SLP; SLP-65; src homology 2 domain-containing leukocyte protein of 65 kDa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391940,917,371 - 40,982,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1940,917,371 - 40,982,978 (-)EnsemblGRCm39 Ensembl
GRCm381940,928,927 - 40,994,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1940,928,927 - 40,994,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv371941,003,417 - 41,069,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361940,982,238 - 41,047,846 (-)NCBIMGSCv36mm8
Celera1941,731,720 - 41,797,451 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1934.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (ISO)
camptothecin  (ISO)
carbon nanotube  (EXP,ISO)
chloroprene  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dexamethasone phosphate  (ISO)
diethylstilbestrol  (EXP)
diuron  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (ISO)
inulin  (EXP)
L-methionine  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
Nutlin-3  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
potassium bromate  (EXP)
progesterone  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
sotorasib  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tungsten  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell apoptosis  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal B cell proliferation  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal immature B cell morphology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal mature B cell morphology  (IAGP)
abnormal plasma cell differentiation  (IAGP)
abnormal pre-B cell morphology  (IAGP)
absent B-1a cells  (IAGP)
absent B-1b cells  (IAGP)
absent immature B cells  (IAGP)
absent mature B cells  (IAGP)
arrested B cell differentiation  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased B-1a cell number  (IAGP)
decreased B-2 B cell number  (IAGP)
decreased basophil cell number  (IEA)
decreased follicular B cell number  (IAGP)
decreased IgG level  (IEA)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immature B cell number  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased leukocyte cell number  (IEA)
decreased lymphocyte cell number  (IEA)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased spleen weight  (IEA)
decreased splenocyte number  (IAGP)
decreased transitional stage B cell number  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased B cell apoptosis  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased eosinophil cell number  (IEA)
increased IgA level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2b level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased leukemia incidence  (IAGP)
increased mature B cell number  (IAGP)
increased neutrophil cell number  (IEA)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased transitional stage B cell number  (IAGP)
increased tumor incidence  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
small spleen  (IEA)
spleen hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. An essential role for BLNK in human B cell development. Minegishi Y, etal., Science. 1999 Dec 3;286(5446):1954-7.
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1358795   PMID:1431091   PMID:1460423   PMID:8499657   PMID:8755568   PMID:9341187   PMID:9683264   PMID:9697839   PMID:9705962   PMID:10349636   PMID:10583957   PMID:10591180  
PMID:10688901   PMID:10700474   PMID:10922068   PMID:11035046   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11449370   PMID:11487585   PMID:11489945   PMID:11859098   PMID:11909947  
PMID:12119344   PMID:12176364   PMID:12387741   PMID:12436112   PMID:12477932   PMID:12618482   PMID:12761551   PMID:12818163   PMID:12835482   PMID:12932362   PMID:14610273   PMID:14635051  
PMID:14638847   PMID:14694181   PMID:15087455   PMID:15102471   PMID:15196959   PMID:15237108   PMID:15331445   PMID:15372077   PMID:15489334   PMID:15528332   PMID:15549729   PMID:15654340  
PMID:15733672   PMID:15879130   PMID:16141072   PMID:16141073   PMID:16300960   PMID:16481047   PMID:16585544   PMID:16585562   PMID:16719564   PMID:16794253   PMID:17007932   PMID:17164342  
PMID:17202334   PMID:17202354   PMID:17277139   PMID:17331747   PMID:17372989   PMID:17681949   PMID:17869135   PMID:18329366   PMID:18799693   PMID:19047679   PMID:19218240   PMID:19592646  
PMID:19620627   PMID:20008789   PMID:20133609   PMID:20194721   PMID:20498019   PMID:20622883   PMID:20818374   PMID:21030983   PMID:21267068   PMID:21464221   PMID:21725061   PMID:21822214  
PMID:21856866   PMID:21873635   PMID:21930792   PMID:22334673   PMID:22363743   PMID:22761313   PMID:22949502   PMID:22956576   PMID:23066158   PMID:23534976   PMID:24558349   PMID:24888588  
PMID:25173132   PMID:25331958   PMID:25759025   PMID:26410627   PMID:26522721   PMID:26703467   PMID:27428827   PMID:27935477   PMID:28290451   PMID:28628091   PMID:32554809   PMID:33416167  
PMID:34653294   PMID:38355793  


Genomics

Comparative Map Data
Blnk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391940,917,371 - 40,982,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1940,917,371 - 40,982,978 (-)EnsemblGRCm39 Ensembl
GRCm381940,928,927 - 40,994,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1940,928,927 - 40,994,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv371941,003,417 - 41,069,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361940,982,238 - 41,047,846 (-)NCBIMGSCv36mm8
Celera1941,731,720 - 41,797,451 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1934.26NCBI
BLNK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381096,189,171 - 96,271,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1096,189,171 - 96,271,587 (-)EnsemblGRCh38hg38GRCh38
GRCh371097,948,927 - 98,031,326 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361097,941,445 - 98,021,316 (-)NCBINCBI36Build 36hg18NCBI36
Build 341097,941,446 - 98,021,316NCBI
Celera1091,692,656 - 91,772,534 (-)NCBICelera
Cytogenetic Map10q24.1NCBI
HuRef1091,579,452 - 91,659,253 (-)NCBIHuRef
CHM1_11098,233,338 - 98,313,206 (-)NCBICHM1_1
T2T-CHM13v2.01097,068,476 - 97,150,877 (-)NCBIT2T-CHM13v2.0
Blnk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,703,064 - 249,770,533 (-)NCBIGRCr8
mRatBN7.21239,753,640 - 239,821,113 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1239,753,648 - 239,821,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,895,953 - 247,963,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01254,593,052 - 254,660,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,246,078 - 247,313,603 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01260,187,023 - 260,254,490 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1260,186,967 - 260,254,600 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01267,630,219 - 267,697,917 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,091,335 - 246,165,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1235,596,883 - 235,664,334 (-)NCBICelera
Cytogenetic Map1q54NCBI
Blnk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555072,397,400 - 2,466,788 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555072,398,694 - 2,466,461 (-)NCBIChiLan1.0ChiLan1.0
BLNK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28108,096,234 - 108,231,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110108,101,552 - 108,236,505 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01092,803,408 - 92,936,868 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11096,310,764 - 96,391,067 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1096,316,103 - 96,391,067 (-)Ensemblpanpan1.1panPan2
BLNK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1289,622,438 - 9,700,335 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl289,622,752 - 9,732,639 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha289,807,140 - 9,884,900 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0289,893,624 - 9,971,969 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl289,893,992 - 9,971,860 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1289,602,489 - 9,652,695 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0289,662,351 - 9,745,957 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0289,805,622 - 9,883,362 (-)NCBIUU_Cfam_GSD_1.0
Blnk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721337,181,439 - 37,250,884 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366363,220,554 - 3,289,588 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366363,220,554 - 3,290,054 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BLNK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14107,625,803 - 107,715,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114107,630,477 - 107,715,421 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214117,265,086 - 117,349,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BLNK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1989,345,040 - 89,426,741 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl989,345,725 - 89,401,375 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604850,221,538 - 50,310,749 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Blnk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247377,565,169 - 7,681,102 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Blnk
2732 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:290
Count of miRNA genes:193
Interacting mature miRNAs:217
Transcripts:ENSMUST00000054769, ENSMUST00000117695, ENSMUST00000134568
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
Blnk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
cM Map1931.0UniSTS
D19Mit121  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381940,938,133 - 40,938,256UniSTSGRCm38
MGSCv371941,012,623 - 41,012,746UniSTSGRCm37
Celera1941,740,931 - 41,741,054UniSTS
Cytogenetic Map19C3UniSTS
cM Map1941.0UniSTS
Whitehead Genetic1928.4UniSTS
D9Mit34.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map2C1.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map1E3UniSTS
Cytogenetic Map5E1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map19D3UniSTS
Cytogenetic Map1H5UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map1H2.1UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map19CUniSTS
Cytogenetic Map17E1.3UniSTS
Cytogenetic Map5A1UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map13A5UniSTS
Cytogenetic MapXA1.1UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map3A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map8CUniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map1H1UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map5G1.3UniSTS
Cytogenetic Map7D1-E2UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map1H2.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map15F2UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map1H4-H6UniSTS
Cytogenetic Map12D2UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map1H3UniSTS
Cytogenetic Map19BUniSTS
cM Map950.0UniSTS
Whitehead Genetic943.7UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000054769   ⟹   ENSMUSP00000057844
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1940,917,371 - 40,982,978 (-)Ensembl
GRCm38.p6 Ensembl1940,928,927 - 40,994,535 (-)Ensembl
Ensembl Acc Id: ENSMUST00000117695   ⟹   ENSMUSP00000112473
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1940,917,371 - 40,982,591 (-)Ensembl
GRCm38.p6 Ensembl1940,928,927 - 40,994,148 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134568
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1940,953,049 - 40,982,978 (-)Ensembl
GRCm38.p6 Ensembl1940,964,605 - 40,994,535 (-)Ensembl
RefSeq Acc Id: NM_001365054   ⟹   NP_001351983
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391940,917,371 - 40,982,664 (-)NCBI
GRCm381940,928,927 - 40,994,221 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008528   ⟹   NP_032554
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391940,917,371 - 40,982,664 (-)NCBI
GRCm381940,928,927 - 40,994,221 (-)NCBI
MGSCv371941,003,417 - 41,069,025 (-)RGD
Celera1941,731,720 - 41,797,451 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032554   ⟸   NM_008528
- Peptide Label: isoform 1
- UniProtKB: O88504 (UniProtKB/Swiss-Prot),   Q9QUN3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001351983   ⟸   NM_001365054
- Peptide Label: isoform 2
- UniProtKB: D3YWR2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000057844   ⟸   ENSMUST00000054769
Ensembl Acc Id: ENSMUSP00000112473   ⟸   ENSMUST00000117695
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUN3-F1-model_v2 AlphaFold Q9QUN3 1-457 view protein structure

Promoters
RGD ID:13679462
Promoter ID:EPDNEW_M23881
Type:initiation region
Name:Blnk_1
Description:Mus musculus B cell linker , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381940,994,167 - 40,994,227EPDNEW
RGD ID:6829869
Promoter ID:MM_KWN:27045
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Spleen
Transcripts:ENSMUST00000117695,   NM_008528,   OTTMUST00000079007
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361941,068,576 - 41,069,327 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96878 AgrOrtholog
Ensembl Genes ENSMUSG00000061132 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000054769 ENTREZGENE
  ENSMUST00000054769.7 UniProtKB/Swiss-Prot
  ENSMUST00000117695 ENTREZGENE
  ENSMUST00000117695.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Immunoreceptor_sig_adapters UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17060 UniProtKB/Swiss-Prot
MGD MGI:96878 ENTREZGENE
NCBI Gene 17060 ENTREZGENE
PANTHER B-CELL LINKER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Blnk PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt BLNK_MOUSE UniProtKB/Swiss-Prot
  D3YWR2 ENTREZGENE, UniProtKB/TrEMBL
  O54737_MOUSE UniProtKB/TrEMBL
  O88504 ENTREZGENE
  Q9QUN3 ENTREZGENE
UniProt Secondary O88504 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Blnk  B cell linker  Blnk  B-cell linker  Symbol and/or name change 5135510 APPROVED