Grhl2 (grainyhead like transcription factor 2) - Rat Genome Database

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Gene: Grhl2 (grainyhead like transcription factor 2) Mus musculus
Analyze
Symbol: Grhl2
Name: grainyhead like transcription factor 2
RGD ID: 1558066
MGI Page MGI
Description: Enables DNA-binding transcription factor activity; chromatin binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epithelial cell differentiation; neural tube closure; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; face development; and lung lobe morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610015A08Rik; BO; BOM; brother of mammalian grainyhead; clft; clft3; grainyhead like 2; grainyhead-like 2; grainyhead-like 2 (Drosophila); grainyhead-like protein 2 homolog; grainyheadlike; Tcfcp2; Tcfcp2l3; transcription factor CP2-like 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391537,233,065 - 37,363,813 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1537,233,280 - 37,363,813 (+)EnsemblGRCm39 Ensembl
GRCm381537,232,821 - 37,363,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1537,233,036 - 37,363,569 (+)EnsemblGRCm38mm10GRCm38
MGSCv371537,162,791 - 37,293,324 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361537,177,836 - 37,308,152 (+)NCBIMGSCv36mm8
Celera1537,856,086 - 37,983,260 (+)NCBICelera
Cytogenetic Map15B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (ISO)
membrane  (IEA)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal wall morphology  (IEA)
abnormal blood vessel morphology  (IEA)
abnormal body wall morphology  (IAGP)
abnormal caudal neuropore morphology  (IAGP)
abnormal craniofacial morphology  (IEA)
abnormal cranium morphology  (IAGP)
abnormal forebrain development  (IEA)
abnormal head shape  (IEA)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hindbrain development  (IEA)
abnormal limb morphology  (IEA)
abnormal midbrain development  (IEA)
abnormal midface morphology  (IAGP)
abnormal neural fold elevation formation  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal optic vesicle formation  (IEA)
abnormal pericardium morphology  (IEA)
abnormal placenta morphology  (IEA)
abnormal respiratory conducting tube morphology  (IAGP)
coloboma  (IAGP)
cranioschisis  (IAGP)
curly tail  (IAGP)
decreased brain size  (IAGP)
decreased embryo size  (IAGP)
decreased litter size  (IAGP)
delayed neural tube closure  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
encephalomeningocele  (IAGP)
everted embryonic neuroepithelium  (IAGP)
exencephaly  (IAGP)
facial cleft  (IAGP)
incomplete caudal neuropore closure  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased freezing behavior  (IEA)
increased startle reflex  (IEA)
interdigital webbing  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
midline facial cleft  (IAGP)
open neural tube  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small lung lobe  (IAGP)
spina bifida  (IAGP)
split sternum  (IAGP)
split vertebrae  (IAGP)
syndactyly  (IAGP)
thin ventricular wall  (IAGP)
thoracoabdominoschisis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28. Peters LM, etal., Hum Mol Genet. 2002 Nov 1;11(23):2877-85.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12175488   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:16831572   PMID:18287559   PMID:18799693   PMID:20059953   PMID:20362541   PMID:20412781   PMID:20654612   PMID:20978075   PMID:21081122   PMID:21262862   PMID:21267068   PMID:21377456  
PMID:21515572   PMID:21693562   PMID:21873635   PMID:21905163   PMID:22696678   PMID:22711520   PMID:22955271   PMID:22988430   PMID:23284647   PMID:23562608   PMID:23690579   PMID:23814079  
PMID:23892456   PMID:24375798   PMID:24952961   PMID:25758223   PMID:25788534   PMID:26177923   PMID:26206133   PMID:26288816   PMID:26527742   PMID:26584622   PMID:26903501   PMID:26989192  
PMID:27564454   PMID:27907249   PMID:29237740   PMID:29735981   PMID:30017589   PMID:30189017   PMID:30194919   PMID:30728831   PMID:31171776   PMID:31340691   PMID:31644911   PMID:31782997  
PMID:32005677   PMID:32324317   PMID:33638290   PMID:33985378   PMID:35512705   PMID:36768838  


Genomics

Comparative Map Data
Grhl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391537,233,065 - 37,363,813 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1537,233,280 - 37,363,813 (+)EnsemblGRCm39 Ensembl
GRCm381537,232,821 - 37,363,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1537,233,036 - 37,363,569 (+)EnsemblGRCm38mm10GRCm38
MGSCv371537,162,791 - 37,293,324 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361537,177,836 - 37,308,152 (+)NCBIMGSCv36mm8
Celera1537,856,086 - 37,983,260 (+)NCBICelera
Cytogenetic Map15B3.1NCBI
GRHL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388101,492,439 - 101,681,200 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl8101,492,439 - 101,669,726 (+)EnsemblGRCh38hg38GRCh38
GRCh378102,504,667 - 102,681,954 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368102,574,162 - 102,750,995 (+)NCBINCBI36Build 36hg18NCBI36
Build 348102,574,161 - 102,750,995NCBI
Celera898,689,599 - 98,866,864 (+)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef897,702,727 - 97,879,982 (+)NCBIHuRef
CHM1_18102,544,909 - 102,722,208 (+)NCBICHM1_1
T2T-CHM13v2.08102,618,002 - 102,807,085 (+)NCBIT2T-CHM13v2.0
Grhl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2768,400,287 - 68,530,269 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl768,400,477 - 68,530,258 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx770,281,213 - 70,410,713 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0772,483,713 - 72,613,205 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0772,351,732 - 72,481,228 (+)NCBIRnor_WKY
Rnor_6.0776,058,623 - 76,197,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl776,059,386 - 76,197,856 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0776,188,138 - 76,317,845 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4772,742,859 - 72,872,351 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera765,469,270 - 65,597,175 (+)NCBICelera
Cytogenetic Map7q22NCBI
Grhl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541726,401,363 - 26,533,297 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541726,401,337 - 26,533,297 (+)NCBIChiLan1.0ChiLan1.0
GRHL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1894,375,363 - 94,559,131 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0898,129,147 - 98,308,120 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18100,295,531 - 100,471,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8100,308,575 - 100,471,830 (+)Ensemblpanpan1.1panPan2
GRHL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1133,204,898 - 3,362,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl133,204,925 - 3,362,096 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha133,204,498 - 3,362,392 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0133,362,118 - 3,520,180 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl133,362,467 - 3,520,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1133,205,577 - 3,363,466 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0133,318,462 - 3,476,089 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0133,335,250 - 3,493,208 (+)NCBIUU_Cfam_GSD_1.0
Grhl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530334,430,577 - 34,577,590 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647041,859,035 - 42,002,844 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647041,856,683 - 41,961,666 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRHL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl435,371,136 - 35,564,919 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1435,368,788 - 35,565,394 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2438,263,513 - 38,412,524 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRHL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1896,340,459 - 96,526,366 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl896,342,189 - 96,526,363 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603944,151,564 - 44,338,050 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grhl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476318,784,187 - 18,916,358 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476318,784,815 - 18,916,358 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grhl2
4795 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1650
Count of miRNA genes:711
Interacting mature miRNAs:923
Transcripts:ENSMUST00000022895, ENSMUST00000159221, ENSMUST00000161405, ENSMUST00000161532, ENSMUST00000161933
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141358Ath22_matherosclerosis 22 (mouse)Not determined346465237464652Mouse
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15347438971197538Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
11252136Modvl4_mmodifier of vacuolated lens (mouse)15562049439620614Mouse
26884409Bzwq16_mbi-zygomatic width QTL 16, 16 week (mouse)15612948138000244Mouse
26884384Skwq12_mskull length QTL 12, 16 week (mouse)15612948150763396Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15612948168271849Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15612948171471849Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15612948172471849Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15612948175871849Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15612948176384200Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15612948178684200Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
26884429Zlq6_mzygomatic length QTL 6, 10 week (mouse)15682948144963396Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15692948175871849Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15692948175871849Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15722948155263396Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15762948155263396Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15762948159271849Mouse
27095922Pglq11_mpelvic girdle length QTL 11, 10 week (mouse)15812948438763395Mouse
26884439Sklq11_mskull length QTL 11, 10 week (mouse)15812948447663396Mouse
10412172Habiir5_mhyperoxic acute lung injury imprinted region 5 (mouse)Not determined15927302243311880Mouse
4140994Shali3_msurvival time to hyperoxic acute lung injury 3 (mouse)Not determined927302243311880Mouse
4141192Ssrq2_mstress response QTL 2 (mouse)Not determined927302256186850Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
1301020Pheo_mpheomelanin (mouse)Not determined151384700647847148Mouse
1302165Yv_myellow value (mouse)Not determined151384700647847148Mouse
4141423Nstr2_mnerve sheath tumor resistance QTL 2 (mouse)Not determined1492758748927756Mouse
1301951Eila3_methanol induced locomotor activity 3 (mouse)Not determined151492758748927756Mouse
1302007Bbaa14_mB.burgdorferi-associated arthritis 14 (mouse)Not determined151492758748927756Mouse
1301499Bdln2_mbody length 2 (mouse)Not determined151564534349645470Mouse
12859288Criq1_mCitrobacter rodentium infection QTL 1 (mouse)151603395450033954Mouse
26884423Zlq10_mzygomatic length QTL 10, 16 week (mouse)152060008650763396Mouse
14928313Manh78_mmandible shape 78 (mouse)152148464155484641Mouse
12859289Criq3_mCitrobacter rodentium infection QTL 3 (mouse)152259376556593765Mouse
4142160Femwf10_mfemur work to failure 10 (mouse)Not determined2289301456893160Mouse
1301557Bbaa22_mB.burgdorferi-associated arthritis 22 (mouse)Not determined152446257258462805Mouse
1300967Bdt6_mbone density traits 6 (mouse)Not determined152529580659295928Mouse
4141409Radsvq1_mradiation sensitivity QTL 1 (mouse)Not determined2548497859484978Mouse
1301760Dob9_mdietary obesity 9 (mouse)Body fat amountadiposity index152603568037781301Mouse
1300772Bglq16_mbody growth late QTL 16 (mouse)Not determined152631178060311880Mouse
1301345Bgeq14_mbody growth early QTL 14 (mouse)Not determined152631178060311880Mouse
1357514Mbis3_mMycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)Not determined162631178060311880Mouse
1301406Egrd2_mearly growth rate (mouse)Not determined152631178060311880Mouse
27226800Scvln20_msacral vertebrae length 2, 16 week (mouse)152660008666371849Mouse
1301450Bpq6_mblood pressure QTL 6 (mouse)Not determined152828264662282739Mouse
1357512Bsbob5_mBSB obesity 5 (mouse)Not determined152828264662282739Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930014676084200Mouse
26884452Sklq17_mskull length QTL 17, 16 week (mouse)153020014657963396Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
1300578Cd8ts3_mCD8 T cell subset 3 (mouse)Not determined153400469468004804Mouse
12904003Opfaq12_mopen field activity QTL 12 (mouse)153435891138447901Mouse
1301324Cdif_mcolor difference (mouse)Not determined153597590669976019Mouse

Markers in Region
41.MMHAP64FRF11.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381537,311,204 - 37,311,356UniSTSGRCm38
MGSCv371537,240,959 - 37,241,111UniSTSGRCm37
Celera1537,930,816 - 37,930,968UniSTS
Cytogenetic Map15CUniSTS
Whitehead_YAC15 UniSTS
D15Mit49  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381537,260,048 - 37,260,225UniSTSGRCm38
MGSCv371537,189,803 - 37,189,980UniSTSGRCm37
Celera1537,878,242 - 37,878,419UniSTS
Cytogenetic Map15CUniSTS
cM Map1515.2UniSTS
Whitehead Genetic1516.4UniSTS
Whitehead_YAC15 UniSTS
Grhl2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15CUniSTS
cM Map1514.84UniSTS
AU049954  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371537,170,891 - 37,171,150UniSTSGRCm37
Celera1537,864,185 - 37,864,444UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_026496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF411213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY018142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY703140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ322576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000022895   ⟹   ENSMUSP00000022895
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,233,280 - 37,363,813 (+)Ensembl
GRCm38.p6 Ensembl1537,233,036 - 37,363,569 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159221   ⟹   ENSMUSP00000123871
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,335,981 - 37,361,184 (+)Ensembl
GRCm38.p6 Ensembl1537,335,737 - 37,360,940 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161405   ⟹   ENSMUSP00000125410
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,233,280 - 37,333,891 (+)Ensembl
GRCm38.p6 Ensembl1537,233,036 - 37,333,647 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161532   ⟹   ENSMUSP00000124903
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,233,302 - 37,279,797 (+)Ensembl
GRCm38.p6 Ensembl1537,233,058 - 37,279,553 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161933
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,318,647 - 37,363,806 (+)Ensembl
GRCm38.p6 Ensembl1537,318,403 - 37,363,562 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228589
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,285,837 - 37,289,156 (+)Ensembl
GRCm38.p6 Ensembl1537,285,593 - 37,288,912 (+)Ensembl
RefSeq Acc Id: NM_026496   ⟹   NP_080772
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,233,280 - 37,363,813 (+)NCBI
GRCm381537,233,036 - 37,363,569 (+)NCBI
MGSCv371537,162,791 - 37,293,324 (+)RGD
Celera1537,856,086 - 37,983,260 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520063   ⟹   XP_006520126
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,233,352 - 37,363,807 (+)NCBI
GRCm381537,233,108 - 37,363,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006520065   ⟹   XP_006520128
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,233,280 - 37,333,893 (+)NCBI
GRCm381537,233,036 - 37,333,649 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316621   ⟹   XP_017172110
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,233,352 - 37,363,807 (+)NCBI
GRCm381537,233,108 - 37,363,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316622   ⟹   XP_017172111
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,233,065 - 37,333,893 (+)NCBI
GRCm381537,232,821 - 37,333,649 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316623   ⟹   XP_017172112
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,233,352 - 37,329,805 (+)NCBI
GRCm381537,233,108 - 37,329,561 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080772   ⟸   NM_026496
- UniProtKB: Q80UZ5 (UniProtKB/Swiss-Prot),   Q8K5C0 (UniProtKB/Swiss-Prot),   A0A8C6MWR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520128   ⟸   XM_006520065
- Peptide Label: isoform X5
- UniProtKB: Q9DCN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520126   ⟸   XM_006520063
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017172110   ⟸   XM_017316621
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017172111   ⟸   XM_017316622
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017172112   ⟸   XM_017316623
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSMUSP00000123871   ⟸   ENSMUST00000159221
RefSeq Acc Id: ENSMUSP00000022895   ⟸   ENSMUST00000022895
RefSeq Acc Id: ENSMUSP00000125410   ⟸   ENSMUST00000161405
RefSeq Acc Id: ENSMUSP00000124903   ⟸   ENSMUST00000161532
Protein Domains
Grh/CP2 DB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K5C0-F1-model_v2 AlphaFold Q8K5C0 1-625 view protein structure

Promoters
RGD ID:6826076
Promoter ID:MM_KWN:18279
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000076417,   OTTMUST00000076418,   OTTMUST00000076420
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361537,162,496 - 37,162,996 (+)MPROMDB
RGD ID:8683608
Promoter ID:EPDNEW_M19835
Type:initiation region
Name:Grhl2_1
Description:Mus musculus grainyhead like transcription factor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19836  EPDNEW_M19837  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381537,233,088 - 37,233,148EPDNEW
RGD ID:8683610
Promoter ID:EPDNEW_M19836
Type:single initiation site
Name:Grhl2_3
Description:Mus musculus grainyhead like transcription factor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19835  EPDNEW_M19837  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381537,318,394 - 37,318,454EPDNEW
RGD ID:8683612
Promoter ID:EPDNEW_M19837
Type:multiple initiation site
Name:Grhl2_2
Description:Mus musculus grainyhead like transcription factor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19835  EPDNEW_M19836  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381537,320,053 - 37,320,113EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2182543 AgrOrtholog
Ensembl Genes ENSMUSG00000022286 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000022895 ENTREZGENE
  ENSMUSP00000022895.9 UniProtKB/Swiss-Prot
  ENSMUSP00000123871.2 UniProtKB/TrEMBL
  ENSMUSP00000124903.2 UniProtKB/TrEMBL
  ENSMUSP00000125410 ENTREZGENE
  ENSMUSP00000125410.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022895 ENTREZGENE
  ENSMUST00000022895.15 UniProtKB/Swiss-Prot
  ENSMUST00000159221.2 UniProtKB/TrEMBL
  ENSMUST00000161405 ENTREZGENE
  ENSMUST00000161405.8 UniProtKB/TrEMBL
  ENSMUST00000161532.2 UniProtKB/TrEMBL
InterPro CP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_CP2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:252973 UniProtKB/Swiss-Prot
MGD MGI:2182543 ENTREZGENE
NCBI Gene 252973 ENTREZGENE
PANTHER GRAINYHEAD-LIKE PROTEIN 2 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR CP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grhl2 PhenoGen
PROSITE GRH_CP2_DB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C6MWR9 ENTREZGENE
  F6TZV3_MOUSE UniProtKB/TrEMBL
  F6UT30_MOUSE UniProtKB/TrEMBL
  GRHL2_MOUSE UniProtKB/Swiss-Prot
  Q3TTU6_MOUSE UniProtKB/TrEMBL
  Q80UZ5 ENTREZGENE
  Q8K5C0 ENTREZGENE
  Q99KA7_MOUSE UniProtKB/TrEMBL
  Q9DCN4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q80UZ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Grhl2  grainyhead like transcription factor 2    grainyhead-like 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED