Hmx2 (H6 homeobox 2) - Rat Genome Database

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Gene: Hmx2 (H6 homeobox 2) Mus musculus
Analyze
Symbol: Hmx2
Name: H6 homeobox 2
RGD ID: 1558027
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including inner ear morphogenesis; positive regulation of cell population proliferation; and positive regulation of mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human HMX2 (H6 family homeobox 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H6 homeo box 2; homeobox protein HMX2; homeobox protein Nkx-5.2; MGC32455; NK-related homeobox; Nkx-5.2; Nkx5-; Nkx5-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397131,150,486 - 131,159,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7131,150,502 - 131,159,743 (+)EnsemblGRCm39 Ensembl
GRCm387131,548,757 - 131,558,014 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7131,548,773 - 131,558,014 (+)EnsemblGRCm38mm10GRCm38
MGSCv377138,697,576 - 138,700,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367131,339,921 - 131,347,272 (+)NCBIMGSCv36mm8
Celera7131,359,572 - 131,362,092 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map774.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
High Myopia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7510254   PMID:7647458   PMID:8541222   PMID:8970821   PMID:9389661   PMID:9421269   PMID:9435283   PMID:10349636   PMID:10543441   PMID:11042159   PMID:11071765   PMID:11076861  
PMID:11091080   PMID:11217851   PMID:11748138   PMID:12466851   PMID:12477932   PMID:15328018   PMID:15363417   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16469766   PMID:16597514  
PMID:16900517   PMID:18287559   PMID:19913004   PMID:20059953   PMID:20932939   PMID:21267068   PMID:21525287   PMID:21873635   PMID:22383091   PMID:23226461   PMID:23457544   PMID:23536097  
PMID:23636947   PMID:24194600   PMID:26166575   PMID:27578785   PMID:27856909   PMID:29031500   PMID:29795232   PMID:32868762   PMID:38355793   PMID:38602877  


Genomics

Comparative Map Data
Hmx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397131,150,486 - 131,159,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7131,150,502 - 131,159,743 (+)EnsemblGRCm39 Ensembl
GRCm387131,548,757 - 131,558,014 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7131,548,773 - 131,558,014 (+)EnsemblGRCm38mm10GRCm38
MGSCv377138,697,576 - 138,700,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367131,339,921 - 131,347,272 (+)NCBIMGSCv36mm8
Celera7131,359,572 - 131,362,092 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map774.34NCBI
HMX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810123,148,136 - 123,150,672 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10123,148,136 - 123,150,672 (+)EnsemblGRCh38hg38GRCh38
GRCh3710124,907,652 - 124,910,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610124,897,628 - 124,900,178 (+)NCBINCBI36Build 36hg18NCBI36
Celera10118,614,169 - 118,616,719 (+)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10118,525,408 - 118,527,978 (+)NCBIHuRef
CHM1_110125,189,354 - 125,191,904 (+)NCBICHM1_1
T2T-CHM13v2.010124,023,154 - 124,025,690 (+)NCBIT2T-CHM13v2.0
Hmx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,749,284 - 195,758,347 (+)NCBIGRCr8
mRatBN7.21186,319,110 - 186,326,771 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1186,319,110 - 186,326,771 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1194,669,263 - 194,676,924 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01201,846,872 - 201,854,533 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01194,519,959 - 194,527,620 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01203,515,605 - 203,523,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1203,515,609 - 203,523,358 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01210,526,870 - 210,534,573 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41191,117,643 - 191,125,304 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1184,073,654 - 184,081,315 (+)NCBICelera
Cytogenetic Map1q41NCBI
Hmx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554771,294,472 - 1,302,505 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554771,294,479 - 1,302,433 (+)NCBIChiLan1.0ChiLan1.0
HMX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28134,993,103 - 134,995,377 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110134,998,454 - 135,000,728 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010119,700,416 - 119,708,444 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HMX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12832,679,585 - 32,687,972 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2832,679,579 - 32,687,982 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2832,744,958 - 32,752,886 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02833,236,182 - 33,244,109 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2833,236,196 - 33,244,546 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12832,793,306 - 32,801,218 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02832,785,467 - 32,793,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02833,035,343 - 33,043,264 (+)NCBIUU_Cfam_GSD_1.0
Hmx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721313,768,795 - 13,772,436 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648611,789,991 - 11,792,068 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648611,789,991 - 11,792,500 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14132,696,380 - 132,699,544 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114132,691,108 - 132,699,477 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214144,283,993 - 144,285,818 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19115,818,448 - 115,825,664 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9115,819,760 - 115,821,508 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604877,128,290 - 77,130,657 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473723,861,756 - 23,871,804 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473723,862,661 - 23,871,723 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hmx2
322 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:143
Interacting mature miRNAs:191
Transcripts:ENSMUST00000051997, ENSMUST00000183219
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse


Sequence


Ensembl Acc Id: ENSMUST00000051997   ⟹   ENSMUSP00000058205
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7131,155,790 - 131,159,743 (+)Ensembl
GRCm38.p6 Ensembl7131,554,061 - 131,558,014 (+)Ensembl
Ensembl Acc Id: ENSMUST00000183219   ⟹   ENSMUSP00000138799
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7131,150,502 - 131,158,318 (+)Ensembl
GRCm38.p6 Ensembl7131,548,773 - 131,556,589 (+)Ensembl
RefSeq Acc Id: NM_001368360   ⟹   NP_001355289
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397131,150,486 - 131,159,743 (+)NCBI
GRCm387131,548,757 - 131,558,014 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145998   ⟹   NP_666110
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397131,156,022 - 131,159,743 (+)NCBI
GRCm387131,554,293 - 131,558,014 (+)NCBI
MGSCv377138,697,576 - 138,700,096 (+)RGD
Celera7131,359,572 - 131,362,092 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_666110   ⟸   NM_145998
- UniProtKB: Q3UUN6 (UniProtKB/Swiss-Prot),   Q8R1Q2 (UniProtKB/Swiss-Prot),   P43687 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001355289   ⟸   NM_001368360
- UniProtKB: Q3UUN6 (UniProtKB/Swiss-Prot),   P43687 (UniProtKB/Swiss-Prot),   Q8R1Q2 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000058205   ⟸   ENSMUST00000051997
Ensembl Acc Id: ENSMUSP00000138799   ⟸   ENSMUST00000183219

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43687-F1-model_v2 AlphaFold P43687 1-273 view protein structure

Promoters
RGD ID:8665839
Promoter ID:EPDNEW_M10951
Type:single initiation site
Name:Hmx2_1
Description:Mus musculus H6 homeobox 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387131,548,757 - 131,548,817EPDNEW
RGD ID:6841284
Promoter ID:MM_KWN:52965
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_145998
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367138,696,816 - 138,697,316 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107159 AgrOrtholog
Ensembl Genes ENSMUSG00000050100 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051997 ENTREZGENE
  ENSMUST00000051997.9 UniProtKB/Swiss-Prot
  ENSMUST00000183219 ENTREZGENE
  ENSMUST00000183219.8 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
InterPro HMX_Homeobox_TF UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
KEGG Report mmu:15372 UniProtKB/Swiss-Prot
MGD MGI:107159 ENTREZGENE
NCBI Gene 15372 ENTREZGENE
PANTHER HOMEOBOX PROTEIN HMX UniProtKB/Swiss-Prot
  HOMEOBOX PROTEIN HMX2 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Hmx2 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt HMX2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UUN6 ENTREZGENE
  Q8R1Q2 ENTREZGENE
UniProt Secondary Q3UUN6 UniProtKB/Swiss-Prot
  Q8R1Q2 UniProtKB/Swiss-Prot