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Gene: Tcf23 (transcription factor 23) Mus musculus

Analyze

Symbol:

Tcf23

Name:

transcription factor 23

RGD ID:

1557984

MGI Page

MGI

Description:

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription regulator inhibitor activity. Involved in negative regulation of muscle cell differentiation and negative regulation of transcription by RNA polymerase II. Located in euchromatin. Is expressed in central nervous system and genitourinary system. Orthologous to human TCF23 (transcription factor 23).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

2010002O16Rik; basic helix-loop-helix transcription factor OUT; bHLHa; bHLHa24; Ou; Out; ovary, uterus and testis protein; TCF-23

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TCF23 (transcription factor 23)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Tcf23 (transcription factor 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tcf23 (transcription factor 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TCF23 (transcription factor 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TCF23 (transcription factor 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tcf23 (transcription factor 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TCF23 (transcription factor 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TCF23 (transcription factor 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tcf23 (transcription factor 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Tcf23 (transcription factor 23)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TCF23 (transcription factor 23)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tcf23 (transcription factor 23)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Related Pseudogenes:

Gm18241

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	31,125,946 - 31,145,406 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	31,126,006 - 31,134,362 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	30,968,602 - 30,988,062 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	30,968,662 - 30,977,018 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	31,271,050 - 31,279,391 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	31,245,258 - 31,253,599 (+)	NCBI		MGSCv36	mm8
Celera	5	28,448,052 - 28,456,393 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	16.9	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Tatton-Brown-Rahman syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

buta-1,3-diene (EXP)

Butylbenzyl phthalate (ISO)

carbon nanotube (EXP)

choline (EXP)

chromium(6+) (EXP)

dexamethasone (EXP)

dibutyl phthalate (EXP,ISO)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

dimethylarsinic acid (EXP)

dioxygen (EXP)

endosulfan (ISO)

folic acid (EXP)

gentamycin (ISO)

glyphosate (ISO)

isoprenaline (EXP)

L-methionine (EXP)

lipopolysaccharide (ISO)

methylarsonic acid (EXP)

naphthalene (EXP)

ozone (EXP)

paracetamol (ISO)

pirinixic acid (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenate (EXP)

sodium arsenite (EXP)

sodium dichromate (EXP)

testosterone (ISO)

tetrachloromethane (ISO)

titanium dioxide (EXP)

tributylstannane (ISO)

triptonide (EXP)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

decidualization (ISO)

developmental process (IBA)

muscle organ development (IEA)

negative regulation of muscle cell differentiation (IDA)

negative regulation of transcription by RNA polymerase II (IDA)

positive regulation of gene expression (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

euchromatin (IDA)

nucleus (IEA)

Molecular Function

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

protein binding (ISO)

protein dimerization activity (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II-specific DNA-binding transcription factor binding (IPI)

transcription regulator inhibitor activity (IDA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal cell adhesion (IAGP)

abnormal decidualization (IAGP)

abnormal extracellular matrix morphology (IAGP)

abnormal myometrium morphology (IAGP)

abnormal parturition (IAGP)

abnormal uterus physiology (IAGP)

cornea opacity (IAGP)

decreased litter size (IAGP)

decreased maternal body weight gain (IAGP)

delayed parturition (IAGP)

dystocia (IAGP)

increased collagen level (IAGP)

reduced female fertility (IAGP)

thin myometrium (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Mouse brain organization revealed through direct genome-scale TF expression analysis.	Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:10652346	PMID:11042159	PMID:11076861	PMID:11701948	PMID:12477932	PMID:14681479	PMID:16141072	PMID:16141073	PMID:18287559	PMID:18557763	PMID:20059953
PMID:21267068	PMID:21873635	PMID:22988430	PMID:24571987	PMID:24952961	PMID:32325033	PMID:38355793	PMID:39014976

Genomics

Comparative Map Data

Tcf23
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	31,125,946 - 31,145,406 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	31,126,006 - 31,134,362 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	30,968,602 - 30,988,062 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	30,968,662 - 30,977,018 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	31,271,050 - 31,279,391 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	31,245,258 - 31,253,599 (+)	NCBI		MGSCv36	mm8
Celera	5	28,448,052 - 28,456,393 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	16.9	NCBI

TCF23
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	27,149,004 - 27,156,974 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	27,149,004 - 27,156,974 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	27,371,872 - 27,379,842 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	27,225,506 - 27,229,239 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	27,218,248 - 27,222,122 (+)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	27,113,796 - 27,117,670 (+)	NCBI		HuRef
CHM1_1	2	27,301,867 - 27,305,741 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	27,190,651 - 27,198,626 (+)	NCBI		T2T-CHM13v2.0

Tcf23
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	31,117,839 - 31,126,575 (-)	NCBI		GRCr8
mRatBN7.2	6	25,397,889 - 25,406,639 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,397,937 - 25,405,880 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	6	26,763,159 - 26,772,074 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	26,762,761 - 26,771,164 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,578,788 - 36,586,815 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	25,384,001 - 25,388,552 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	24,888,605 - 24,897,506 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

Tcf23
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	9,123,987 - 9,127,633 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	9,123,987 - 9,130,728 (+)	NCBI	ChiLan1.0	ChiLan1.0

TCF23
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	99,358,503 - 99,366,443 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	99,362,471 - 99,370,475 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	27,148,122 - 27,152,006 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	27,237,282 - 27,241,149 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	27,237,282 - 27,241,149 (+)	Ensembl	panpan1.1		panPan2

TCF23
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	21,139,408 - 21,145,014 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	21,140,794 - 21,144,053 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	21,032,667 - 21,037,060 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	21,461,572 - 21,465,965 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	21,461,740 - 21,464,999 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	21,148,277 - 21,152,683 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	21,159,382 - 21,163,788 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	21,206,240 - 21,210,647 (+)	NCBI		UU_Cfam_GSD_1.0

Tcf23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	65,441,223 - 65,447,315 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	5,395,283 - 5,398,141 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	5,395,222 - 5,398,141 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TCF23
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	111,976,845 - 111,983,790 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	111,976,848 - 111,983,879 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	118,975,334 - 118,982,436 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TCF23
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	80,459,590 - 80,466,272 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	80,461,732 - 80,465,499 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	31,675,387 - 31,681,683 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tcf23
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	9,256,670 - 9,263,332 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	9,256,432 - 9,262,894 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tcf23
1139 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1204
Count of miRNA genes:	633
Interacting mature miRNAs:	770
Transcripts:	ENSMUST00000006818
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301555	Alcp10_m	alcohol preference locus 10 (mouse)			Not determined		5	31024275	65024480	Mouse
1301776	Skts3_m	skin tumor susceptibility 3 (mouse)			Not determined		5	21667295	55667403	Mouse
1301685	Estq2_m	estradiol regulated response QTL 2 (mouse)			Not determined		5	15634084	49634190	Mouse
11537367	Hmtb11_m	hemostasis and thrombosis 11 (mouse)					5	22100823	64806579	Mouse
4141207	Imrfq1_m	immune response to Factor IX QTL 1 (mouse)			Not determined		5	8124117	42124239	Mouse
11537368	Hmtb10_m	hemostasis and thrombosis 10 (mouse)					5	22100823	54500318	Mouse
1301403	Alcp9_m	alcohol preference locus 9 (mouse)			Not determined		5	31024275	65024480	Mouse
7394748	Mom5_m	modifier of Min 5 (mouse)			Not determined		5	8847672	33475637	Mouse
15039371	Nmrs21_m	NAFLD-associated magnetic resonance shift 21 (mouse)					5	3504823	37504823	Mouse
1301693	Sle6_m	systemic lupus erythematosus susceptibility 6 (mouse)			Not determined		5	8890693	87841837	Mouse
1300701	Cd8ts1_m	CD8 T cell subset 1 (mouse)			Not determined		5	27215348	61215451	Mouse
1357478	Kdnw1_m	kidney weight 1 (mouse)			Not determined		5	8915949	40529869	Mouse
11341716	Rvfs3_m	Rift Valley fever susceptibility 3 (mouse)					5	26441234	138455402	Mouse
14696730	Kidlq1_m	kidney weight, left QTL 1 (mouse)					5	13563152	47563152	Mouse
10401122	Pgia41_m	proteoglycan induced arthritis 41 (mouse)			Not determined		5	823144	34823280	Mouse
1300719	Iba5_m	induction of brown adipocytes 5 (mouse)			Not determined		5	20686993	54687134	Mouse
1301806	Actd2_m	activity-distance traveled 2 (mouse)			Not determined		5	5384520	39384652	Mouse

Markers in Region

RH118284

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	30,976,003 - 30,976,163	UniSTS	GRCm38
MGSCv37	5	31,278,376 - 31,278,536	UniSTS	GRCm37
Celera	5	28,455,378 - 28,455,538	UniSTS
Cytogenetic Map	5	B1	UniSTS
Whitehead/MRC_RH	5	388.11	UniSTS
Whitehead/MRC_RH	5	379.71	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006504095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006504096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB059397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC109606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC109608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF142405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK008056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK030277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK030297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC119346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC120609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000006818 ⟹ ENSMUSP00000006818

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	31,126,006 - 31,134,362 (+)	Ensembl
GRCm38.p6 Ensembl	5	30,968,662 - 30,977,018 (+)	Ensembl

RefSeq Acc Id:

NM_053085 ⟹ NP_444315

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	31,126,021 - 31,134,362 (+)	NCBI
GRCm38	5	30,968,677 - 30,977,018 (+)	NCBI
MGSCv37	5	31,271,050 - 31,279,391 (+)	RGD
Celera	5	28,448,052 - 28,456,393 (+)	RGD
cM Map	5		ENTREZGENE

Sequence:

show sequence

TGGCTGGATGGCCACCCTGTCAGGGCGAGCTTGAGCCCAAGGCTCCCTTGGGTACTGTGTCCCT
GCTCTAGGGCCTACAGCCTCATACTTCATGATAGCGGCATGTCACAGGAGGCCACAGAGGCACC
AGCAATGCCAGGAGAAGGGCATGGTCATAATAAGGCCAAGGCACGGTGGCTTCTAGGCACTGAC
AGGAAGAGGAGTCGCATCAACAGGACAAGGCAGGACCTGTGGGAGGACACTAGCTGGAGCAATC
ACAGACTGAGCAGAGCCACCTCTGCCCCTCGAGGGACCAGAGCTAGGGGAACAGCTCATGGCAG
GAGTGAGGCCAGCCCGGAGAACGCAGCACGGGAACGGACTCGGGTGAAGACGCTTCGTCAGGCC
TTTCTGGCCCTGCAGGCTGCTCTGCCCGCAGTGCCACCCGACACCAAGCTTTCCAAGTTGGATG
TGCTCGTGCTGGCCACAAGCTACATTGCCCACCTCACCCGGACCCTCGGCCATGAGTTGCCTGG
CCCTGCCTGGCCTCCCTTCGTGCGTGGACTCCGTTACTTGCACCCGCTAAAGAAGTGGCCCATG
CGATCTCGTCTCTATGCAGGAGGCTTGGGATGCTCTGACCTCGATTCCACCACAGCTATCACGA
CCGGCCAAAGATGCAAGGATGCAGAGCTGGGGTCTCAAGACTCTGTAGCCGCAGAAAGTCTCCT
GACCTCTCCAGCTTTTGGTAACAAATGACCACCATGATCATCCTATTCTCTTAGACGGTGCCTC
TGCTTAAGGACCTGGATTTTCTGCCTGCTTTACTTGTCTTCCCCTTGACTCCCAGCCTTTGGAT
TTGTCTCAGGCTCAAGTTTCAAGTTCAGGCTTGGCTTCCAGCAGGCAGAAGAAGCAGTAATGAC
ATCAGTAATAGAGAGTCCCCAGGAAACCCAGGATGGAGTTCATTCACCTTTGGCTCGTCTATGG
CAGTGACAGGAAGTGACAGAGAAACCGAGGTTGACATGGTTCAGTCAAGTTAGGGAATCACATC
CCCCTCCCCCAGGGCTCTTCAAGACAAGAAGGCAGGAAGACAGAAATTGCTCTGCCAATACAGC
GTGGGGTTAGGACAGCAGTAGCCCCTGGTGCTCATGGGCATAGCAGGGTGCCTGAAGGGCTTTT
GGAAGCAGTAAGTATGAACACGTCTGGGGTCAGGTCACAAAGCCAGACAGGAAGCTAAAGAATG
GAGTGATTTCTTTTTGAAATTTCCCGACGAGATGTTTATTCAACATCAAAGAGTTTAGAGTCCT
TCTCTCTGGAATATGGTCTCTCCAGTGGTCCCTTGTCACCGCCTTCCTGCACCAGGGCCCTGCT
GCCTTTCACATTTCAGCAGATGAAGCCCCCAGACTTACATGGCTGACAATCCAGGGAAATTTAG
CTAGTCCAAGCTATCTAGGGTCAGATCATTTTATCCCACAGGCAGCTCTGCCTTTGCTCAAAGA
GGCAGCCACTCACAGCCCTGCCTGTAAAGGACAGCAATCCTTCCAGCTTTATCTCCTTGATGGC
CCAAGATAAAGCAGGTGCATCACTCTCCCGGTGTGATAAGCAGTGTCTCCCCCCCCCCCCACCC
TCATGTTAGTATGTTAGAAACATCATCTCACAGGGCTTCGGCAAGATTCCTGTACCATCAGCGA
TGGGGGCTTTATTGGTTTTGGTACAATCTGTGCATTTCTATATATCAGCTCCCAAGGCCAACTT
CTTTCCATAGGCATTGACATCCCAGGCTTGCCCCAATTCCTGGTACAAGGTGTCAAAAGTTTTC
TAGAGCTTTAGTGGCATTTGTCCTTGACCCTGAAGAAATAACTGGAGACCAACCATACACTAAG
GTGGGCTTTGCAAGTCAGGTATAGTTTCAGGTTGGTCCCTGGGGTCTGAACATAGCAGGAACTG
CCTGCCTCTCAAATTTTAGTCACTGAGGCCAAGTCGAGTCCCAGCAGGCTGCTCATGAGTTGAG
TGGAGGCTCTGACAGGCTGGGAGGGACTGGGCCTGCTCCTCCATAGGGATGACCCCCTAAGGCA
TCCAGGAAAGGGGGATTGATGGGGTGACTCAGCAAGCTGGGGTGGAGGTAGAAGACAGAACGTC
CCAGCCTCAGCTGCATGGGCTGTGGGAGAGCAGCTGGACTATGGCTGGGAGCCATGGCGGACAG
CCTCAGCCAAGGCCAAACCCATAAATCTGCCTGGTCCCACATTTCTCCTAGGGGACCCTGAGAA
CTTGTAGAGAGCTGATCCAGCAGCTGGACAGGGCCAAGCAGGGGCAGCGACCAGGTGTGGGAGA
GCAGGAGCCGTGTTCCTAACAAGACCATAAAAGCCCAGTCTGGGTGTTCTATTTTTAAAACCAG
ATGGCAGCATCTCCCTGGTTGAGTTGGAGGGTGGTAAAAAGGAGCGGGCATGATTTCTTCCCAG
TCGGTAGCATACGATCTGTGTCTGGGCAGGCTGGGGACTGGCTTTGGGTACCTGCTGGGAGTCT
GCTCATAGCTTAAAGCATCTCCCAGTAACTGAGGAGAGTTTGATCTGGAGCTTGAAGTGTCCAC
ACTGTCCAGACTCAGGCTTTTGCCTCCTTCCACAAACCCTTCAGGGCTGACCACATAACACAAC
CCCGGTGGAGAATCTGAGGAGGGAAAGGAGGATGAAGTTGGCAGAGGGCCAGGTAAAGAACAAG
TCCCACCAGGAAGGGTGTTTTGCTTTGTTTTGTTTTGTTTTGTTTTCTTGACATGGCTCATTGT
GTAGCCCAGGCTGCCTTTGAACTTGAAATCCTTCTGCCTCAGCAAGGATTATGGGCTCATAGGC
CTATACCACTCTGCCCAATTAGGACAAATTTGGAAGTCTGTTCCCAGAGAATCTGTTTTTCCCC
ACTGACTAGGACAGTCACCTGGCCTGAGGAGGCAAAGGGGCTGGCTGTGGGGAGGGGACCAAAG
GAACACCCAGGGGCATGACTGGGGCCTCACCCTCCCTGACCAGCACAAGGCTTCCATGGGCAAC
ACCATGCTGGAGACTGGGGTCTCTAAGCCAAGCTGAACCAGGAATGGATCCCTTTGTTTCCACA
GCAGAGGAAGAAGAGCACCTGCTGACTGGAGTTCTATGCTCGCCTGTGGTGGGGAGGCAGTAGA
AGAAGCTGAAATCTGTCTCCAACAATAGCTATTGTTCCCTAGGCACAAGGATGTATAGGGAAGA
GTATGCAAAAGTTAAGGAGCACAGACAGCCAGTGGTGTATGTGTGCCCTGGTGAGTCAGAGGGG
TGGCCCCTGTGACCCTAGTCCAGTTTTCTTCCTGTCCCTCTCAGGGTGAGGTGCAGGTAGAGTG
AAGAGGGAGATTTCCCTGTTGCCCTCCTCCAATGGCTAACCTTGGCTGTCAACTTCTTTGGACT
GAGAGATGAAGAGCGGGTTAGTAAAGTGGGCCTCTGGCTTTGTCTGTGAGGGCTTTTACCTCCT
GAATGGCTTAGTCCATGGATGGATAAACTGGGCATGGTGGTGCATGCCTTCAATCCTAGCACTC
AGGAGACAGAGGCAGGAGGATCTTTGTGAGTTGGAGACCAGCCAGGCCAACCAGTGAGACACTA
TCTCAAAAAAAAAAAATTAGACTAGTGGGTGGTGGTAGAATTGTGGACAGGCTGGGGCTATGTG
TTTCGGGCCGTGTATTGCCCCTGACTCCCTCCATGTCGCTGCCGCACCCCTGACATGACATTAC
ATGAGAAAAAGAGCCGTCCCTTCCACATACTCCTGATACCATGATGTTTTGCACAAAGCCATGA
CACCAAGAAGCTATGGACTGTCTCTGAGATTTTGGATCAAAATAAATCTTTCCTACTTGACATT
GTTTCTATCCTGAATTAGGTCACAGCAATGTGGACTCTAACGGAGAGTGAAAAGATCAAGATGG
TTTCTAAGAAATAATCCCTTTTTCTCCTGGGAAGACCCTGGCTAGGATGAATTAGATAATGTCG
GCCTCTCCCTTTCATAATACTAGCCCTGGAAGCTTATTCAATTCTAGATCAAGGGAGGGCAAGT
CAGGGCCAGTAGACCAAATCCAACCTTTACTTGTTTGTATGAATAAAGTTTTATTGGGATAGCC
CTGTA

hide sequence

RefSeq Acc Id:

XM_006504095 ⟹ XP_006504158

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	31,125,946 - 31,145,406 (+)	NCBI
GRCm38	5	30,968,602 - 30,988,062 (+)	NCBI

Sequence:

show sequence

GGGTGGGCAGTTTTCCCAGAGCAAGGAGTGAAGTAGGACTGAGTTGGCGCCAGCTCCTTCAGAC
ACTGACATTGCTGGCTGGATGGCCACCCTGTCAGGGCGAGCTTGAGCCCAAGGCTCCCTTGGGT
ACTGTGTCCCTGCTCTAGGGCCTACAGCCTCATACTTCATGATAGCGGCATGTCACAGGAGGCC
ACAGAGGCACCAGCAATGCCAGGAGAAGGGCATGGTCATAATAAGGCCAAGGCACGGTGGCTTC
TAGGCACTGACAGGAAGAGGAGTCGCATCAACAGGACAAGGCAGGACCTGTGGGAGGACACTAG
CTGGAGCAATCACAGACTGAGCAGAGCCACCTCTGCCCCTCGAGGGACCAGAGCTAGGGGAACA
GCTCATGGCAGGAGTGAGGCCAGCCCGGAGAACGCAGCACGGGAACGGACTCGGGTGAAGACGC
TTCGTCAGGCCTTTCTGGCCCTGCAGGCTGCTCTGCCCGCAGTGCCACCCGACACCAAGCTTTC
CAAGTTGGATGTGCTCGTGCTGGCCACAAGCTACATTGCCCACCTCACCCGGACCCTCGGCCAT
GAGTTGCCTGGCCCTGCCTGGCCTCCCTTCGTGCGTGGACTCCGTTACTTGCACCCGCTAAAGA
AGTGGCCCATGCGATCTCGTCTCTATGCAGGAGGCTTGGGATGCTCTGACCTCGATTCCACCAC
AGCTATCACGACCGGCCAAAGATGCAAGGATGCAGAGCTGGGGTCTCAAGACTCTGTAGCCGCA
GAAAGTCTCCTGACCTCTCCAGCTTTTGGCCAGCACTTTGCTGTCCAGTACTTCCTGTAGTGCG
TCCACCTCACGTTCCATGTTCAGGATTGCAGTTGCTCCTGTGAAGCTGTCTTTATCAGCCAGGA
ATGGTGTGGGGAGCCGCCCTCACATTCGCCGTT

hide sequence

RefSeq Acc Id:

XM_006504096 ⟹ XP_006504159

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	31,127,085 - 31,145,405 (+)	NCBI
GRCm38	5	30,969,741 - 30,988,061 (+)	NCBI

Sequence:

show sequence

ACCTTCTAGTCATCTGATCTCAGCCTAGGCCTCCTTCATTTGTATTATGAGGCATGGCTTAGAC
ACAGTGAGGCCCATTAGTTCCAGCAGAAGACATGGTACTAATGGGCCCGTGGAAATCAGGGTCA
ACCAGAGTGAGGCCAGCCCGGAGAACGCAGCACGGGAACGGACTCGGGTGAAGACGCTTCGTCA
GGCCTTTCTGGCCCTGCAGGCTGCTCTGCCCGCAGTGCCACCCGACACCAAGCTTTCCAAGTTG
GATGTGCTCGTGCTGGCCACAAGCTACATTGCCCACCTCACCCGGACCCTCGGCCATGAGTTGC
CTGGCCCTGCCTGGCCTCCCTTCGTGCGTGGACTCCGTTACTTGCACCCGCTAAAGAAGTGGCC
CATGCGATCTCGTCTCTATGCAGGAGGCTTGGGATGCTCTGACCTCGATTCCACCACAGCTATC
ACGACCGGCCAAAGATGCAAGGATGCAGAGCTGGGGTCTCAAGACTCTGTAGCCGCAGAAAGTC
TCCTGACCTCTCCAGCTTTTGGCCAGCACTTTGCTGTCCAGTACTTCCTGTAGTGCGTCCACCT
CACGTTCCATGTTCAGGATTGCAGTTGCTCCTGTGAAGCTGTCTTTATCAGCCAGGAATGGTGT
GGGGAGCCGCCCTCACATTCGCCGT

hide sequence

Protein Sequences


Protein RefSeqs	NP_444315	(Get FASTA)	NCBI Sequence Viewer
	XP_006504158	(Get FASTA)	NCBI Sequence Viewer
	XP_006504159	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF31168	(Get FASTA)	NCBI Sequence Viewer
	AAI19347	(Get FASTA)	NCBI Sequence Viewer
	AAI20610	(Get FASTA)	NCBI Sequence Viewer
	BAB69473	(Get FASTA)	NCBI Sequence Viewer
	BAC26873	(Get FASTA)	NCBI Sequence Viewer
	BAC26885	(Get FASTA)	NCBI Sequence Viewer
	EDL37319	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000006818
	ENSMUSP00000006818.3
GenBank Protein	Q9JLR5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_444315 ⟸ NM_053085

- UniProtKB:

Q9JLR5 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSQEATEAPAMPGEGHGHNKAKARWLLGTDRKRSRINRTRQDLWEDTSWSNHRLSRATSAPRGT
RARGTAHGRSEASPENAARERTRVKTLRQAFLALQAALPAVPPDTKLSKLDVLVLATSYIAHLT
RTLGHELPGPAWPPFVRGLRYLHPLKKWPMRSRLYAGGLGCSDLDSTTAITTGQRCKDAELGSQ
DSVAAESLLTSPAFGNK

hide sequence

RefSeq Acc Id:

XP_006504158 ⟸ XM_006504095

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSQEATEAPAMPGEGHGHNKAKARWLLGTDRKRSRINRTRQDLWEDTSWSNHRLSRATSAPRGT
RARGTAHGRSEASPENAARERTRVKTLRQAFLALQAALPAVPPDTKLSKLDVLVLATSYIAHLT
RTLGHELPGPAWPPFVRGLRYLHPLKKWPMRSRLYAGGLGCSDLDSTTAITTGQRCKDAELGSQ
DSVAAESLLTSPAFGQHFAVQYFL

hide sequence

RefSeq Acc Id:	XP_006504159 ⟸ XM_006504096
- Peptide Label:	isoform X2
- Sequence:	show sequence MRHGLDTVRPISSSRRHGTNGPVEIRVNQSEASPENAARERTRVKTLRQAFLALQAALPAVPPD TKLSKLDVLVLATSYIAHLTRTLGHELPGPAWPPFVRGLRYLHPLKKWPMRSRLYAGGLGCSDL DSTTAITTGQRCKDAELGSQDSVAAESLLTSPAFGQHFAVQYFL hide sequence

Ensembl Acc Id:

ENSMUSP00000006818 ⟸ ENSMUST00000006818

Protein Domains

bHLH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JLR5-F1-model_v2	AlphaFold	Q9JLR5	1-209	view protein structure

Promoters

RGD ID:

6886324

Promoter ID:

EPDNEW_M6613

Type:

multiple initiation site

Name:

Tcf23_1

Description:

Mus musculus transcription factor 23 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	5	30,968,662 - 30,968,722	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1934960	AgrOrtholog
Ensembl Genes	ENSMUSG00000006642	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000006818	ENTREZGENE
	ENSMUST00000006818.4	UniProtKB/Swiss-Prot
Gene3D-CATH	4.10.280.10	UniProtKB/Swiss-Prot
InterPro	bHLH_dom	UniProtKB/Swiss-Prot
	E-box_TF_Regulators	UniProtKB/Swiss-Prot
	HLH_DNA-bd_sf	UniProtKB/Swiss-Prot
KEGG Report	mmu:69852	UniProtKB/Swiss-Prot
MGD	MGI:1934960	ENTREZGENE
NCBI Gene	69852	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST	UniProtKB/Swiss-Prot
	TRANSCRIPTION FACTOR 23	UniProtKB/Swiss-Prot
Pfam	HLH	UniProtKB/Swiss-Prot
PhenoGen	Tcf23	PhenoGen
PROSITE	BHLH	UniProtKB/Swiss-Prot
SMART	HLH	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47459	UniProtKB/Swiss-Prot
UniProt	Q9JLR5	ENTREZGENE, UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype