Grm2 (glutamate receptor, metabotropic 2)

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Gene: Grm2 (glutamate receptor, metabotropic 2) Mus musculus

Analyze

Symbol:

Grm2

Name:

glutamate receptor, metabotropic 2

RGD ID:

1557983

MGI Page

MGI

Description:

Enables calcium channel regulator activity and group II metabotropic glutamate receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within gene expression; intracellular glutamate homeostasis; and long-term synaptic depression. Located in neuron projection. Is active in glutamatergic synapse. Is expressed in brain. Orthologous to human GRM2 (glutamate metabotropic receptor 2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; Gprc; Gprc1b; metabotropic glutamate receptor 2; mGlu; mGluR2; mGluR7

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	106,521,733 - 106,533,308 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	106,520,294 - 106,533,281 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	106,644,534 - 106,656,109 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	106,643,095 - 106,656,082 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	106,546,865 - 106,558,440 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	106,546,755 - 106,558,434 (-)	NCBI		MGSCv36	mm8
Celera	9	106,265,562 - 106,277,130 (-)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amphetamine abuse (ISO)

Cocaine-Related Disorders (ISO)

genetic disease (ISO)

heroin dependence (ISO)

schizophrenia (ISO)

substance-induced psychosis (ISO)

temporal lobe epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (ISO)

(S)-nicotine (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-amino-2,6-dinitrotoluene (ISO)

6-propyl-2-thiouracil (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

amiodarone (ISO)

ammonium chloride (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chaetocin (ISO)

chlordecone (EXP)

chlorpyrifos (ISO)

cocaine (ISO)

curcumin (EXP)

diazinon (ISO)

entinostat (ISO)

epoxiconazole (EXP)

ethanol (EXP)

fonofos (ISO)

haloperidol (ISO)

mescaline (EXP)

methamphetamine (EXP,ISO)

methylisothiazolinone (ISO)

N-acetyl-L-cysteine (ISO)

nicotine (ISO)

Nonylphenol (ISO)

paraquat (ISO)

parathion (ISO)

piperidines (EXP)

rotenone (ISO)

sodium arsenite (EXP)

sodium fluoride (EXP)

Soman (ISO)

terbufos (ISO)

titanium dioxide (EXP)

triclosan (ISO)

triptonide (EXP)

tunicamycin (EXP)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

behavioral response to nicotine (ISO)

G protein-coupled glutamate receptor signaling pathway (IBA)

G protein-coupled receptor signaling pathway (IEA)

gene expression (IMP)

glutamate secretion (ISO)

intracellular glutamate homeostasis (IGI)

long-term synaptic depression (IMP)

presynaptic modulation of chemical synaptic transmission (EXP,IDA)

regulation of dopamine secretion (ISO)

regulation of glutamate secretion (ISO)

regulation of protein kinase B signaling (ISO)

regulation of response to drug (ISO)

regulation of synaptic transmission, glutamatergic (IBA)

response to cocaine (ISO)

signal transduction (IEA)

Cellular Component

astrocyte projection (ISO)

axon (ISO)

cell projection (IEA)

glutamatergic synapse (EXP,IDA)

membrane (IEA)

neuron projection (IDA)

plasma membrane (IEA)

presynaptic membrane (ISO)

synapse (IEA)

Molecular Function

calcium channel regulator activity (IDA)

G protein-coupled receptor activity (IEA)

group II metabotropic glutamate receptor activity (IBA,IDA,ISO)

protein binding (ISO)

scaffold protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glutamate signaling pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal anxiety-related response (IAGP)

abnormal excitatory postsynaptic potential (IAGP)

abnormal GABAergic neuron physiology (IAGP)

abnormal motor capabilities/coordination/movement (IAGP)

cocaine preference (IAGP)

decreased susceptibility to neuronal excitotoxicity (IAGP)

impaired coordination (IAGP)

increased dopamine level (IAGP)

increased locomotor activity (IAGP)

reduced long term depression (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Deletion of the type 2 metabotropic glutamate receptor increases heroin abuse vulnerability in transgenic rats.	Gao JT, etal., Neuropsychopharmacology. 2018 Dec;43(13):2615-2626. doi: 10.1038/s41386-018-0231-5. Epub 2018 Oct 3.
2.	Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.	Kaupmann K, etal., Nature 1997 Mar 20;386(6622):239-46.
3.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4.	MGDs mouse GO annotations	MGD data from the GO Consortium
5.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.	Yang HJ, etal., Cell Rep. 2017 Jul 11;20(2):319-332. doi: 10.1016/j.celrep.2017.06.046.

Additional References at PubMed

PMID:7965099	PMID:8189254	PMID:8662555	PMID:8838577	PMID:8889548	PMID:9920659	PMID:10349636	PMID:11042159	PMID:11076861	PMID:11584003	PMID:11805343	PMID:12074840
PMID:12091320	PMID:12213275	PMID:12477932	PMID:12679517	PMID:15081787	PMID:15619115	PMID:15753323	PMID:16141072	PMID:16141073	PMID:16602821	PMID:16606834	PMID:16733060
PMID:16764720	PMID:16957075	PMID:17510730	PMID:17670976	PMID:18297054	PMID:18720515	PMID:19477188	PMID:19554387	PMID:19633665	PMID:19638469	PMID:20875805	PMID:20970439
PMID:21057775	PMID:21267068	PMID:21276828	PMID:21289196	PMID:21360593	PMID:21628565	PMID:21677750	PMID:21832989	PMID:21873635	PMID:22089319	PMID:22118459	PMID:22243746
PMID:22723691	PMID:23129762	PMID:23261870	PMID:23333599	PMID:23382250	PMID:23392308	PMID:23508685	PMID:23558090	PMID:23616537	PMID:23624743	PMID:24053122	PMID:24082084
PMID:24243579	PMID:24381270	PMID:24821401	PMID:24952961	PMID:25158312	PMID:25378213	PMID:25434487	PMID:25583490	PMID:25741727	PMID:25781000	PMID:25950516	PMID:25979088
PMID:26758213	PMID:27056679	PMID:27432639	PMID:27818290	PMID:27878759	PMID:27911756	PMID:28159646	PMID:28285415	PMID:28671696	PMID:28706196	PMID:28781167	PMID:28821279
PMID:28912684	PMID:29024663	PMID:29079293	PMID:29446202	PMID:30276662	PMID:30939596	PMID:31665922	PMID:31735403	PMID:32525061	PMID:33846537	PMID:34090896	PMID:34170322
PMID:34217776	PMID:34330748	PMID:34620856

Genomics

Comparative Map Data

Grm2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	106,521,733 - 106,533,308 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	106,520,294 - 106,533,281 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	106,644,534 - 106,656,109 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	106,643,095 - 106,656,082 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	106,546,865 - 106,558,440 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	106,546,755 - 106,558,434 (-)	NCBI		MGSCv36	mm8
Celera	9	106,265,562 - 106,277,130 (-)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI

GRM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	51,707,068 - 51,718,613 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	51,707,068 - 51,718,613 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	51,741,084 - 51,752,629 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	51,718,004 - 51,727,669 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	51,718,037 - 51,727,168	NCBI
Celera	3	51,718,848 - 51,731,506 (+)	NCBI		Celera
Cytogenetic Map	3	p21.2	NCBI
HuRef	3	51,802,839 - 51,816,142 (+)	NCBI		HuRef
CHM1_1	3	51,693,893 - 51,705,447 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	51,738,578 - 51,751,605 (+)	NCBI		T2T-CHM13v2.0

Grm2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	107,280,099 - 107,293,159 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	107,280,099 - 107,293,146 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	112,903,031 - 112,916,129 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	8	111,102,213 - 111,115,309 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	8	108,944,991 - 108,958,085 (-)	NCBI	Rnor_WKY
Rnor_6.0	8	115,344,999 - 115,358,628 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	115,344,999 - 115,358,046 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	114,705,123 - 114,718,193 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	111,837,086 - 111,850,133 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	111,857,819 - 111,869,581 (-)	NCBI
Celera	8	106,592,051 - 106,605,096 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Grm2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	3,309,028 - 3,320,966 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	3,309,034 - 3,320,954 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	52,873,144 - 52,884,401 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	52,873,144 - 52,884,395 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	51,639,792 - 51,652,779 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

GRM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	37,915,178 - 37,926,276 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	37,915,665 - 37,924,296 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	37,895,193 - 37,906,256 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	38,264,331 - 38,275,394 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	38,264,304 - 38,275,372 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	37,627,888 - 37,638,953 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	38,036,604 - 38,047,669 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	38,321,755 - 38,332,818 (-)	NCBI		UU_Cfam_GSD_1.0

Grm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	66,281,725 - 66,293,182 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	3,042,248 - 3,053,673 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936529	3,042,220 - 3,053,670 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	33,926,804 - 33,938,269 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	33,924,303 - 33,938,279 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	37,130,553 - 37,141,351 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	13,044,974 - 13,056,469 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	13,046,641 - 13,056,453 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	153,898,374 - 153,910,372 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grm2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	5,419,896 - 5,431,361 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	5,419,892 - 5,431,268 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	253
Count of miRNA genes:	184
Interacting mature miRNAs:	209
Transcripts:	ENSMUST00000023959
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
13207569	Tcq13_m	total cholesterol QTL 13 (mouse)					9	59897283	109089068	Mouse
4141833	W10q13_m	weight 10 weeks QTL 13 (mouse)			Not determined			63239711	120191934	Mouse
4141545	Tailaq2_m	tail length adjusted QTL 2 (mouse)			Not determined			63239711	120191934	Mouse
1357635	Splq4_m	spleen weight QTL 4 (mouse)			Not determined		9	63239711	120191934	Mouse
1301573	Etohcta8_m	ethanol conditioned taste aversion 8 (mouse)			Not determined		9	72859058	106859205	Mouse
10054068	El8_m	epilepsy 8 (mouse)			Not determined		9	72859058	106859205	Mouse
1301725	Lifespan1_m	life span 1 (mouse)			Not determined		9	74250230	108250378	Mouse
1302065	El1_m	epilepsy 1 (mouse)			Not determined		9	75682646	114303447	Mouse
10054492	El7_m	epilepsy 7 (mouse)			Not determined		9	75682646	114303447	Mouse
1301407	Rapop2_m	radiation-induced apoptosis 2 (mouse)			Not determined		9	76417989	110418183	Mouse
1301192	Skts6_m	skin tumor susceptibility 6 (mouse)			Not determined		9	78522698	112522808	Mouse
10401247	Bglu14_m	blood glucose level 14 (mouse)			Not determined		9	79279863	113279941	Mouse
1301732	Char1_m	P. chabaudi malaria resistance QTL 1 (mouse)			Not determined		9	81680321	115680445	Mouse
10766454	Char10_m	P. chabaudi malaria resistance QTL 10 (mouse)					9	82792386	116792481	Mouse
1300884	Sluc11_m	susceptibility to lung cancer 11 (mouse)			Not determined		9	82792386	116792481	Mouse
1357461	Idd2_m	insulin dependent diabetes susceptibility 2 (mouse)			Not determined		9	82792386	116792481	Mouse
1301487	Nociq1_m	nociceptive sensitivity inflammatory QTL 1 (mouse)			Not determined		9	84406017	118406120	Mouse
10412180	Msam3_m	muscle, skeletal, activity measure 3 (mouse)			Not determined		9	85779563	108518385	Mouse
1300549	Bbaa17_m	B. burgdorferi-associated arthritis 17 (mouse)			Not determined		9	86107600	120107729	Mouse
1302103	Dob2_m	dietary obesity 2 (mouse)			Not determined		9	86121898	120118690	Mouse
11251716	Siim2_m	stress induced immobility 2 (mouse)					9	86625682	120625682	Mouse
12880422	V25Dq6_m	vitamin D inactive form serum level QTL 6 (mouse)					9	87677199	121677199	Mouse
10412242	Alpq8_m	alcohol preference QTL 8 (mouse)			Not determined		9	89162124	123162124	Mouse
1301649	Psl1_m	promotion susceptibility QTL 1 (mouse)			Not determined		9	89289476	123289595	Mouse
18182932	Metl3_m	metabolite locus 3, N-acetylglutamate (mouse)					9	89440541	123440541	Mouse
1357657	Pymr_m	Plasmodium yoelli malaria resistance (mouse)			Not determined		9	89859058	118767089	Mouse
12910770	Splic1_m	spleen iron content 1 (mouse)					9	91291078	124359700	Mouse
12910772	Lvic6_m	liver iron content 6 (mouse)					9	91291078	124359700	Mouse
12910773	Splic3_m	spleen iron content 3 (mouse)					9	91291078	124359700	Mouse
1558767	Skmw11_m	skeletal muscle weight 11 (mouse)			Not determined		9	91518283	124359700	Mouse
13463474	Hbbcq5_m	hemoglobin concentration QTL 5 (mouse)					9	91518283	124359700	Mouse
13463475	Hctq7_m	hematocrit QTL 7 (mouse)					9	91518283	124359700	Mouse
13463477	Rbc9_m	red blood cell count 9 (mouse)					9	91518283	124359700	Mouse
13463478	Mchq18_m	mean corpuscular hemoglobin QTL 18 (mouse)					9	91518283	124359700	Mouse
13463480	Mchcq2_m	mean corpuscular hemoglobin concentration QTL 2 (mouse)					9	91518283	124359700	Mouse
12904937	Edlmmq9_m	extensor digitorum longus muscle mass QTL 9 (mouse)					9	91560372	124359700	Mouse
12904947	Tammq7_m	tibialis anterior muscle mass QTL 7 (mouse)					9	91560372	124359700	Mouse
12904961	Gmmq7_m	gastrocnemius muscle mass QTL 7 (mouse)					9	91560372	124359700	Mouse
1301484	Bwq6_m	body weight (mouse)			Not determined		9	93591658	124359700	Mouse
1302001	Bdln5_m	body length 5 (mouse)			Not determined		9	93591658	124359700	Mouse
14746992	Manh67_m	mandible shape 67 (mouse)					9	93865836	124359700	Mouse
11081166	Psl5_m	promotion susceptibility QTL 5 (mouse)					9	94863354	112701997	Mouse
11537364	Cnes5_m	C. neoformans susceptibility locus 5 (mouse)					9	96746658	124359700	Mouse
1301297	Lcho1_m	liver cholesterol 1 (mouse)			Not determined		9	100889929	124359700	Mouse
1357648	Obq18_m	obesity QTL 18 (mouse)			Not determined		9	101829255	124359700	Mouse
1357627	Tgq2_m	triglyceride QTL 2 (mouse)			Not determined		9	101829255	124359700	Mouse
10412290	Pvacm1l_m	plasma vascular cell adhesion molecule 1 levels (mouse)			Not determined		9	103118511	124359700	Mouse
12879896	Berr3_m	berghei resistance locus 3 (mouse)					9	103118511	124359700	Mouse
1301789	Pbwg4_m	postnatal body weight growth 4 (mouse)			Not determined		9	103118511	124359700	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001160353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC152452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK015353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK034263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK046803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY255603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC115866	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ174642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY290719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK619406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000023959 ⟹ ENSMUSP00000023959

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	9	106,520,316 - 106,533,279 (-)	Ensembl
GRCm38.p6 Ensembl	9	106,643,117 - 106,656,080 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000200826 ⟹ ENSMUSP00000144076

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	9	106,520,294 - 106,525,302 (-)	Ensembl
GRCm38.p6 Ensembl	9	106,643,095 - 106,648,103 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000201681 ⟹ ENSMUSP00000144631

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	9	106,522,084 - 106,533,281 (-)	Ensembl
GRCm38.p6 Ensembl	9	106,644,885 - 106,656,082 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000201955

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	9	106,522,183 - 106,523,812 (-)	Ensembl
GRCm38.p6 Ensembl	9	106,644,984 - 106,646,613 (-)	Ensembl

RefSeq Acc Id:

NM_001160353 ⟹ NP_001153825

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	9	106,521,733 - 106,533,308 (-)	NCBI
GRCm38	9	106,644,534 - 106,656,109 (-)	ENTREZGENE
MGSCv37	9	106,546,865 - 106,558,440 (-)	RGD
Celera	9	106,265,562 - 106,277,130 (-)	RGD
cM Map	9		ENTREZGENE

Sequence:

show sequence

AGGGCGGGCCGGCGGAGAGCGCAGAGCCAGCGAGAGAGCCAGCAAGCGGGAACCGGAGCCCCGC
GCCAGAGCTGGGAGCGCCAGGAGCTGGCCCCCTTCTCATCTCTCTTCCTGTCTGTCCTTTCCCG
GCCCCTGTTTGCTCCTTTCTTTGCCTTTGCCGCTTCTGTCCTCACCCCTCGAAGACCCCAGTCT
GCTGGACCTAGCCGTCCCTTGGGGGGCCATGGAATCCCTGCTTAGGTTCCTGGCACTGCTGCTG
CTGCGGGGTGCTGTGGCCGAGGGCCCGGCCAAGAAGGTGCTGACCCTGGAGGGGGACCTGGTGC
TGGGTGGGCTGTTCCCAGTGCACCAGAAGGGTGGCCCAGCAGAGGAGTGTGGACCTGTTAATGA
GCACCGTGGCATACAGCGCCTAGAGGCCATGCTTTTTGCACTGGACCGCATCAACCGCGACCCC
CATCTGCTGCCTGGGGTGCGTTTGGGCGCGCACATCCTCGACAGCTGCTCCAAGGATACACACG
CCCTGGAGCAGGCCCTGGACTTTGTGCGTGCCTCACTCAGCCGTGGGGCTGATGGCTCACGCCA
CATCTGTCCTGACGGCTCCTATGCTACTCTCAGTGATGCTCCCACAGCTATCACCGGTGTCATT
GGCGGCTCCTACAGTGATGTCTCCATCCAGGTGGCCAATCTCCTGCGGCTGTTCCAGATCCCAC
AGATCAGCTATGCCTCCACCAGCGCCAAGCTGAGCGACAAGTCCCGTTATGATTACTTTGCTCG
CACCGTGCCCCCAGACTTCTTCCAAGCCAAGGCCATGGCTGAGATTCTCCGCTTTTTCAACTGG
ACGTATGTGTCTACGGTGGCATCTGAGGGTGACTATGGAGAGACAGGCATTGAGGCCTTCGAGC
TCGAGGCTCGGGCACGCAACATCTGCGTGGCCACTTCGGAGAAGGTGGGCCGTGCCATGAGCCG
CGCAGCCTTCGAGGGTGTGGTGCGAGCCCTGTTGCAGAAGCCCAGCGCCCGTGTGGCTGTGCTC
TTCACCCGGTCAGAGGATGCCCGTGAGCTGCTTGCAGCCACCCAGCGTCTCAACGCCAGCTTCA
CCTGGGTAGCCAGCGACGGCTGGGGGGCCCTAGAGAGCGTGGTGGCAGGCAGTGAAAGGGCTGC
CGAGGGCGCCATCACCATTGAGCTGGCCTCCTACCCCATCAGTGACTTTGCCTCCTACTTCCAG
AACTTGGATCCCTGGAACAACAGCAGGAACCCTTGGTTCCGTGAGTTCTGGGAGGAGAGGTTCC
GTTGCAGCTTCCGGCAGCGAGACTGCGCCGCCCACTCTCTGCGGGCCGTACCCTTTGAACAGGA
GTCAAAGATCATGTTTGTGGTCAATGCCGTGTATGCCATGGCCCACGCTCTGCACAACATGCAC
CGTGCCCTCTGTCCCAACACCACCCGCCTCTGCGATGCCATGAGACCTGTCAATGGGCGCCGCC
TCTACAAGGACTTCGTGCTCAATGTCAAGTTTGATGCCCCCTTCCGCCCAGCAGATACCGACGA
CGAGGTCCGCTTTGACCGCTTTGGAGATGGTATTGGCCGCTACAACATCTTCACCTATCTGCGG
GCAGGCAATGGGCGCTATCGCTACCAGAAGGTAGGCTACTGGGCAGAAGGTCTGACTCTGGATA
CTAGCATCATCCCATGGGCCTCCCCATCAGCTGGCACCCTCCCTGCCTCTCGCTGTAGCGAGCC
CTGCCTTCAGAATGAGGTGAAGAGCGTGCAGCCCGGCGAGGTCTGCTGCTGGCTCTGCATCCCC
TGTCAGCCCTATGAGTACAGGCTGGATGAGTTCACCTGTGCTGACTGTGGCCTGGGCTACTGGC
CTAATGCCAGTCTGACTGGATGCTTTGAGCTGCCCCAGGAGTACATCCGCTGGGGCGACGCCTG
GGCGGTGGGACCTGTCACCATCGCCTGCCTAGGTGCCCTGGCCACCCTCTTTGTGTTGGGTGTC
TTCGTGCGGCATAACGCCACACCCGTGGTCAAGGCCTCGGGGCGGGAGCTTTGCTACATTCTGC
TGGGAGGCGTCTTCCTCTGCTACTGCATGACCTTCATCTTCATCGCCAAGCCCTCCACGGCCGT
CTGCACCTTAAGGCGCCTCGGGTTGGGGACCGCCTTCTCTGTCTGCTACTCAGCCCTCCTCACC
AAGACCAATCGCATCGCTCGCATCTTTGGCGGGGCCCGGGAGGGTGCCCAGCGGCCGCGCTTCA
TCAGTCCCGCCTCACAGGTGGCCATCTGCCTGGCACTTATCTCGGGCCAGCTGCTCATTGTTGC
TGCCTGGCTGGTGGTGGAGGCACCTGGCATAGGCAAGGAGACAGCCCCTGAGCGGCGGGAAGTG
GTGACCTTGCGCTGTAACCACCGTGACGCAAGCATGCTTGGCTCGCTGGCCTACAACGTGCTCC
TCATCGCTCTCTGCACGCTCTATGCCTTCAAGACCCGCAAGTGCCCGGAGAACTTCAACGAGGC
CAAGTTCATCGGCTTTACCATGTACACCACCTGTATCATCTGGCTGGCTTTCCTTCCCATCTTC
TACGTCACCTCCAGTGATTATCGGGTGCAGACCACTACGATGTGCGTGTCCGTCAGCCTCAGTG
GCTCTGTGGTGCTCGGCTGCCTCTTTGCACCCAAGCTGCACATTATCCTCTTCCAGCCACAGAA
GAACGTGGTGAGCCACCGGGCACCTACCAGCCGCTTTGGCAGTGCTGCCCCCAGGGCCAGCGCC
AACCTTGGTCAAGGGTCTGGATCCCAGCTTGTTCCTACTGTTTGCAATGGCCGTGAGGTGGTAG
ACTCAACAACATCGTCGCTTTGAAGATCCCACACTCCTGCCCTGACATGGCTGCTCCCGAACCC
AGCGTAGACCCTCTTCCATGGCCAGGAGGAAGTTGGCTGGAGCCTTGCAATAACACCTACCCCA
TGCCTGCCCCCAAAGTCACCTACCCACCTCCTGGATTCCCCAGCCCTTTAGGCCAGAAGTCAGA
GTCCTTAGCTGGGAGTCTCTGCATTGGCCAGTAACTATCCTTGTAGCTATGCCCCGTGTTTGCC
AGGCCTGGGAATCAGAGGGGAGAAATTCAGTGTCTACCGTGTTTTAGAACAGCGTGGCTGAGGA
CGACAGGCCCAACCCCCATGCAAAGGTGCTTCCAGTCCAGCCCCTGCCCCAGGCCTTTTTAATT
TTTTATAAGTTACTCTGGGTTAGAGAGGAAGGTTATTGTGGGGACCAGTCCCTCCCTCCTTACC
CAGTAGTTTGTCCCGTGGTTTATTTTGTATTACCTGTAAATAAAGTGTCTTTATTTAAAAAAAA
AAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001153825	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI15867	(Get FASTA)	NCBI Sequence Viewer
	AAO85115	(Get FASTA)	NCBI Sequence Viewer
	EDL21160	(Get FASTA)	NCBI Sequence Viewer
	Q14BI2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001153825 ⟸ NM_001160353
- Peptide Label:	precursor
- UniProtKB:	Q14BI2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MESLLRFLALLLLRGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEA MLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYAT LSDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQA KAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRA LLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELA SYPISDFASYFQNLDPWNNSRNPWFREFWEERFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNA VYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGD GIGRYNIFTYLRAGNGRYRYQKVGYWAEGLTLDTSIIPWASPSAGTLPASRCSEPCLQNEVKSV QPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIAC LGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLG TAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPG IGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYT TCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPT SRFGSAAPRASANLGQGSGSQLVPTVCNGREVVDSTTSSL hide sequence

RefSeq Acc Id:

ENSMUSP00000144631 ⟸ ENSMUST00000201681

RefSeq Acc Id:

ENSMUSP00000023959 ⟸ ENSMUST00000023959

RefSeq Acc Id:

ENSMUSP00000144076 ⟸ ENSMUST00000200826

Protein Domains

G-protein coupled receptors family 3 profile Receptor ligand binding region

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q14BI2-F1-model_v2	AlphaFold	Q14BI2	1-872	view protein structure

Promoters

RGD ID:

6844638

Promoter ID:

MM_KWN:58685

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Brain

Transcripts:

UC009RKI.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	106,549,376 - 106,549,876 (-)	MPROMDB

RGD ID:

8670754

Promoter ID:

EPDNEW_M13408

Type:

single initiation site

Name:

Grm2_1

Description:

Mus musculus glutamate receptor, metabotropic 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	9	106,656,089 - 106,656,149	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1351339	AgrOrtholog
Ensembl Genes	ENSMUSG00000023192	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSMUSG00000063284
Ensembl Protein	ENSMUSP00000023959	ENTREZGENE
	ENSMUSP00000023959.8	UniProtKB/Swiss-Prot
	ENSMUSP00000144076.2	UniProtKB/TrEMBL
	ENSMUSP00000144631.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000023959	ENTREZGENE
	ENSMUST00000023959.13	UniProtKB/Swiss-Prot
	ENSMUST00000200826.4	UniProtKB/TrEMBL
	ENSMUST00000201681.2	UniProtKB/TrEMBL
Gene3D-CATH	2.10.50.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.2300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ANF_lig-bd_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_3_9-Cys_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_3_9-Cys_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_3_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_3_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_3_mtglu_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_3_mtglu_rcpt_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peripla_BP_I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:108068	UniProtKB/Swiss-Prot
MGD	MGI:1351339	ENTREZGENE
NCBI Gene	108068	ENTREZGENE
PANTHER	METABOTROPIC GLUTAMATE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	METABOTROPIC GLUTAMATE RECEPTOR 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANF_receptor	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NCD3G	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Grm2	PhenoGen
PRINTS	GPCRMGR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MTABOTROPC2R	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MTABOTROPICR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F3_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F3_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F3_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53822	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0J9YU95_MOUSE	UniProtKB/TrEMBL
	A0A0J9YVF0_MOUSE	UniProtKB/TrEMBL
	GRM2_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q80T43_MOUSE	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype