Foxp3 (forkhead box P3) - Rat Genome Database

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Gene: Foxp3 (forkhead box P3) Mus musculus
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Symbol: Foxp3
Name: forkhead box P3
RGD ID: 1557838
MGI Page MGI
Description: Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of cytokine production and regulation of T cell anergy. Acts upstream of or within several processes, including positive regulation of T cell tolerance induction; regulation of T cell activation; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; and retina. Used to study Wiskott-Aldrich syndrome and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: forkhead box protein P3; JM2; scu; scurfin; scurfy; sf
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,445,915 - 7,461,482 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,439,883 - 7,461,484 (+)EnsemblGRCm39 Ensembl
GRCm38X7,579,676 - 7,595,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,573,644 - 7,595,245 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,156,819 - 7,172,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,736,652 - 6,752,193 (+)NCBIMGSCv36mm8
CeleraX3,876,537 - 3,892,077 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute-On-Chronic Liver Failure  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Airway Remodeling  (IDA)
allergic disease  (ISO)
anemia  (ISO)
Animal Toxoplasmosis  (IEP)
anogenital venereal wart  (ISO)
asthma  (IDA,ISO)
autistic disorder  (ISO)
bacterial pneumonia  (IEP)
bone marrow disease  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
cervical squamous cell carcinoma  (ISO)
chlamydia  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
colorectal cancer  (ISO)
congenital disorder of glycosylation type IIm  (ISO)
cutaneous leishmaniasis  (ISO)
dermatitis  (IMP)
diabetes mellitus  (ISO)
Dysbiosis  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Epstein-Barr virus infectious disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Colitis  (IEP,ISO)
Experimental Diabetes Mellitus  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hydranencephaly with Renal Aplasia-Dysplasia  (ISO)
Hydrops Fetalis  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  (IAGP,ISO)
infectious mononucleosis  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Korean hemorrhagic fever  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (ISO)
multidrug-resistant tuberculosis  (ISO)
Neuralgia  (IDA,ISO)
neurodegeneration with brain iron accumulation 5  (ISO)
Neurodevelopmental Disorders  (ISO)
occupational dermatitis  (ISO)
pancytopenia  (ISO)
papillomavirus infectious disease  (ISO)
pleural tuberculosis  (ISO)
polycystic ovary syndrome  (ISO)
primary biliary cholangitis  (ISO)
pulmonary tuberculosis  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
spermatogenic failure 3  (ISO)
Spinal Cord Injuries  (ISO)
Squamous Intraepithelial Lesions of the Cervix  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
syphilis  (ISO)
Thrombocytopenia 1  (ISO)
Transplant Rejection  (IEP,ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
vaccinia  (IMP)
Wiskott-Aldrich syndrome  (IAGP,ISO)
Wound Infection  (ISO)
X-linked epilepsy with variable learning disabilities and behavior disorders  (ISO)
X-linked severe congenital neutropenia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-Tetrandrine  (EXP)
(S)-nicotine  (EXP)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP)
aflatoxin B1  (ISO)
alloxan  (EXP)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (ISO)
amiodarone  (ISO)
amphetamine  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
benzalkonium chloride  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
calcitriol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP)
chrysin  (EXP)
cisplatin  (EXP)
cyclophosphamide  (EXP)
deoxynivalenol  (ISO)
dextran sulfate  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dorsomorphin  (ISO)
fingolimod hydrochloride  (ISO)
fragrance  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gentamycin  (ISO)
hydralazine  (EXP)
hydroxysafflor yellow A  (EXP)
iron dichloride  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (EXP)
levamisole  (EXP)
lipopolysaccharide  (EXP)
methimazole  (ISO)
mevalonic acid  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nicotine  (EXP)
nitrogen dioxide  (ISO)
obeticholic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenanthrene  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
platycodin D  (EXP)
procainamide  (EXP)
progesterone  (EXP,ISO)
quinacrine  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
thioacetamide  (ISO)
toluene  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
Triptolide  (EXP)
triptonide  (EXP)
troglitazone  (EXP)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell proliferation  (IMP)
B cell homeostasis  (IMP)
CD4-positive, alpha-beta T cell differentiation  (IDA)
CD4-positive, alpha-beta T cell proliferation  (IDA)
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  (IMP,ISO)
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment  (TAS)
chromatin remodeling  (IDA)
DNA-templated transcription  (IDA)
establishment of endothelial blood-brain barrier  (ISO)
gene expression  (IMP)
immature T cell proliferation in thymus  (IMP)
inflammatory response  (IMP)
isotype switching to IgE isotypes  (IMP)
lymphocyte proliferation  (IMP)
myeloid cell homeostasis  (IMP)
negative regulation of alpha-beta T cell proliferation  (IMP)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (IDA)
negative regulation of cell population proliferation  (ISO)
negative regulation of chronic inflammatory response  (IDA,IMP)
negative regulation of CREB transcription factor activity  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of defense response to virus  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of gene expression  (IDA)
negative regulation of immune response  (ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of interleukin-10 production  (IMP,ISO)
negative regulation of interleukin-17 production  (IMP,ISO)
negative regulation of interleukin-2 production  (IDA,IMP,ISO)
negative regulation of interleukin-4 production  (IDA,IMP,ISO)
negative regulation of interleukin-5 production  (IDA,IMP)
negative regulation of interleukin-6 production  (IMP)
negative regulation of isotype switching to IgE isotypes  (IMP)
negative regulation of lymphocyte proliferation  (IMP)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of T cell cytokine production  (ISO)
negative regulation of T cell proliferation  (IDA,IMP,ISO)
negative regulation of T-helper 17 cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IMP)
negative regulation of tumor necrosis factor production  (IMP)
negative regulation of type II interferon production  (IDA,IMP,ISO)
positive regulation of CD4-positive, alpha-beta T cell differentiation  (IDA)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  (IMP,TAS)
positive regulation of DNA-templated transcription  (IDA,IMP,ISO)
positive regulation of gene expression  (IDA)
positive regulation of immature T cell proliferation in thymus  (IMP)
positive regulation of interleukin-4 production  (IMP)
positive regulation of peripheral T cell tolerance induction  (IMP)
positive regulation of regulatory T cell differentiation  (IDA,IMP,ISO)
positive regulation of T cell anergy  (IMP)
positive regulation of T cell tolerance induction  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transforming growth factor beta1 production  (IDA)
regulation of DNA-templated transcription  (IEA)
regulation of immunoglobulin production  (IMP)
regulation of isotype switching to IgG isotypes  (IMP)
regulation of T cell anergy  (IMP)
regulation of transcription by RNA polymerase II  (IBA,IGI)
regulatory T cell differentiation  (IDA,ISO)
response to lipopolysaccharide  (ISO)
response to rapamycin  (ISO)
response to virus  (ISO)
T cell activation  (IMP,ISO)
T cell anergy  (IMP)
T cell mediated immunity  (IMP)
T cell proliferation  (IDA,IMP)
T cell receptor signaling pathway  (IMP)
T cell tolerance induction  (IMP)
tolerance induction  (IDA)
tolerance induction to self antigen  (IMP)
transcription by RNA polymerase II  (IDA,IMP)
transforming growth factor beta1 production  (IDA)

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adaptive immunity  (IAGP)
abnormal alpha-beta T cell number  (IAGP)
abnormal atrial thrombosis  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal CD4-positive helper T cell morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal double-positive T cell morphology  (IAGP)
abnormal effector T cell morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal gut-associated lymphoid tissue morphology  (IAGP)
abnormal hepatic cord morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interferon-gamma secretion  (IAGP)
abnormal interleukin level  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal interleukin-4 secretion  (IAGP)
abnormal intraepithelial T cell morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lymph node B cell domain morphology  (IAGP)
abnormal lymph node medullary cord morphology  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lymph node T cell domain morphology  (IAGP)
abnormal lymph organ size  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal lymphocyte physiology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal megakaryocyte progenitor cell morphology  (IAGP)
abnormal mesenteric lymph node morphology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal regulatory T cell morphology  (IAGP)
abnormal regulatory T cell number  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal reproductive system development  (IEA)
abnormal respiratory mucosa goblet cell morphology  (IAGP)
abnormal reticulocyte morphology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal T-helper 2 cell differentiation  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tail ring morphology  (IAGP)
abnormal thymus cortex morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal type IV hypersensitivity reaction  (IAGP)
absent prostate gland anterior lobe  (IEA)
absent regulatory T cells  (IAGP)
absent scrotum  (IAGP)
absent seminal vesicle  (IEA)
absent spleen marginal zone  (IAGP)
alopecia  (IEA)
anemia  (IAGP)
anisocytosis  (IAGP)
autoimmune response  (IAGP)
azoospermia  (IEA)
blepharitis  (IAGP)
blood vessel inflammation  (IAGP)
bradykinesia  (IAGP)
cachexia  (IAGP)
chronic inflammation  (IAGP)
colitis  (IAGP)
conjunctivitis  (IAGP)
cryptorchism  (IAGP)
crypts of Lieberkuhn abscesses  (IAGP)
decreased blood oxygen saturation level  (IAGP)
decreased body size  (IAGP)
decreased body surface temperature  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating lipase level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-17 secretion  (IAGP)
decreased locomotor activity  (IAGP)
decreased megakaryocyte cell number  (IAGP)
decreased mitochondrial size  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased small intestinal microvillus size  (IAGP)
decreased spleen B cell follicle number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
decreased tumor growth/size  (IAGP)
delayed eyelid opening  (IAGP)
dermatitis  (IAGP)
diarrhea  (IAGP)
dilated liver sinusoidal space  (IAGP)
distended abdomen  (IAGP)
dry skin  (IEA)
ear inflammation  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
focal hair loss  (IAGP)
gastrointestinal hemorrhage  (IAGP)
glomerulonephritis  (IAGP)
granulomatous inflammation  (IAGP)
hemosiderosis  (IAGP)
hunched posture  (IAGP)
increased activated T cell number  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-17 level  (IAGP)
increased circulating interleukin-4 level  (IAGP)
increased circulating interleukin-5 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased dendritic cell number  (IAGP)
increased effector memory T-helper cell number  (IAGP)
increased eosinophil cell number  (IAGP)
increased germinal center B cell number  (IAGP)
increased IgA level  (IAGP)
increased IgD level  (IAGP)
increased IgE level  (IAGP)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased immunoglobulin level  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased interleukin-5 secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver tumor incidence  (IAGP)
increased lymphocyte cell number  (IAGP)
increased mean corpuscular volume  (IAGP)
increased mean platelet volume  (IAGP)
increased memory T cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased plasma cell number  (IAGP)
increased regulatory T cell apoptosis  (IAGP)
increased regulatory T cell number  (IAGP)
increased spleen B cell follicle number  (IAGP)
increased spleen germinal center number  (IAGP)
increased spleen germinal center size  (IAGP)
increased spleen red pulp amount  (IAGP)
increased spleen weight  (IAGP)
increased spleen white pulp amount  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased susceptibility to diet-induced hepatic steatosis  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to Orthomyxoviridae infection  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased susceptibility to type IV hypersensitivity reaction  (IAGP)
increased T cell apoptosis  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
increased T follicular helper cell number  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
intermingled spleen red and white pulp  (IAGP)
jaundice  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
lethargy  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
lymph node hyperplasia  (IAGP)
lymph node inflammation  (IAGP)
male infertility  (IAGP)
melena  (IAGP)
multifocal hepatic necrosis  (IAGP)
myocarditis  (IAGP)
narrow eye opening  (IAGP)
no abnormal phenotype detected  (IAGP)
orthokeratosis  (IAGP)
pale kidney  (IAGP)
pale liver  (IAGP)
pancreas atrophy  (IAGP)
pancreas inflammation  (IAGP)
parakeratosis  (IAGP)
paralysis  (IAGP)
pleural effusion  (IAGP)
poikilocytosis  (IAGP)
polychromatophilia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
respiratory system inflammation  (IAGP)
ruffled hair  (IAGP)
salivary gland inflammation  (IAGP)
scaly ears  (IAGP)
scaly skin  (IAGP)
short perineum  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
small ears  (IAGP)
small gonad  (IAGP)
small intestinal inflammation  (IAGP)
small testis  (IAGP)
small thymus  (IAGP)
spleen hyperplasia  (IAGP)
stomach inflammation  (IAGP)
thick ears  (IAGP)
thrombocytopenia  (IAGP)
thymus hypoplasia  (IAGP)
tight skin  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
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