Myo7b (myosin VIIB) - Rat Genome Database

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Gene: Myo7b (myosin VIIB) Mus musculus
Analyze
Symbol: Myo7b
Name: myosin VIIB
RGD ID: 1557767
MGI Page MGI
Description: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including actin filament organization; brush border assembly; and sensory perception of sound. Predicted to act upstream of or within cell differentiation. Located in apical cytoplasm; brush border; and microvillus. Is expressed in genitourinary system and gut. Orthologous to human MYO7B (myosin VIIB).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: myosin-VIIb; unconventional myosin-VIIb
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,092,287 - 32,169,984 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,092,287 - 32,170,014 (-)EnsemblGRCm39 Ensembl
GRCm381831,959,234 - 32,036,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1831,959,234 - 32,036,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv371832,118,888 - 32,196,585 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,102,244 - 32,188,671 (-)NCBIMGSCv36mm8
Celera1832,449,602 - 32,527,043 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8884266   PMID:11212352   PMID:11401444   PMID:12477932   PMID:14581517   PMID:14610273   PMID:16186105   PMID:21267068   PMID:21873635   PMID:22114352   PMID:24194600   PMID:24725409  
PMID:27626380   PMID:28700664   PMID:32209652   PMID:34124068   PMID:38355793  


Genomics

Comparative Map Data
Myo7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,092,287 - 32,169,984 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,092,287 - 32,170,014 (-)EnsemblGRCm39 Ensembl
GRCm381831,959,234 - 32,036,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1831,959,234 - 32,036,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv371832,118,888 - 32,196,585 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,102,244 - 32,188,671 (-)NCBIMGSCv36mm8
Celera1832,449,602 - 32,527,043 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.89NCBI
MYO7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382127,535,683 - 127,637,726 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2127,535,683 - 127,637,729 (+)EnsemblGRCh38hg38GRCh38
GRCh372128,293,259 - 128,395,301 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362128,009,848 - 128,111,773 (+)NCBINCBI36Build 36hg18NCBI36
Celera2121,604,332 - 121,706,245 (+)NCBICelera
Cytogenetic Map2q14.3NCBI
HuRef2120,600,353 - 120,701,678 (+)NCBIHuRef
CHM1_12128,297,893 - 128,399,731 (+)NCBICHM1_1
T2T-CHM13v2.02127,970,920 - 128,072,980 (+)NCBIT2T-CHM13v2.0
Myo7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81823,862,533 - 23,944,081 (-)NCBIGRCr8
mRatBN7.21823,588,307 - 23,669,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,588,307 - 23,669,809 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,716,400 - 23,797,906 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,465,407 - 24,547,198 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01823,811,370 - 23,892,888 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,742,329 - 24,823,889 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,742,329 - 24,823,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,456,652 - 24,538,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,382,252 - 24,463,999 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1823,340,877 - 23,422,331 (-)NCBICelera
Cytogenetic Map18p12NCBI
Myo7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554592,914,628 - 2,976,436 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554592,914,409 - 2,990,591 (-)NCBIChiLan1.0ChiLan1.0
MYO7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21348,005,959 - 48,111,287 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B48,020,937 - 48,126,265 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B32,637,807 - 32,742,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B128,200,766 - 128,304,116 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B128,226,236 - 128,303,816 (+)Ensemblpanpan1.1panPan2
MYO7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11922,979,078 - 23,064,815 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1922,979,074 - 23,050,834 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,226,255 - 23,312,176 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01924,305,058 - 24,391,001 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1924,305,359 - 24,377,145 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11923,008,932 - 23,094,792 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01923,203,451 - 23,289,323 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01924,335,348 - 24,421,303 (-)NCBIUU_Cfam_GSD_1.0
Myo7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,873,403 - 97,951,859 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646943,666,057 - 43,728,167 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646943,665,836 - 43,732,680 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1559,709,943 - 59,803,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11559,709,938 - 59,803,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21566,420,238 - 66,434,903 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYO7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,578,211 - 2,657,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606120,079,138 - 20,181,020 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473214,033,495 - 14,101,713 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473214,001,973 - 14,101,924 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myo7b
2243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:169
Interacting mature miRNAs:179
Transcripts:ENSMUST00000134663
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
1301950Otx2m1_morthodenticle homolog 2 (Drosophila) modifier 1 (mouse)Not determined182156868236187740Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000134663   ⟹   ENSMUSP00000118046
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,092,287 - 32,170,014 (-)Ensembl
GRCm38.p6 Ensembl1831,959,234 - 32,036,961 (-)Ensembl
Ensembl Acc Id: ENSMUST00000238990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,114,138 - 32,116,421 (-)Ensembl
GRCm38.p6 Ensembl1831,981,085 - 31,983,368 (-)Ensembl
RefSeq Acc Id: NM_032394   ⟹   NP_115770
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,092,287 - 32,169,984 (-)NCBI
GRCm381831,959,234 - 32,036,931 (-)ENTREZGENE
MGSCv371832,118,888 - 32,196,585 (-)RGD
Celera1832,449,602 - 32,527,043 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_115770   ⟸   NM_032394
- UniProtKB: Q571N7 (UniProtKB/Swiss-Prot),   B9EHR5 (UniProtKB/Swiss-Prot),   Q8R0U3 (UniProtKB/Swiss-Prot),   Q99MZ6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000118046   ⟸   ENSMUST00000134663
Protein Domains
FERM   IQ   Myosin motor   MyTH4   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MZ6-F1-model_v2 AlphaFold Q99MZ6 1-2113 view protein structure

Promoters
RGD ID:13677310
Promoter ID:EPDNEW_M22804
Type:initiation region
Name:Myo7b_1
Description:Mus musculus myosin VIIB , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381832,036,979 - 32,037,039EPDNEW
RGD ID:6829390
Promoter ID:MM_KWN:24845
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000025251,   OTTMUST00000085749
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361832,196,366 - 32,196,866 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107709 AgrOrtholog
Ensembl Genes ENSMUSG00000024388 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000134663 ENTREZGENE
  ENSMUST00000134663.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot
  1.20.5.190 UniProtKB/Swiss-Prot
  1.20.58.530 UniProtKB/Swiss-Prot
  1.20.80.10 UniProtKB/Swiss-Prot
  1.25.40.530 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
  6.20.240.20 UniProtKB/Swiss-Prot
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro Band_41_domain UniProtKB/Swiss-Prot
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_central UniProtKB/Swiss-Prot
  FERM_domain UniProtKB/Swiss-Prot
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  Myosin_head_motor_dom UniProtKB/Swiss-Prot
  MyoVII_FERM_C1 UniProtKB/Swiss-Prot
  MyoVII_FERM_C2 UniProtKB/Swiss-Prot
  MYSc_Myo7 UniProtKB/Swiss-Prot
  MyTH4_dom UniProtKB/Swiss-Prot
  MyTH4_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  Unconventional_Myosin_ATPase UniProtKB/Swiss-Prot
KEGG Report mmu:17922 UniProtKB/Swiss-Prot
MGD MGI:107709 ENTREZGENE
NCBI Gene 17922 ENTREZGENE
PANTHER MYOSIN VII, XV UniProtKB/Swiss-Prot
  MYOSIN VIIB UniProtKB/Swiss-Prot
Pfam FERM_M UniProtKB/Swiss-Prot
  Myosin_head UniProtKB/Swiss-Prot
  MyTH4 UniProtKB/Swiss-Prot
  PF00612 UniProtKB/Swiss-Prot
PhenoGen Myo7b PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot
PROSITE FERM_3 UniProtKB/Swiss-Prot
  MYOSIN_MOTOR UniProtKB/Swiss-Prot
  MYTH4 UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
SMART B41 UniProtKB/Swiss-Prot
  MYSc UniProtKB/Swiss-Prot
  MyTH4 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  SM00015 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47031 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt B9EHR5 ENTREZGENE
  MYO7B_MOUSE UniProtKB/Swiss-Prot
  Q571N7 ENTREZGENE
  Q8R0U3 ENTREZGENE
  Q99MZ6 ENTREZGENE
UniProt Secondary B9EHR5 UniProtKB/Swiss-Prot
  Q571N7 UniProtKB/Swiss-Prot
  Q8R0U3 UniProtKB/Swiss-Prot