Wnk4 (WNK lysine deficient protein kinase 4) - Rat Genome Database

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Gene: Wnk4 (WNK lysine deficient protein kinase 4) Mus musculus
Analyze
Symbol: Wnk4
Name: WNK lysine deficient protein kinase 4
RGD ID: 1557765
MGI Page MGI
Description: Enables chloride ion binding activity and ion channel inhibitor activity. Involved in several processes, including intracellular signal transduction; metal ion transport; and regulation of protein kinase activity. Acts upstream of or within chloride transport; negative regulation of pancreatic juice secretion; and protein localization. Located in bicellular tight junction and cytoplasm. Part of protein-containing complex. Is active in cell body. Is expressed in several structures, including alimentary system; metanephros; metatarsal bone; sensory organ; and turbinate bone primordium. Used to study Gitelman syndrome and pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010002J11Rik; Pha2b; Prkw; Prkwnk4; protein kinase lysine-deficient 4; protein kinase with no lysine 4; protein kinase, lysine deficient 4; serine/threonine-protein kinase WNK4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,151,363 - 101,168,235 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,151,393 - 101,168,235 (+)EnsemblGRCm39 Ensembl
GRCm3811101,260,537 - 101,277,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,260,567 - 101,277,409 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,121,881 - 101,138,723 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,076,701 - 101,093,499 (+)NCBIMGSCv36mm8
MGSCv3611102,039,322 - 102,056,494 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Bhuiyan MIH, etal., J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10. Monti J, etal., Hypertension 2003 Apr;41(4):938-42.
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. WNK Kinases, Renal Ion Transport and Hypertension. San-Cristobal P, etal., Am J Nephrol. 2008 Jun 12;28(5):860-870.
11. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. Yang CL, etal., J Clin Invest 2003 Apr;111(7):1039-45.
12. Conserved synteny in rat and mouse for a blood pressure QTL on human chromosome 17. Zimdahl H, etal., Hypertension 2002 Jun;39(6):1050-2.
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11498583   PMID:12477932   PMID:12515852   PMID:14608358   PMID:14769928   PMID:15172686   PMID:15350218   PMID:15465913  
PMID:15489334   PMID:15907795   PMID:15930150   PMID:16141072   PMID:16141073   PMID:16788137   PMID:16899520   PMID:16964266   PMID:17360470   PMID:17360471   PMID:17488636   PMID:17851470  
PMID:17975670   PMID:18701621   PMID:18800028   PMID:19008908   PMID:19240212   PMID:19401467   PMID:19587141   PMID:19633012   PMID:19690383   PMID:20181799   PMID:21267068   PMID:21317537  
PMID:21486947   PMID:21499270   PMID:21660484   PMID:21670282   PMID:21733846   PMID:21873635   PMID:22114204   PMID:22294159   PMID:22342722   PMID:22550170   PMID:22846565   PMID:23576762  
PMID:23684652   PMID:24026181   PMID:24039833   PMID:24089410   PMID:24206662   PMID:24434184   PMID:24655003   PMID:24761002   PMID:24811174   PMID:24821705   PMID:25113964   PMID:25250572  
PMID:25313067   PMID:26073538   PMID:26349538   PMID:26422504   PMID:26728390   PMID:28096417   PMID:28314693   PMID:28365586   PMID:28414128   PMID:28743496   PMID:29384416   PMID:29392534  
PMID:29412704   PMID:29459793   PMID:29659575   PMID:29667910   PMID:29921588   PMID:30765526   PMID:31138677   PMID:31382627   PMID:31496133   PMID:31736353   PMID:31786261   PMID:32325033  
PMID:33439774   PMID:33719576   PMID:34315884   PMID:34384519  


Genomics

Comparative Map Data
Wnk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,151,363 - 101,168,235 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,151,393 - 101,168,235 (+)EnsemblGRCm39 Ensembl
GRCm3811101,260,537 - 101,277,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,260,567 - 101,277,409 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,121,881 - 101,138,723 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,076,701 - 101,093,499 (+)NCBIMGSCv36mm8
MGSCv3611102,039,322 - 102,056,494 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
WNK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,780,610 - 42,797,066 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1742,780,610 - 42,797,066 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,932,628 - 40,949,084 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,186,222 - 38,202,610 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,186,221 - 38,202,605NCBI
Celera1737,588,637 - 37,605,071 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,697,144 - 36,713,472 (+)NCBIHuRef
CHM1_11741,168,235 - 41,184,670 (+)NCBICHM1_1
T2T-CHM13v2.01743,637,750 - 43,654,206 (+)NCBIT2T-CHM13v2.0
Wnk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21086,202,552 - 86,219,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,240,610 - 91,257,398 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01090,715,120 - 90,731,930 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01086,108,283 - 86,125,098 (+)NCBIRnor_WKY
Rnor_6.01089,181,139 - 89,198,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,181,165 - 89,198,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,979,661 - 88,997,344 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,289,273 - 90,306,225 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,303,667 - 90,320,558 (+)NCBI
Celera1084,920,709 - 84,937,662 (+)NCBICelera
Cytogenetic Map10q31NCBI
Wnk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,594,408 - 16,606,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,593,840 - 16,606,817 (+)NCBIChiLan1.0ChiLan1.0
WNK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11724,078,401 - 24,095,648 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,520,448 - 14,537,799 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,746,058 - 14,762,513 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,746,365 - 14,762,423 (-)Ensemblpanpan1.1panPan2
VPS25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,242,230 - 20,247,396 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,703,536 - 19,708,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,960,604 - 20,965,761 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,960,860 - 20,965,682 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,745,515 - 19,750,667 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,011,720 - 20,016,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,114,439 - 20,119,596 (-)NCBIUU_Cfam_GSD_1.0
Wnk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,567,157 - 19,582,658 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,492,753 - 17,509,582 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493649017,492,718 - 17,508,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,065,061 - 20,081,762 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,064,688 - 20,081,781 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,279,617 - 20,296,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,494,090 - 63,512,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607734,286,917 - 34,303,255 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,416,886 - 1,427,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,416,479 - 1,428,350 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnk4
520 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2637
Count of miRNA genes:654
Interacting mature miRNAs:793
Transcripts:ENSMUST00000103108, ENSMUST00000139487, ENSMUST00000147741, ENSMUST00000170056, ENSMUST00000170372
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
13513919Heal56_mwound healing/ regeneration 56 (mouse)11101156468101540293Mouse

Markers in Region
AW107467  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,259,087 - 101,259,178UniSTSGRCm38
MGSCv3711101,120,401 - 101,120,492UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS
Whitehead/MRC_RH111351.47UniSTS
RH124894  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,259,277 - 101,259,409UniSTSGRCm38
MGSCv3711101,120,591 - 101,120,723UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS
PMC357052P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,269,067 - 101,269,681UniSTSGRCm38
MGSCv3711101,130,381 - 101,130,995UniSTSGRCm37
Cytogenetic Map11DUniSTS
RH66580  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,259,275 - 101,259,393UniSTSGRCm38
MGSCv3711101,120,589 - 101,120,707UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS
D11Wsu68e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,259,279 - 101,259,528UniSTSGRCm38
MGSCv3711101,120,593 - 101,120,842UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_175638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006534136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006534137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006534138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006534139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006534141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK008047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY184228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY187027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY260059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000103108   ⟹   ENSMUSP00000099397
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,151,424 - 101,168,235 (+)Ensembl
GRCm38.p6 Ensembl11101,260,598 - 101,277,409 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139487   ⟹   ENSMUSP00000129666
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,151,393 - 101,168,235 (+)Ensembl
GRCm38.p6 Ensembl11101,260,567 - 101,277,409 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147741   ⟹   ENSMUSP00000131298
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,151,481 - 101,168,100 (+)Ensembl
GRCm38.p6 Ensembl11101,260,655 - 101,277,274 (+)Ensembl
RefSeq Acc Id: ENSMUST00000170056   ⟹   ENSMUSP00000132123
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,156,134 - 101,164,955 (+)Ensembl
GRCm38.p6 Ensembl11101,265,308 - 101,274,129 (+)Ensembl
RefSeq Acc Id: ENSMUST00000170372   ⟹   ENSMUSP00000131954
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,167,472 - 101,168,232 (+)Ensembl
GRCm38.p6 Ensembl11101,276,646 - 101,277,406 (+)Ensembl
RefSeq Acc Id: NM_175638   ⟹   NP_783569
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,151,393 - 101,168,235 (+)NCBI
GRCm3811101,260,567 - 101,277,409 (+)NCBI
MGSCv3711101,121,881 - 101,138,723 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534136   ⟹   XP_006534199
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,151,363 - 101,168,235 (+)NCBI
GRCm3811101,260,537 - 101,277,409 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006534137   ⟹   XP_006534200
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,151,363 - 101,168,235 (+)NCBI
GRCm3811101,260,537 - 101,277,409 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006534138   ⟹   XP_006534201
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,151,363 - 101,168,235 (+)NCBI
GRCm3811101,260,537 - 101,277,409 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006534139   ⟹   XP_006534202
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,151,363 - 101,168,235 (+)NCBI
GRCm3811101,260,537 - 101,277,409 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006534141   ⟹   XP_006534204
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,151,365 - 101,168,235 (+)NCBI
GRCm3811101,261,218 - 101,277,409 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314744   ⟹   XP_017170233
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,151,365 - 101,168,235 (+)NCBI
GRCm3811101,260,538 - 101,277,409 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156970   ⟹   XP_036012863
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,151,363 - 101,168,235 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_783569   ⟸   NM_175638
- UniProtKB: Q8R340 (UniProtKB/Swiss-Prot),   Q80UE6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006534199   ⟸   XM_006534136
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006534200   ⟸   XM_006534137
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006534202   ⟸   XM_006534139
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006534201   ⟸   XM_006534138
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006534204   ⟸   XM_006534141
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017170233   ⟸   XM_017314744
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSMUSP00000131954   ⟸   ENSMUST00000170372
RefSeq Acc Id: ENSMUSP00000132123   ⟸   ENSMUST00000170056
RefSeq Acc Id: ENSMUSP00000129666   ⟸   ENSMUST00000139487
RefSeq Acc Id: ENSMUSP00000131298   ⟸   ENSMUST00000147741
RefSeq Acc Id: ENSMUSP00000099397   ⟸   ENSMUST00000103108
RefSeq Acc Id: XP_036012863   ⟸   XM_036156970
- Peptide Label: isoform X3
Protein Domains
Protein kinase   Serine/threonine-protein kinase OSR1/WNK CCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80UE6-F1-model_v2 AlphaFold Q80UE6 1-1222 view protein structure

Promoters
RGD ID:6822460
Promoter ID:MM_KWN:9871
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_175638,   NM_175638_WNK4,   OTTMUST00000005512
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,121,026 - 101,122,122 (+)MPROMDB
RGD ID:6846934
Promoter ID:MM_ACW:8944
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:WNK4.CSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,126,221 - 101,126,721 (+)MPROMDB
RGD ID:6846935
Promoter ID:MM_ACW:8945
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:WNK4.DSEP07-UNSPLICED,   WNK4.ESEP07,   WNK4.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,137,719 - 101,138,219 (+)MPROMDB
RGD ID:6848605
Promoter ID:MM_TRO:1764
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain
Transcripts:MTR012180.11.2577.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,137,841 - 101,138,341 (+)MPROMDB
RGD ID:8676782
Promoter ID:EPDNEW_M16421
Type:multiple initiation site
Name:Wnk4_1
Description:Mus musculus WNK lysine deficient protein kinase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811101,260,591 - 101,260,651EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917097 AgrOrtholog
Ensembl Genes ENSMUSG00000035112 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000099397 ENTREZGENE
  ENSMUSP00000099397.2 UniProtKB/Swiss-Prot
  ENSMUSP00000129666.2 UniProtKB/TrEMBL
  ENSMUSP00000131298.2 UniProtKB/TrEMBL
  ENSMUSP00000131954.2 UniProtKB/TrEMBL
  ENSMUSP00000132123.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000103108 ENTREZGENE
  ENSMUST00000103108.8 UniProtKB/Swiss-Prot
  ENSMUST00000139487.8 UniProtKB/TrEMBL
  ENSMUST00000147741.9 UniProtKB/TrEMBL
  ENSMUST00000170056.2 UniProtKB/TrEMBL
  ENSMUST00000170372.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:69847 UniProtKB/Swiss-Prot
MGD MGI:1917097 ENTREZGENE
NCBI Gene 69847 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE WNK4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wnk4 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PZ38_MOUSE UniProtKB/TrEMBL
  E9Q470_MOUSE UniProtKB/TrEMBL
  F6X7K7_MOUSE UniProtKB/TrEMBL
  F6Z709_MOUSE UniProtKB/TrEMBL
  Q3U0H9_MOUSE UniProtKB/TrEMBL
  Q56VR4_MOUSE UniProtKB/TrEMBL
  Q80UE6 ENTREZGENE
  Q8C1P8_MOUSE UniProtKB/TrEMBL
  Q8R340 ENTREZGENE
  WNK4_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2A4J7 UniProtKB/Swiss-Prot
  Q4VAC1 UniProtKB/Swiss-Prot
  Q80XB5 UniProtKB/Swiss-Prot
  Q80XN2 UniProtKB/Swiss-Prot
  Q8R0N0 UniProtKB/Swiss-Prot
  Q8R340 UniProtKB/Swiss-Prot