Cyb5r3 (cytochrome b5 reductase 3) - Rat Genome Database

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Gene: Cyb5r3 (cytochrome b5 reductase 3) Mus musculus
Analyze
Symbol: Cyb5r3
Name: cytochrome b5 reductase 3
RGD ID: 1557763
MGI Page MGI
Description: Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H and nucleotide binding activity. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in nitric oxide biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R3 (cytochrome b5 reductase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610016L08Rik; 2500002N19Rik; B5R; C85115; Di; Dia; Dia-1; Dia1; diaphorase 1 (NADH); diaphorase-1; NADH-cytochrome b5 reductase 3; null; WU:AL591952.1-001; WU:AL591952.1-002; WU:AL591952.1-003; WU:Cyb5r3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,037,696 - 83,060,641 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1583,037,695 - 83,056,793 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381583,153,495 - 83,176,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,153,494 - 83,172,592 (-)Ensemblmm10GRCm38
MGSCv371582,983,931 - 83,002,638 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361582,981,267 - 82,999,974 (-)NCBIMGSCv36mm8
Celera1585,286,802 - 85,305,568 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-nitrofluorene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
benzamidoxime  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
beta-lapachone  (ISO)
bezafibrate  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
choline  (EXP)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
epoxiconazole  (EXP)
erythromycin estolate  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fenthion  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
furfural  (ISO)
genistein  (EXP)
glafenine  (ISO)
hydralazine  (ISO)
hydrogen cyanide  (EXP)
hydroxylamine  (ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
ketamine  (ISO)
kojic acid  (ISO)
L-methionine  (EXP)
methidathion  (EXP)
methylmercury chloride  (EXP)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nitrates  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (EXP)
pirinixic acid  (EXP,ISO)
potassium cyanide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
quinidine  (ISO)
resveratrol  (EXP)
ritonavir  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
sulfamethoxazole hydroxylamine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
Triptolide  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zingerone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A case of methemoglobinemia type II due to NADH-cytochrome b5 reductase deficiency: determination of the molecular basis. Aalfs CM, etal., Hum Mutat 2000;16(1):18-22.
2. Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women. Blanke KL, etal., Cancer Causes Control. 2014 Nov;25(11):1513-21. doi: 10.1007/s10552-014-0454-7. Epub 2014 Sep 16.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
5. Molecular basis of recessive congenital methemoglobinemia, types I and II: Exon skipping and three novel missense mutations in the NADH-cytochrome b5 reductase (diaphorase 1) gene. Kugler W, etal., Hum Mutat. 2001 Apr;17(4):348.
6. Molecular basis of two novel mutations found in type I methemoglobinemia. Lorenzo FR 5th, etal., Blood Cells Mol Dis. 2011 Apr 15;46(4):277-81. doi: 10.1016/j.bcmd.2011.01.005. Epub 2011 Feb 24.
7. NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer. Lund RR, etal., Mol Cell Proteomics. 2015 Nov;14(11):2988-99. doi: 10.1074/mcp.M115.050385. Epub 2015 Sep 8.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:6118238   PMID:6893763   PMID:7527060   PMID:7677784   PMID:8401507   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11471062   PMID:12477932  
PMID:12865426   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15591319   PMID:15741177   PMID:15782199   PMID:15944396   PMID:16141072   PMID:16141073   PMID:16916647   PMID:16998848  
PMID:17620407   PMID:19691493   PMID:20566685   PMID:20927338   PMID:21677750   PMID:21873635   PMID:22008794   PMID:23055941   PMID:24194600   PMID:25144769   PMID:28130547   PMID:29222160  
PMID:29706024   PMID:30550785   PMID:30796188   PMID:31162944   PMID:31487266   PMID:32180563   PMID:32323139   PMID:32325033   PMID:32554809   PMID:32913122   PMID:34536439   PMID:34656824  
PMID:34709266   PMID:36106636   PMID:36114006   PMID:36417873   PMID:36543799   PMID:36724243   PMID:36749633   PMID:37389954   PMID:37463636   PMID:38253797   PMID:38335173   PMID:38355793  
PMID:38830896   PMID:39069267  


Genomics

Comparative Map Data
Cyb5r3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,037,696 - 83,060,641 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1583,037,695 - 83,056,793 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381583,153,495 - 83,176,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,153,494 - 83,172,592 (-)Ensemblmm10GRCm38
MGSCv371582,983,931 - 83,002,638 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361582,981,267 - 82,999,974 (-)NCBIMGSCv36mm8
Celera1585,286,802 - 85,305,568 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
CYB5R3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382242,617,840 - 42,649,392 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2242,615,730 - 42,720,870 (-)Ensemblhg38GRCh38
GRCh372243,013,846 - 43,045,398 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,344,763 - 41,375,349 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342241,339,318 - 41,367,516NCBI
Celera2226,924,326 - 26,955,882 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,974,473 - 26,005,949 (-)NCBIHuRef
CHM1_12242,972,995 - 43,004,519 (-)NCBICHM1_1
T2T-CHM13v2.02243,098,710 - 43,130,267 (-)NCBIT2T-CHM13v2.0
Cyb5r3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,186,729 - 116,204,290 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7116,186,729 - 116,204,306 (-)EnsemblGRCr8
mRatBN7.27114,306,686 - 114,324,247 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,306,685 - 114,324,298 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7116,061,829 - 116,079,400 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,286,246 - 118,303,784 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,255,692 - 118,273,230 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,024,003 - 124,041,564 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,023,995 - 124,041,594 (-)Ensemblrn6Rnor6.0
Rnor_5.07124,006,942 - 124,024,503 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47121,187,821 - 121,205,382 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7110,620,903 - 110,638,468 (-)NCBICelera
RGSC_v3.17121,222,050 - 121,239,612 (-)NCBI
Cytogenetic Map7q34NCBI
LOC102012303
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541327,969,949 - 27,979,909 (-)Ensembl
ChiLan1.0NW_00495541327,971,140 - 27,979,905 (-)NCBIChiLan1.0ChiLan1.0
LOC100982559
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22352,453,476 - 52,484,518 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12255,145,984 - 55,177,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,513,724 - 23,544,746 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12241,666,548 - 41,694,104 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2241,666,548 - 41,694,104 (-)EnsemblpanPan2panpan1.1
CYB5R3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,829,898 - 22,848,284 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1022,819,221 - 22,848,284 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1022,756,034 - 22,783,841 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01023,565,239 - 23,592,996 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1023,565,191 - 23,595,635 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11023,282,809 - 23,310,756 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,602,619 - 23,630,348 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,777,463 - 23,805,206 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101962805
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049456,411,149 - 6,427,796 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936718549,938 - 564,195 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936718552,369 - 564,195 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYB5R3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,146,276 - 6,170,212 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.156,146,230 - 6,170,209 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,604,124 - 3,628,138 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYB5R3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,172,513 - 25,191,139 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045100,266,413 - 100,298,273 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101718541
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247526,182,129 - 6,198,400 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247526,182,156 - 6,198,395 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116914394
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11252,575,716 - 252,597,835 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyb5r3
798 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1063
Count of miRNA genes:604
Interacting mature miRNAs:724
Transcripts:ENSMUST00000018186, ENSMUST00000162178, ENSMUST00000162834
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
11532732Pitm5_mprion incubation time 5 (mouse)158296406187054388Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse

Markers in Region
RH127129  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381583,153,507 - 83,153,719UniSTSGRCm38
MGSCv371582,983,937 - 82,984,149UniSTSGRCm37
Celera1585,286,808 - 85,287,020UniSTS
Cytogenetic Map15EUniSTS
cM Map1545.2UniSTS
Whitehead/MRC_RH15730.29UniSTS
Cyb5r3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15EUniSTS
cM Map1545.2UniSTS
cM Map1545.2UniSTS
Cyb5r3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15EUniSTS
cM Map1545.2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_029787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEKQ02064601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF323953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI839369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000018186   ⟹   ENSMUSP00000018186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1583,037,695 - 83,056,793 (-)Ensembl
GRCm38.p6 Ensembl1583,153,494 - 83,172,592 (-)Ensembl
Ensembl Acc Id: ENSMUST00000162178   ⟹   ENSMUSP00000125636
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1583,041,265 - 83,054,707 (-)Ensembl
GRCm38.p6 Ensembl1583,157,064 - 83,170,506 (-)Ensembl
Ensembl Acc Id: ENSMUST00000162834   ⟹   ENSMUSP00000124062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1583,037,695 - 83,054,378 (-)Ensembl
GRCm38.p6 Ensembl1583,153,494 - 83,170,177 (-)Ensembl
RefSeq Acc Id: NM_029787   ⟹   NP_084063
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391583,037,696 - 83,056,384 (-)NCBI
GRCm381583,153,495 - 83,172,183 (-)NCBI
MGSCv371582,983,931 - 83,002,638 (-)RGD
Celera1585,286,802 - 85,305,568 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520282   ⟹   XP_006520345
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391583,037,696 - 83,054,723 (-)NCBI
GRCm381583,153,495 - 83,170,524 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006520283   ⟹   XP_006520346
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391583,037,702 - 83,054,409 (-)NCBI
GRCm381583,153,741 - 83,170,208 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248273   ⟹   XP_030104133
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391583,037,696 - 83,060,641 (-)NCBI
GRCm381583,153,495 - 83,176,440 (-)NCBI
Sequence:
RefSeq Acc Id: NP_084063   ⟸   NM_029787
- UniProtKB: Q9DCN2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520345   ⟸   XM_006520282
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006520346   ⟸   XM_006520283
- Peptide Label: isoform X3
- UniProtKB: Q9DCN2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030104133   ⟸   XM_030248273
- Peptide Label: isoform X2
- UniProtKB: Q9DCN2 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000124062   ⟸   ENSMUST00000162834
Ensembl Acc Id: ENSMUSP00000125636   ⟸   ENSMUST00000162178
Ensembl Acc Id: ENSMUSP00000018186   ⟸   ENSMUST00000018186
Protein Domains
FAD-binding FR-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DCN2-F1-model_v2 AlphaFold Q9DCN2 1-301 view protein structure

Promoters
RGD ID:6848654
Promoter ID:MM_TRO:3634
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:MTR000695.15.1336.4
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361582,990,636 - 82,991,136 (-)MPROMDB
RGD ID:6848653
Promoter ID:MM_TRO:3635
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:MTR000695.15.1336.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361582,996,536 - 82,997,512 (-)MPROMDB
RGD ID:6825889
Promoter ID:MM_KWN:19236
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000075995,   OTTMUST00000078715
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361583,000,506 - 83,001,242 (-)MPROMDB
RGD ID:6825890
Promoter ID:MM_KWN:19237
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:ENSMUST00000057383,   OTTMUST00000075994
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361583,002,501 - 83,003,001 (-)MPROMDB
RGD ID:8684580
Promoter ID:EPDNEW_M20307
Type:multiple initiation site
Name:Cyb5r3_3
Description:Mus musculus cytochrome b5 reductase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20308  EPDNEW_M20309  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381583,170,178 - 83,170,238EPDNEW
RGD ID:8684554
Promoter ID:EPDNEW_M20308
Type:single initiation site
Name:Cyb5r3_2
Description:Mus musculus cytochrome b5 reductase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20309  EPDNEW_M20307  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381583,170,506 - 83,170,566EPDNEW
RGD ID:8684556
Promoter ID:EPDNEW_M20309
Type:initiation region
Name:Cyb5r3_1
Description:Mus musculus cytochrome b5 reductase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20308  EPDNEW_M20307  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381583,172,183 - 83,172,243EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94893 AgrOrtholog
Ensembl Genes ENSMUSG00000018042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000018186 ENTREZGENE
  ENSMUST00000018186.16 UniProtKB/Swiss-Prot
  ENSMUST00000162834 ENTREZGENE
  ENSMUST00000162834.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.80 UniProtKB/Swiss-Prot
  Translation factors UniProtKB/Swiss-Prot
InterPro CBR-like UniProtKB/Swiss-Prot
  Cbr1-like_FAD-bd_dom UniProtKB/Swiss-Prot
  FAD-bd_FR_type UniProtKB/Swiss-Prot
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot
  FNR_nucleotide-bd UniProtKB/Swiss-Prot
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot
KEGG Report mmu:109754 UniProtKB/Swiss-Prot
MGD MGI:94893 ENTREZGENE
NCBI Gene Cyb5r3 ENTREZGENE
PANTHER NADH-CYTOCHROME B5 REDUCTASE 3 UniProtKB/Swiss-Prot
  PTHR19370 UniProtKB/Swiss-Prot
Pfam FAD_binding_6 UniProtKB/Swiss-Prot
  NAD_binding_1 UniProtKB/Swiss-Prot
PharmGKB CYB5R3 RGD
PhenoGen Cyb5r3 PhenoGen
PRINTS CYTB5RDTASE UniProtKB/Swiss-Prot
  FPNCR UniProtKB/Swiss-Prot
PROSITE FAD_FR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52343 UniProtKB/Swiss-Prot
  SSF63380 UniProtKB/Swiss-Prot
UniProt F2Z456_MOUSE UniProtKB/TrEMBL
  NB5R3_MOUSE UniProtKB/Swiss-Prot
  Q9CY59_MOUSE UniProtKB/TrEMBL
  Q9DCN2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-07-22 Cyb5r3  cytochrome b5 reductase 3  Dia1  diaphorase 1 (NADH)  Symbol and/or name change 5135510 APPROVED
2025-07-22 Dia1  diaphorase 1 (NADH)  Cyb5r3  cytochrome b5 reductase 3  Symbol and/or name change 5135510 APPROVED
2024-08-21 Cyb5r3  cytochrome b5 reductase 3  Dia1  diaphorase 1 (NADH)  Symbol and/or name change 5135510 APPROVED
2024-08-21 Dia1  diaphorase 1 (NADH)  Cyb5r3  cytochrome b5 reductase 3  Symbol and/or name change 5135510 APPROVED
2016-02-26 Cyb5r3  cytochrome b5 reductase 3  Dia1    Data merged from RGD:731732 737654 PROVISIONAL