Lrrk2 (leucine-rich repeat kinase 2) - Rat Genome Database

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Gene: Lrrk2 (leucine-rich repeat kinase 2) Mus musculus
Analyze
Symbol: Lrrk2
Name: leucine-rich repeat kinase 2
RGD ID: 1557751
MGI Page MGI
Description: Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; protein import into nucleus; and protein phosphorylation. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb bud; and spinal cord. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4921513O20Rik; 9330188B09Rik; AW561911; cI-4; cI-46; D630001M17Rik; Gm927; leucine-rich repeat serine/threonine-protein kinase 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391591,556,994 - 91,700,327 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1591,557,378 - 91,700,323 (+)EnsemblGRCm39 Ensembl
GRCm381591,672,791 - 91,816,124 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1591,673,175 - 91,816,120 (+)EnsemblGRCm38mm10GRCm38
MGSCv371591,503,655 - 91,646,555 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361591,501,048 - 91,643,302 (+)NCBIMGSCv36mm8
Celera1593,785,543 - 93,930,186 (+)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1546.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-methyladenine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antimony(0)  (ISO)
arsenite(3-)  (EXP)
bafilomycin A1  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (EXP)
DDE  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenamidone  (EXP)
folic acid  (EXP)
furan  (ISO)
gentamycin  (ISO)
GTP  (ISO)
hydrogen peroxide  (EXP,ISO)
lactacystin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
maneb  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
pirinixic acid  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
calcium-mediated signaling  (IEA,ISO)
cellular response to curcumin  (ISO)
cellular response to dopamine  (IEA,ISO)
cellular response to manganese ion  (IEA,ISO)
cellular response to oxidative stress  (ISO)
cellular response to reactive oxygen species  (IEA,ISO)
cellular response to starvation  (IEA,ISO)
chromatin remodeling  (IEA)
determination of adult lifespan  (IEA,ISO)
endocytosis  (IEA,ISO)
endoplasmic reticulum organization  (IBA,IMP,ISO)
excitatory postsynaptic potential  (IMP)
exploration behavior  (ISO)
Golgi organization  (IBA,IGI,ISO)
GTP metabolic process  (IEA,ISO)
intracellular distribution of mitochondria  (IEA,ISO)
intracellular signal transduction  (IBA,IMP)
JNK cascade  (IEA,ISO)
locomotory exploration behavior  (IMP)
lysosome organization  (ISO)
MAPK cascade  (ISO)
mitochondrion localization  (ISO)
mitochondrion organization  (IEA,ISO)
negative regulation of autophagosome assembly  (IEA,ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of excitatory postsynaptic potential  (IMP)
negative regulation of GTPase activity  (ISO)
negative regulation of macroautophagy  (ISO)
negative regulation of neuron projection development  (IEA,ISO)
negative regulation of Notch signaling pathway  (IDA)
negative regulation of protein processing  (IEA,ISO)
negative regulation of protein targeting to mitochondrion  (IEA,ISO)
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation  (ISO)
neuromuscular junction development  (IEA,ISO)
neuron differentiation  (IDA)
neuron projection arborization  (IEA,ISO)
neuron projection morphogenesis  (ISO,ISS)
olfactory bulb development  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of autophagy  (IBA,IMP,ISO)
positive regulation of canonical Wnt signaling pathway  (ISO,ISS)
positive regulation of dopamine receptor signaling pathway  (IEA,ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of microglial cell activation  (IEA,ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
positive regulation of programmed cell death  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
positive regulation of protein autoubiquitination  (IEA,ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of synaptic vesicle endocytosis  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
protein autophosphorylation  (ISO)
protein import into nucleus  (IDA,IMP)
protein localization  (IMP)
protein localization to endoplasmic reticulum exit site  (IMP,ISO)
protein phosphorylation  (IDA,IMP,ISO)
regulation of autophagy  (ISO)
regulation of branching morphogenesis of a nerve  (IEA,ISO)
regulation of CAMKK-AMPK signaling cascade  (IEA,ISO)
regulation of cAMP/PKA signal transduction  (IMP)
regulation of canonical Wnt signaling pathway  (IBA,IPI)
regulation of cell projection organization  (IBA)
regulation of dendritic spine morphogenesis  (IGI,ISO)
regulation of dopamine receptor signaling pathway  (IBA,IMP)
regulation of ER to Golgi vesicle-mediated transport  (IMP)
regulation of gene expression  (IMP)
regulation of kidney size  (IMP)
regulation of locomotion  (IEA,ISO)
regulation of lysosomal lumen pH  (IEA,ISO)
regulation of membrane potential  (ISO)
regulation of mitochondrial depolarization  (IEA,ISO)
regulation of neuroblast proliferation  (IEA,ISO)
regulation of neuron maturation  (IEA,ISO)
regulation of protein stability  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of retrograde transport, endosome to Golgi  (IEA,ISO)
regulation of SNARE complex assembly  (ISO)
regulation of synaptic transmission, glutamatergic  (IMP)
regulation of synaptic vesicle endocytosis  (IBA,IDA,IMP)
regulation of synaptic vesicle exocytosis  (IEA,ISO)
regulation of synaptic vesicle transport  (IMP)
response to oxidative stress  (ISO)
Rho protein signal transduction  (IEA,ISO)
spermatogenesis  (IEA,ISO)
striatum development  (IEA,ISO)
synaptic vesicle recycling  (TAS)
tangential migration from the subventricular zone to the olfactory bulb  (IEA,ISO)
Wnt signalosome assembly  (IC,ISO)

Molecular Function
3-phosphoinositide-dependent protein kinase activity  (IEA)
actin binding  (IEA,ISO)
AMP-activated protein kinase activity  (IEA)
ATP binding  (IEA)
beta-catenin destruction complex binding  (IPI)
clathrin binding  (IEA,ISO)
DNA-dependent protein kinase activity  (IEA)
eukaryotic translation initiation factor 2alpha kinase activity  (IEA)
GTP binding  (ISO)
GTP-dependent protein kinase activity  (ISO)
GTPase activator activity  (IEA,ISO)
GTPase activity  (IEA,ISO)
histone H2AS1 kinase activity  (IEA)
histone H2AS121 kinase activity  (IEA)
histone H2AT120 kinase activity  (IEA)
histone H2AXS139 kinase activity  (IEA)
histone H2BS14 kinase activity  (IEA)
histone H2BS36 kinase activity  (IEA)
histone H3S10 kinase activity  (IEA)
histone H3S28 kinase activity  (IEA)
histone H3S57 kinase activity  (IEA)
histone H3T11 kinase activity  (IEA)
histone H3T3 kinase activity  (IEA)
histone H3T45 kinase activity  (IEA)
histone H3T6 kinase activity  (IEA)
histone H4S1 kinase activity  (IEA)
identical protein binding  (IPI,ISO)
JUN kinase kinase kinase activity  (IBA,IEA,ISO)
kinase activity  (ISO,ISS)
magnesium ion binding  (IEA,ISO)
MAP kinase kinase kinase activity  (ISO)
peroxidase inhibitor activity  (IEA,ISO)
protein binding  (IPI)
protein homodimerization activity  (IEA,ISO)
protein kinase A binding  (IPI,ISO)
protein kinase activity  (IDA,ISO)
protein serine kinase activity  (IEA)
protein serine/threonine kinase activity  (IDA,IMP,ISO)
protein-containing complex binding  (IC)
Rho-dependent protein serine/threonine kinase activity  (IEA)
ribosomal protein S6 kinase activity  (IEA)
signaling receptor complex adaptor activity  (IC,ISO)
small GTPase binding  (IPI,ISO)
SNARE binding  (ISO)
syntaxin-1 binding  (IEA,ISO)
transmembrane transporter binding  (IEA,ISO)
tubulin binding  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal adrenal gland secretion  (IAGP)
abnormal autophagy  (IAGP)
abnormal axon extension  (IAGP)
abnormal axon morphology  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal dopamine level  (IAGP)
abnormal dorsal striatum morphology  (IAGP)
abnormal excitatory postsynaptic current amplitude  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal Golgi vesicle transport  (IAGP)
abnormal hippocampal mossy fiber morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
abnormal mitochondrial fission  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal mitochondrial shape  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neurite morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal synaptic dopamine release  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal vesicle-mediated transport  (IAGP)
accumulation of giant lysosomes in kidney/renal tubule cells  (IAGP)
alopecia  (IAGP)
astrocytosis  (IAGP)
decreased kidney weight  (IAGP)
decreased mitochondrial number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
dilated mitochondrion  (IAGP)
dilated renal tubule  (IAGP)
enhanced coordination  (IAGP)
granular kidney  (IAGP)
impaired behavioral response to addictive substance  (IAGP)
impaired behavioral response to xenobiotic  (IAGP)
increased excitatory postsynaptic current frequency  (IAGP)
increased grooming behavior  (IAGP)
increased kidney apoptosis  (IAGP)
increased kidney weight  (IAGP)
increased locomotor activity  (IAGP)
increased neuronal precursor cell number  (IAGP)
increased renal glomerulus apoptosis  (IAGP)
increased renal tubule apoptosis  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased urine protein level  (IAGP)
kidney atrophy  (IAGP)
kidney inflammation  (IAGP)
lipofuscinosis  (IAGP)
microgliosis  (IAGP)
neurodegeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
small kidney  (IAGP)
tau protein deposits  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease. Aasly JO, etal., Mov Disord. 2010 Oct 15;25(13):2156-63.
2. Genes associated with Parkinson's disease: regulation of autophagy and beyond. Beilina A and Cookson MR, J Neurochem. 2015 Jul 30. doi: 10.1111/jnc.13266.
3. Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers. Brockmann K, etal., Mov Disord. 2011 Oct 11. doi: 10.1002/mds.23991.
4. LRRK2 R1398H polymorphism is associated with decreased risk of Parkinson's disease in a Han Chinese population. Chen L, etal., Parkinsonism Relat Disord. 2011 May;17(4):291-2. Epub 2010 Dec 14.
5. Abrogation of a-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. Daher JP, etal., Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9289-94. doi: 10.1073/pnas.1403215111. Epub 2014 Jun 9.
6. Impaired intracellular trafficking defines early Parkinson's disease. Hunn BH, etal., Trends Neurosci. 2015 Mar;38(3):178-88. doi: 10.1016/j.tins.2014.12.009. Epub 2015 Jan 29.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Lee BD, etal., Nat Med. 2010 Sep;16(9):998-1000. Epub 2010 Aug 22.
9. Lrrk2 S1647T and BDNF V66M interact with environmental factors to increase risk of Parkinson's disease. Lin CH, etal., Parkinsonism Relat Disord. 2011 Feb;17(2):84-8. Epub 2010 Dec 16.
10. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Liu Z, etal., Nat Immunol. 2011 Oct 9. doi: 10.1038/ni.2113.
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation. Miklossy J, etal., Acta Neuropathol. 2007 Sep;114(3):243-54. Epub 2007 Jul 17.
13. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. Nakamura N, etal., DNA Res. 2006 Aug 31;13(4):169-83.
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain). Ruiz-Martinez J, etal., Mov Disord. 2010 Oct 30;25(14):2340-5.
21. LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease. Saunders-Pullman R, etal., Mov Disord. 2010 Nov 15;25(15):2536-41.
22. Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease. Seki N, etal., J Hum Genet. 2011 Sep;56(9):671-5. doi: 10.1038/jhg.2011.79. Epub 2011 Jul 28.
23. Differential gene expression in patients with amyotrophic lateral sclerosis. Shtilbans A, etal., Amyotroph Lateral Scler. 2011 Jul;12(4):250-6. Epub 2011 Mar 4.
24. High frequency and reduced penetrance of lRRK2 g2019S mutation among Parkinson's disease patients in Cantabria (Spain). Sierra M, etal., Mov Disord. 2011 Sep 27. doi: 10.1002/mds.23965.
25. LRRK2 G2019S mutation does not contribute to Parkinson's disease in South India. Vijayan B, etal., Neurol India. 2011 Mar-Apr;59(2):157-60.
26. Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease. Vitte J, etal., J Neuropathol Exp Neurol. 2010 Sep;69(9):959-72.
27. Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model. Yang S, etal., Cell Death Dis. 2014 May 8;5:e1217. doi: 10.1038/cddis.2014.184.
Additional References at PubMed
PMID:10349636   PMID:11004510   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:15541309   PMID:16141072   PMID:16141073   PMID:16487147   PMID:16504409   PMID:16532471  
PMID:16771836   PMID:16980962   PMID:17101029   PMID:17114044   PMID:17120249   PMID:17341485   PMID:17623048   PMID:18045479   PMID:18367605   PMID:18445495   PMID:18790059   PMID:19142648  
PMID:19176810   PMID:19196961   PMID:19536328   PMID:19545277   PMID:19667187   PMID:19740074   PMID:19890007   PMID:20016100   PMID:20064389   PMID:20079710   PMID:20130188   PMID:20146535  
PMID:20403420   PMID:20457918   PMID:20595391   PMID:20642453   PMID:20659021   PMID:20728949   PMID:20850369   PMID:20876399   PMID:20949042   PMID:21048939   PMID:21168496   PMID:21307259  
PMID:21370995   PMID:21390248   PMID:21677750   PMID:21695257   PMID:21828077   PMID:21857923   PMID:21873635   PMID:21972245   PMID:22080837   PMID:22166428   PMID:22230652   PMID:22253261  
PMID:22302802   PMID:22357653   PMID:22363216   PMID:22423108   PMID:22496842   PMID:22539006   PMID:22612223   PMID:22615783   PMID:22639965   PMID:22647713   PMID:22713584   PMID:22736029  
PMID:22850484   PMID:22899650   PMID:22952686   PMID:22988862   PMID:23082216   PMID:23125283   PMID:23183827   PMID:23231918   PMID:23241745   PMID:23270607   PMID:23318930   PMID:23395371  
PMID:23526378   PMID:23600457   PMID:23646112   PMID:23675505   PMID:23886663   PMID:23936174   PMID:23937259   PMID:23949442   PMID:24046356   PMID:24113872   PMID:24167564   PMID:24275654  
PMID:24282027   PMID:24427314   PMID:24464040   PMID:24510904   PMID:24633735   PMID:24652679   PMID:24682598   PMID:24687852   PMID:24733019   PMID:24794857   PMID:24952961   PMID:25107341  
PMID:25201882   PMID:25301747   PMID:25309331   PMID:25343991   PMID:25356398   PMID:25500533   PMID:25501810   PMID:25609428   PMID:25830304   PMID:25834052   PMID:25836420   PMID:25854701  
PMID:25926623   PMID:25939886   PMID:26067490   PMID:26123485   PMID:26237551   PMID:26251043   PMID:26268594   PMID:26269629   PMID:26282470   PMID:26355680   PMID:26363496   PMID:26365310  
PMID:26375402   PMID:26384650   PMID:26546614   PMID:26646749   PMID:26758690   PMID:26811536   PMID:26824392   PMID:26943952   PMID:26979073   PMID:27273569   PMID:27357661   PMID:27364102  
PMID:27378696   PMID:27383589   PMID:27411784   PMID:27413152   PMID:27424887   PMID:27474410   PMID:27539321   PMID:27798112   PMID:27830463   PMID:27872856   PMID:27890708   PMID:27903237  
PMID:27914807   PMID:28098219   PMID:28103901   PMID:28120865   PMID:28168579   PMID:28202664   PMID:28330897   PMID:28508149   PMID:28576705   PMID:28582422   PMID:28710481   PMID:28720718  
PMID:28821568   PMID:28893563   PMID:28930069   PMID:29038245   PMID:29054882   PMID:29056298   PMID:29088368   PMID:29125462   PMID:29212815   PMID:29246723   PMID:29305532   PMID:29386392  
PMID:29408508   PMID:29434188   PMID:29472933   PMID:29541021   PMID:29743203   PMID:29760073   PMID:29789389   PMID:29800472   PMID:29855356   PMID:29875204   PMID:29891719   PMID:29908325  
PMID:29917075   PMID:30048714   PMID:30089035   PMID:30150626   PMID:30172844   PMID:30194047   PMID:30209220   PMID:30249796   PMID:30291536   PMID:30398148   PMID:30420654   PMID:30571694  
PMID:30670047   PMID:30720180   PMID:30890692   PMID:30927072   PMID:30983487   PMID:31046837   PMID:31102768   PMID:31166814   PMID:31554740   PMID:31555076   PMID:31813996   PMID:31821596  
PMID:32057291   PMID:32075681   PMID:32111741   PMID:32164260   PMID:32247534   PMID:32325033   PMID:32374202   PMID:32375042   PMID:32434048   PMID:32477237   PMID:32631998   PMID:32643832  
PMID:32853409   PMID:32926469   PMID:33006315   PMID:33007689   PMID:33055242   PMID:33105882   PMID:33132310   PMID:33135724   PMID:33213462   PMID:33230847   PMID:33300446   PMID:33459343  
PMID:33483550   PMID:33498474   PMID:33523017   PMID:33629273   PMID:33679324   PMID:33706934   PMID:34030727   PMID:34043193   PMID:34077533   PMID:34145320   PMID:34313548   PMID:34340748  
PMID:34409578   PMID:34419621   PMID:34446559   PMID:34555357   PMID:34658337   PMID:34686322   PMID:34749824   PMID:34759048   PMID:34831434   PMID:34918122   PMID:34918781   PMID:35012605  
PMID:35499056   PMID:35521944   PMID:35534227   PMID:35596783   PMID:35732218   PMID:35907404   PMID:35998231   PMID:36055602   PMID:36336242   PMID:36357506   PMID:36358985   PMID:36415932  
PMID:36654782   PMID:36675159   PMID:37196079   PMID:37269951   PMID:37289222   PMID:37300531   PMID:37366237   PMID:37443833   PMID:37487100   PMID:37625589   PMID:37633049   PMID:37640963  
PMID:37672887   PMID:37684522   PMID:37845194   PMID:37847786   PMID:37874635   PMID:37904222   PMID:38355793   PMID:38435455   PMID:38438877   PMID:38477420   PMID:38527708   PMID:38607004  
PMID:38686804   PMID:38725082   PMID:38740348   PMID:38750146   PMID:38811759   PMID:38849592   PMID:38862989   PMID:38968112   PMID:39217812   PMID:39282291   PMID:39390438   PMID:39537338  


Genomics

Comparative Map Data
Lrrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391591,556,994 - 91,700,327 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1591,557,378 - 91,700,323 (+)EnsemblGRCm39 Ensembl
GRCm381591,672,791 - 91,816,124 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1591,673,175 - 91,816,120 (+)EnsemblGRCm38mm10GRCm38
MGSCv371591,503,655 - 91,646,555 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361591,501,048 - 91,643,302 (+)NCBIMGSCv36mm8
Celera1593,785,543 - 93,930,186 (+)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1546.07NCBI
LRRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381240,224,997 - 40,369,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1240,196,744 - 40,369,285 (+)EnsemblGRCh38hg38GRCh38
GRCh371240,618,799 - 40,763,087 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,905,081 - 39,049,354 (+)NCBINCBI36Build 36hg18NCBI36
Celera1239,422,059 - 39,566,110 (+)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1237,646,624 - 37,790,676 (+)NCBIHuRef
CHM1_11240,584,126 - 40,728,194 (+)NCBICHM1_1
T2T-CHM13v2.01240,177,355 - 40,321,422 (+)NCBIT2T-CHM13v2.0
Lrrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87124,706,246 - 124,867,234 (+)NCBIGRCr8
mRatBN7.27122,826,696 - 122,987,711 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7122,826,696 - 122,987,703 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7124,609,699 - 124,765,717 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07126,835,567 - 126,991,586 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07126,763,694 - 126,919,689 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07132,857,311 - 133,018,549 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7132,857,628 - 133,018,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07132,531,591 - 132,694,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47130,105,902 - 130,267,747 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7119,264,946 - 119,423,875 (+)NCBICelera
Cytogenetic Map7q35NCBI
Lrrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495550581,796 - 216,923 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495550584,324 - 216,923 (-)NCBIChiLan1.0ChiLan1.0
LRRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21053,787,599 - 53,931,814 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11253,783,370 - 53,928,117 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01248,343,621 - 48,488,337 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11249,205,930 - 49,350,462 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1249,205,930 - 49,350,462 (-)Ensemblpanpan1.1panPan2
LRRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12713,282,824 - 13,420,917 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2713,283,756 - 13,420,870 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2733,032,944 - 33,171,543 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02713,454,479 - 13,594,189 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2713,454,985 - 13,594,935 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12713,240,908 - 13,387,064 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02713,302,124 - 13,442,060 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02733,159,660 - 33,299,460 (+)NCBIUU_Cfam_GSD_1.0
Lrrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494573,794,012 - 73,929,347 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936607626,991 - 761,123 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936607628,469 - 761,117 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl571,800,225 - 71,945,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1571,800,337 - 71,945,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2574,510,979 - 74,653,410 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11136,490,775 - 36,634,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1136,492,011 - 36,634,216 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037210,139,337 - 210,285,872 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624778108,761 - 279,230 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624778106,594 - 279,325 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrrk2
6183 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:276
Interacting mature miRNAs:304
Transcripts:ENSMUST00000060642, ENSMUST00000133743, ENSMUST00000137657, ENSMUST00000140734, ENSMUST00000156900, ENSMUST00000172797
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse

Markers in Region
D15Mit281  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381591,684,840 - 91,684,957UniSTSGRCm38
MGSCv371591,515,271 - 91,515,388UniSTSGRCm37
Celera1593,797,141 - 93,797,254UniSTS
Cytogenetic Map15F1UniSTS
cM Map15 UniSTS
Whitehead_YAC15 UniSTS
D15Roc4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381591,803,563 - 91,803,851UniSTSGRCm38
MGSCv371591,633,994 - 91,634,282UniSTSGRCm37
Celera1593,917,636 - 93,917,928UniSTS
Cytogenetic Map15F1UniSTS
D15Roc3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381591,780,731 - 91,781,015UniSTSGRCm38
MGSCv371591,611,162 - 91,611,446UniSTSGRCm37
Celera1593,895,137 - 93,895,423UniSTS
Cytogenetic Map15F1UniSTS
Lrrk2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F1UniSTS
cM Map15 UniSTS
REN25577  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381591,728,915 - 91,729,141UniSTSGRCm38
MGSCv371591,559,346 - 91,559,572UniSTSGRCm37
Celera1593,841,214 - 93,841,440UniSTS
Cytogenetic Map15F1UniSTS
ECD18401  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381591,723,096 - 91,723,859UniSTSGRCm38
MGSCv371591,553,527 - 91,554,290UniSTSGRCm37
Celera1593,835,395 - 93,836,158UniSTS
Cytogenetic Map15F1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_025730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004938860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY792512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF660966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000060642   ⟹   ENSMUSP00000052584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1591,557,378 - 91,700,323 (+)Ensembl
GRCm38.p6 Ensembl1591,673,175 - 91,816,120 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133743
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1591,664,581 - 91,700,229 (+)Ensembl
GRCm38.p6 Ensembl1591,780,378 - 91,816,026 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137657
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1591,692,441 - 91,700,229 (+)Ensembl
GRCm38.p6 Ensembl1591,808,238 - 91,816,026 (+)Ensembl
Ensembl Acc Id: ENSMUST00000140734
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1591,623,151 - 91,673,313 (+)Ensembl
GRCm38.p6 Ensembl1591,738,948 - 91,789,110 (+)Ensembl
Ensembl Acc Id: ENSMUST00000156900
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1591,656,548 - 91,662,694 (+)Ensembl
GRCm38.p6 Ensembl1591,772,345 - 91,778,491 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172797
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1591,698,831 - 91,700,322 (+)Ensembl
GRCm38.p6 Ensembl1591,814,628 - 91,816,119 (+)Ensembl
RefSeq Acc Id: NM_025730   ⟹   NP_080006
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391591,557,427 - 91,700,327 (+)NCBI
GRCm381591,673,224 - 91,816,124 (+)NCBI
MGSCv371591,503,655 - 91,646,555 (+)RGD
Celera1593,785,543 - 93,930,186 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521277   ⟹   XP_006521340
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391591,556,994 - 91,678,521 (+)NCBI
GRCm381591,672,791 - 91,794,322 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159546   ⟹   XP_036015439
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391591,557,141 - 91,700,327 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004938860
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391591,556,994 - 91,699,708 (+)NCBI
Sequence:
RefSeq Acc Id: NP_080006   ⟸   NM_025730
- UniProtKB: Q8CI84 (UniProtKB/Swiss-Prot),   Q8BZJ6 (UniProtKB/Swiss-Prot),   Q8BWG7 (UniProtKB/Swiss-Prot),   E9QNJ2 (UniProtKB/Swiss-Prot),   Q8K062 (UniProtKB/Swiss-Prot),   Q5S006 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521340   ⟸   XM_006521277
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000052584   ⟸   ENSMUST00000060642
RefSeq Acc Id: XP_036015439   ⟸   XM_036159546
- Peptide Label: isoform X1
Protein Domains
COR   Protein kinase   Roc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5S006-F1-model_v2 AlphaFold Q5S006 1-2527 view protein structure

Promoters
RGD ID:6826161
Promoter ID:MM_KWN:19473
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000060642
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361591,503,284 - 91,503,784 (+)MPROMDB
RGD ID:6826163
Promoter ID:MM_KWN:19476
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:UC007XIA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361591,610,079 - 91,610,579 (+)MPROMDB
RGD ID:6826160
Promoter ID:MM_KWN:19477
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000049326
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361591,638,861 - 91,639,361 (+)MPROMDB
RGD ID:8684782
Promoter ID:EPDNEW_M20422
Type:initiation region
Name:Lrrk2_1
Description:Mus musculus leucine-rich repeat kinase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381591,673,211 - 91,673,271EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913975 AgrOrtholog
Ensembl Genes ENSMUSG00000036273 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000060642 ENTREZGENE
  ENSMUST00000060642.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
  2.130.10.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  COR UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  ROC_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Ser_Thr_Kinases_DiverseReg UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:66725 UniProtKB/Swiss-Prot
MGD MGI:1913975 ENTREZGENE
NCBI Gene 66725 ENTREZGENE
PANTHER LEUCINE RICH REPEAT KINASE 2 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE DDB_G0278509-RELATED UniProtKB/Swiss-Prot
Pfam COR UniProtKB/Swiss-Prot
  LRR_1 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Roc UniProtKB/Swiss-Prot
PhenoGen Lrrk2 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE LRR UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  ROC UniProtKB/Swiss-Prot
SMART LRR_BAC UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  RAB UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF48371 UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
  SSF50978 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt E9QNJ2 ENTREZGENE
  LRRK2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BU87_MOUSE UniProtKB/TrEMBL
  Q8BWG7 ENTREZGENE
  Q8BZJ6 ENTREZGENE
  Q8CI84 ENTREZGENE
  Q8K062 ENTREZGENE
  Q9CQG8_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QNJ2 UniProtKB/Swiss-Prot
  Q8BWG7 UniProtKB/Swiss-Prot
  Q8BZJ6 UniProtKB/Swiss-Prot
  Q8CI84 UniProtKB/Swiss-Prot
  Q8K062 UniProtKB/Swiss-Prot