Nfatc1 (nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1) - Rat Genome Database

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Gene: Nfatc1 (nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1) Mus musculus
Analyze
Symbol: Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
RGD ID: 1557692
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mitogen-activated protein kinase p38 binding activity. Involved in heart development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; leukocyte differentiation; and negative regulation of cell population proliferation. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including eye; genitourinary system; heart; hemolymphoid system; and limb mesenchyme. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2210017P03Rik; AI449492; AV076380; NF-A; NF-ATc; NF-ATc1; NFA; NFAT transcription complex cytosolic component; NFAT2; NFATc; Nfatcb; nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; transcription factor NF-ATc
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391880,649,418 - 80,756,286 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1880,649,420 - 80,756,286 (-)EnsemblGRCm39 Ensembl
GRCm381880,606,205 - 80,713,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1880,606,205 - 80,713,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv371880,802,944 - 80,909,810 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361880,768,264 - 80,875,117 (-)NCBIMGSCv36mm8
Celera1881,715,612 - 81,822,471 (-)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1853.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-matairesinol  (EXP)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-aminopurine  (EXP)
2-tert-butylhydroquinone  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
9-phenanthrol  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Alisol B  (EXP)
all-trans-retinoic acid  (EXP)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
apocynin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (EXP,ISO)
atrazine  (ISO)
azetidine  (EXP)
benzamide  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
benzyl isothiocyanate  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
cadmium atom  (EXP)
Calcimycin  (EXP,ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chlorpromazine  (EXP)
choline  (EXP)
chromium(3+) trichloride  (EXP)
chrysene  (EXP)
cisapride  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
coenzyme Q10  (EXP)
copper(II) sulfate  (ISO)
corilagin  (EXP)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
diosmetin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (EXP)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
formononetin  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
ginsenoside Rb1  (EXP)
glyburide  (EXP)
harmine  (ISO)
hydrogen peroxide  (EXP)
hydroxychloroquine  (ISO)
hypoxanthine  (EXP)
inulin  (EXP)
ionomycin  (EXP)
isoprenaline  (ISO)
KN-93  (EXP)
L-methionine  (EXP)
lead(0)  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methylglyoxal  (EXP)
Morroniside  (EXP)
N-acetyl-L-cysteine  (EXP)
niclosamide  (EXP,ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
platycodin D  (EXP,ISO)
quercetin  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
Ro 41-5253  (EXP)
rotenone  (ISO)
ruxolitinib  (ISO)
Sanggenon C  (EXP,ISO)
SB 203580  (EXP)
SB 431542  (ISO)
sclareol  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
SKF-96365 hydrochloride  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (EXP)
tofacitinib  (ISO)
topotecan  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
xanthohumol  (EXP)
zinc atom  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve development  (IMP)
aortic valve morphogenesis  (IMP)
B-1a B cell differentiation  (IMP)
branching involved in lymph vessel morphogenesis  (IMP)
calcineurin-NFAT signaling cascade  (IBA,IMP,ISO)
calcium ion transport  (IMP)
cellular response to calcium ion  (IDA)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
endocardial cushion development  (IGI)
epithelial to mesenchymal transition  (IMP)
G1/S transition of mitotic cell cycle  (IMP)
gene expression  (IMP)
heart development  (IMP)
heart trabecula morphogenesis  (IMP)
heart valve development  (IMP)
heart valve morphogenesis  (IMP)
intracellular signal transduction  (ISO)
keratinocyte proliferation  (IMP)
lymphangiogenesis  (IGI)
mononuclear cell differentiation  (ISO)
negative regulation of keratinocyte proliferation  (IMP)
negative regulation of osteoblast differentiation  (IDA)
negative regulation of stem cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IGI,IMP)
negative regulation of vascular associated smooth muscle cell differentiation  (ISO)
osteoclast differentiation  (IGI)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
pulmonary valve development  (IMP)
pulmonary valve morphogenesis  (IMP)
regulation of hair cycle  (IMP)
regulation of transcription by RNA polymerase II  (IMP)
response to muscle activity  (ISO)
semi-lunar valve development  (IMP)
skeletal muscle adaptation  (ISO)
stem cell proliferation  (IMP)
transcription by RNA polymerase II  (IDA,IGI,IMP)
transition between fast and slow fiber  (IMP)
ventricular septum morphogenesis  (IMP)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal aortic sinus morphology  (IAGP)
abnormal aortic valve cusp morphology  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal B cell calcium ion homeostasis  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal blood circulation  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cardiac jelly morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal coronary vein morphology  (IAGP)
abnormal endochondral bone ossification  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart valve morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal interferon-gamma secretion  (IAGP)
abnormal interleukin-2 secretion  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal locomotor behavior  (IEA)
abnormal lymphocyte cell number  (IAGP)
abnormal lymphocyte physiology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal marginal zone B cell physiology  (IAGP)
abnormal mitral valve cusp morphology  (IAGP)
abnormal mitral valve development  (IAGP)
abnormal mitral valve morphology  (IAGP)
abnormal motile cilium morphology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal pulmonary valve cusp morphology  (IAGP)
abnormal semilunar valve development  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal tricuspid valve cusp morphology  (IAGP)
abnormal tricuspid valve development  (IAGP)
absent aortic valve cusps  (IAGP)
absent lower incisors  (IAGP)
absent pulmonary valve cusps  (IAGP)
anemia  (IAGP)
aortic valve regurgitation  (IAGP)
atrial septal defect  (IAGP)
atrioventricular cushion hypoplasia  (IAGP)
bicuspid aortic valve  (IAGP)
cardiac hypertrophy  (IAGP)
cardiomyopathy  (IAGP)
decreased atrioventricular cushion size  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1a cell number  (IAGP)
decreased body size  (IAGP)
decreased cardiac jelly amount  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased IgE level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-17 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased length of long bones  (IAGP)
decreased locomotor activity  (IEA)
decreased lymphocyte cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to graft versus host disease  (IAGP)
dilated heart atrium  (IAGP)
dilated heart ventricle  (IAGP)
edema  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic lethality during organogenesis  (IAGP)
enlarged heart  (IAGP)
gastrointestinal hemorrhage  (IAGP)
heart hemorrhage  (IAGP)
hemorrhage  (IAGP)
increased B cell apoptosis  (IAGP)
increased bone volume  (IAGP)
increased double-negative T cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG2a level  (IAGP)
increased IgM level  (IAGP)
increased immunoglobulin level  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased regulatory T cell number  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver inflammation  (IAGP)
long upper incisors  (IAGP)
lung inflammation  (IAGP)
lymph node inflammation  (IAGP)
mitral valve prolapse  (IAGP)
no abnormal phenotype detected  (IAGP)
osteopetrosis  (IAGP)
pallor  (IAGP)
partial atrioventricular septal defect  (IAGP)
pericardial effusion  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality  (IAGP)
preweaning lethality, complete penetrance  (IEA)
semilunar valve regurgitation  (IAGP)
short femur  (IAGP)
short lower incisors  (IAGP)
short tibia  (IAGP)
small atrioventricular valve  (IAGP)
small semilunar valve  (IAGP)
stomach inflammation  (IAGP)
thick aortic valve  (IAGP)
thick aortic valve cusps  (IAGP)
thick heart valve cusps  (IAGP)
thick myocardium  (IAGP)
thick pulmonary valve  (IAGP)
thin myocardium  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy. Barzegar-Fallah A, etal., Eur J Pharmacol. 2015 Nov 15;767:152-9. doi: 10.1016/j.ejphar.2015.10.019. Epub 2015 Oct 21.
2. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. Cai YQ, etal., J Pharmacol Exp Ther. 2013 Apr;345(1):161-8. doi: 10.1124/jpet.112.202192. Epub 2013 Feb 5.
3. Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF‑κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis. Ding D, etal., Int J Mol Med. 2022 Jan;49(1):4. doi: 10.3892/ijmm.2021.5059. Epub 2021 Nov 5.
4. Association of a tandem repeat polymorphism in NFATc1 with increased risk of perimembranous ventricular septal defect in a Chinese population. Gu H, etal., Biochem Genet. 2011 Oct;49(9-10):592-600. doi: 10.1007/s10528-011-9434-8. Epub 2011 Apr 17.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat. Lee KY, etal., BMC Complement Altern Med. 2019 Aug 9;19(1):207. doi: 10.1186/s12906-019-2611-8.
7. Correlation between NFATC1 gene polymorphisms and congenital heart disease in children. Li CL, etal., Eur Rev Med Pharmacol Sci. 2017 Aug;21(15):3441-3446.
8. Recombinant human erythropoietin pretreatment alleviates renal glomerular injury induced by cardiopulmonary bypass by reducing transient receptor potential channel 6-nuclear factor of activated T-cells pathway activation. Liu X, etal., J Thorac Cardiovasc Surg. 2013 Mar 24. pii: S0022-5223(13)00274-2. doi: 10.1016/j.jtcvs.2013.02.076.
9. PIAS1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice through a Mechanism Involving NFATc1 SUMOylation. Luo J, etal., Dis Markers. 2022 Aug 31;2022:4988539. doi: 10.1155/2022/4988539. eCollection 2022.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Rengarajan J, etal., Immunity 2000 Mar;12(3):293-300.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Association of NFATc1 gene polymorphism with ventricular septal defect in the Chinese Han population. Shen L, etal., Chin Med J (Engl). 2013 Jan;126(1):78-81.
18. [Histopathologic features of degenerative aortic valve and its mechanisms]. Sun J, etal., Zhonghua Yi Xue Za Zhi. 2013 Jan 22;93(4):280-4.
Additional References at PubMed
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PMID:12121669   PMID:12163407   PMID:12171919   PMID:12370307   PMID:12469121   PMID:12477932   PMID:12479813   PMID:12594266   PMID:12598522   PMID:12660151   PMID:12738787   PMID:12808150  
PMID:12810687   PMID:12970181   PMID:14595020   PMID:14681302   PMID:14738882   PMID:14749367   PMID:15030770   PMID:15057750   PMID:15058383   PMID:15096597   PMID:15117818   PMID:15166096  
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PMID:20037154   PMID:20059953   PMID:20133620   PMID:20214815   PMID:20235153   PMID:20375015   PMID:20412781   PMID:20417662   PMID:20421389   PMID:20547767   PMID:20554534   PMID:20631193  
PMID:20651158   PMID:20721934   PMID:20816797   PMID:20824138   PMID:20881962   PMID:20939024   PMID:20960543   PMID:21068407   PMID:21131365   PMID:21148038   PMID:21187378   PMID:21262800  
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PMID:21735477   PMID:21751242   PMID:21839714   PMID:21873635   PMID:21880741   PMID:21924079   PMID:21982707   PMID:22019888   PMID:22125315   PMID:22131333   PMID:22190184   PMID:22198385  
PMID:22300732   PMID:22306086   PMID:22312437   PMID:22392845   PMID:22451653   PMID:22457635   PMID:22490438   PMID:22522930   PMID:22549180   PMID:22560297   PMID:22573816   PMID:22579476  
PMID:22615493   PMID:22642569   PMID:22687751   PMID:22688515   PMID:22749887   PMID:22814600   PMID:22843703   PMID:22865050   PMID:22865292   PMID:22922818   PMID:22932696   PMID:22985540  
PMID:22991461   PMID:23112101   PMID:23123663   PMID:23125425   PMID:23126497   PMID:23141092   PMID:23178125   PMID:23184643   PMID:23197258   PMID:23246654   PMID:23259949   PMID:23263556  
PMID:23264614   PMID:23271346   PMID:23293002   PMID:23340267   PMID:23347887   PMID:23365084   PMID:23389455   PMID:23437302   PMID:23446734   PMID:23499491   PMID:23560082   PMID:23593329  
PMID:23602386   PMID:23629863   PMID:23665018   PMID:23672204   PMID:23755169   PMID:23797856   PMID:23824573   PMID:23825189   PMID:23867221   PMID:23894673   PMID:23928189   PMID:23946498  
PMID:23974039   PMID:23980096   PMID:23990468   PMID:24012369   PMID:24023563   PMID:24039232   PMID:24045961   PMID:24248346   PMID:24269279   PMID:24282298   PMID:24293546   PMID:24301466  
PMID:24335970   PMID:24352425   PMID:24371139   PMID:24415751   PMID:24508799   PMID:24526256   PMID:24590764   PMID:24680826   PMID:24694735   PMID:24697899   PMID:24711622   PMID:24732379  
PMID:24735878   PMID:24831012   PMID:24916406   PMID:24937432   PMID:24970700   PMID:24994653   PMID:25023277   PMID:25100642   PMID:25142972   PMID:25152440   PMID:25179582   PMID:25187507  
PMID:25216923   PMID:25242327   PMID:25271623   PMID:25318679   PMID:25332179   PMID:25359771   PMID:25377552   PMID:25497097   PMID:25556111   PMID:25576926   PMID:25583478   PMID:25623042  
PMID:25625206   PMID:25630465   PMID:25640055   PMID:25680272   PMID:25689841   PMID:25722188   PMID:25918731   PMID:26017771   PMID:26100917   PMID:26173181   PMID:26176759   PMID:26310443  
PMID:26343857   PMID:26410627   PMID:26430214   PMID:26472929   PMID:26483414   PMID:26483549   PMID:26491108   PMID:26564789   PMID:26600673   PMID:26627060   PMID:26631626   PMID:26642432  
PMID:26644563   PMID:26653852   PMID:26659641   PMID:26712011   PMID:26740180   PMID:26851216   PMID:26876178   PMID:26893350   PMID:26916723   PMID:26921718   PMID:26949511   PMID:26953188  
PMID:26971224   PMID:26992132   PMID:27019112   PMID:27035226   PMID:27043494   PMID:27056912   PMID:27077737   PMID:27158674   PMID:27222343   PMID:27273006   PMID:27312418   PMID:27346349  
PMID:27348588   PMID:27348591   PMID:27353300   PMID:27391226   PMID:27482889   PMID:27516371   PMID:27558652   PMID:27563728   PMID:27597886   PMID:27723141   PMID:27821837   PMID:27829167  
PMID:27856256   PMID:27859049   PMID:27897222   PMID:27917924   PMID:27935966   PMID:28161640   PMID:28172500   PMID:28172997   PMID:28183532   PMID:28188746   PMID:28257846   PMID:28341745  
PMID:28391779   PMID:28414795   PMID:28512199   PMID:28515152   PMID:28520214   PMID:28548091   PMID:28556366   PMID:28559377   PMID:28576770   PMID:28770466   PMID:28790014   PMID:28791425  
PMID:28809397   PMID:28849049   PMID:28890073   PMID:28894104   PMID:28924218   PMID:28970470   PMID:28978472   PMID:29018150   PMID:29030115   PMID:29045828   PMID:29056552   PMID:29077264  
PMID:29083488   PMID:29246443   PMID:29305867   PMID:29371594   PMID:29416540   PMID:29422515   PMID:29463002   PMID:29691251   PMID:29727635   PMID:29743679   PMID:29891551   PMID:29899403  
PMID:29904917   PMID:29907883   PMID:29973725   PMID:30036881   PMID:30061196   PMID:30078210   PMID:30101837   PMID:30128894   PMID:30201295   PMID:30204862   PMID:30347193   PMID:30556925  
PMID:30721543   PMID:30736420   PMID:30799229   PMID:30815894   PMID:30828328   PMID:30910863   PMID:31010826   PMID:31023876   PMID:31112136   PMID:31118289   PMID:31127627   PMID:31138536  
PMID:31171768   PMID:31207603   PMID:31269439   PMID:31286998   PMID:31289211   PMID:31319059   PMID:31360740   PMID:31387361   PMID:31462535   PMID:31591237   PMID:31591643   PMID:31789590  
PMID:31793068   PMID:31801950   PMID:31846070   PMID:31898934   PMID:31908034   PMID:31921172   PMID:32014271   PMID:32098917   PMID:32151560   PMID:32165499   PMID:32186512   PMID:32253237  
PMID:32546759   PMID:32569872   PMID:32581014   PMID:32686149   PMID:32741026   PMID:32779844   PMID:32790690   PMID:32983140   PMID:32986812   PMID:33255852   PMID:33299176   PMID:33773996  
PMID:33809261   PMID:33821668   PMID:33846290   PMID:33851764   PMID:33934370   PMID:34108685   PMID:34157307   PMID:34158848   PMID:34234374   PMID:34279605   PMID:34358968   PMID:34367143  
PMID:34624205   PMID:34767447   PMID:34882194   PMID:34943970   PMID:35069572   PMID:35148462   PMID:35236105   PMID:35310332   PMID:35364006   PMID:35364055   PMID:35365570   PMID:35482005  
PMID:35864959   PMID:36127325   PMID:36620995   PMID:36718671   PMID:36758798   PMID:36790146   PMID:36926655   PMID:37002228   PMID:37002575   PMID:37148740   PMID:37215988   PMID:37300531  
PMID:37342957   PMID:37348503   PMID:37371137   PMID:37392543   PMID:37689753   PMID:37702066   PMID:37891230   PMID:37914750   PMID:37933452   PMID:38200114   PMID:38252822   PMID:38523790  
PMID:38653356   PMID:38755146   PMID:38967255   PMID:38977785   PMID:39024412  


Genomics

Comparative Map Data
Nfatc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391880,649,418 - 80,756,286 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1880,649,420 - 80,756,286 (-)EnsemblGRCm39 Ensembl
GRCm381880,606,205 - 80,713,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1880,606,205 - 80,713,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv371880,802,944 - 80,909,810 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361880,768,264 - 80,875,117 (-)NCBIMGSCv36mm8
Celera1881,715,612 - 81,822,471 (-)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1853.66NCBI
NFATC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381879,395,930 - 79,529,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1879,395,856 - 79,529,325 (+)EnsemblGRCh38hg38GRCh38
GRCh371877,155,930 - 77,289,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361875,256,760 - 75,390,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 341875,256,759 - 75,329,165NCBI
Celera1873,929,368 - 74,061,687 (+)NCBICelera
Cytogenetic Map18q23NCBI
HuRef1873,783,058 - 73,914,637 (+)NCBIHuRef
CHM1_11877,150,992 - 77,284,501 (+)NCBICHM1_1
T2T-CHM13v2.01879,649,928 - 79,782,943 (+)NCBIT2T-CHM13v2.0
Nfatc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81876,321,386 - 76,430,997 (-)NCBIGRCr8
mRatBN7.21874,046,422 - 74,156,041 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1874,046,904 - 74,156,028 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1876,149,324 - 76,258,603 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01876,818,657 - 76,927,924 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01874,664,215 - 74,773,420 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01877,203,517 - 77,322,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1877,203,525 - 77,322,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01876,309,900 - 76,426,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41877,498,654 - 77,581,231 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1872,704,426 - 72,813,069 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
Nfatc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540262,558,286 - 62,674,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540262,558,392 - 62,674,347 (+)NCBIChiLan1.0ChiLan1.0
NFATC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21796,966,431 - 97,102,776 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11882,659,055 - 82,795,399 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01872,948,067 - 73,083,180 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11876,020,443 - 76,133,790 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1876,017,454 - 76,094,453 (+)Ensemblpanpan1.1panPan2
NFATC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.111,027,021 - 1,121,362 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl11,028,695 - 1,121,588 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12,030,800 - 2,126,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,991 - 923,076 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1827,017 - 923,153 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11879,585 - 975,578 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,423 - 922,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01996,485 - 1,092,567 (-)NCBIUU_Cfam_GSD_1.0
Nfatc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494415,162,918 - 15,264,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936616484,045 - 587,891 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936616484,062 - 584,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,911,046 - 146,008,139 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,940,099 - 146,002,897 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21161,528,147 - 161,632,555 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118690,313 - 815,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18689,671 - 811,100 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606025,265,195 - 25,449,498 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfatc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624806905,174 - 1,022,800 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624806905,487 - 1,022,784 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfatc1
3585 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3299
Count of miRNA genes:756
Interacting mature miRNAs:990
Transcripts:ENSMUST00000035800, ENSMUST00000078049, ENSMUST00000167977, ENSMUST00000170905
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
4141757Sicd1_mseizure-induced cell death 1 (mouse)Not determined188017526489590914Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
15014786Mvlq2_mmacrovesicular liver lesion QTL 2 (mouse)187156938890720763Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
10401904Sicd4_mseizure-induced cell death 4 (mouse)Not determined186980527685514143Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
1302183Pas7_mpulmonary adenoma susceptibility 7 (mouse)Not determined187274559484144595Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186714438990720763Mouse
4142153Idd21.1_minsulin dependent diabetes susceptibility 21.1 (mouse)Not determined187456233884144595Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse

Markers in Region
01.MMHAP47FLA1.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381880,613,162 - 80,613,359UniSTSGRCm38
MGSCv371880,809,901 - 80,810,098UniSTSGRCm37
Celera1881,722,570 - 81,722,767UniSTS
Cytogenetic Map18E4UniSTS
cM Map1854.0UniSTS
Whitehead_YAC18 UniSTS
01.MMHAP62FLA1.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381880,659,103 - 80,659,290UniSTSGRCm38
MGSCv371880,855,842 - 80,856,029UniSTSGRCm37
Celera1881,768,508 - 81,768,695UniSTS
Cytogenetic Map18E4UniSTS
cM Map1854.0UniSTS
Whitehead_YAC18 UniSTS
AF087434  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381880,648,603 - 80,648,714UniSTSGRCm38
MGSCv371880,845,342 - 80,845,453UniSTSGRCm37
Celera1881,758,008 - 81,758,119UniSTS
Cytogenetic Map18E4UniSTS
cM Map1854.0UniSTS
Whitehead/MRC_RH18963.96UniSTS
Nfatc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371880,894,418 - 80,894,642UniSTSGRCm37
Celera1881,807,056 - 81,807,280UniSTS
Cytogenetic Map18E4UniSTS
cM Map1854.0UniSTS
AI449492  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381880,647,679 - 80,647,816UniSTSGRCm38
MGSCv371880,844,418 - 80,844,555UniSTSGRCm37
Celera1881,757,085 - 81,757,222UniSTS
Cytogenetic Map18E4UniSTS
cM Map1854.0UniSTS
Whitehead/MRC_RH18970.01UniSTS
Nfatc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E4UniSTS
Nfatc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381880,697,679 - 80,697,903UniSTSGRCm38
MGSCv371880,894,418 - 80,894,642UniSTSGRCm37
Celera1881,807,056 - 81,807,280UniSTS
Cytogenetic Map18E4UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001164109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001164110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001164111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001164112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_198429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC149054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF049606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF087434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF239169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF480838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI449492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB647702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000035800   ⟹   ENSMUSP00000046312
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1880,690,650 - 80,751,388 (-)Ensembl
GRCm38.p6 Ensembl1880,647,435 - 80,708,173 (-)Ensembl
Ensembl Acc Id: ENSMUST00000078049   ⟹   ENSMUSP00000077196
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1880,649,420 - 80,756,273 (-)Ensembl
GRCm38.p6 Ensembl1880,606,205 - 80,713,058 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167977   ⟹   ENSMUSP00000126884
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1880,649,420 - 80,751,388 (-)Ensembl
GRCm38.p6 Ensembl1880,606,205 - 80,708,173 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170905   ⟹   ENSMUSP00000129001
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1880,649,420 - 80,755,981 (-)Ensembl
GRCm38.p6 Ensembl1880,606,205 - 80,712,766 (-)Ensembl
Ensembl Acc Id: ENSMUST00000236310   ⟹   ENSMUSP00000158284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1880,649,420 - 80,751,388 (-)Ensembl
GRCm38.p6 Ensembl1880,606,205 - 80,708,173 (-)Ensembl
Ensembl Acc Id: ENSMUST00000236711   ⟹   ENSMUSP00000158358
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1880,690,650 - 80,756,286 (-)Ensembl
GRCm38.p6 Ensembl1880,647,435 - 80,713,071 (-)Ensembl
Ensembl Acc Id: ENSMUST00000237776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1880,650,605 - 80,652,190 (-)Ensembl
GRCm38.p6 Ensembl1880,607,390 - 80,608,975 (-)Ensembl
RefSeq Acc Id: NM_001164109   ⟹   NP_001157581
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,690,650 - 80,756,286 (-)NCBI
GRCm381880,647,435 - 80,713,071 (-)NCBI
MGSCv371880,802,944 - 80,909,810 (-)RGD
Celera1881,715,612 - 81,822,471 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001164110   ⟹   NP_001157582
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,649,420 - 80,756,286 (-)NCBI
GRCm381880,606,205 - 80,713,071 (-)ENTREZGENE
MGSCv371880,802,944 - 80,909,810 (-)RGD
Celera1881,715,612 - 81,822,471 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001164111   ⟹   NP_001157583
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,649,420 - 80,751,388 (-)NCBI
GRCm381880,606,205 - 80,708,173 (-)NCBI
MGSCv371880,802,944 - 80,909,810 (-)RGD
Celera1881,715,612 - 81,822,471 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001164112   ⟹   NP_001157584
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,649,420 - 80,751,388 (-)NCBI
GRCm381880,606,205 - 80,708,173 (-)NCBI
MGSCv371880,802,944 - 80,909,810 (-)RGD
Celera1881,715,612 - 81,822,471 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_016791   ⟹   NP_058071
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,690,650 - 80,751,388 (-)NCBI
GRCm381880,647,435 - 80,708,173 (-)NCBI
MGSCv371880,802,944 - 80,909,810 (-)RGD
Celera1881,715,612 - 81,822,471 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_198429   ⟹   NP_940821
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,649,420 - 80,756,286 (-)NCBI
GRCm381880,606,205 - 80,713,071 (-)ENTREZGENE
MGSCv371880,802,944 - 80,909,810 (-)RGD
Celera1881,715,612 - 81,822,471 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036161026   ⟹   XP_036016919
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,649,418 - 80,754,328 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161027   ⟹   XP_036016920
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,649,418 - 80,754,328 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161029   ⟹   XP_036016922
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,649,418 - 80,754,278 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001157581 (Get FASTA)   NCBI Sequence Viewer  
  NP_001157582 (Get FASTA)   NCBI Sequence Viewer  
  NP_001157583 (Get FASTA)   NCBI Sequence Viewer  
  NP_001157584 (Get FASTA)   NCBI Sequence Viewer  
  NP_058071 (Get FASTA)   NCBI Sequence Viewer  
  NP_940821 (Get FASTA)   NCBI Sequence Viewer  
  XP_036016919 (Get FASTA)   NCBI Sequence Viewer  
  XP_036016920 (Get FASTA)   NCBI Sequence Viewer  
  XP_036016922 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC05505 (Get FASTA)   NCBI Sequence Viewer  
  AAC36725 (Get FASTA)   NCBI Sequence Viewer  
  AAF40225 (Get FASTA)   NCBI Sequence Viewer  
  AAH61509 (Get FASTA)   NCBI Sequence Viewer  
  AAL96484 (Get FASTA)   NCBI Sequence Viewer  
  ACG55587 (Get FASTA)   NCBI Sequence Viewer  
  ACG55588 (Get FASTA)   NCBI Sequence Viewer  
  ACG55589 (Get FASTA)   NCBI Sequence Viewer  
  ACG55590 (Get FASTA)   NCBI Sequence Viewer  
  ACG55591 (Get FASTA)   NCBI Sequence Viewer  
  ACG55592 (Get FASTA)   NCBI Sequence Viewer  
  BAB23581 (Get FASTA)   NCBI Sequence Viewer  
  BAE26158 (Get FASTA)   NCBI Sequence Viewer  
  EDL09401 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000046312
  ENSMUSP00000046312.8
  ENSMUSP00000077196
  ENSMUSP00000077196.5
  ENSMUSP00000126884
  ENSMUSP00000126884.2
  ENSMUSP00000129001
  ENSMUSP00000129001.2
  ENSMUSP00000158284
  ENSMUSP00000158284.2
  ENSMUSP00000158358
  ENSMUSP00000158358.2
GenBank Protein O88942 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058071   ⟸   NM_016791
- Peptide Label: isoform 1
- UniProtKB: O88942 (UniProtKB/Swiss-Prot),   O70345 (UniProtKB/Swiss-Prot),   Q9DBQ6 (UniProtKB/TrEMBL),   Q3UME0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_940821   ⟸   NM_198429
- Peptide Label: isoform 2
- UniProtKB: Q6P7T9 (UniProtKB/TrEMBL),   Q3UME0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157582   ⟸   NM_001164110
- Peptide Label: isoform 4
- UniProtKB: B5B2N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157583   ⟸   NM_001164111
- Peptide Label: isoform 6
- UniProtKB: O88942 (UniProtKB/Swiss-Prot),   O70345 (UniProtKB/Swiss-Prot),   B5B2N4 (UniProtKB/TrEMBL),   Q3UME0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157584   ⟸   NM_001164112
- Peptide Label: isoform 5
- UniProtKB: B5B2N7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157581   ⟸   NM_001164109
- Peptide Label: isoform 3
- UniProtKB: B5B2N5 (UniProtKB/TrEMBL),   Q3UME0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000158358   ⟸   ENSMUST00000236711
Ensembl Acc Id: ENSMUSP00000158284   ⟸   ENSMUST00000236310
Ensembl Acc Id: ENSMUSP00000129001   ⟸   ENSMUST00000170905
Ensembl Acc Id: ENSMUSP00000046312   ⟸   ENSMUST00000035800
Ensembl Acc Id: ENSMUSP00000126884   ⟸   ENSMUST00000167977
Ensembl Acc Id: ENSMUSP00000077196   ⟸   ENSMUST00000078049
RefSeq Acc Id: XP_036016920   ⟸   XM_036161027
- Peptide Label: isoform X2
- UniProtKB: O88942 (UniProtKB/Swiss-Prot),   O70345 (UniProtKB/Swiss-Prot),   Q3UME0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036016919   ⟸   XM_036161026
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036016922   ⟸   XM_036161029
- Peptide Label: isoform X3
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88942-F1-model_v2 AlphaFold O88942 1-717 view protein structure

Promoters
RGD ID:13678260
Promoter ID:EPDNEW_M23279
Type:initiation region
Name:Nfatc1_1
Description:Mus musculus nuclear factor of activated T cells, cytoplasmic,calcineurin dependent 1 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381880,708,137 - 80,708,197EPDNEW
RGD ID:6829410
Promoter ID:MM_KWN:25825
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_001164111,   NM_001164112,   NM_016791
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361880,904,456 - 80,905,292 (-)MPROMDB
RGD ID:6829407
Promoter ID:MM_KWN:25826
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   Lung
Transcripts:NM_001164109,   NM_001164110,   NM_198429
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361880,909,471 - 80,909,971 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102469 AgrOrtholog
Ensembl Genes ENSMUSG00000033016 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035800 ENTREZGENE
  ENSMUST00000035800.8 UniProtKB/TrEMBL
  ENSMUST00000078049 ENTREZGENE
  ENSMUST00000078049.12 UniProtKB/TrEMBL
  ENSMUST00000167977 ENTREZGENE
  ENSMUST00000167977.8 UniProtKB/TrEMBL
  ENSMUST00000170905 ENTREZGENE
  ENSMUST00000170905.9 UniProtKB/TrEMBL
  ENSMUST00000236310 ENTREZGENE
  ENSMUST00000236310.2 UniProtKB/TrEMBL
  ENSMUST00000236711 ENTREZGENE
  ENSMUST00000236711.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NFAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18018 UniProtKB/TrEMBL
MGD MGI:102469 ENTREZGENE
NCBI Gene 18018 ENTREZGENE
PANTHER PTHR12533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12533:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nfatc1 PhenoGen
PRINTS NUCFACTORATC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B5B2N2 ENTREZGENE, UniProtKB/TrEMBL
  B5B2N4 ENTREZGENE, UniProtKB/TrEMBL
  B5B2N5 ENTREZGENE, UniProtKB/TrEMBL
  B5B2N7 ENTREZGENE, UniProtKB/TrEMBL
  NFAC1_MOUSE UniProtKB/Swiss-Prot
  O70345 ENTREZGENE
  O88942 ENTREZGENE
  Q3UME0 ENTREZGENE, UniProtKB/TrEMBL
  Q6P7T9 ENTREZGENE, UniProtKB/TrEMBL
  Q9DBQ6 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHD3_MOUSE UniProtKB/TrEMBL
UniProt Secondary O70345 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Nfatc1  nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1  Nfatc1  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1  Symbol and/or name change 5135510 APPROVED