Fundc2 (FUN14 domain containing 2) - Rat Genome Database

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Gene: Fundc2 (FUN14 domain containing 2) Mus musculus
Analyze
Symbol: Fundc2
Name: FUN14 domain containing 2
RGD ID: 1557611
MGI Page MGI
Description: Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in regulation of platelet activation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human FUNDC2 (FUN14 domain containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4833415N24Rik; DC44; FUN14 domain-containing protein 2; HCBP; HCBP6; hepatitis C virus core-binding protein 6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,426,005 - 74,440,764 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,426,005 - 74,440,065 (+)EnsemblGRCm39 Ensembl
GRCm38X75,382,399 - 75,397,158 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,382,399 - 75,396,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X72,627,738 - 72,642,497 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,635,142 - 71,648,836 (+)NCBIMGSCv36mm8
CeleraX66,783,170 - 66,799,149 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:29222160  
PMID:29786068   PMID:30550785   PMID:30576423   PMID:32325033   PMID:32535386   PMID:35449600   PMID:35710796   PMID:36037337   PMID:37196079   PMID:37700593  


Genomics

Comparative Map Data
Fundc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,426,005 - 74,440,764 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,426,005 - 74,440,065 (+)EnsemblGRCm39 Ensembl
GRCm38X75,382,399 - 75,397,158 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,382,399 - 75,396,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X72,627,738 - 72,642,497 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,635,142 - 71,648,836 (+)NCBIMGSCv36mm8
CeleraX66,783,170 - 66,799,149 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.22NCBI
FUNDC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X155,026,844 - 155,060,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX155,025,980 - 155,060,304 (+)EnsemblGRCh38hg38GRCh38
GRCh37X154,255,119 - 154,288,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,908,258 - 153,938,385 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X153,818,825 - 153,847,085NCBI
CeleraX154,413,800 - 154,443,906 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,800,036 - 142,830,182 (+)NCBIHuRef
CHM1_1X154,166,689 - 154,196,808 (+)NCBICHM1_1
T2T-CHM13v2.0X153,263,246 - 153,296,709 (+)NCBIT2T-CHM13v2.0
Fundc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818142,829 - 155,123 (-)NCBIGRCr8
mRatBN7.218128,473 - 138,232 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18132,248 - 138,345 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18143,997 - 149,596 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018931,838 - 937,437 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018145,906 - 151,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018401,878 - 407,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18402,295 - 407,954 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018447,139 - 453,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418112,408 - 118,067 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera18125,282 - 130,946 (-)NCBICelera
Cytogenetic Map18p13NCBI
Fundc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594625,701 - 656,400 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955594627,839 - 656,241 (-)NCBIChiLan1.0ChiLan1.0
FUNDC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X155,004,611 - 155,032,998 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X155,008,219 - 155,037,432 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X144,505,703 - 144,534,871 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X154,345,251 - 154,373,806 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX154,345,251 - 154,374,743 (+)Ensemblpanpan1.1panPan2
FUNDC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X123,046,451 - 123,064,580 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX123,045,954 - 123,064,580 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX108,039,832 - 108,057,960 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X126,174,003 - 126,192,133 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X121,921,891 - 121,940,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,444,308 - 124,462,462 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X124,165,031 - 124,183,161 (+)NCBIUU_Cfam_GSD_1.0
Fundc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,945,691 - 119,960,506 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936927304,197 - 318,271 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936927304,162 - 318,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FUNDC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,354,021 - 125,372,610 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,354,032 - 125,366,029 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,117,012 - 143,129,015 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FUNDC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,315,315 - 129,342,395 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX129,315,465 - 129,342,193 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606567,293,273 - 67,320,970 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fundc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624963226,564 - 251,113 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624963223,145 - 250,841 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fundc2
301 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1045
Count of miRNA genes:603
Interacting mature miRNAs:728
Transcripts:ENSMUST00000033541, ENSMUST00000123540, ENSMUST00000147998
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse
1357730Hstx1_mhybrid sterility, X chromosome 1 (mouse)Not determinedX7145385277600812Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse

Markers in Region
px-72f2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X75,387,769 - 75,387,892UniSTSGRCm38
MGSCv37X72,633,108 - 72,633,231UniSTSGRCm37
CeleraX66,788,545 - 66,788,668UniSTS
px-72f7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X75,387,519 - 75,387,858UniSTSGRCm38
MGSCv37X72,632,858 - 72,633,197UniSTSGRCm37
CeleraX66,788,295 - 66,788,634UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000033541   ⟹   ENSMUSP00000033541
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,426,005 - 74,440,065 (+)Ensembl
GRCm38.p6 EnsemblX75,382,399 - 75,396,459 (+)Ensembl
Ensembl Acc Id: ENSMUST00000123540
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,430,708 - 74,437,934 (+)Ensembl
GRCm38.p6 EnsemblX75,387,102 - 75,394,328 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147998
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,426,028 - 74,431,081 (+)Ensembl
GRCm38.p6 EnsemblX75,382,422 - 75,387,475 (+)Ensembl
RefSeq Acc Id: NM_026126   ⟹   NP_080402
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X74,426,005 - 74,440,764 (+)NCBI
GRCm38X75,382,399 - 75,397,158 (+)ENTREZGENE
MGSCv37X72,627,738 - 72,642,497 (+)RGD
CeleraX66,783,170 - 66,799,149 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080402   ⟸   NM_026126
- UniProtKB: Q8BSM8 (UniProtKB/Swiss-Prot),   Q80YD9 (UniProtKB/Swiss-Prot),   Q80VT2 (UniProtKB/Swiss-Prot),   Q9D617 (UniProtKB/Swiss-Prot),   Q9D6K8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000033541   ⟸   ENSMUST00000033541

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D6K8-F1-model_v2 AlphaFold Q9D6K8 1-151 view protein structure

Promoters
RGD ID:13680820
Promoter ID:EPDNEW_M24559
Type:multiple initiation site
Name:Fundc2_1
Description:Mus musculus FUN14 domain containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X75,382,417 - 75,382,477EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914641 AgrOrtholog
Ensembl Genes ENSMUSG00000031198 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033541 ENTREZGENE
  ENSMUST00000033541.5 UniProtKB/Swiss-Prot
InterPro FUN14 UniProtKB/Swiss-Prot
KEGG Report mmu:67391 UniProtKB/Swiss-Prot
MGD MGI:1914641 ENTREZGENE
NCBI Gene 67391 ENTREZGENE
PANTHER FUN14 DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR21346 UniProtKB/Swiss-Prot
Pfam FUN14 UniProtKB/Swiss-Prot
PhenoGen Fundc2 PhenoGen
UniProt FUND2_MOUSE UniProtKB/Swiss-Prot
  Q80VT2 ENTREZGENE
  Q80YD9 ENTREZGENE
  Q8BSM8 ENTREZGENE
  Q9D617 ENTREZGENE
  Q9D6K8 ENTREZGENE
UniProt Secondary Q80VT2 UniProtKB/Swiss-Prot
  Q80YD9 UniProtKB/Swiss-Prot
  Q8BSM8 UniProtKB/Swiss-Prot
  Q9D617 UniProtKB/Swiss-Prot