Cad (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Cad (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) Mus musculus
Analyze
Symbol: Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
RGD ID: 1557585
MGI Page MGI
Description: Enables aspartate carbamoyltransferase activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; and dihydroorotase activity. Involved in 'de novo' UMP biosynthetic process. Predicted to be located in neuronal cell body; nuclear matrix; and terminal bouton. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2410008J01Rik; AU018859; carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; Cpad; multifunctional protein CAD
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,211,964 - 31,235,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,212,124 - 31,235,823 (+)EnsemblGRCm39 Ensembl
GRCm38531,054,620 - 31,078,479 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,054,780 - 31,078,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,357,184 - 31,380,852 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,331,392 - 31,355,060 (+)NCBIMGSCv36mm8
Celera528,526,834 - 28,551,927 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bisphenol A  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fipronil  (ISO)
flutamide  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
GSK-J4  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
ozone  (ISO)
paracetamol  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
trovafloxacin  (EXP)
tunicamycin  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (ISO)
cytoplasm  (IBA,ISO)
cytosol  (IBA,ISO)
neuronal cell body  (IEA,ISO)
nuclear matrix  (IEA,ISO)
nucleus  (ISO)
protein-containing complex  (IEA,ISO)
terminal bouton  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Regulatory properties and behavior of activity of carbamoyl phosphate synthetase II (glutamine-hydrolyzing) in normal and proliferating tissues. Aoki T, etal., J Biol Chem. 1982 Jan 10;257(1):432-8.
2. Carbamyl phosphate-aspartate transcarbamylase activity in tumors. CALVA E, etal., Cancer Res. 1959 Jan;19(1):101-3.
3. Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway. Evans DR and Guy HI, J Biol Chem. 2004 Aug 6;279(32):33035-8. Epub 2004 Apr 19.
4. Activity of aspartate transcarbamylase in mammary tumours induced by 7,12-dimethyl-benzanthracene in the rat. Gorlich M and Heise E, Nature. 1967 Mar 4;213(5079):934-5.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
7. Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes. Kunjara S, etal., Biochem Med Metab Biol. 1992 Dec;48(3):263-74.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. [Ammonia metabolism of liver of the fetus induced experimental IUGR in rats--in respect of the enzymes in pyrimidin biosynthesis and urea cycle system] Nagasaki T Nippon Sanka Fujinka Gakkai Zasshi. 1985 Jan;37(1):24-30.
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells. Otto E, etal., J Biol Chem. 1989 Feb 25;264(6):3390-6.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Increased messenger RNA concentration for carbamoyl-phosphate synthase II in hepatoma 3924A. Reardon MA, etal., Biochem Biophys Res Commun. 1987 Aug 31;147(1):494-500.
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:5125237   PMID:8889548   PMID:9811896   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14681479   PMID:15735755  
PMID:16141072   PMID:16141073   PMID:17510285   PMID:20362542   PMID:21565611   PMID:21677750   PMID:21873635   PMID:22692683   PMID:22922362   PMID:25044020   PMID:25646292   PMID:25678555  
PMID:25859222   PMID:26365490   PMID:28378742   PMID:28671696   PMID:29459677   PMID:29551634   PMID:29768498   PMID:32968282   PMID:33771897   PMID:36114006   PMID:36417873   PMID:36800290  
PMID:37142655   PMID:38355793  


Genomics

Comparative Map Data
Cad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,211,964 - 31,235,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,212,124 - 31,235,823 (+)EnsemblGRCm39 Ensembl
GRCm38531,054,620 - 31,078,479 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,054,780 - 31,078,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,357,184 - 31,380,852 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,331,392 - 31,355,060 (+)NCBIMGSCv36mm8
Celera528,526,834 - 28,551,927 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.95NCBI
CAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,217,369 - 27,243,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,217,369 - 27,243,943 (+)EnsemblGRCh38hg38GRCh38
GRCh37227,440,237 - 27,466,811 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,293,762 - 27,320,158 (+)NCBINCBI36Build 36hg18NCBI36
Build 34227,351,908 - 27,378,305NCBI
Celera227,286,585 - 27,312,981 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,181,964 - 27,208,360 (+)NCBIHuRef
CHM1_1227,370,163 - 27,396,559 (+)NCBICHM1_1
T2T-CHM13v2.0227,259,008 - 27,285,579 (+)NCBIT2T-CHM13v2.0
Cad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,012,091 - 31,035,098 (-)NCBIGRCr8
mRatBN7.2625,292,133 - 25,315,078 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,292,133 - 25,319,861 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,592,847 - 25,615,794 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,908,706 - 25,931,663 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,387,772 - 25,410,661 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,657,507 - 26,680,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,657,780 - 26,680,284 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,472,498 - 36,495,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,272,416 - 25,296,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera624,783,039 - 24,805,943 (-)NCBICelera
Cytogenetic Map6q14NCBI
Cad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,203,434 - 9,227,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,203,433 - 9,227,526 (+)NCBIChiLan1.0ChiLan1.0
CAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,269,360 - 99,295,801 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,273,328 - 99,299,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,218,699 - 27,245,156 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,306,488 - 27,332,804 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,306,527 - 27,332,804 (+)Ensemblpanpan1.1panPan2
CAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,198,839 - 21,221,897 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,197,826 - 21,221,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,090,639 - 21,113,701 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,519,811 - 21,542,872 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,514,893 - 21,542,872 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,206,567 - 21,229,628 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,217,636 - 21,240,698 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,264,518 - 21,287,583 (+)NCBIUU_Cfam_GSD_1.0
Cad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,506,657 - 65,529,337 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,310,228 - 5,332,918 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,308,268 - 5,332,934 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,887,020 - 111,914,492 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,887,017 - 111,914,511 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,371,154 - 80,399,193 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,371,096 - 80,398,914 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,756,113 - 31,783,666 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,318,232 - 9,340,925 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,318,213 - 9,340,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cad
1325 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2585
Count of miRNA genes:692
Interacting mature miRNAs:889
Transcripts:ENSMUST00000013773, ENSMUST00000031049, ENSMUST00000114646, ENSMUST00000126382, ENSMUST00000137541, ENSMUST00000139994, ENSMUST00000148145, ENSMUST00000152004, ENSMUST00000152509, ENSMUST00000155001, ENSMUST00000170329, ENSMUST00000174367
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5884767233475637Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse

Markers in Region
RH136118  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,054,425 - 31,054,621UniSTSGRCm38
MGSCv37531,356,798 - 31,356,994UniSTSGRCm37
Celera528,526,448 - 28,526,644UniSTS
Cytogenetic Map5B1UniSTS
PMC139788P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,074,269 - 31,075,144UniSTSGRCm38
MGSCv37531,376,642 - 31,377,517UniSTSGRCm37
Celera528,547,715 - 28,548,590UniSTS
Cytogenetic Map5B1UniSTS
MARC4015-4016  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,076,686 - 31,077,187UniSTSGRCm38
MGSCv37531,379,059 - 31,379,560UniSTSGRCm37
Celera528,550,133 - 28,550,635UniSTS
Cytogenetic Map5B1UniSTS
CAD  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,076,254 - 31,076,712UniSTSGRCm38
MGSCv37531,378,627 - 31,379,085UniSTSGRCm37
Celera528,549,700 - 28,550,159UniSTS
Cytogenetic Map5B1UniSTS
cM Map516.95UniSTS
Cad  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B1UniSTS
cM Map516.95UniSTS
Cad  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001289522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_023525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ104747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000013773   ⟹   ENSMUSP00000013773
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,212,124 - 31,235,823 (+)Ensembl
GRCm38.p6 Ensembl531,054,780 - 31,078,479 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200917
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,233,157 - 31,234,008 (+)Ensembl
GRCm38.p6 Ensembl531,075,813 - 31,076,664 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200953   ⟹   ENSMUSP00000144307
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,212,299 - 31,235,539 (+)Ensembl
GRCm38.p6 Ensembl531,054,955 - 31,078,195 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201182   ⟹   ENSMUSP00000144684
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,212,272 - 31,235,576 (+)Ensembl
GRCm38.p6 Ensembl531,054,928 - 31,078,232 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201256
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,227,813 - 31,230,049 (+)Ensembl
GRCm38.p6 Ensembl531,070,469 - 31,072,705 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201838   ⟹   ENSMUSP00000144127
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,212,155 - 31,225,107 (+)Ensembl
GRCm38.p6 Ensembl531,054,811 - 31,067,763 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201844
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,219,138 - 31,224,312 (+)Ensembl
GRCm38.p6 Ensembl531,061,794 - 31,066,968 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201870
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,227,899 - 31,230,326 (+)Ensembl
GRCm38.p6 Ensembl531,070,555 - 31,072,982 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202227
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,223,639 - 31,224,524 (+)Ensembl
GRCm38.p6 Ensembl531,066,295 - 31,067,180 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202391
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,227,700 - 31,229,538 (+)Ensembl
GRCm38.p6 Ensembl531,070,356 - 31,072,194 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202795   ⟹   ENSMUSP00000144009
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,212,272 - 31,235,576 (+)Ensembl
GRCm38.p6 Ensembl531,054,928 - 31,078,232 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202827
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,229,653 - 31,230,924 (+)Ensembl
GRCm38.p6 Ensembl531,072,309 - 31,073,580 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,216,018 - 31,217,308 (+)Ensembl
GRCm38.p6 Ensembl531,058,674 - 31,059,964 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202973   ⟹   ENSMUSP00000144679
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,231,461 - 31,233,372 (+)Ensembl
GRCm38.p6 Ensembl531,074,117 - 31,076,028 (+)Ensembl
RefSeq Acc Id: NM_001289522   ⟹   NP_001276451
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,212,140 - 31,235,823 (+)NCBI
GRCm38531,054,780 - 31,078,479 (+)NCBI
Celera528,526,803 - 28,551,927 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289523   ⟹   NP_001276452
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,212,140 - 31,235,823 (+)NCBI
GRCm38531,054,780 - 31,078,479 (+)NCBI
Celera528,526,803 - 28,551,927 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001403399   ⟹   NP_001390328
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,212,140 - 31,235,823 (+)NCBI
RefSeq Acc Id: NM_001403400   ⟹   NP_001390329
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,212,140 - 31,225,107 (+)NCBI
RefSeq Acc Id: NM_023525   ⟹   NP_076014
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,212,140 - 31,235,823 (+)NCBI
GRCm38531,054,780 - 31,078,479 (+)NCBI
MGSCv37531,357,184 - 31,380,852 (+)RGD
Celera528,526,803 - 28,551,927 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004942556
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,211,964 - 31,230,579 (+)NCBI
Sequence:
RefSeq Acc Id: NP_076014   ⟸   NM_023525
- Peptide Label: isoform 1
- UniProtKB: B7ZN27 (UniProtKB/Swiss-Prot),   B2RQC6 (UniProtKB/Swiss-Prot),   E9QAI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276452   ⟸   NM_001289523
- Peptide Label: isoform 3
- UniProtKB: G3UWN2 (UniProtKB/TrEMBL),   E9QAI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276451   ⟸   NM_001289522
- Peptide Label: isoform 2
- UniProtKB: E9QAI5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000013773   ⟸   ENSMUST00000013773
Ensembl Acc Id: ENSMUSP00000144009   ⟸   ENSMUST00000202795
Ensembl Acc Id: ENSMUSP00000144679   ⟸   ENSMUST00000202973
Ensembl Acc Id: ENSMUSP00000144684   ⟸   ENSMUST00000201182
Ensembl Acc Id: ENSMUSP00000144127   ⟸   ENSMUST00000201838
Ensembl Acc Id: ENSMUSP00000144307   ⟸   ENSMUST00000200953
RefSeq Acc Id: NP_001390328   ⟸   NM_001403399
- Peptide Label: isoform 4
- UniProtKB: E9QAI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001390329   ⟸   NM_001403400
- Peptide Label: isoform 5
- UniProtKB: E9QAT6 (UniProtKB/TrEMBL),   Q7TN13 (UniProtKB/TrEMBL)
Protein Domains
Amidohydrolase-related   Aspartate/ornithine carbamoyltransferase Asp/Orn-   Aspartate/ornithine carbamoyltransferase carbamoyl-P   ATP-grasp   Glutamine amidotransferase type-1   MGS-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RQC6-F1-model_v2 AlphaFold B2RQC6 1-2225 view protein structure

Promoters
RGD ID:6886332
Promoter ID:EPDNEW_M6617
Type:initiation region
Name:Cad_1
Description:Mus musculus carbamoyl-phosphate synthetase 2, aspartate transcarbamylase,and dihydroorotase , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38531,054,796 - 31,054,856EPDNEW
RGD ID:6837209
Promoter ID:MM_KWN:41801
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000031049,   ENSMUST00000114646,   OTTMUST00000053506
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36531,356,806 - 31,357,612 (+)MPROMDB
RGD ID:6837211
Promoter ID:MM_KWN:41807
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000053533
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36531,377,911 - 31,378,411 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916969 AgrOrtholog
Ensembl Genes ENSMUSG00000013629 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000013773 ENTREZGENE
  ENSMUST00000013773.12 UniProtKB/Swiss-Prot
  ENSMUST00000201182 ENTREZGENE
  ENSMUST00000201182.4 UniProtKB/Swiss-Prot
  ENSMUST00000201838 ENTREZGENE
  ENSMUST00000202795 ENTREZGENE
Gene3D-CATH 1.10.1030.10 UniProtKB/Swiss-Prot
  3.30.1490.20 UniProtKB/Swiss-Prot
  3.40.50.1370 UniProtKB/Swiss-Prot
  3.40.50.1380 UniProtKB/Swiss-Prot
  3.40.50.20 UniProtKB/Swiss-Prot
  3.40.50.880 UniProtKB/Swiss-Prot
  3.50.30.20 UniProtKB/Swiss-Prot
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot
  Metal-dependent hydrolases UniProtKB/Swiss-Prot
InterPro Amidohydro-rel UniProtKB/Swiss-Prot
  Asp/Orn_carbamoyltranf_P-bd UniProtKB/Swiss-Prot
  Asp/Orn_carbamoylTrfase UniProtKB/Swiss-Prot
  Asp/Orn_carbamoylTrfase_sf UniProtKB/Swiss-Prot
  Asp_carbamoyltransf UniProtKB/Swiss-Prot
  Asp_carbamoyltransf_Asp/Orn-bd UniProtKB/Swiss-Prot
  ATP-grasp UniProtKB/Swiss-Prot
  ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot
  CarbamoylP_synth_lsu UniProtKB/Swiss-Prot
  CarbamoylP_synth_lsu_oligo UniProtKB/Swiss-Prot
  CarbamoylP_synth_lsu_oligo_sf UniProtKB/Swiss-Prot
  CarbamoylP_synth_ssu UniProtKB/Swiss-Prot
  CarbamoylP_synth_ssu_N UniProtKB/Swiss-Prot
  CarbP_synth_ssu_N_sf UniProtKB/Swiss-Prot
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/Swiss-Prot
  CbamoylP_synth_lsu_CPSase_dom UniProtKB/Swiss-Prot
  Class_I_gatase-like UniProtKB/Swiss-Prot
  CPSase_GATase1 UniProtKB/Swiss-Prot
  Dihydroorotase_CS UniProtKB/Swiss-Prot
  GATASE UniProtKB/Swiss-Prot
  Metal-dep_hydrolase_composite UniProtKB/Swiss-Prot
  Metal_Hydrolase UniProtKB/Swiss-Prot
  MGS-like_dom UniProtKB/Swiss-Prot
  MGS-like_dom_sf UniProtKB/Swiss-Prot
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:69719 UniProtKB/Swiss-Prot
MGD MGI:1916969 ENTREZGENE
NCBI Gene 69719 ENTREZGENE
PANTHER CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN UniProtKB/Swiss-Prot
  CARBAMOYLTRANSFERASE FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam Amidohydro_1 UniProtKB/Swiss-Prot
  CPSase_L_D2 UniProtKB/Swiss-Prot
  CPSase_L_D3 UniProtKB/Swiss-Prot
  CPSase_sm_chain UniProtKB/Swiss-Prot
  GATase UniProtKB/Swiss-Prot
  MGS UniProtKB/Swiss-Prot
  OTCace UniProtKB/Swiss-Prot
  OTCace_N UniProtKB/Swiss-Prot
PhenoGen Cad PhenoGen
PRINTS AOTCASE UniProtKB/Swiss-Prot
  ATCASE UniProtKB/Swiss-Prot
  CPSASE UniProtKB/Swiss-Prot
  CPSGATASE UniProtKB/Swiss-Prot
PROSITE ATP_GRASP UniProtKB/Swiss-Prot
  CARBAMOYLTRANSFERASE UniProtKB/Swiss-Prot
  CPSASE_1 UniProtKB/Swiss-Prot
  CPSASE_2 UniProtKB/Swiss-Prot
  DIHYDROOROTASE_1 UniProtKB/Swiss-Prot
  DIHYDROOROTASE_2 UniProtKB/Swiss-Prot
  GATASE_TYPE_1 UniProtKB/Swiss-Prot
  MGS UniProtKB/Swiss-Prot
SMART CPSase_L_D3 UniProtKB/Swiss-Prot
  CPSase_sm_chain UniProtKB/Swiss-Prot
  MGS UniProtKB/Swiss-Prot
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot
  SSF48108 UniProtKB/Swiss-Prot
  SSF51338 UniProtKB/Swiss-Prot
  SSF51556 UniProtKB/Swiss-Prot
  SSF52021 UniProtKB/Swiss-Prot
  SSF52317 UniProtKB/Swiss-Prot
  SSF52335 UniProtKB/Swiss-Prot
  SSF52440 UniProtKB/Swiss-Prot
  SSF53671 UniProtKB/Swiss-Prot
UniProt B2RQC6 ENTREZGENE
  B7ZN27 ENTREZGENE
  E9QAI5 ENTREZGENE, UniProtKB/TrEMBL
  E9QAT6 ENTREZGENE, UniProtKB/TrEMBL
  F6S3Z3_MOUSE UniProtKB/TrEMBL
  G3UWN2 ENTREZGENE, UniProtKB/TrEMBL
  O88862_MOUSE UniProtKB/TrEMBL
  PYR1_MOUSE UniProtKB/Swiss-Prot
  Q6P9L1_MOUSE UniProtKB/TrEMBL
  Q7TN13 ENTREZGENE, UniProtKB/TrEMBL
  Q80VF8_MOUSE UniProtKB/TrEMBL
  Q9CWQ9_MOUSE UniProtKB/TrEMBL
UniProt Secondary B7ZN27 UniProtKB/Swiss-Prot