Sppl2a (signal peptide peptidase like 2A) - Rat Genome Database

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Gene: Sppl2a (signal peptide peptidase like 2A) Mus musculus
Analyze
Symbol: Sppl2a
Name: signal peptide peptidase like 2A
RGD ID: 1557460
MGI Page MGI
Description: Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in membrane protein proteolysis and regulation of immune response. Located in late endosome membrane and lysosomal membrane. Is expressed in genitourinary system; skeleton; and thymus primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SPPL2A (signal peptide peptidase like 2A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010106G01Rik; C130089K23Rik; IMP-3; intramembrane protease 3; presenilin-like protein 2; RP23-130L11.5; signal peptide peptidase-like 2A; SPP-like 2A protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,732,311 - 126,775,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,732,311 - 126,775,155 (-)EnsemblGRCm39 Ensembl
GRCm382126,890,391 - 126,933,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,890,391 - 126,933,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv372126,716,127 - 126,758,971 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,585,573 - 126,624,676 (-)NCBIMGSCv36mm8
Celera2128,131,294 - 128,174,122 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell calcium ion homeostasis  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal mature B cell morphology  (IAGP)
abnormal T cell number  (IAGP)
abnormal transitional stage B cell morphology  (IAGP)
arrested B cell differentiation  (IAGP)
decreased activation-induced B cell apoptosis  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased B-2 B cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased follicular B cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgG level  (IEA)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased myeloid dendritic cell number  (IAGP)
decreased Peyer's patch number  (IAGP)
decreased plasmacytoid dendritic cell number  (IAGP)
decreased response to antigen  (IEA)
decreased T cell number  (IAGP)
decreased transitional stage T2 B cell number  (IAGP)
decreased transitional stage T3 B cell number  (IAGP)
increased mature B cell number  (IAGP)
increased plasmacytoid dendritic cell number  (IAGP)
small Peyer's patches  (IAGP)
small spleen  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18287559  
PMID:18799693   PMID:21267068   PMID:21873635   PMID:21896273   PMID:23267013   PMID:23267015   PMID:23267016   PMID:23426979   PMID:24492962   PMID:24872421   PMID:26157172   PMID:26987812  
PMID:28550201   PMID:30127434   PMID:30733281   PMID:30819724   PMID:31146259   PMID:32325033   PMID:33239420   PMID:36047592  


Genomics

Comparative Map Data
Sppl2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,732,311 - 126,775,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,732,311 - 126,775,155 (-)EnsemblGRCm39 Ensembl
GRCm382126,890,391 - 126,933,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,890,391 - 126,933,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv372126,716,127 - 126,758,971 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,585,573 - 126,624,676 (-)NCBIMGSCv36mm8
Celera2128,131,294 - 128,174,122 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
SPPL2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381550,702,266 - 50,765,706 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1550,702,266 - 50,765,948 (-)EnsemblGRCh38hg38GRCh38
GRCh371550,994,463 - 51,057,903 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361548,787,022 - 48,845,202 (-)NCBINCBI36Build 36hg18NCBI36
Celera1527,892,656 - 27,950,835 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1527,830,092 - 27,887,195 (-)NCBIHuRef
CHM1_11551,117,735 - 51,175,916 (-)NCBICHM1_1
T2T-CHM13v2.01548,509,322 - 48,573,674 (-)NCBIT2T-CHM13v2.0
Sppl2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,602,684 - 134,646,752 (-)NCBIGRCr8
mRatBN7.23114,149,337 - 114,193,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,151,069 - 114,193,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,038,543 - 118,079,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,634,069 - 126,675,351 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,294,450 - 124,335,732 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,361,651 - 119,405,453 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,361,655 - 119,405,453 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,885,610 - 125,930,156 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,428,234 - 114,469,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3112,992,568 - 113,033,419 (-)NCBICelera
Cytogenetic Map3q36NCBI
Sppl2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554093,645,555 - 3,670,551 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554093,642,113 - 3,670,779 (+)NCBIChiLan1.0ChiLan1.0
SPPL2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21639,955,464 - 40,013,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11544,135,883 - 44,194,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01529,660,190 - 29,718,477 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11547,997,304 - 48,055,334 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1547,997,304 - 48,055,239 (-)Ensemblpanpan1.1panPan2
SPPL2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,593,834 - 16,638,435 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,596,967 - 16,745,608 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,521,419 - 16,576,375 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03016,739,659 - 16,794,816 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3016,737,324 - 16,794,056 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13016,662,066 - 16,717,186 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03016,780,177 - 16,835,314 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03016,886,809 - 16,941,959 (-)NCBIUU_Cfam_GSD_1.0
Sppl2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864094,850,035 - 94,882,446 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647112,701,014 - 12,729,995 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647112,700,777 - 12,730,509 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPPL2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,067,454 - 121,134,888 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,067,638 - 121,134,896 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21134,517,344 - 134,571,344 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPPL2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12632,574,585 - 32,633,473 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2632,574,612 - 32,634,034 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048108,522,070 - 108,582,241 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sppl2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247319,430,790 - 9,473,839 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,430,702 - 9,469,961 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sppl2a
2155 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1397
Count of miRNA genes:650
Interacting mature miRNAs:834
Transcripts:ENSMUST00000028844, ENSMUST00000125592, ENSMUST00000143700
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126041920135441920Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112024987128173821Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112024987128173821Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114288075132714157Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122207146142532135Mouse

Markers in Region
RH118253  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382126,934,684 - 126,934,848UniSTSGRCm38
MGSCv372126,760,420 - 126,760,584UniSTSGRCm37
Celera2128,175,570 - 128,175,734UniSTS
Cytogenetic Map2F3UniSTS
Whitehead/MRC_RH21576.83UniSTS
Whitehead/MRC_RH21579.08UniSTS
UniSTS:234518  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382126,891,016 - 126,891,119UniSTSGRCm38
MGSCv372126,716,752 - 126,716,855UniSTSGRCm37
Celera2128,131,919 - 128,132,022UniSTS
Cytogenetic Map2F3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_023220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB041547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI853709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000028844   ⟹   ENSMUSP00000028844
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2126,732,311 - 126,775,155 (-)Ensembl
GRCm38.p6 Ensembl2126,890,391 - 126,933,235 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125592
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2126,756,794 - 126,765,608 (-)Ensembl
GRCm38.p6 Ensembl2126,914,874 - 126,923,688 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143700   ⟹   ENSMUSP00000119064
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2126,736,184 - 126,762,265 (-)Ensembl
GRCm38.p6 Ensembl2126,894,264 - 126,920,345 (-)Ensembl
RefSeq Acc Id: NM_023220   ⟹   NP_075709
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,732,311 - 126,775,155 (-)NCBI
GRCm382126,890,391 - 126,933,235 (-)NCBI
MGSCv372126,716,127 - 126,758,971 (-)RGD
Celera2128,131,294 - 128,174,122 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036162455   ⟹   XP_036018348
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,732,311 - 126,775,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162456   ⟹   XP_036018349
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,734,220 - 126,774,955 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162457   ⟹   XP_036018350
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,734,220 - 126,773,808 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940682
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,732,311 - 126,775,706 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940683
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,732,311 - 126,775,706 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940684
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,732,311 - 126,775,706 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940685
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,732,311 - 126,774,955 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940686
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,735,627 - 126,775,706 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940687
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392126,732,311 - 126,774,962 (-)NCBI
Sequence:
RefSeq Acc Id: NP_075709   ⟸   NM_023220
- Peptide Label: precursor
- UniProtKB: Q9JJF9 (UniProtKB/Swiss-Prot),   A2AI51 (UniProtKB/Swiss-Prot),   Q8R354 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000119064   ⟸   ENSMUST00000143700
Ensembl Acc Id: ENSMUSP00000028844   ⟸   ENSMUST00000028844
RefSeq Acc Id: XP_036018348   ⟸   XM_036162455
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036018349   ⟸   XM_036162456
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036018350   ⟸   XM_036162457
- Peptide Label: isoform X2
Protein Domains
PA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJF9-F1-model_v2 AlphaFold Q9JJF9 1-523 view protein structure

Promoters
RGD ID:6830558
Promoter ID:MM_KWN:31568
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver
Transcripts:UC008MEJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362126,716,781 - 126,720,582 (-)MPROMDB
RGD ID:6832348
Promoter ID:MM_KWN:31569
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000038174
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362126,745,981 - 126,746,632 (-)MPROMDB
RGD ID:6832349
Promoter ID:MM_KWN:31570
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:OTTMUST00000037954
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362126,748,976 - 126,750,377 (-)MPROMDB
RGD ID:6830566
Promoter ID:MM_KWN:31571
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000110397,   OTTMUST00000037953
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362126,758,776 - 126,759,882 (-)MPROMDB
RGD ID:6878616
Promoter ID:EPDNEW_M2759
Type:initiation region
Name:Sppl2a_1
Description:Mus musculus signal peptide peptidase like 2A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2760  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382126,933,035 - 126,933,095EPDNEW
RGD ID:6878618
Promoter ID:EPDNEW_M2760
Type:initiation region
Name:Sppl2a_2
Description:Mus musculus signal peptide peptidase like 2A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2759  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382126,933,332 - 126,933,392EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913802 AgrOrtholog
Ensembl Genes ENSMUSG00000027366 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028844 ENTREZGENE
  ENSMUST00000028844.11 UniProtKB/Swiss-Prot
  ENSMUST00000143700.2 UniProtKB/TrEMBL
Gene3D-CATH 3.50.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_A22B_SPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Preselin/SPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66552 UniProtKB/Swiss-Prot
MGD MGI:1913802 ENTREZGENE
NCBI Gene 66552 ENTREZGENE
PANTHER PTHR12174 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12174:SF34 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Peptidase_A22B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF02225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sppl2a PhenoGen
SMART PSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PA domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AI51 ENTREZGENE
  F6RJQ8_MOUSE UniProtKB/TrEMBL
  Q8R354 ENTREZGENE
  Q9CPY9_MOUSE UniProtKB/TrEMBL
  Q9CVG0_MOUSE UniProtKB/TrEMBL
  Q9JJF9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2AI51 UniProtKB/Swiss-Prot
  Q8R354 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-15 Sppl2a  signal peptide peptidase like 2A  2010106G01Rik  RIKEN cDNA 2010106G01 gene  Symbol and/or name change 5135510 APPROVED