Rc3h1 (RING CCCH (C3H) domains 1) - Rat Genome Database

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Gene: Rc3h1 (RING CCCH (C3H) domains 1) Mus musculus
Analyze
Symbol: Rc3h1
Name: RING CCCH (C3H) domains 1
RGD ID: 1557447
MGI Page MGI
Description: Enables RNA binding activity and zinc ion binding activity. Involved in several processes, including P-body assembly; negative regulation of lymphocyte activation; and regulation of RNA metabolic process. Acts upstream of or within several processes, including T cell activation; hematopoietic or lymphoid organ development; and lymphocyte homeostasis. Located in P-body and cytoplasmic stress granule. Used to study peripheral T-cell lymphoma and systemic lupus erythematosus. Orthologous to human RC3H1 (ring finger and CCCH-type domains 1); INTERACTS WITH (1->4)-beta-D-glucan; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
Previously known as: 5730557L09Rik; Gm551; mKIAA2025; N28103; probable E3 ubiquitin-protein ligase Roquin; protein Sanroque; RIKEN cDNA 5730557L09 gene; RING finger and C3H zinc finger protein 1; RING finger and CCCH-type zinc finger domain-containing protein 1; ro; roquin; roquin-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,733,981 - 160,802,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,733,988 - 160,802,548 (+)EnsemblGRCm39 Ensembl
GRCm381160,906,411 - 160,974,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,906,418 - 160,974,978 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,836,542 - 162,905,107 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,743,147 - 162,804,531 (+)NCBIMGSCv36mm8
Celera1163,345,875 - 163,414,502 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA)
cytoplasmic stress granule  (IBA,IDA)
P-body  (IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal B cell number  (IAGP)
abnormal effector T cell morphology  (IAGP)
abnormal germinal center B cell physiology  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal intraepithelial T cell number  (IAGP)
abnormal lung development  (IAGP)
abnormal lymph node germinal center morphology  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal spleen B cell follicle morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen periarteriolar lymphoid sheath morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T follicular helper cell physiology  (IAGP)
abnormal thymus development  (IAGP)
abnormal vertebral column morphology  (IAGP)
anemia  (IAGP)
cecum inflammation  (IAGP)
chronic liver inflammation  (IAGP)
colitis  (IAGP)
crypts of Lieberkuhn abscesses  (IAGP)
curly tail  (IAGP)
decreased B cell number  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG3 level  (IAGP)
decreased immature B cell number  (IAGP)
decreased lymphoma incidence  (IAGP)
decreased T cell number  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
glomerulonephritis  (IAGP)
granulomatous inflammation  (IAGP)
hepatic necrosis  (IAGP)
ileum inflammation  (IAGP)
increased activated T cell number  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased B cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased eosinophil cell number  (IAGP)
increased germinal center B cell number  (IAGP)
increased IgG level  (IAGP)
increased IgG2b level  (IAGP)
increased inflammatory response  (IAGP)
increased macrophage cell number  (IAGP)
increased regulatory T cell number  (IAGP)
increased spleen weight  (IAGP)
increased splenocyte number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell proliferation  (IAGP)
increased T follicular helper cell number  (IAGP)
intestinal inflammation  (IAGP)
intestinal ulcer  (IAGP)
kidney inflammation  (IAGP)
liver inflammation  (IAGP)
lymphoid hyperplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
primary atelectasis  (IAGP)
small intestinal inflammation  (IAGP)
spleen hyperplasia  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Rc3h1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,733,981 - 160,802,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,733,988 - 160,802,548 (+)EnsemblGRCm39 Ensembl
GRCm381160,906,411 - 160,974,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,906,418 - 160,974,978 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,836,542 - 162,905,107 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,743,147 - 162,804,531 (+)NCBIMGSCv36mm8
Celera1163,345,875 - 163,414,502 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
RC3H1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,931,084 - 174,022,357 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,931,084 - 174,022,357 (-)EnsemblGRCh38hg38GRCh38
GRCh371173,900,222 - 173,991,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,166,975 - 172,228,833 (-)NCBINCBI36Build 36hg18NCBI36
Celera1147,009,820 - 147,071,680 (-)NCBICelera
Cytogenetic Map1q25.1NCBI
HuRef1145,125,474 - 145,187,339 (-)NCBIHuRef
CHM1_11175,322,816 - 175,384,658 (-)NCBICHM1_1
T2T-CHM13v2.01173,289,302 - 173,380,330 (-)NCBIT2T-CHM13v2.0
Rc3h1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81375,707,098 - 75,779,114 (+)NCBIGRCr8
mRatBN7.21373,174,075 - 73,245,762 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1373,173,946 - 73,238,839 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01378,723,028 - 78,794,663 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1378,722,763 - 78,789,266 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01383,619,665 - 83,689,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41376,493,343 - 76,530,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1372,962,695 - 73,034,187 (+)NCBICelera
Cytogenetic Map13q22NCBI
Rc3h1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540614,053,122 - 14,123,029 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540614,053,122 - 14,123,023 (-)NCBIChiLan1.0ChiLan1.0
RC3H1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2175,698,811 - 75,794,508 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1175,372,872 - 75,468,532 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01149,454,748 - 149,539,566 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11153,153,048 - 153,213,402 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1153,160,661 - 153,213,402 (-)Ensemblpanpan1.1panPan2
RC3H1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1725,265,836 - 25,312,417 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl725,233,235 - 25,305,174 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha724,766,202 - 24,845,548 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0724,983,310 - 25,063,044 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl724,983,031 - 25,055,836 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1724,903,636 - 24,982,946 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0724,985,200 - 25,064,573 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0725,130,410 - 25,209,772 (+)NCBIUU_Cfam_GSD_1.0
Rc3h1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,072,540 - 96,127,125 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648113,919,257 - 13,966,677 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648113,919,006 - 13,973,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RC3H1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9116,208,799 - 116,292,381 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19116,204,807 - 116,292,455 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29127,839,470 - 127,927,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103230557
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12555,167,418 - 55,258,964 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2555,167,077 - 55,279,088 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236664807,917 - 55,965 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rc3h1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247717,837,547 - 7,948,217 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rc3h1
1651 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2295
Count of miRNA genes:817
Interacting mature miRNAs:1100
Transcripts:ENSMUST00000035911, ENSMUST00000161609, ENSMUST00000161708
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
1301818Ap1q_malcohol preference 1 QTL (mouse)Not determined1146908199167586222Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
4141075Bmd1a_mbone mineral density 1a (mouse)Not determined1155837814162145325Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
4142149Ctex_mCtla4 expression QTL (mouse)Not determined1153557406175468938Mouse
10449381Actre11_mactivity response to ethanol 11 (mouse)1160284665161840065Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
12910521Scgq1_mspontaneous crescentic glomerulonephritis QTL 1 (mouse)1156602037176262693Mouse
12910522Scgq2_mspontaneous crescentic glomerulonephritis QTL 2 (mouse)1147125258171632257Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
13452397Leusq4_mleucocytosis susceptibility QTL 4 (mouse)1156602037170803640Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
13452393Ity3b_mimmunity to S. typhimurium 3b (mouse)1156497439172097436Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
13452394Leusq1_mleucocytosis susceptibility QTL 1 (mouse)1156602037168186402Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301232Hcs7_mhepatocarcinogenesis susceptibility 7 (mouse)Not determined1156602037168186402Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
1357567Nidd3k_mNidd3 on KK-A<y> (mouse)Not determined7147125258169038913Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse

Markers in Region
18.MMHAP50FLF3.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381160,967,067 - 160,967,224UniSTSGRCm38
MGSCv371162,897,198 - 162,897,355UniSTSGRCm37
Celera1163,406,587 - 163,406,744UniSTS
Cytogenetic Map1H2.1UniSTS
Whitehead_YAC1 UniSTS
RH125050  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381160,951,796 - 160,951,926UniSTSGRCm38
MGSCv371162,881,927 - 162,882,057UniSTSGRCm37
Celera1163,391,259 - 163,391,389UniSTS
Cytogenetic Map1H2.1UniSTS
UniSTS:234249  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381160,973,625 - 160,973,880UniSTSGRCm38
MGSCv371162,903,756 - 162,904,011UniSTSGRCm37
Celera1163,413,151 - 163,413,406UniSTS
Cytogenetic Map1H2.1UniSTS
AA997206  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381160,967,886 - 160,968,035UniSTSGRCm38
MGSCv371162,898,017 - 162,898,166UniSTSGRCm37
Celera1163,407,406 - 163,407,555UniSTS
Cytogenetic Map1H2.1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001024952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000035911   ⟹   ENSMUSP00000037178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,757,594 - 160,795,387 (+)Ensembl
GRCm38.p6 Ensembl1160,930,024 - 160,967,817 (+)Ensembl
Ensembl Acc Id: ENSMUST00000161609   ⟹   ENSMUSP00000124871
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,733,988 - 160,802,548 (+)Ensembl
GRCm38.p6 Ensembl1160,906,418 - 160,974,978 (+)Ensembl
Ensembl Acc Id: ENSMUST00000161708
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,778,547 - 160,779,701 (+)Ensembl
GRCm38.p6 Ensembl1160,950,977 - 160,952,131 (+)Ensembl
Ensembl Acc Id: ENSMUST00000239200   ⟹   ENSMUSP00000159278
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,733,988 - 160,802,548 (+)Ensembl
GRCm38.p6 Ensembl1160,906,418 - 160,974,978 (+)Ensembl
RefSeq Acc Id: NM_001024952   ⟹   NP_001020123
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391160,733,981 - 160,802,546 (+)NCBI
GRCm381160,906,411 - 160,974,976 (+)ENTREZGENE
MGSCv371162,836,542 - 162,905,107 (+)RGD
Celera1163,345,875 - 163,414,502 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
Ensembl Protein ENSMUSP00000037178.5
  ENSMUSP00000124871.2
  ENSMUSP00000159278.2
RefSeq Acc Id: NP_001020123   ⟸   NM_001024952
- Sequence:
Ensembl Acc Id: ENSMUSP00000159278   ⟸   ENSMUST00000239200
Ensembl Acc Id: ENSMUSP00000037178   ⟸   ENSMUST00000035911
Ensembl Acc Id: ENSMUSP00000124871   ⟸   ENSMUST00000161609
Protein Domains
C3H1-type   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4VGL6-F1-model_v2 AlphaFold Q4VGL6 1-1130 view protein structure

Promoters
RGD ID:6875420
Promoter ID:EPDNEW_M1161
Type:initiation region
Name:Rc3h1_1
Description:Mus musculus RING CCCH domains 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381160,906,411 - 160,906,471EPDNEW
RGD ID:6818376
Promoter ID:MM_KWN:2601
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001024952
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361162,836,251 - 162,836,751 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685397 AgrOrtholog
Ensembl Genes ENSMUSG00000040423 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035911.5 UniProtKB/TrEMBL
  ENSMUST00000161609.8 UniProtKB/Swiss-Prot
  ENSMUST00000239200.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zinc finger, CCCH-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ROQ_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Roquin_1_2-like_ROQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Roquin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:381305 UniProtKB/Swiss-Prot
MGD MGI:2685397 ENTREZGENE
NCBI Gene Rc3h1 ENTREZGENE
PANTHER PTHR13139:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ROQ_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Roquin_1_2-like_ROQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-RING_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rc3h1 PhenoGen
PROSITE ZF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A668KLW6_MOUSE UniProtKB/TrEMBL
  H7BX02_MOUSE UniProtKB/TrEMBL
  Q3TS82_MOUSE UniProtKB/TrEMBL
  Q3UT88_MOUSE UniProtKB/TrEMBL
  RC3H1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B2RS13 UniProtKB/Swiss-Prot
  Q69Z31 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Rc3h1  RING CCCH (C3H) domains 1  5730557L09Rik  RIKEN cDNA 5730557L09 gene  Data merged from RGD:1617425 737654 PROVISIONAL