Tmem120a (transmembrane protein 120A) - Rat Genome Database

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Gene: Tmem120a (transmembrane protein 120A) Mus musculus
Analyze
Symbol: Tmem120a
Name: transmembrane protein 120A
RGD ID: 1557241
MGI Page MGI
Description: Enables monoatomic ion channel activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of pain; fat cell differentiation; and protein complex oligomerization. Located in plasma membrane. Is expressed in central nervous system and ganglia. Orthologous to human TMEM120A (transmembrane protein 120A).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2010310D06Rik; ion channel TACAN; Tmp; Tmpit; transmembrane protein induced by tumor necrosis factor alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,764,344 - 135,773,026 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,764,339 - 135,773,302 (-)EnsemblGRCm39 Ensembl
GRCm385135,735,490 - 135,744,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,735,485 - 135,744,448 (-)EnsemblGRCm38mm10GRCm38
MGSCv375136,211,360 - 136,220,042 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,020,117 - 136,028,799 (-)NCBIMGSCv36mm8
Celera5132,742,669 - 132,751,351 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
5. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:15782199   PMID:16141072   PMID:16141073   PMID:20091084   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:26024229   PMID:27113764   PMID:32084332   PMID:32554809   PMID:34374644   PMID:34409941   PMID:35013224   PMID:35027552   PMID:35819364  


Genomics

Comparative Map Data
Tmem120a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,764,344 - 135,773,026 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,764,339 - 135,773,302 (-)EnsemblGRCm39 Ensembl
GRCm385135,735,490 - 135,744,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,735,485 - 135,744,448 (-)EnsemblGRCm38mm10GRCm38
MGSCv375136,211,360 - 136,220,042 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,020,117 - 136,028,799 (-)NCBIMGSCv36mm8
Celera5132,742,669 - 132,751,351 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.38NCBI
TMEM120A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38775,986,831 - 75,994,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl775,986,831 - 75,994,656 (-)EnsemblGRCh38hg38GRCh38
GRCh37775,616,149 - 75,623,913 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,454,243 - 75,461,889 (-)NCBINCBI36Build 36hg18NCBI36
Celera770,484,699 - 70,492,531 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,702,967 - 70,710,827 (-)NCBIHuRef
CHM1_1775,546,225 - 75,554,037 (-)NCBICHM1_1
T2T-CHM13v2.0777,274,487 - 77,282,162 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2774,949,219 - 74,957,056 (-)NCBI
Tmem120a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,578,859 - 26,587,524 (+)NCBIGRCr8
mRatBN7.21220,942,243 - 20,950,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,942,439 - 20,990,316 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,083,966 - 22,092,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,696,400 - 22,705,078 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,762,859 - 21,771,533 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,989,596 - 23,998,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,989,596 - 23,998,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,986,848 - 25,995,509 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,069,814 - 22,078,475 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,057,077 - 22,065,739 (+)NCBI
Celera1222,704,874 - 22,713,535 (+)NCBICelera
Cytogenetic Map12q12NCBI
Tmem120a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,747,621 - 14,754,270 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,748,666 - 14,754,270 (-)NCBIChiLan1.0ChiLan1.0
TMEM120A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2693,960,294 - 93,968,798 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17142,224,932 - 142,233,436 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0768,026,666 - 68,034,896 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,437,650 - 82,444,882 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,437,650 - 82,444,882 (-)Ensemblpanpan1.1panPan2
TMEM120A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,316,257 - 7,321,992 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,316,477 - 7,389,842 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha69,013,030 - 9,019,258 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.067,137,088 - 7,143,313 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,137,263 - 7,210,023 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,106,460 - 7,112,688 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,069,926 - 7,076,153 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,233,166 - 7,239,394 (-)NCBIUU_Cfam_GSD_1.0
Tmem120a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,760,568 - 131,766,176 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,270,609 - 2,275,679 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,270,444 - 2,275,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM120A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,206,630 - 10,212,610 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,206,581 - 10,212,612 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMEM120A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,230,961 - 10,238,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,231,152 - 10,238,226 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,183,818 - 6,191,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem120a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,790,876 - 14,796,635 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,790,876 - 14,796,673 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:768
Count of miRNA genes:455
Interacting mature miRNAs:525
Transcripts:ENSMUST00000043378, ENSMUST00000127156, ENSMUST00000141779, ENSMUST00000153399
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse

Markers in Region
D17571  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385135,735,000 - 135,735,128UniSTSGRCm38
MGSCv375136,210,870 - 136,210,998UniSTSGRCm37
Celera5132,742,179 - 132,742,307UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Whitehead/MRC_RH51642.87UniSTS
Whitehead/MRC_RH51643.61UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000043378   ⟹   ENSMUSP00000045252
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,764,339 - 135,773,302 (-)Ensembl
GRCm38.p6 Ensembl5135,735,485 - 135,744,448 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127156
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,765,109 - 135,771,253 (-)Ensembl
GRCm38.p6 Ensembl5135,736,255 - 135,742,399 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141779
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,764,358 - 135,765,444 (-)Ensembl
GRCm38.p6 Ensembl5135,735,504 - 135,736,590 (-)Ensembl
Ensembl Acc Id: ENSMUST00000153399   ⟹   ENSMUSP00000120834
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,766,062 - 135,773,062 (-)Ensembl
GRCm38.p6 Ensembl5135,737,208 - 135,744,208 (-)Ensembl
Ensembl Acc Id: ENSMUST00000199952
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,764,392 - 135,766,090 (-)Ensembl
GRCm38.p6 Ensembl5135,735,538 - 135,737,236 (-)Ensembl
RefSeq Acc Id: NM_172541   ⟹   NP_766129
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395135,764,344 - 135,773,026 (-)NCBI
GRCm385135,735,490 - 135,744,172 (-)ENTREZGENE
MGSCv375136,211,360 - 136,220,042 (-)RGD
Celera5132,742,669 - 132,751,351 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_766129   ⟸   NM_172541
- UniProtKB: Q8BWP7 (UniProtKB/Swiss-Prot),   Q8C1E7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000120834   ⟸   ENSMUST00000153399
Ensembl Acc Id: ENSMUSP00000045252   ⟸   ENSMUST00000043378

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C1E7-F1-model_v2 AlphaFold Q8C1E7 1-343 view protein structure

Promoters
RGD ID:6888332
Promoter ID:EPDNEW_M7617
Type:initiation region
Name:Tmem120a_1
Description:Mus musculus transmembrane protein 120A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385135,744,251 - 135,744,311EPDNEW
RGD ID:6838508
Promoter ID:MM_KWN:44373
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000073460
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365136,212,031 - 136,213,387 (-)MPROMDB
RGD ID:6838507
Promoter ID:MM_KWN:44374
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6
Transcripts:OTTMUST00000073459
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365136,218,591 - 136,219,172 (-)MPROMDB
RGD ID:6838501
Promoter ID:MM_KWN:44375
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000073443,   OTTMUST00000073458
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365136,219,849 - 136,220,349 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2686991 AgrOrtholog
Ensembl Genes ENSMUSG00000039886 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000043378 ENTREZGENE
  ENSMUST00000043378.9 UniProtKB/Swiss-Prot
  ENSMUST00000153399.2 UniProtKB/TrEMBL
InterPro TMPIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:215210 UniProtKB/Swiss-Prot
MGD MGI:2686991 ENTREZGENE
NCBI Gene 215210 ENTREZGENE
PANTHER ION CHANNEL TACAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21433 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TMPIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem120a PhenoGen
UniProt D3Z0U3_MOUSE UniProtKB/TrEMBL
  Q8BWP7 ENTREZGENE
  Q8C1E7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8BWP7 UniProtKB/Swiss-Prot