Bsx (brain specific homeobox) - Rat Genome Database

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Gene: Bsx (brain specific homeobox) Mus musculus
Analyze
Symbol: Bsx
Name: brain specific homeobox
RGD ID: 1557168
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within eating behavior; locomotory behavior; and mammary gland involution. Located in nucleus. Part of transcription regulator complex. Is expressed in brain; metanephros; and renal vasculature. Orthologous to human BSX (brain specific homeobox).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: brain-specific homeobox protein homolog; Bsx1; Bsx1a; Bsx1b; MGC129478; MGC129479
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,782,994 - 40,790,258 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl940,785,423 - 40,791,353 (+)EnsemblGRCm39 Ensembl
GRCm38940,874,127 - 40,878,962 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,874,127 - 40,880,057 (+)EnsemblGRCm38mm10GRCm38
MGSCv37940,682,210 - 40,686,055 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36940,625,196 - 40,629,041 (+)NCBIMGSCv36mm8
Celera938,108,339 - 38,112,231 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14678827   PMID:16602821   PMID:17353277   PMID:17485440   PMID:17550780   PMID:17944879   PMID:18287559   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23276958  
PMID:23671185   PMID:24952961   PMID:25864637   PMID:27133129   PMID:27209204   PMID:27578785   PMID:29795232   PMID:30063881   PMID:36302841  


Genomics

Comparative Map Data
Bsx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,782,994 - 40,790,258 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl940,785,423 - 40,791,353 (+)EnsemblGRCm39 Ensembl
GRCm38940,874,127 - 40,878,962 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,874,127 - 40,880,057 (+)EnsemblGRCm38mm10GRCm38
MGSCv37940,682,210 - 40,686,055 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36940,625,196 - 40,629,041 (+)NCBIMGSCv36mm8
Celera938,108,339 - 38,112,231 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.65NCBI
BSX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811122,977,570 - 122,981,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11122,977,570 - 122,981,834 (-)EnsemblGRCh38hg38GRCh38
GRCh3711122,848,278 - 122,852,542 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,353,567 - 122,357,589 (-)NCBINCBI36Build 36hg18NCBI36
Celera11120,007,843 - 120,011,864 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11118,791,194 - 118,795,215 (-)NCBIHuRef
CHM1_111122,734,114 - 122,738,138 (-)NCBICHM1_1
T2T-CHM13v2.011123,005,290 - 123,009,556 (-)NCBIT2T-CHM13v2.0
Bsx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,151,204 - 50,154,960 (+)NCBIGRCr8
mRatBN7.2841,254,105 - 41,257,861 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,254,105 - 41,257,861 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx846,753,980 - 46,757,730 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0845,032,569 - 45,036,319 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0842,900,173 - 42,903,923 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0845,061,670 - 45,065,430 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl845,061,670 - 45,065,430 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0843,548,484 - 43,552,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,855,822 - 43,860,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera840,853,382 - 40,857,138 (+)NCBICelera
Cytogenetic Map8q22NCBI
Bsx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541223,797,630 - 23,801,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541223,796,973 - 23,801,479 (-)NCBIChiLan1.0ChiLan1.0
BSX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29123,675,988 - 123,683,677 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111124,780,810 - 124,788,435 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011117,807,856 - 117,815,571 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111121,731,049 - 121,735,101 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11121,731,049 - 121,735,101 (-)Ensemblpanpan1.1panPan2
BSX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1511,365,635 - 11,369,575 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl511,365,805 - 11,369,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha511,421,482 - 11,425,252 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0511,316,513 - 11,320,283 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl511,316,513 - 11,320,283 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1511,419,843 - 11,423,613 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0511,358,923 - 11,362,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0511,396,771 - 11,400,541 (+)NCBIUU_Cfam_GSD_1.0
BSX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,905,428 - 49,909,226 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,873,031 - 49,910,581 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2955,249,305 - 55,254,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BSX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,366,225 - 114,373,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,368,217 - 114,372,282 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604311,756,497 - 11,762,214 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bsx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248802,131,722 - 2,135,685 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248802,128,744 - 2,137,465 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bsx
286 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:202
Interacting mature miRNAs:223
Transcripts:ENSMUST00000067375
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92850333341799326Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93715336244251323Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93410461942764866Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse


Sequence


Ensembl Acc Id: ENSMUST00000067375   ⟹   ENSMUSP00000068057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl940,785,423 - 40,791,353 (+)Ensembl
GRCm38.p6 Ensembl940,874,127 - 40,880,057 (+)Ensembl
RefSeq Acc Id: NM_178245   ⟹   NP_839976
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39940,785,423 - 40,789,268 (+)NCBI
GRCm38940,874,127 - 40,877,972 (+)NCBI
MGSCv37940,682,210 - 40,686,055 (+)RGD
Celera938,108,339 - 38,112,231 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510306   ⟹   XP_006510369
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39940,785,696 - 40,790,258 (+)NCBI
GRCm38940,874,400 - 40,878,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154982   ⟹   XP_036010875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39940,782,994 - 40,790,258 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_839976 (Get FASTA)   NCBI Sequence Viewer  
  XP_006510369 (Get FASTA)   NCBI Sequence Viewer  
  XP_036010875 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI04387 (Get FASTA)   NCBI Sequence Viewer  
  AAI04388 (Get FASTA)   NCBI Sequence Viewer  
  AAO84023 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000068057
  ENSMUSP00000068057.4
GenBank Protein Q810B3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_839976   ⟸   NM_178245
- UniProtKB: Q3SXB1 (UniProtKB/Swiss-Prot),   Q810B3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006510369   ⟸   XM_006510306
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000068057   ⟸   ENSMUST00000067375
RefSeq Acc Id: XP_036010875   ⟸   XM_036154982
- Peptide Label: isoform X1
- UniProtKB: Q810B3 (UniProtKB/Swiss-Prot),   Q3SXB1 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q810B3-F1-model_v2 AlphaFold Q810B3 1-232 view protein structure

Promoters
RGD ID:8669296
Promoter ID:EPDNEW_M12679
Type:multiple initiation site
Name:Bsx_1
Description:Mus musculus brain specific homeobox , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38940,874,084 - 40,874,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2669849 AgrOrtholog
Ensembl Genes ENSMUSG00000054360 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000067375 ENTREZGENE
  ENSMUST00000067375.5 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
  Homeobox_TF UniProtKB/Swiss-Prot
KEGG Report mmu:244813 UniProtKB/Swiss-Prot
MGD MGI:2669849 ENTREZGENE
NCBI Gene 244813 ENTREZGENE
PANTHER HOMEO BOX HB9 LIKE A-RELATED UniProtKB/Swiss-Prot
  HOMEOBOX PROTEIN CEH-62 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Bsx PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt BSH_MOUSE UniProtKB/Swiss-Prot
  Q3SXB1 ENTREZGENE
  Q810B3 ENTREZGENE
UniProt Secondary Q3SXB1 UniProtKB/Swiss-Prot