Tmem70 (transmembrane protein 70) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tmem70 (transmembrane protein 70) Mus musculus
Analyze
Symbol: Tmem70
Name: transmembrane protein 70
RGD ID: 1557127
MGI Page MGI
Description: Predicted to enable mitochondrial proton-transporting ATP synthase complex binding activity. Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrion. Is expressed in several structures, including brain; gut; nasal cavity epithelium; orbito-sphenoid; and urinary system. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 2. Orthologous to human TMEM70 (transmembrane protein 70).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110020A09Rik; 2210416J16Rik; transmembrane protein 70, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,735,415 - 16,748,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,735,431 - 16,748,499 (+)EnsemblGRCm39 Ensembl
GRCm38116,665,191 - 16,678,275 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,665,207 - 16,678,275 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,655,272 - 16,668,356 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,650,432 - 16,663,487 (+)NCBIMGSCv36mm8
Celera116,597,042 - 16,611,752 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18614015   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:28173120   PMID:30550785   PMID:31652072  


Genomics

Comparative Map Data
Tmem70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,735,415 - 16,748,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,735,431 - 16,748,499 (+)EnsemblGRCm39 Ensembl
GRCm38116,665,191 - 16,678,275 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,665,207 - 16,678,275 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,655,272 - 16,668,356 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,650,432 - 16,663,487 (+)NCBIMGSCv36mm8
Celera116,597,042 - 16,611,752 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.1NCBI
TMEM70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38873,976,195 - 73,982,783 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl873,972,437 - 73,982,783 (+)EnsemblGRCh38hg38GRCh38
GRCh37874,888,430 - 74,895,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36875,050,984 - 75,057,570 (+)NCBINCBI36Build 36hg18NCBI36
Celera870,886,069 - 70,892,868 (+)NCBICelera
Cytogenetic Map8q21.11NCBI
HuRef870,379,298 - 70,385,926 (+)NCBIHuRef
CHM1_1874,940,306 - 74,946,947 (+)NCBICHM1_1
T2T-CHM13v2.0874,405,457 - 74,412,045 (+)NCBIT2T-CHM13v2.0
Tmem70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.252,637,102 - 2,654,729 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl52,637,102 - 2,654,729 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx54,755,660 - 4,773,292 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.056,394,524 - 6,412,156 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.056,093,125 - 6,110,745 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.052,019,852 - 2,037,038 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl52,019,852 - 2,037,038 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.052,019,520 - 2,036,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.451,983,166 - 2,007,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera52,258,902 - 2,277,040 (-)NCBICelera
Cytogenetic Map5q11NCBI
Tmem70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554446,393,023 - 6,397,115 (-)NCBIChiLan1.0ChiLan1.0
TMEM70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1865,346,042 - 65,352,613 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0870,509,897 - 70,515,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1872,154,872 - 72,161,500 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl872,154,872 - 72,163,239 (+)Ensemblpanpan1.1panPan2
TMEM70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12922,475,961 - 22,487,920 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2922,478,941 - 22,487,741 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2922,741,251 - 22,752,935 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02922,586,852 - 22,598,751 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12922,645,846 - 22,657,537 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02922,680,708 - 22,692,691 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02922,964,370 - 22,976,052 (+)NCBIUU_Cfam_GSD_1.0
Tmem70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530356,798,273 - 56,811,914 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366482,636,667 - 2,650,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl461,958,605 - 61,966,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1461,958,605 - 61,966,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2467,664,533 - 67,671,743 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1869,576,786 - 69,582,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl869,576,808 - 69,583,308 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603971,789,274 - 71,794,974 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474417,259,245 - 17,266,115 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474417,256,749 - 17,265,507 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem70
232 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:665
Count of miRNA genes:349
Interacting mature miRNAs:384
Transcripts:ENSMUST00000065373, ENSMUST00000176451, ENSMUST00000177501, ENSMUST00000177532
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412226Alpq4_malcohol preference QTL 4 (mouse)Not determined1122976684Mouse
1301891Alcp25_malcohol preference locus 25 (mouse)Not determined1125203185Mouse
1300834Cia20_mcollagen induced arthritis 20 (mouse)Not determined1125203185Mouse
1301482Morph1_mmorphine antinociception 1 (mouse)Not determined1130367747Mouse
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1288219436882352Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1288219436882352Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
15092044Wtgrme1_mweek ten growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092046Wngrme1_mweek nine growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092048Wsigrme1_mweek six growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092050Wsegrme1_mweek seven growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092051Wegrme1_mweek eight growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092055Lgrme1_mlate growth rate, maternal effect 1 (mouse)1328014237782236Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1394162037941887Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse
4141646Fecq3_mfecundity QTL 3 (mouse)Not determined11291692026517685Mouse

Markers in Region
RH126878  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38116,677,885 - 16,678,127UniSTSGRCm38
MGSCv37116,667,966 - 16,668,208UniSTSGRCm37
Celera116,611,362 - 16,611,604UniSTS
Cytogenetic Map1A3UniSTS
Whitehead/MRC_RH1280.25UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000065373   ⟹   ENSMUSP00000070497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,735,434 - 16,748,499 (+)Ensembl
GRCm38.p6 Ensembl116,665,210 - 16,678,275 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,735,460 - 16,736,035 (+)Ensembl
GRCm38.p6 Ensembl116,665,236 - 16,665,811 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177501   ⟹   ENSMUSP00000135483
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,735,431 - 16,748,419 (+)Ensembl
GRCm38.p6 Ensembl116,665,207 - 16,678,195 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177532
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,735,434 - 16,747,439 (+)Ensembl
GRCm38.p6 Ensembl116,665,210 - 16,677,215 (+)Ensembl
RefSeq Acc Id: NM_026392   ⟹   NP_080668
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,735,415 - 16,748,499 (+)NCBI
GRCm38116,665,191 - 16,678,275 (+)ENTREZGENE
MGSCv37116,655,272 - 16,668,356 (+)RGD
Celera116,597,042 - 16,611,752 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_027415   ⟹   NP_081691
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,735,415 - 16,748,499 (+)NCBI
GRCm38116,665,191 - 16,678,275 (+)ENTREZGENE
MGSCv37116,655,272 - 16,668,356 (+)RGD
Celera116,597,042 - 16,611,752 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036153613   ⟹   XP_036009506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,736,574 - 16,748,501 (+)NCBI
Sequence:
RefSeq Acc Id: NP_080668   ⟸   NM_026392
- Peptide Label: isoform 2
- UniProtKB: A0A0R4J272 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_081691   ⟸   NM_027415
- Peptide Label: isoform 1
- UniProtKB: Q9CQY4 (UniProtKB/Swiss-Prot),   Q3UAP8 (UniProtKB/Swiss-Prot),   Q3TKB6 (UniProtKB/Swiss-Prot),   Q9D7R8 (UniProtKB/Swiss-Prot),   Q921N7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000070497   ⟸   ENSMUST00000065373
RefSeq Acc Id: ENSMUSP00000135483   ⟸   ENSMUST00000177501
RefSeq Acc Id: XP_036009506   ⟸   XM_036153613
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q921N7-F1-model_v2 AlphaFold Q921N7 1-253 view protein structure

Promoters
RGD ID:6818611
Promoter ID:MM_KWN:192
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026392,   NM_027415
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36116,655,074 - 16,655,574 (+)MPROMDB
RGD ID:6873234
Promoter ID:EPDNEW_M68
Type:initiation region
Name:Tmem70_1
Description:Mus musculus transmembrane protein 70 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38116,665,249 - 16,665,309EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915068 AgrOrtholog
Ensembl Genes ENSMUSG00000025940 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000065373 ENTREZGENE
  ENSMUST00000065373.6 UniProtKB/Swiss-Prot
  ENSMUST00000177501 ENTREZGENE
  ENSMUST00000177501.2 UniProtKB/TrEMBL
InterPro TMEM70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TMEM70/TMEM186/TMEM223 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:70397 UniProtKB/Swiss-Prot
MGD MGI:1915068 ENTREZGENE
NCBI Gene 70397 ENTREZGENE
PANTHER PTHR13281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TMEM70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem70 PhenoGen
UniProt A0A0R4J272 ENTREZGENE, UniProtKB/TrEMBL
  Q3TKB6 ENTREZGENE
  Q3UAP8 ENTREZGENE
  Q921N7 ENTREZGENE
  Q9CQY4 ENTREZGENE
  Q9D7R8 ENTREZGENE
  TMM70_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3TKB6 UniProtKB/Swiss-Prot
  Q3UAP8 UniProtKB/Swiss-Prot
  Q9CQY4 UniProtKB/Swiss-Prot
  Q9D7R8 UniProtKB/Swiss-Prot