Srgap3 (SLIT-ROBO Rho GTPase activating protein 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Srgap3 (SLIT-ROBO Rho GTPase activating protein 3) Mus musculus
Analyze
Symbol: Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
RGD ID: 1557097
MGI Page MGI
Description: Predicted to enable GTPase activator activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study schizophrenia. Orthologous to human SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI452337; Arhg; Arhgap14; brain stress early protein Gbi; D130026O08Rik; GAP3; Gbi; MEGAP; mKIAA0411; rho GTPase activating protein 14; rho GTPase-activating protein 14; SLIT-ROBO Rho GTPase activating protein 2; SLIT-ROBO Rho GTPase-activating protein 3; srGAP2; WARP; WAVE-associated Rac GTPase-activating protein; WRP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,694,932 - 112,924,466 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6112,694,932 - 112,924,227 (-)EnsemblGRCm39 Ensembl
GRCm386112,717,971 - 112,947,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,717,971 - 112,947,266 (-)EnsemblGRCm38mm10GRCm38
MGSCv376112,667,965 - 112,897,260 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366112,683,748 - 112,795,398 (-)NCBIMGSCv36mm8
Celera6114,543,131 - 114,774,424 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
fluoranthene  (EXP)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
HC toxin  (ISO)
inulin  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nitrofen  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
prothioconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11672528   PMID:12447388   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15226823  
PMID:15328020   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16944949   PMID:17114649   PMID:17215396   PMID:18343202   PMID:18617019   PMID:19137586   PMID:20569485   PMID:21325512  
PMID:21350945   PMID:21655271   PMID:21873635   PMID:22159416   PMID:22271578   PMID:22794259   PMID:22820399   PMID:23007397   PMID:23127797   PMID:23505444   PMID:26104135   PMID:27184948  
PMID:28671696   PMID:28706196   PMID:30674877   PMID:32325033   PMID:32581705   PMID:33514561   PMID:34321999   PMID:36417873   PMID:37142655  


Genomics

Comparative Map Data
Srgap3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,694,932 - 112,924,466 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6112,694,932 - 112,924,227 (-)EnsemblGRCm39 Ensembl
GRCm386112,717,971 - 112,947,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,717,971 - 112,947,266 (-)EnsemblGRCm38mm10GRCm38
MGSCv376112,667,965 - 112,897,260 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366112,683,748 - 112,795,398 (-)NCBIMGSCv36mm8
Celera6114,543,131 - 114,774,424 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.54NCBI
SRGAP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3838,980,591 - 9,363,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl38,980,591 - 9,363,053 (-)EnsemblGRCh38hg38GRCh38
GRCh3739,022,275 - 9,291,330 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,997,278 - 9,266,311 (-)NCBINCBI36Build 36hg18NCBI36
Build 3438,997,277 - 9,265,737NCBI
Celera38,956,988 - 9,226,019 (-)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef38,956,444 - 9,225,356 (-)NCBIHuRef
CHM1_138,972,526 - 9,241,578 (-)NCBICHM1_1
T2T-CHM13v2.038,971,761 - 9,354,865 (-)NCBIT2T-CHM13v2.0
Srgap3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,391,082 - 147,626,407 (-)NCBIGRCr8
mRatBN7.24145,839,369 - 146,070,556 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,840,078 - 146,070,575 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,232,340 - 151,460,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,013,154 - 147,240,832 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04145,634,410 - 145,862,095 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04144,638,782 - 144,869,961 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,638,335 - 144,869,919 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,938,122 - 208,167,826 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,562,981 - 148,798,613 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4134,407,634 - 134,635,394 (-)NCBICelera
Cytogenetic Map4q42NCBI
Srgap3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561617,001 - 835,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955561612,152 - 835,209 (-)NCBIChiLan1.0ChiLan1.0
SRGAP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v228,994,561 - 9,374,714 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan138,999,319 - 9,379,472 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v038,935,179 - 9,315,264 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.139,178,709 - 9,445,905 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl39,183,641 - 9,327,559 (-)Ensemblpanpan1.1panPan2
SRGAP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,894,150 - 9,147,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,894,155 - 9,142,066 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,852,211 - 9,178,887 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,849,280 - 9,175,822 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,922,985 - 9,175,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1208,571,174 - 8,897,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,916,552 - 9,242,890 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,889,935 - 9,215,979 (+)NCBIUU_Cfam_GSD_1.0
Srgap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,889,669 - 15,139,397 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366023,770,259 - 4,016,536 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366023,770,323 - 4,020,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRGAP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,367,608 - 65,721,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11365,367,596 - 65,759,892 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SRGAP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,979,675 - 45,355,753 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2244,984,615 - 45,246,209 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041121,319,319 - 121,586,653 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srgap3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247313,712,361 - 3,824,206 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247313,707,934 - 3,937,175 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srgap3
8161 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4901
Count of miRNA genes:861
Interacting mature miRNAs:1197
Transcripts:ENSMUST00000060215, ENSMUST00000088373, ENSMUST00000113169, ENSMUST00000131835, ENSMUST00000143475
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687480321121480516Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686783787113521563Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
1357793Pnhdlc1_mplasma non-HDL cholesterol 1 (mouse)Not determined6105541783114345810Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined105982366120894102Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse

Markers in Region
RH131868  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386112,718,201 - 112,718,401UniSTSGRCm38
MGSCv376112,668,195 - 112,668,395UniSTSGRCm37
Celera6114,543,361 - 114,543,561UniSTS
Cytogenetic Map6E3UniSTS
30.MMHAP28FRB12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386112,741,086 - 112,741,283UniSTSGRCm38
MGSCv376112,691,080 - 112,691,277UniSTSGRCm37
Celera6114,566,246 - 114,566,443UniSTS
Cytogenetic Map6E3UniSTS
Whitehead_YAC6 UniSTS
D6Mit328  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386112,779,350 - 112,779,474UniSTSGRCm38
MGSCv376112,729,344 - 112,729,468UniSTSGRCm37
Celera6114,604,540 - 114,604,686UniSTS
Cytogenetic Map6E3UniSTS
cM Map649.3UniSTS
Whitehead Genetic644.8UniSTS
Whitehead/MRC_RH61158.68UniSTS
Whitehead_YAC6 UniSTS
AI452337  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386112,719,658 - 112,719,855UniSTSGRCm38
MGSCv376112,669,652 - 112,669,849UniSTSGRCm37
Celera6114,544,818 - 114,545,015UniSTS
Cytogenetic Map6E3UniSTS
Whitehead/MRC_RH61158.68UniSTS
Srgap3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386112,722,075 - 112,723,198UniSTSGRCm38
MGSCv376112,672,069 - 112,673,192UniSTSGRCm37
Celera6114,547,235 - 114,548,358UniSTS
Cytogenetic Map6E3UniSTS
cM Map6 UniSTS
D6Oda19  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386112,893,351 - 112,893,593UniSTSGRCm38
MGSCv376112,843,345 - 112,843,587UniSTSGRCm37
Celera6114,719,181 - 114,719,423UniSTS
Cytogenetic Map6E3UniSTS
cM Map649.4UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF338472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF481964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF496547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY057899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC152363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC152364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC152366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF744803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK032058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000060215
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6112,743,525 - 112,924,227 (-)Ensembl
GRCm38.p6 Ensembl6112,766,564 - 112,947,266 (-)Ensembl
Ensembl Acc Id: ENSMUST00000088373   ⟹   ENSMUSP00000085712
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6112,694,932 - 112,924,227 (-)Ensembl
GRCm38.p6 Ensembl6112,717,971 - 112,947,266 (-)Ensembl
Ensembl Acc Id: ENSMUST00000113169   ⟹   ENSMUSP00000108794
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6112,694,935 - 112,923,715 (-)Ensembl
GRCm38.p6 Ensembl6112,717,974 - 112,946,754 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131835   ⟹   ENSMUSP00000130063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6112,715,986 - 112,743,898 (-)Ensembl
GRCm38.p6 Ensembl6112,739,025 - 112,766,937 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143475
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6112,772,381 - 112,806,420 (-)Ensembl
GRCm38.p6 Ensembl6112,795,420 - 112,829,459 (-)Ensembl
RefSeq Acc Id: NM_080448   ⟹   NP_536696
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396112,694,932 - 112,924,227 (-)NCBI
GRCm386112,717,971 - 112,947,266 (-)NCBI
MGSCv376112,667,965 - 112,897,260 (-)RGD
Celera6114,543,131 - 114,774,424 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506144   ⟹   XP_006506207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396112,694,932 - 112,924,466 (-)NCBI
GRCm386112,717,971 - 112,947,505 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006506145   ⟹   XP_006506208
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396112,694,932 - 112,924,466 (-)NCBI
GRCm386112,717,971 - 112,947,505 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006506146   ⟹   XP_006506209
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396112,694,932 - 112,924,466 (-)NCBI
GRCm386112,717,971 - 112,947,505 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255398   ⟹   XP_030111258
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396112,694,932 - 112,924,466 (-)NCBI
GRCm386112,717,971 - 112,947,505 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004942958
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396112,704,174 - 112,924,466 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004942959
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396112,700,074 - 112,924,466 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004942960
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396112,700,074 - 112,924,466 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004942961
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396112,723,896 - 112,924,466 (-)NCBI
Sequence:
RefSeq Acc Id: NP_536696   ⟸   NM_080448
- UniProtKB: Q925I2 (UniProtKB/Swiss-Prot),   Q8BLD0 (UniProtKB/Swiss-Prot),   Q8BKP4 (UniProtKB/Swiss-Prot),   Q812A2 (UniProtKB/Swiss-Prot),   Q80U09 (UniProtKB/Swiss-Prot),   F8VPQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506208   ⟸   XM_006506145
- Peptide Label: isoform X2
- UniProtKB: Q925I2 (UniProtKB/Swiss-Prot),   Q8BLD0 (UniProtKB/Swiss-Prot),   Q8BKP4 (UniProtKB/Swiss-Prot),   Q812A2 (UniProtKB/Swiss-Prot),   Q80U09 (UniProtKB/Swiss-Prot),   E9QN14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506207   ⟸   XM_006506144
- Peptide Label: isoform X1
- UniProtKB: Q925I2 (UniProtKB/Swiss-Prot),   Q8BLD0 (UniProtKB/Swiss-Prot),   Q8BKP4 (UniProtKB/Swiss-Prot),   Q812A2 (UniProtKB/Swiss-Prot),   Q80U09 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506209   ⟸   XM_006506146
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_030111258   ⟸   XM_030255398
- Peptide Label: isoform X4
Ensembl Acc Id: ENSMUSP00000085712   ⟸   ENSMUST00000088373
Ensembl Acc Id: ENSMUSP00000108794   ⟸   ENSMUST00000113169
Ensembl Acc Id: ENSMUSP00000130063   ⟸   ENSMUST00000131835
Protein Domains
F-BAR   Rho-GAP   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q812A2-F1-model_v2 AlphaFold Q812A2 1-1099 view protein structure

Promoters
RGD ID:6840022
Promoter ID:MM_KWN:47135
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000054374
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366112,716,836 - 112,717,537 (-)MPROMDB
RGD ID:6840021
Promoter ID:MM_KWN:47137
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000113171,   OTTMUST00000054373
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366112,779,691 - 112,780,191 (-)MPROMDB
RGD ID:6840020
Promoter ID:MM_KWN:47139
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000060215,   ENSMUST00000113169,   OTTMUST00000054370,   OTTMUST00000054371,   UC009DEI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366112,896,934 - 112,897,434 (-)MPROMDB
RGD ID:6890604
Promoter ID:EPDNEW_M8753
Type:initiation region
Name:Srgap3_1
Description:Mus musculus SLIT-ROBO Rho GTPase activating protein 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386112,947,266 - 112,947,326EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2152938 AgrOrtholog
Ensembl Genes ENSMUSG00000030257 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000088373 ENTREZGENE
  ENSMUST00000088373.11 UniProtKB/TrEMBL
  ENSMUST00000113169 ENTREZGENE
  ENSMUST00000113169.9 UniProtKB/TrEMBL
  ENSMUST00000131835.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FCH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLIT-ROBO_RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  srGAP1/2/3_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SrGAP3_F-BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:259302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2152938 ENTREZGENE
NCBI Gene Srgap3 ENTREZGENE
PANTHER SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Srgap3 PhenoGen
PRINTS SH3DOMAIN UniProtKB/TrEMBL
  SPECTRNALPHA UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QN14 ENTREZGENE, UniProtKB/TrEMBL
  F6QZR7_MOUSE UniProtKB/TrEMBL
  F8VPQ4 ENTREZGENE, UniProtKB/TrEMBL
  Q80U09 ENTREZGENE
  Q812A2 ENTREZGENE
  Q8BKP4 ENTREZGENE
  Q8BLD0 ENTREZGENE
  Q8R4D3_MOUSE UniProtKB/TrEMBL
  Q91Z68_MOUSE UniProtKB/TrEMBL
  Q925I2 ENTREZGENE
  SRGP3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q80U09 UniProtKB/Swiss-Prot
  Q8BKP4 UniProtKB/Swiss-Prot
  Q8BLD0 UniProtKB/Swiss-Prot
  Q925I2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Srgap3  SLIT-ROBO Rho GTPase activating protein 3  Srgap2  SLIT-ROBO Rho GTPase activating protein 2  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Srgap2  SLIT-ROBO Rho GTPase activating protein 2  Srgap3  SLIT-ROBO Rho GTPase activating protein 3  Symbol and/or name change 5135510 APPROVED