Bmper (BMP-binding endothelial regulator)

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Gene: Bmper (BMP-binding endothelial regulator) Mus musculus

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Symbol:

Bmper

Name:

BMP-binding endothelial regulator

RGD ID:

1557017

MGI Page

MGI

Description:

Predicted to be an extracellular matrix structural constituent. Involved in cell surface receptor protein serine/threonine kinase signaling pathway; regulation of protein localization; and ureteric bud development. Acts upstream of or within inner ear development and negative regulation of BMP signaling pathway. Located in extracellular region. Is expressed in several structures, including branchial arch; cardiovascular system; embryo mesenchyme; jaw; and neural ectoderm. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

3110056H04Rik; BMP-binding endothelial regulator protein; bone morphogenetic protein-binding endothelial cell precursor-derived regulator; Cri; Crim3; crossveinless 2 homolog; crossveinless-2; Cv; CV-; CV-2; Cv2; mCV2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BMPER (BMP binding endothelial regulator)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Bmper (BMP-binding endothelial regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BMPER (BMP binding endothelial regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BMPER (BMP binding endothelial regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bmper (BMP binding endothelial regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BMPER (BMP binding endothelial regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BMPER (BMP binding endothelial regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bmper (BMP binding endothelial regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Bmper (BMP-binding endothelial regulator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BMPER (BMP binding endothelial regulator)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bmper (BMP binding endothelial regulator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	cv-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	bmper	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	23,134,372 - 23,396,511 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	23,134,372 - 23,396,496 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	23,223,076 - 23,485,215 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	23,223,076 - 23,485,200 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	23,027,520 - 23,289,646 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	22,973,478 - 23,235,604 (+)	NCBI		MGSCv36	mm8
Celera	9	20,484,051 - 20,745,958 (+)	NCBI		Celera
Cytogenetic Map	9	A3	NCBI
cM Map	9	9.55	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Diaphanospondylodysostosis (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

opiate dependence (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (EXP)

1,2-dimethylhydrazine (EXP)

1,3-dinitrobenzene (ISO)

1-nitropyrene (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3-Nitrobenzanthrone (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (EXP)

5-aza-2'-deoxycytidine (EXP)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (EXP,ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

belinostat (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

carbon nanotube (EXP)

CGP 52608 (ISO)

chloroprene (EXP)

chlorpyrifos (EXP)

choline (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

D-glucose (EXP)

dexamethasone (EXP)

diazinon (ISO)

dichloroacetic acid (EXP)

dorsomorphin (ISO)

endosulfan (ISO)

entinostat (ISO)

epoxiconazole (EXP)

folic acid (EXP)

fonofos (ISO)

fructose (EXP)

fulvestrant (ISO)

furan (EXP,ISO)

gentamycin (ISO)

glucose (EXP)

glyphosate (EXP)

inulin (EXP)

iron dichloride (ISO)

L-methionine (EXP)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

methotrexate (EXP)

mono(2-ethylhexyl) phthalate (EXP)

nickel sulfate (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (EXP)

pirinixic acid (EXP)

potassium chromate (ISO)

pravastatin (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propanal (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (EXP,ISO)

terbufos (ISO)

testosterone (ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

tolcapone (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

triptonide (EXP)

valproic acid (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood vessel development (IBA)

blood vessel endothelial cell proliferation involved in sprouting angiogenesis (ISO)

BMP signaling pathway (IMP)

endothelial cell activation (ISO)

inner ear development (IDA)

negative regulation of BMP signaling pathway (IDA)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of SMAD protein signal transduction (ISO)

positive regulation of sprouting angiogenesis (ISO)

regulation of angiogenesis (IBA)

regulation of endothelial cell migration (ISO)

regulation of protein localization (IMP)

SMAD protein signal transduction (IMP)

ureteric bud development (IEP)

Cellular Component

collagen-containing extracellular matrix (HDA)

extracellular matrix (IBA)

extracellular region (IDA)

extracellular space (HDA,IBA,ISO)

Molecular Function

extracellular matrix structural constituent (RCA)

protein binding (IPI)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal basisphenoid bone morphology (IAGP)

abnormal branching involved in lung morphogenesis (IAGP)

abnormal cartilage development (IAGP)

abnormal cartilage morphology (IAGP)

abnormal cranium morphology (IAGP)

abnormal cricoid cartilage morphology (IAGP)

abnormal embryo development (IAGP)

abnormal induced retina neovascularization (IAGP)

abnormal kidney corticomedullary boundary morphology (IAGP)

abnormal kidney morphology (IAGP)

abnormal lung development (IAGP)

abnormal lung saccule morphology (IAGP)

abnormal metopic suture morphology (IAGP)

abnormal pubic symphysis morphology (IAGP)

abnormal pubis body morphology (IAGP)

abnormal pubis morphology (IAGP)

abnormal Reichert's cartilage morphology (IAGP)

abnormal scapula morphology (IAGP)

abnormal skeleton morphology (IAGP)

abnormal temporal bone squamous part morphology (IAGP)

abnormal thyroid cartilage morphology (IAGP)

abnormal trachea morphology (IAGP)

abnormal tracheal cartilage morphology (IAGP)

abnormal tympanic ring morphology (IAGP)

abnormal vertebrae development (IAGP)

abnormal vertebral arch development (IAGP)

abnormal vertebral arch morphology (IAGP)

abnormal vertebral body development (IAGP)

abnormal vertebral column morphology (IAGP)

absent deltoid tuberosity (IAGP)

absent retrotympanic process (IAGP)

absent tracheal cartilage rings (IAGP)

absent vertebral arch (IAGP)

basisphenoid bone foramen (IAGP)

curly tail (IAGP)

decreased body length (IAGP)

decreased fetal size (IAGP)

decreased nephron number (IAGP)

decreased renal glomerulus number (IAGP)

decreased rib number (IAGP)

exencephaly (IAGP)

increased type II pneumocyte number (IAGP)

microphthalmia (IAGP)

neonatal lethality, complete penetrance (IAGP)

prenatal lethality, incomplete penetrance (IAGP)

respiratory failure (IAGP)

scapular bone foramen (IAGP)

short tail (IAGP)

small cricoid cartilage (IAGP)

small interparietal bone (IAGP)

small kidney (IAGP)

small lung saccule (IAGP)

small scapula (IAGP)

small supraoccipital bone (IAGP)

small thyroid cartilage (IAGP)

small vertebrae (IAGP)

small vertebral body (IAGP)

thick lung-associated mesenchyme (IAGP)

thoracic vertebral transformation (IAGP)

wide metopic suture (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Substance dependence low-density whole genome association study in two distinct American populations.	Yu Y, etal., Hum Genet. 2008 Jun;123(5):495-506. doi: 10.1007/s00439-008-0501-0. Epub 2008 Apr 26.

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:12477932	PMID:12897139	PMID:14516682	PMID:15188429	PMID:15489334	PMID:16141072	PMID:16141073	PMID:16545622	PMID:17035289
PMID:17483092	PMID:18287559	PMID:18644438	PMID:18662983	PMID:18697905	PMID:18787191	PMID:18789316	PMID:19026994	PMID:19221194	PMID:19627984	PMID:19914233	PMID:20359476
PMID:20436479	PMID:20807528	PMID:21737784	PMID:21791559	PMID:21795542	PMID:21873635	PMID:21900199	PMID:22020334	PMID:22144676	PMID:22159717	PMID:22280990	PMID:22342504
PMID:22474252	PMID:22560297	PMID:22772758	PMID:22833126	PMID:23103586	PMID:23200275	PMID:23213481	PMID:23716395	PMID:23863486	PMID:24006456	PMID:24373957	PMID:25503991
PMID:26450967	PMID:26483492	PMID:26573818	PMID:27657450	PMID:28464239	PMID:28467908	PMID:28596374	PMID:28964716	PMID:29093060	PMID:29798841	PMID:30478225	PMID:30550785
PMID:32468615	PMID:32715478	PMID:32857879	PMID:33772019	PMID:34904361	PMID:35297995	PMID:36902380	PMID:37311809

Genomics

Comparative Map Data

Bmper
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	23,134,372 - 23,396,511 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	23,134,372 - 23,396,496 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	23,223,076 - 23,485,215 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	23,223,076 - 23,485,200 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	23,027,520 - 23,289,646 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	22,973,478 - 23,235,604 (+)	NCBI		MGSCv36	mm8
Celera	9	20,484,051 - 20,745,958 (+)	NCBI		Celera
Cytogenetic Map	9	A3	NCBI
cM Map	9	9.55	NCBI

BMPER
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	33,904,915 - 34,156,427 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	33,904,308 - 34,156,427 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	33,944,527 - 34,196,039 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	33,911,048 - 34,162,009 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	33,926,362 - 34,175,842 (+)	NCBI		Celera
Cytogenetic Map	7	p14.3	NCBI
HuRef	7	33,824,354 - 34,076,851 (+)	NCBI		HuRef
CHM1_1	7	33,944,099 - 34,195,741 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	34,044,656 - 34,296,293 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	33,988,876 - 34,239,892 (+)	NCBI

Bmper
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	30,008,049 - 30,253,201 (+)	NCBI		GRCr8
mRatBN7.2	8	21,732,225 - 21,977,261 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	21,732,225 - 21,977,256 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	25,759,640 - 26,007,649 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	24,056,975 - 24,305,001 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	21,963,092 - 22,208,120 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	24,369,916 - 24,615,484 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	24,369,916 - 24,615,479 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	24,409,998 - 24,655,253 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	22,975,570 - 23,096,066 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	23,311,494 - 23,555,945 (+)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

BMPER
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	38,706,699 - 38,956,652 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	87,031,420 - 87,281,703 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	34,508,583 - 34,759,860 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	34,903,178 - 35,152,110 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	34,903,178 - 35,152,110 (+)	Ensembl	panpan1.1		panPan2

BMPER
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	45,910,634 - 46,154,922 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	45,910,739 - 46,153,501 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	45,346,415 - 45,596,871 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	45,846,768 - 46,092,065 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	45,846,476 - 46,092,065 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	45,953,080 - 46,196,685 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	45,632,493 - 45,876,468 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	46,006,152 - 46,250,841 (+)	NCBI		UU_Cfam_GSD_1.0

Bmper
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	90,493,879 - 90,846,200 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936478	9,705,604 - 9,941,340 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936478	9,705,634 - 9,941,382 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BMPER
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	39,412,838 - 39,663,592 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	39,417,830 - 39,664,010 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	43,216,784 - 43,461,673 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BMPER
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	24,255,857 - 24,500,790 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	24,255,866 - 24,500,720 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	80,155,605 - 80,400,846 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bmper
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624776	19,160,501 - 19,459,227 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624776	19,159,906 - 19,462,607 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bmper
7815 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	348
Count of miRNA genes:	232
Interacting mature miRNAs:	279
Transcripts:	ENSMUST00000071982
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300849	Sles4_m	systemic lupus erythmatosus suppressor 4 (mouse)			Not determined		9	9107562	37306370	Mouse
12880416	V125Dq8_m	vitamin D active form serum level QTL 8 (mouse)					9	16011296	50011296	Mouse
13434920	Dcollq1_m	differential colonization level QTL 1 (mouse)					9	1	30341840	Mouse
1301045	Sluc10_m	susceptibility to lung cancer 10 (mouse)			Not determined		9	20306197	54306370	Mouse
1300532	Tbs2_m	tuberculosis severity 2 (mouse)			Not determined		9	12369970	46370114	Mouse
4141591	Cq4_m	cholesterol QTL 4 (mouse)			Not determined		9	15411751	49411890	Mouse
1301883	Skull12_m	skull morphology 12 (mouse)			Not determined		9	20306197	54306370	Mouse
11354951	Pdcc3_m	plasmacytoid dentritic cell compartment 3 (mouse)					9	15749627	49749627	Mouse
13504834	Hdlq109_m	HDL QTL 109 (mouse)					9	16709641	50709641	Mouse
1301439	Morph2_m	morphine antinociception 2 (mouse)			Not determined		9	20153362	54153492	Mouse
1357465	Vtbt6_m	vertebral trabecular bone trait 6 (mouse)			Not determined		9	16978840	50978943	Mouse
13504833	Bglu19_m	blood glucose level 19 (mouse)					9	9910768	43910768	Mouse
4142352	Lmr17_m	leishmaniasis resistance 17 (mouse)			Not determined		9	20306197	54306370	Mouse
12904939	Edlmmq8_m	extensor digitorum longus muscle mass QTL 8 (mouse)					9	20852740	54852740	Mouse
1300899	Chol6_m	cholesterol 6 (mouse)			Not determined		9	1	29902913	Mouse
1300643	Pvcan2_m	protection against vaginal candidiasis 2 (mouse)			Not determined		9	19943406	53943525	Mouse
1357637	Si5lq2_m	serum IGFBP-5 level QTL 2 (mouse)			Not determined		9	15411751	49411890	Mouse
12790993	Adq1_m	aortic diameter QTL 1 (mouse)					9	15749627	49749627	Mouse
10043917	Obq37_m	obesity QTL 37 (mouse)			Not determined		9	13391175	47391175	Mouse
12790997	Adq2_m	aortic diameter QTL 2 (mouse)					9	15749627	49749627	Mouse
10043950	Pbft5_m	percent body fat 5 (mouse)			Not determined		9	20306197	54306370	Mouse
4141447	Cfmq2_m	cystic fibrosis modifier QTL 2 (mouse)			Not determined		9	15411751	49411890	Mouse
12880415	V125Dq7_m	vitamin D active form serum level QTL 7 (mouse)					9	16011296	50011296	Mouse
1301421	Lgth4_m	body length 4 (mouse)			Not determined		9	15411751	49411890	Mouse

Markers in Region

Bmper

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	9	A4	UniSTS
cM Map	9		UniSTS

16.MMHAP11FRF7.seq

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	9	23,432,825 - 23,432,980	UniSTS	GRCm38
MGSCv37	9	23,237,269 - 23,237,424	UniSTS	GRCm37
Celera	9	20,693,544 - 20,693,699	UniSTS
Cytogenetic Map	9	A4	UniSTS
Whitehead_YAC	9		UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_028472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC140355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC154658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC154737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF454954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK014221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK049718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY263358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC042718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC066153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000071982 ⟹ ENSMUSP00000071872

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	9	23,134,372 - 23,396,496 (+)	Ensembl
GRCm38.p6 Ensembl	9	23,223,076 - 23,485,200 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000214050 ⟹ ENSMUSP00000149700

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	9	23,285,228 - 23,318,127 (+)	Ensembl
GRCm38.p6 Ensembl	9	23,373,932 - 23,406,831 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000217648

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	9	23,134,582 - 23,140,645 (+)	Ensembl
GRCm38.p6 Ensembl	9	23,223,286 - 23,229,349 (+)	Ensembl

RefSeq Acc Id:

NM_028472 ⟹ NP_082748

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	9	23,134,372 - 23,396,511 (+)	NCBI
GRCm38	9	23,223,076 - 23,485,215 (+)	NCBI
MGSCv37	9	23,027,520 - 23,289,646 (+)	RGD
Celera	9	20,484,051 - 20,745,971 (+)	NCBI
cM Map	9		ENTREZGENE

Sequence:

show sequence

GCCGGGGCTGGGCTAGACCGCCTGGCTGGGCGTTCGCGTGCGCCGCTGTCGCTTCTGAGCCGGC
ATAGCTCCGGCGCCAGGATCGTAGTCCCTCGTGCGACCCTGCGGATTCCGCGCAGAGCCTAGTA
CGCCCCTCGGTCCCGCACGGAGCAAGCGCGCGGGCCGGACACCGCGCTCGGGGGCCGGGCCGGA
GCTGCGCGTGCGGGAGCCGGAGCTCAGCCGGGCTCCAGAGCTGCGAGCGCACTCGGCAGTCGCC
GCCGCCGCTCCCCAGATCCCGCCGCTCAGCCACCCCTCCTCCCGGCCCAGCTCTGGCGCGGAGG
GGCTGACGGCTAACCCGCTGAGAGCAACTCCCTTAGAAAAAAGCCGCCGCATTGGCCGAGGCTG
GCCGCAGGACCCCTCCTCCCGGGGCGCCCCCACTCCTCCCCCGCCGCTCCGGGCGCCCGCCTCC
CTCAGCCGACTGTCTCCCGGCACGCCGGCCCACAGCCCTTTTGACTGCGAGCAGCGGCTGCCGA
GCAGAGGCGGCGACGCGGGACCTGCAGTCGCCCGGGATTCCCTCCAGGTGACGATGCTCTGGTT
CTTCAGCGTCAGGGCTCTGGCTGAGCGTCCTTGCCGACGCTCGCCTGGGATTACCTGCTGCGTC
TTGCTGCTGCTCAATTGCTCCGGGGTCCCCATGTCTCTGGCTTCCTCCTTCCTGACAGGGTCTG
TTGCAAAATGTGAAAATGAAGGGGAGGTCCTCCAAATTCCATTTATCACAGACAACCCTTGCAT
AATGTGTGTGTGTTTGAACAAAGAGGTGACTTGTAAGAGGGAGAAGTGCCCTGTGCTGTCACGG
GACTGTGCGCTGGCCATCAAGCAGAGAGGCGCCTGCTGTGAACGATGCAAAGGTTGTACCCATG
AAGGAAGAACCTACAACAGTTCCTTCAAGTGGCAAACCCCGGCTGAGCCATGTGTCCTTCGGCA
GTGCCAGGAGGGTGTGGTGACAGAGTCTGAGGTGCGCTGTGTTGTTCATTGTAAAAATCCCGCA
GAGCATCAAGGAGCCTGCTGCCCTACCTGCCCAGGCTGTGTGTTTGAAGGTGTGCAATACCGGG
AAGGAGAAGAATTTCAGCCAGAAGGAAACAAATGTATTACATGCTCCTGCGTTGGAGGCAGGAC
ACAGTGCGTGAGAGAAGTCTGTCCCATTCTCTCTTGTCCCCAGCACCTTAGTCACACACCCTCA
GGACAGTGCTGCCCCAAATGTTTGGGTCAGAGAAAAGTATTCGACCTTCCCTTTGGGAGCTGCC
TGTTTCGCAGTGATGTTTATGACAATGGAGCCTCATTTGTCTATGATAACTGCACAGTATGCAC
TTGCAAGGACTCAACAATGGTTTGTAAGAAGAAGTGCTCCCACCCTGGTGTCTGTAACAGTGAT
GAGGATGCCTGTTGTGAAGACTGTCTCTTACGGGTGCCCCCTGAAGACATCAAAGTGTGCAAGT
TCGGTAGCAAGATTTTCAGGGATGGAGAGATGTGGTCCTCAGTCAACTGCAGCATCTGTGCTTG
TGTGAAGGGGAAGACAGAGTGTCGAAAGAAGCAGTGTGTTCCTGTCAGCAGCTGCCCACAGGGT
AAAATTCTCAACAGGAAAGGATGCTGTCCTATCTGCACTGAAAAACCTGGTGTGTGCACAGTAT
TCGGAGATCCCCACTACAACACTTTTGATGGGCGGACATTTAACTTTCAGGGGACGTGTCAGTA
TGTTTTGACAAAAGACTGCTCCTCCCCAGCCTCACCCTTCCAGGTGCTGGTGAAGAATGATGCA
CGGAGGACCCGTTCCTTCTCCTGGACCAAGTCTGTGGAGCTGATGCTGGGCGAAAGCACAGTCA
GCCTGCAGCAGCACCTCACTGTGCGCTGGAATGGCTCTCGCATTGCCCTTCCCTGCCACACACC
CCACTTCCACATCGACCTGGACGGCTACCTTTTGAAAGTGACTACCAGAGCAGGTTTGGAGATA
TCGTGGGATGGAGACAGTTTTGTGGAGGTCATGGCTGCCCCTCATCTCAAGGGCAAGCTCTGTG
GTCTTTGTGGCAACTACAATGGTCATAAACGTGATGACTTGATTGGTGGAGATGGGAACTTCAA
GTTTGACGTGGATGACTTTGCTGAATCGTGGAGGGTGGAATCCAACGAATTCTGCAACCGACCA
CAGAGAAAACCAGTACCTGAGCTCTGTCAAGGCACAGTGAAGGTGAAGCTTCGAGCCCATCGAG
AATGCCAGAAACTCAAGTCCTGGGAGTTCCAGACCTGCCACTCTACAGTGGACTATACCACTTT
CTACCGGTCCTGTGTAACAGACATGTGTGAATGTCCAGTCCATAAAAACTGTTACTGTGAGTCA
TTTCTGGCGTATACCCGTGCCTGTCAGAGAGAGGGAATCAAAGTGCACTGGGAACCTCAGCAGA
GCTGTGCAGCCACCCAGTGCAAACATGGTGCTGTGTATGATACCTGTGGCCCAGGATGTGTGAA
GACATGTGATAACTGGAATGAGATCGGCCCATGCAATAAGCCCTGCATTGCAGGTTGCCACTGC
CCAGCAAATCTGGTCCTTCATAAGGGAAGGTGCATCAAGCCAGTCCTCTGTCCTCAGCGATGAC
CTTTGTTCTAGTCCATAGACTTTGAAATCCAGTGTCTTTGACACTGACATGCAAGAGCCAGTGA
AGGACTGTTGTATTTGTGTGCCTGATTCTGCAAATACACAGAGTATATATGTGTACATATATAT
AGATATATAGATATATTCGAAACATTTCATCATTTATATAAACTATAGGTGGATTATTATATGT
ATATTTTTTGCTATAAGACATGTATTATTTCTAGAATCCTAATATCTAAGCCATTGGATGCATC
ATATACATAGGTGCTTTTAATTTAATAAGATGGCATGCAGACTCATCAGGTCTCTTTAAGAGTG
CGTTCATGTGTCATTCTGGGGACATTTCCTAAGAGCCCTCATGCCTACCTGCATTAATTAAAGA
TTTGAGTCAGGACCTTTGAGTGAGATTTTCTTGGAGAAGGGTACTTTATCTGGGGGTATTTTGT
ATTTCCAAAGACTGGAATGTATGCCAGAGAAAGATGGCATGAGATTGGGGATGAGCCCTCGTGA
GTGCAAACCAAGGAGAGTCTGTCAGATTTCACCGGGTCAGAGCTGGATATTGTCCCCCAAACTG
GATAGTTGCCACGGAATATGTATTTTTCACTAGCATATTGCCAAATAATTTCTTTTCATTTTTT
GCATATGTCATGAGTCTCCTCATTACTTATGTGTGCAATGGATATGACCATTTGCATGTCCTGC
ACTGAAGTCAAAGGATGTCTGGATAACATTTTATTAAACACGAAAAGCTATTTGGAGAGAACAT
TGCACAACATATAAAGAATCTCAGAGCAATTTAGGATTGGCAAATCCATTGAGTGGCTAGGGGC
CATCTACGTTTTGTCACTATCTCATGGTGTATAAAATGAAAGCCTTCGGCTATTCTGTCTCATT
ACTGTCCAGTGTTGTTTGCTGGGTACTCATATGTTATGGGTATTGGGCAGGAGGGAAGGGACTG
CTGACCAGTTGTTTTAGCTTCATTCCAAAAGAGAATTGTTTCTGTATTTGTTCTAATTTACTGA
TGTTACTAACAGTTATTGGTTCTTGTTTTCTGTTGGATAAATAAAAATGTCAAAAAGCAAAAAC
AAAAAACCCCACCCCCAACTCACTGATGTTGAAAAGTAAAATGTTCTGCATTGTAGTAAATAAA
AGGCTTAAGATTTAAGCAAACAGTTTTCAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_082748	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH42718	(Get FASTA)	NCBI Sequence Viewer
	AAH66153	(Get FASTA)	NCBI Sequence Viewer
	AAN45857	(Get FASTA)	NCBI Sequence Viewer
	AAP88382	(Get FASTA)	NCBI Sequence Viewer
	BAB29213	(Get FASTA)	NCBI Sequence Viewer
	EDL25283	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000071872
	ENSMUSP00000071872.6
	ENSMUSP00000149700.2
GenBank Protein	Q8CJ69	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_082748 ⟸ NM_028472
- Peptide Label:	precursor
- UniProtKB:	Q80UZ1 (UniProtKB/Swiss-Prot), Q7TN57 (UniProtKB/Swiss-Prot), Q9CXM8 (UniProtKB/Swiss-Prot), Q8CJ69 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLWFFSVRALAERPCRRSPGITCCVLLLLNCSGVPMSLASSFLTGSVAKCENEGEVLQIPFITD NPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCERCKGCTHEGRTYNSSFKWQTPAEPC VLRQCQEGVVTESEVRCVVHCKNPAEHQGACCPTCPGCVFEGVQYREGEEFQPEGNKCITCSCV GGRTQCVREVCPILSCPQHLSHTPSGQCCPKCLGQRKVFDLPFGSCLFRSDVYDNGASFVYDNC TVCTCKDSTMVCKKKCSHPGVCNSDEDACCEDCLLRVPPEDIKVCKFGSKIFRDGEMWSSVNCS ICACVKGKTECRKKQCVPVSSCPQGKILNRKGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQG TCQYVLTKDCSSPASPFQVLVKNDARRTRSFSWTKSVELMLGESTVSLQQHLTVRWNGSRIALP CHTPHFHIDLDGYLLKVTTRAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDLIGGD GNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQGTVKVKLRAHRECQKLKSWEFQTCHSTVD YTTFYRSCVTDMCECPVHKNCYCESFLAYTRACQREGIKVHWEPQQSCAATQCKHGAVYDTCGP GCVKTCDNWNEIGPCNKPCIAGCHCPANLVLHKGRCIKPVLCPQR hide sequence

Ensembl Acc Id:

ENSMUSP00000071872 ⟸ ENSMUST00000071982

Ensembl Acc Id:

ENSMUSP00000149700 ⟸ ENSMUST00000214050

Protein Domains

TIL VWFC VWFD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8CJ69-F1-model_v2	AlphaFold	Q8CJ69	1-685	view protein structure

Promoters

RGD ID:

6844253

Promoter ID:

MM_KWN:56644

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, ES_Cell, Liver, Lung, MEF_B4, MEF_B6

Transcripts:

NM_028472

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	23,027,136 - 23,028,052 (+)	MPROMDB

RGD ID:

8669140

Promoter ID:

EPDNEW_M12555

Type:

initiation region

Name:

Bmper_1

Description:

Mus musculus BMP-binding endothelial regulator , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M12556

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	9	23,223,090 - 23,223,150	EPDNEW

RGD ID:

8669050

Promoter ID:

EPDNEW_M12556

Type:

initiation region

Name:

Bmper_2

Description:

Mus musculus BMP-binding endothelial regulator , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M12555

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	9	23,223,566 - 23,223,626	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1920480	AgrOrtholog
Ensembl Genes	ENSMUSG00000031963	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000071982	ENTREZGENE
	ENSMUST00000071982.7	UniProtKB/Swiss-Prot
	ENSMUST00000214050.2	UniProtKB/TrEMBL
Gene3D-CATH	6.20.200.20	UniProtKB/Swiss-Prot
	Complement Module, domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Laminin	UniProtKB/Swiss-Prot
InterPro	Kielin_Chordin-BMP_Reg	UniProtKB/Swiss-Prot
	Mucin_vWF_Thrombospondin_sf	UniProtKB/TrEMBL
	Ser_inhib-like_sf	UniProtKB/Swiss-Prot
	TIL_dom	UniProtKB/Swiss-Prot
	Unchr_dom_Cys-rich	UniProtKB/Swiss-Prot
	VWF_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWF_type-D	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:73230	UniProtKB/Swiss-Prot
MGD	MGI:1920480	ENTREZGENE
NCBI Gene	73230	ENTREZGENE
PANTHER	BMP-BINDING ENDOTHELIAL REGULATOR PROTEIN	UniProtKB/TrEMBL
	CROSSVEINLESS 2	UniProtKB/Swiss-Prot
	CROSSVEINLESS 2	UniProtKB/Swiss-Prot
	EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED	UniProtKB/TrEMBL
Pfam	PF08742	UniProtKB/Swiss-Prot
	TIL	UniProtKB/Swiss-Prot
	VWC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Bmper	PhenoGen
PROSITE	VWFC_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWFC_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWFD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SM00832	UniProtKB/Swiss-Prot
	VWC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWD	UniProtKB/Swiss-Prot
Superfamily-SCOP	FnI-like domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57567	UniProtKB/Swiss-Prot
UniProt	A0A1L1SS01_MOUSE	UniProtKB/TrEMBL
	BMPER_MOUSE	UniProtKB/Swiss-Prot
	Q7TN57	ENTREZGENE
	Q80UZ1	ENTREZGENE
	Q8CJ69	ENTREZGENE
	Q9CXM8	ENTREZGENE
UniProt Secondary	Q7TN57	UniProtKB/Swiss-Prot
	Q80UZ1	UniProtKB/Swiss-Prot
	Q9CXM8	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype

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