Mrgprx1 (MAS-related GPR, member X1) - Rat Genome Database

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Gene: Mrgprx1 (MAS-related GPR, member X1) Mus musculus
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Symbol: Mrgprx1
Name: MAS-related GPR, member X1
RGD ID: 1556901
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within chemosensory behavior and hematopoietic progenitor cell differentiation. Predicted to be active in plasma membrane. Orthologous to several human genes including MRGPRX4 (MAS related GPR family member X4).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mas-related G-protein coupled receptor member C11; mas-related G-protein coupled receptor member X1; MAS-related GPR, member C11; MrgC1; MrgC11; Mrgpr; Mrgprc11; sensory neuron-specific G-protein coupled receptor 1
RGD Orthologs
Human
Rat
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18348   Gm18350   Gm9322   Mrgprc1-ps   Mrgprc3-ps   Mrgprc4-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39747,670,719 - 47,677,345 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl747,670,719 - 47,677,345 (-)EnsemblGRCm39 Ensembl
GRCm38748,020,971 - 48,027,597 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl748,020,971 - 48,027,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv37755,276,341 - 55,282,967 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36747,888,993 - 47,895,623 (-)NCBIMGSCv36mm8
MGSCv36737,623,113 - 37,641,258 (-)NCBIMGSCv36mm8
Cytogenetic Map7B4NCBI
cM Map731.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.
Additional References at PubMed
PMID:10504302   PMID:10662793   PMID:11551509   PMID:11821156   PMID:12397184   PMID:12477932   PMID:18250432   PMID:21267068   PMID:21775281   PMID:21873635   PMID:23000623   PMID:23074220  
PMID:24029230   PMID:26022362   PMID:26216096   PMID:27215903   PMID:28768771   PMID:31119828   PMID:33358893   PMID:33727332   PMID:33876765   PMID:35875660   PMID:36864656   PMID:38355793  


Genomics

Comparative Map Data
Mrgprx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39747,670,719 - 47,677,345 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl747,670,719 - 47,677,345 (-)EnsemblGRCm39 Ensembl
GRCm38748,020,971 - 48,027,597 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl748,020,971 - 48,027,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv37755,276,341 - 55,282,967 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36747,888,993 - 47,895,623 (-)NCBIMGSCv36mm8
MGSCv36737,623,113 - 37,641,258 (-)NCBIMGSCv36mm8
Cytogenetic Map7B4NCBI
cM Map731.09NCBI
MRGPRX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,172,837 - 18,174,280 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,172,837 - 18,174,280 (+)EnsemblGRCh38hg38GRCh38
GRCh371118,194,384 - 18,195,827 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,150,960 - 18,152,401 (+)NCBINCBI36Build 36hg18NCBI36
Celera1118,326,688 - 18,328,131 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,877,287 - 17,878,730 (+)NCBIHuRef
CHM1_11118,193,904 - 18,195,347 (+)NCBICHM1_1
T2T-CHM13v2.01118,268,336 - 18,269,779 (+)NCBIT2T-CHM13v2.0
Mrgprx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,942,343 - 106,943,314 (-)NCBIGRCr8
mRatBN7.2197,806,099 - 97,807,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,806,099 - 97,807,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1103,184,574 - 103,185,587 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,656,540 - 111,657,553 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,954,373 - 104,955,386 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01103,378,242 - 103,388,240 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01104,442,354 - 104,451,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,919,939 - 97,920,952 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,997,918 - 97,999,233 (-)NCBI
Celera192,046,235 - 92,047,248 (-)NCBICelera
Cytogenetic Map1q22NCBI
MRGPRX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,504,297 - 20,505,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,464,682 - 20,466,131 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,225,283 - 18,226,720 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,905,593 - 17,907,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,906,013 - 17,906,981 (+)Ensemblpanpan1.1panPan2
MGRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11847,212,903 - 47,215,195 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1845,820,986 - 45,823,278 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,893,505 - 47,895,798 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11847,334,379 - 47,336,671 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,920,538 - 46,922,830 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01847,667,032 - 47,669,325 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Mrgprx1
417 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:63
Interacting mature miRNAs:63
Transcripts:ENSMUST00000094390
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
25314304Vmm1_mvariable multisystem mineralization 1, muzzle (mouse)74714974856549748Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
25314302Vmm2_mvariable multisystem mineralization 2, heart (mouse)74714974874149748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse


Sequence


Ensembl Acc Id: ENSMUST00000094390   ⟹   ENSMUSP00000091954
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl747,670,719 - 47,677,345 (-)Ensembl
GRCm38.p6 Ensembl748,020,971 - 48,027,597 (-)Ensembl
RefSeq Acc Id: NM_207540   ⟹   NP_997423
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39747,670,719 - 47,677,345 (-)NCBI
GRCm38748,020,971 - 48,027,597 (-)ENTREZGENE
MGSCv37755,276,341 - 55,282,967 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_997423   ⟸   NM_207540
- UniProtKB: Q8CIP3 (UniProtKB/Swiss-Prot),   B2RWR5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000091954   ⟸   ENSMUST00000094390
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CIP3-F1-model_v2 AlphaFold Q8CIP3 1-322 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3033139 AgrOrtholog
Ensembl Genes ENSMUSG00000066454
  ENSMUSG00000070552 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000094390 ENTREZGENE
  ENSMUST00000094390.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:404242 UniProtKB/Swiss-Prot
MGD MGI:3033139 ENTREZGENE
NCBI Gene 404242 ENTREZGENE
PANTHER MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER X1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrgprx1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RWR5 ENTREZGENE, UniProtKB/TrEMBL
  MRGX1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE