Itga2 (integrin alpha 2) - Rat Genome Database

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Gene: Itga2 (integrin alpha 2) Mus musculus
Analyze
Symbol: Itga2
Name: integrin alpha 2
RGD ID: 1553829
MGI Page MGI
Description: Enables amyloid-beta binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell migration; and positive regulation of cellular component organization. Located in basal part of cell and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD49 antigen-like family member B; CD49B; collagen receptor; DX5; GPIa; integrin alpha-2; platelet membrane glycoprotein Ia; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,969,617 - 115,068,588 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,969,617 - 115,068,636 (-)EnsemblGRCm39 Ensembl
GRCm3813114,833,081 - 114,932,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,833,081 - 114,932,100 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,626,120 - 115,722,249 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,956,790 - 116,052,919 (-)NCBIMGSCv36mm8
Celera13119,179,611 - 119,279,864 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
(R)-adrenaline  (ISO)
1,2-dichloroethane  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-amanitin  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carnosic acid  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
fenfluramine  (ISO)
Fulvic acid  (ISO)
furfural  (ISO)
genistein  (EXP,ISO)
geranylgeraniol  (ISO)
glyphosate  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
medroxyprogesterone acetate  (ISO)
methylisothiazolinone  (ISO)
mevalonic acid  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morusin  (ISO)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nevirapine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (EXP)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
progesterone  (ISO)
prostaglandin E2  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
Rutecarpine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serotonin  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium chloride  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion mediated by integrin  (IBA,IEA,ISO)
cell-cell adhesion  (IBA)
cell-matrix adhesion  (IBA,ISO)
cell-substrate adhesion  (ISO)
cellular response to estradiol stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
collagen-activated signaling pathway  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of pain  (IEA,ISO)
female pregnancy  (IEA,ISO)
focal adhesion assembly  (IEA,ISO)
hepatocyte differentiation  (IEA,ISO)
hypotonic response  (IEA,ISO)
integrin-mediated signaling pathway  (IBA,IEA,ISO)
mammary gland development  (IEA,ISO)
mesodermal cell differentiation  (IEA)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of cell adhesion  (IEA,ISO)
positive regulation of cell projection organization  (IEA,ISO)
positive regulation of collagen biosynthetic process  (IEA,ISO)
positive regulation of DNA binding  (ISO)
positive regulation of epithelial cell migration  (IEA,ISO)
positive regulation of leukocyte migration  (IEA,ISO)
positive regulation of phagocytosis, engulfment  (IEA,ISO)
positive regulation of positive chemotaxis  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of translation  (IEA,ISO)
positive regulation of transmission of nerve impulse  (IEA,ISO)
response to amine  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to L-ascorbic acid  (IEA,ISO)
response to muscle activity  (IEA,ISO)
response to parathyroid hormone  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
skin morphogenesis  (IEA,ISO)
substrate-dependent cell migration  (IEA,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction. Antoniades C, etal., J Am Coll Cardiol. 2006 May 16;47(10):1959-66. Epub 2006 Apr 27.
2. Platelet glycoprotein Ia gene dimorphism alpha2-807 in malignant arrhythmia in coronary artery disease. Anvari A, etal., Thromb Res. 2000 May 15;98(4):281-6.
3. No association between the ITGA2 807T allele and retinopathy in french patients with type 2 diabetes. Arsene S, etal., Thromb Res. 2011 Sep;128(3):293-5. doi: 10.1016/j.thromres.2011.05.009. Epub 2011 Jun 1.
4. Association analysis of genetic variations of eNOS and alpha2beta1 integrin genes with type 2 diabetic retinopathy. Azmy R, etal., Appl Clin Genet. 2012 Jul 24;5:55-65. doi: 10.2147/TACG.S31979. Print 2012.
5. Idiopathic sudden sensorineural hearing loss: classic cardiovascular and new genetic risk factors. Ballesteros F, etal., Audiol Neurootol. 2012;17(6):400-8. doi: 10.1159/000341989. Epub 2012 Aug 30.
6. Iron deficiency anaemia in young women. Carlsson LE, etal., Eur J Haematol. 2002 Jun;68(6):341-4.
7. Infiltrating cells and IFNgamma production in the injected eye after uniocular anterior chamber inoculation of HSV-1. Cathcart HM, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2269-75. doi: 10.1167/iovs.08-2874.
8. Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke. Cole VJ, etal., J Thromb Haemost. 2003 May;1(5):963-70.
9. Glanzmann's thrombasthenia: modulation of clinical phenotype by alpha2C807T gene polymorphism. D'Andrea G and Margaglione M, Haematologica. 2003 Dec;88(12):1378-82.
10. The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion. Dodson PM, etal., Eye (Lond). 2003 Aug;17(6):772-7.
11. Improved metabolic control decreases platelet activation markers in patients with type-2 diabetes. Eibl N, etal., Eur J Clin Invest. 2004 Mar;34(3):205-9.
12. Placental gene expression in a rat 'model' of placental insufficiency. Goyal R, etal., Placenta. 2010 Jul;31(7):568-75. Epub 2010 Jun 8.
13. Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis? Huang Y, etal., Diabetes. 2008 Sep;57(9):2360-70. Epub 2008 Jun 20.
14. Distribution of integrin subunits in human diabetic kidneys. Jin DK, etal., J Am Soc Nephrol. 1996 Dec;7(12):2636-45.
15. Enhanced laminin carbonylation by monocytes in diabetes mellitus. Kostidou E, etal., Clin Biochem. 2007 Jun;40(9-10):671-9. Epub 2007 Mar 28.
16. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Kunicki TJ, etal., Blood. 2004 Oct 15;104(8):2359-67. Epub 2004 Jun 29.
17. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
18. Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection. Laine O, etal., Thromb Res. 2012 May;129(5):611-5. doi: 10.1016/j.thromres.2011.11.007. Epub 2011 Nov 30.
19. Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells. Lan F, etal., J Immunol. 2001 Aug 15;167(4):2087-96.
20. EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes. Li H, etal., Mol Vis. 2008 Sep 15;14:1698-704.
21. Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer. Lin Y, etal., Reproduction. 2009 Jun;137(6):943-55. Epub 2009 Mar 25.
22. Polymorphism in Integrin ITGA2 is Associated with Ischemic Stroke and Altered Serum Cholesterol in Chinese Individuals. Lu JX, etal., Balkan Med J. 2014 Mar;31(1):55-9. doi: 10.5152/balkanmedj.2013.7993. Epub 2014 Mar 1.
23. Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice. Lundberg S, etal., Inflamm Bowel Dis. 2006 Mar;12(3):172-7.
24. The 807T allele in alpha2 integrin is protective against atherosclerotic arterial wall thickening and the occurrence of plaque in patients with type 2 diabetes. Maeno T, etal., Diabetes. 2002 May;51(5):1523-8.
25. MGDs mouse GO annotations MGD data from the GO Consortium
26. MGD IEA MGD IEA
27. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. Park S, etal., Yonsei Med J. 2004 Jun 30;45(3):428-34.
30. Platelet membrane glycoprotein polymorphisms do not influence the clinical expressivity of von Willebrand disease type 1. Pereira J, etal., Thromb Haemost. 2003 Dec;90(6):1135-40.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
33. Polymorphism of the glycoprotein Ia and IIIa in the group of women in childbirth does not correlate with an increased risk of developing thrombosis. Podciechowski L, etal., Neuro Endocrinol Lett. 2005 Dec;26(6):789-94.
34. Association of the platelet glycoprotein Ia C807T/G873A gene polymorphism and thrombosis in Behcet patients. Polat G, etal., Haematologia (Budap). 2002;32(2):121-8.
35. Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. Reiner AP, etal., Thromb Haemost. 2003 Jan;89(1):142-8.
36. Mouse MP Annotation Import Pipeline RGD automated import pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation. Ridger VC, etal., J Immunol. 2001 Mar 1;166(5):3484-90.
40. Vascular risk factors in sudden hearing loss. Rudack C, etal., Thromb Haemost. 2006 Mar;95(3):454-61.
41. Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients. Santoso S, etal., Blood. 1999 Apr 15;93(8):2449-53.
42. Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans. Sperr WR, etal., Thromb Res. 1998 May 1;90(3):117-23.
43. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
44. Improvement of fertility with adoptive CD25+ natural killer cell transfer in subfertile non-obese diabetic mice. Wang W, etal., Reprod Biomed Online. 2009 Jan;18(1):95-103.
45. Role of thrombophilic gene polymorphisms in branch retinal vein occlusion. Weger M, etal., Ophthalmology. 2005 Nov;112(11):1910-5. Epub 2005 Sep 12.
46. Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. Wu JE and Santoro SA, Dev Dyn 1994 Apr;199(4):292-314.
47. Correlation between the polymorphism of glycoprotein Ia gene and acute coronary syndrome. Zhao Y, etal., Chin Med Sci J. 2004 Mar;19(1):13-8.
Additional References at PubMed
PMID:1431091   PMID:2545729   PMID:7589890   PMID:7691492   PMID:7790117   PMID:8081889   PMID:8306881   PMID:8521519   PMID:8626034   PMID:8725284   PMID:8828042   PMID:8948576  
PMID:9119362   PMID:9339637   PMID:9361014   PMID:9427478   PMID:9858678   PMID:10090148   PMID:10206722   PMID:10349636   PMID:10501972   PMID:10706142   PMID:10742111   PMID:11038351  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11431366   PMID:11438667   PMID:11767049   PMID:11788609   PMID:12107118   PMID:12477932   PMID:12721290   PMID:12843252   PMID:12893751  
PMID:12904471   PMID:12960301   PMID:14645004   PMID:14707119   PMID:14739220   PMID:14994542   PMID:15132990   PMID:15183724   PMID:15368439   PMID:15370361   PMID:15886326   PMID:16054021  
PMID:16141072   PMID:16141073   PMID:16166590   PMID:16373693   PMID:16455949   PMID:16618804   PMID:16636073   PMID:16818752   PMID:16882656   PMID:16919269   PMID:16973387   PMID:16977325  
PMID:17032352   PMID:17068473   PMID:17638891   PMID:18000613   PMID:18042800   PMID:18086863   PMID:18198349   PMID:18436621   PMID:18498633   PMID:18802064   PMID:18983510   PMID:18990704  
PMID:19192113   PMID:19258597   PMID:19411307   PMID:19463772   PMID:19648922   PMID:19668337   PMID:19686679   PMID:19789387   PMID:19815553   PMID:19840869   PMID:20592186   PMID:20651280  
PMID:20818394   PMID:20860797   PMID:21126803   PMID:21134100   PMID:21135504   PMID:21267068   PMID:21270253   PMID:21344393   PMID:21558389   PMID:21873635   PMID:21897373   PMID:22046385  
PMID:22083543   PMID:22103309   PMID:22210772   PMID:22318609   PMID:22687584   PMID:23023225   PMID:23152823   PMID:23165626   PMID:23169063   PMID:23226541   PMID:23359821   PMID:23385480  
PMID:23448258   PMID:23624599   PMID:23680479   PMID:23897120   PMID:24194600   PMID:24244022   PMID:24472646   PMID:24480069   PMID:24917135   PMID:24939421   PMID:25352128   PMID:25375377  
PMID:25391964   PMID:25415203   PMID:25634355   PMID:25808553   PMID:25849460   PMID:25859222   PMID:26051322   PMID:26196244   PMID:26556301   PMID:27412481   PMID:27505889   PMID:27626380  
PMID:28032533   PMID:28251149   PMID:28389839   PMID:28402857   PMID:29333090   PMID:30355617   PMID:30926747   PMID:31398205   PMID:32015010   PMID:32325033   PMID:32325713   PMID:32692932  
PMID:32998468   PMID:33124775   PMID:35182768   PMID:37142655   PMID:37839992   PMID:38355793  


Genomics

Comparative Map Data
Itga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,969,617 - 115,068,588 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,969,617 - 115,068,636 (-)EnsemblGRCm39 Ensembl
GRCm3813114,833,081 - 114,932,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,833,081 - 114,932,100 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,626,120 - 115,722,249 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,956,790 - 116,052,919 (-)NCBIMGSCv36mm8
Celera13119,179,611 - 119,279,864 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.61NCBI
ITGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38552,989,352 - 53,094,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl552,989,340 - 53,094,779 (+)EnsemblGRCh38hg38GRCh38
GRCh37552,285,182 - 52,390,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,320,913 - 52,426,366 (+)NCBINCBI36Build 36hg18NCBI36
Build 34552,321,013 - 52,423,947NCBI
Celera549,238,739 - 49,344,187 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,257,212 - 49,362,658 (+)NCBIHuRef
CHM1_1552,287,738 - 52,393,158 (+)NCBICHM1_1
T2T-CHM13v2.0553,817,115 - 53,922,565 (+)NCBIT2T-CHM13v2.0
Itga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,253,412 - 48,354,509 (-)NCBIGRCr8
mRatBN7.2246,520,345 - 46,621,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,523,948 - 46,621,481 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0246,996,904 - 47,097,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,536,102 - 71,636,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,967,681 - 47,080,909 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera242,276,508 - 42,376,910 (-)NCBICelera
Cytogenetic Map2q14NCBI
Itga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544614,309,349 - 14,422,170 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544614,309,516 - 14,421,991 (-)NCBIChiLan1.0ChiLan1.0
ITGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,843,032 - 60,952,088 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1558,996,794 - 59,105,394 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0560,935,452 - 61,040,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,554,387 - 62,659,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,555,370 - 62,659,720 (-)Ensemblpanpan1.1panPan2
ITGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1462,170,137 - 62,268,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl462,170,452 - 62,268,983 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,941,741 - 62,043,869 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,664,801 - 62,766,959 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,668,472 - 62,766,954 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,440,055 - 62,542,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,564,620 - 62,666,770 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0463,091,317 - 63,193,515 (-)NCBIUU_Cfam_GSD_1.0
Itga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,383,765 - 205,481,351 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648014,320,692 - 14,417,786 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648014,320,292 - 14,417,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,336,292 - 32,437,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,336,240 - 32,440,311 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,164,830 - 34,262,490 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,280,289 - 49,382,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,317,648 - 49,380,051 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,745,561 - 1,848,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247596,281,561 - 6,376,712 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247596,281,698 - 6,376,702 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itga2
4606 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:138
Interacting mature miRNAs:140
Transcripts:ENSMUST00000056117
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142334Svtms_msurvival time modifier of Sod2 (mouse)Not determined13107613580119476372Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100741519120883175Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4141704Hipq1_mhyperinsulin production QTL 1 (mouse)Not determined110409487119476372Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
4141826Tbqt5_mtibia bone quality traits 5 (mouse)Not determined13103341617117043216Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
14746974Manh75_mmandible shape 75 (mouse)1399386647120883175Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102602630120883175Mouse

Markers in Region
Itga2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.2UniSTS
cM Map1364.0UniSTS
Itga2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813114,837,106 - 114,837,208UniSTSGRCm38
MGSCv3713115,627,314 - 115,627,416UniSTSGRCm37
Celera13119,180,802 - 119,180,904UniSTS
Cytogenetic Map13D2.2UniSTS
cM Map1364.0UniSTS
Itga2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.2UniSTS
cM Map1364.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000056117   ⟹   ENSMUSP00000053891
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13114,969,617 - 115,068,636 (-)Ensembl
GRCm38.p6 Ensembl13114,833,081 - 114,932,100 (-)Ensembl
Ensembl Acc Id: ENSMUST00000224204   ⟹   ENSMUSP00000153056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13115,017,193 - 115,038,479 (-)Ensembl
GRCm38.p6 Ensembl13114,880,657 - 114,901,943 (-)Ensembl
RefSeq Acc Id: NM_008396   ⟹   NP_032422
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913114,969,617 - 115,068,588 (-)NCBI
GRCm3813114,833,081 - 114,932,100 (-)NCBI
MGSCv3713115,626,120 - 115,722,249 (-)RGD
Celera13119,179,611 - 119,279,864 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032422 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH65139 (Get FASTA)   NCBI Sequence Viewer  
  BAC29485 (Get FASTA)   NCBI Sequence Viewer  
  CAA53178 (Get FASTA)   NCBI Sequence Viewer  
  CAA82877 (Get FASTA)   NCBI Sequence Viewer  
  EDL18370 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000053891
  ENSMUSP00000053891.9
GenBank Protein Q62469 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032422   ⟸   NM_008396
- Peptide Label: precursor
- UniProtKB: Q62163 (UniProtKB/Swiss-Prot),   Q6P1C7 (UniProtKB/Swiss-Prot),   Q62469 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000153056   ⟸   ENSMUST00000224204
Ensembl Acc Id: ENSMUSP00000053891   ⟸   ENSMUST00000056117
Protein Domains
VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62469-F1-model_v2 AlphaFold Q62469 1-1178 view protein structure

Promoters
RGD ID:8681358
Promoter ID:EPDNEW_M18708
Type:initiation region
Name:Itga2_1
Description:Mus musculus integrin alpha 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813114,932,052 - 114,932,112EPDNEW
RGD ID:6824077
Promoter ID:MM_KWN:15326
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ENSMUST00000056117
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613115,721,636 - 115,722,136 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96600 AgrOrtholog
Ensembl Genes ENSMUSG00000015533 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000056117 ENTREZGENE
  ENSMUST00000056117.10 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot
  3.40.50.410 UniProtKB/Swiss-Prot
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot
InterPro FG-GAP UniProtKB/Swiss-Prot
  Int_alpha_beta-p UniProtKB/Swiss-Prot
  Integrin_alpha UniProtKB/Swiss-Prot
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_3 UniProtKB/Swiss-Prot
  Integrin_alpha_N UniProtKB/Swiss-Prot
  Integrin_dom_sf UniProtKB/Swiss-Prot
  VWF_A UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:16398 UniProtKB/Swiss-Prot
MGD MGI:96600 ENTREZGENE
NCBI Gene 16398 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot
  INTEGRIN ALPHA-2 UniProtKB/Swiss-Prot
Pfam FG-GAP UniProtKB/Swiss-Prot
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot
  Integrin_A_Ig_3 UniProtKB/Swiss-Prot
  Integrin_alpha UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
PharmGKB ITGA2 RGD
PhenoGen Itga2 PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot
  VWFADOMAIN UniProtKB/Swiss-Prot
PROSITE FG_GAP UniProtKB/Swiss-Prot
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot
  VWFA UniProtKB/Swiss-Prot
SMART Int_alpha UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot
  SSF69179 UniProtKB/Swiss-Prot
  SSF69318 UniProtKB/Swiss-Prot
UniProt A0A286YCM1_MOUSE UniProtKB/TrEMBL
  ITA2_MOUSE UniProtKB/Swiss-Prot
  Q62163 ENTREZGENE
  Q62469 ENTREZGENE
  Q6P1C7 ENTREZGENE
  Q8CB84_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q62163 UniProtKB/Swiss-Prot
  Q6P1C7 UniProtKB/Swiss-Prot