Srsf2 (serine and arginine-rich splicing factor 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Srsf2 (serine and arginine-rich splicing factor 2) Mus musculus
Analyze
Symbol: Srsf2
Name: serine and arginine-rich splicing factor 2
RGD ID: 1553658
MGI Page MGI
Description: Enables pre-mRNA binding activity. Acts upstream of or within regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of spliceosomal complex. Is expressed in several structures, including central nervous system; early conceptus; hemolymphoid system gland; reproductive system; and retina. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to human SRSF2 (serine and arginine rich splicing factor 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: D11Wsu175; D11Wsu175e; MRF-; MRF-1; myelin regulatory factor 1; Pr264; putative myelin regulatory factor 1; SC3; SC35; serine/arginine-rich splicing factor 2; Sf; Sfr; Sfrs10; Sfrs2; splicing component, 35 kDa; splicing factor Sc35; splicing factor, arginine/serine-rich 2; splicing factor, arginine/serine-rich 2 (SC-35)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,740,723 - 116,744,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,740,727 - 116,743,920 (-)EnsemblGRCm39 Ensembl
GRCm3811116,849,897 - 116,853,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,849,901 - 116,853,094 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711116,711,211 - 116,714,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,665,997 - 116,669,172 (-)NCBIMGSCv36mm8
Celera11128,590,379 - 128,593,569 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,6-dinitrotoluene  (ISO)
3',5'-cyclic UMP  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
artesunate  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
butan-2-one  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diuron  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
haloperidol  (ISO)
Heptachlor epoxide  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
kojic acid  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP,ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
parathion  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
PhIP  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. A new function of the splicing factor SRSF2 in the control of E2F1-mediated cell cycle progression in neuroendocrine lung tumors. Edmond V, etal., Cell Cycle. 2013 Apr 15;12(8):1267-78. doi: 10.4161/cc.24363. Epub 2013 Mar 21.
3. The biogenesis of the coiled body during early mouse development. Ferreira J and Carmo-Fonseca M, Development 1995 Feb;121(2):601-12.
4. Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma. Gout S, etal., PLoS One. 2012;7(10):e46539. doi: 10.1371/journal.pone.0046539. Epub 2012 Oct 10.
5. Mutational analysis of splicing machinery genes SF3B1, U2AF1 and SRSF2 in myelodysplasia and other common tumors. Je EM, etal., Int J Cancer. 2013 Jul;133(1):260-5. doi: 10.1002/ijc.28011. Epub 2013 Feb 5.
6. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
7. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. Kiefer KC, etal., ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28.
8. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
9. SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development. Luo C, etal., Cancer Res. 2017 Mar 1;77(5):1168-1178. doi: 10.1158/0008-5472.CAN-16-1919. Epub 2017 Jan 12.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Uterine expression of alternatively spliced mRNAs of mouse splicing factor SC35 during early pregnancy. Nie GY, etal., Mol Hum Reprod 2000 Dec;6(12):1131-9.
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors. Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Exon 11 skipping of E-cadherin RNA downregulates its expression in head and neck cancer cells. Sharma S, etal., Mol Cancer Ther. 2011 Sep;10(9):1751-9. doi: 10.1158/1535-7163.MCT-11-0248. Epub 2011 Jul 15.
20. Serine/arginine rich splicing factor 2 expression and clinic pathological features indicating a prognostic factor in human hepatocellular carcinoma patients. Wang P, etal., Cancer Biomark. 2018 Feb 14;21(3):681-687. doi: 10.3233/CBM-170770.
21. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. Yang L, etal., J Biol Chem 1998 Oct 23;273(43):27761-4.
22. Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice. Zhang C, etal., Commun Biol. 2020 May 5;3(1):210. doi: 10.1038/s42003-020-0893-5.
23. Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. Zhang SJ, etal., Blood. 2012 May 10;119(19):4480-5. doi: 10.1182/blood-2011-11-390252. Epub 2012 Mar 19.
Additional References at PubMed
PMID:1409578   PMID:2030943   PMID:7527040   PMID:8530103   PMID:8798720   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11239462   PMID:11641275   PMID:11739632  
PMID:11827461   PMID:12441651   PMID:12477932   PMID:12858338   PMID:14602710   PMID:14610273   PMID:14617810   PMID:14654002   PMID:14963485   PMID:15489334   PMID:15564382   PMID:15782199  
PMID:15798186   PMID:16033648   PMID:16141072   PMID:16141073   PMID:16285923   PMID:16376875   PMID:16427813   PMID:16602821   PMID:17526736   PMID:18564434   PMID:18641664   PMID:18703419  
PMID:19740913   PMID:20190275   PMID:20356838   PMID:20516191   PMID:20657840   PMID:21135118   PMID:21470964   PMID:21565611   PMID:21873635   PMID:21984414   PMID:22262462   PMID:22570411  
PMID:22794259   PMID:22840402   PMID:22855529   PMID:23512658   PMID:23562324   PMID:23562910   PMID:23663783   PMID:23665500   PMID:23932931   PMID:23937658   PMID:24346698   PMID:25412662  
PMID:25896510   PMID:25965569   PMID:25965571   PMID:26013685   PMID:26124281   PMID:26336360   PMID:26534959   PMID:26999604   PMID:27022105   PMID:27113764   PMID:27135740   PMID:27160897  
PMID:27622329   PMID:28077658   PMID:28378742   PMID:28592444   PMID:29146882   PMID:29395063   PMID:29459677   PMID:29903888   PMID:30068389   PMID:30107174   PMID:30457570   PMID:30550785  
PMID:31138677   PMID:31578525   PMID:32325033   PMID:32338600   PMID:33846634   PMID:34464972   PMID:34965385   PMID:34972250   PMID:34995116   PMID:36206200   PMID:36271153   PMID:37039821  
PMID:37045808   PMID:37100881   PMID:37142655   PMID:37252988   PMID:37867192   PMID:38012156   PMID:38017104   PMID:38713535   PMID:38806724  


Genomics

Comparative Map Data
Srsf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,740,723 - 116,744,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,740,727 - 116,743,920 (-)EnsemblGRCm39 Ensembl
GRCm3811116,849,897 - 116,853,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,849,901 - 116,853,094 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711116,711,211 - 116,714,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,665,997 - 116,669,172 (-)NCBIMGSCv36mm8
Celera11128,590,379 - 128,593,569 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.49NCBI
SRSF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,734,115 - 76,737,411 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,734,115 - 76,737,333 (-)EnsemblGRCh38hg38GRCh38
GRCh371774,730,197 - 74,733,493 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361772,241,792 - 72,245,007 (-)NCBINCBI36Build 36hg18NCBI36
Build 341772,241,793 - 72,245,007NCBI
Celera1771,322,570 - 71,325,785 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1770,157,912 - 70,161,208 (-)NCBIHuRef
CHM1_11774,795,009 - 74,798,305 (-)NCBICHM1_1
T2T-CHM13v2.01777,631,102 - 77,634,398 (-)NCBIT2T-CHM13v2.0
Srsf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,550,962 - 102,554,200 (-)NCBIGRCr8
mRatBN7.210102,052,158 - 102,055,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10102,052,314 - 102,055,338 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10107,156,134 - 107,159,309 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,619,223 - 106,622,399 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,972,989 - 101,976,169 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,792,779 - 105,795,986 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,792,779 - 105,795,958 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,451,332 - 105,454,538 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,954,365 - 106,956,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,968,870 - 106,971,311 (-)NCBI
Celera10100,620,618 - 100,623,797 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
Srsf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,569,302 - 5,570,120 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555065,569,280 - 5,572,164 (+)NCBIChiLan1.0ChiLan1.0
SRSF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,782,655 - 92,786,542 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,608,369 - 97,612,256 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,809,931 - 70,813,191 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11776,375,957 - 76,379,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1776,375,957 - 76,379,759 (-)Ensemblpanpan1.1panPan2
SRSF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,028,414 - 4,032,371 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,028,482 - 4,030,793 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,709,901 - 4,713,865 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,704,238 - 4,708,205 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,704,294 - 4,708,202 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,730,113 - 4,734,075 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.094,849,750 - 4,853,714 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.094,930,800 - 4,934,764 (+)NCBIUU_Cfam_GSD_1.0
Srsf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,633,549 - 4,636,547 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,777,376 - 1,778,164 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,775,412 - 1,778,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl124,800,624 - 4,801,675 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1124,800,578 - 4,803,767 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,652,818 - 4,653,543 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRSF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11644,945,193 - 44,948,496 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1644,945,200 - 44,946,438 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607715,682,841 - 15,686,671 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srsf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,575,325 - 6,578,468 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248016,575,322 - 6,578,429 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srsf2
157 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:720
Count of miRNA genes:322
Interacting mature miRNAs:371
Transcripts:ENSMUST00000092404, ENSMUST00000136914, ENSMUST00000138484, ENSMUST00000176834, ENSMUST00000177429
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
Sfrs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811116,850,801 - 116,852,227UniSTSGRCm38
MGSCv3711116,712,115 - 116,713,541UniSTSGRCm37
Celera11128,591,281 - 128,592,702UniSTS
Cytogenetic Map11E2UniSTS
cM Map1173.0UniSTS
D11Wsu175e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811116,849,994 - 116,850,215UniSTSGRCm38
MGSCv3711116,711,308 - 116,711,529UniSTSGRCm37
Celera11128,590,476 - 128,590,695UniSTS
Cytogenetic Map11E2UniSTS
cM Map1175.0UniSTS
cM Map1173.0UniSTS
D4S2570E  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811116,852,772 - 116,852,878UniSTSGRCm38
MGSCv3711116,714,086 - 116,714,192UniSTSGRCm37
Celera11128,593,247 - 128,593,353UniSTS
Cytogenetic Map11E2UniSTS
cM Map1173.0UniSTS
Sfrs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811116,850,626 - 116,851,386UniSTSGRCm38
MGSCv3711116,711,940 - 116,712,700UniSTSGRCm37
Celera11128,591,106 - 128,591,861UniSTS
Cytogenetic Map11E2UniSTS
Sfrs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
Sfrs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811116,852,067 - 116,852,902UniSTSGRCm38
MGSCv3711116,713,381 - 116,714,216UniSTSGRCm37
Celera11128,592,542 - 128,593,377UniSTS
Cytogenetic Map11E2UniSTS
Sfrs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011248835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003949363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003949364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003949365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003949366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF077858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF250132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF250133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF250134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF250135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG093253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ043688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X98511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000092404   ⟹   ENSMUSP00000090059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11116,740,727 - 116,743,920 (-)Ensembl
GRCm38.p6 Ensembl11116,849,901 - 116,853,094 (-)Ensembl
Ensembl Acc Id: ENSMUST00000136914   ⟹   ENSMUSP00000120086
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11116,740,870 - 116,743,898 (-)Ensembl
GRCm38.p6 Ensembl11116,850,044 - 116,853,072 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138484
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11116,740,730 - 116,743,045 (-)Ensembl
GRCm38.p6 Ensembl11116,849,904 - 116,852,219 (-)Ensembl
Ensembl Acc Id: ENSMUST00000176834   ⟹   ENSMUSP00000134907
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11116,740,732 - 116,742,912 (-)Ensembl
GRCm38.p6 Ensembl11116,849,906 - 116,852,086 (-)Ensembl
Ensembl Acc Id: ENSMUST00000177429
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11116,740,934 - 116,742,397 (-)Ensembl
GRCm38.p6 Ensembl11116,850,108 - 116,851,571 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190993   ⟹   ENSMUSP00000140016
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11116,740,880 - 116,743,898 (-)Ensembl
GRCm38.p6 Ensembl11116,850,054 - 116,853,072 (-)Ensembl
RefSeq Acc Id: NM_011358   ⟹   NP_035488
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,740,723 - 116,743,920 (-)NCBI
GRCm3811116,849,897 - 116,853,094 (-)NCBI
MGSCv3711116,711,211 - 116,714,408 (-)RGD
Celera11128,590,379 - 128,593,569 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011248835   ⟹   XP_011247137
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,740,730 - 116,744,511 (-)NCBI
GRCm3811116,849,904 - 116,853,148 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245724   ⟹   XP_030101584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,740,730 - 116,744,511 (-)NCBI
GRCm3811116,849,904 - 116,853,134 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003949363
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,740,730 - 116,744,511 (-)NCBI
GRCm3811116,849,904 - 116,853,134 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003949364
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,740,730 - 116,744,511 (-)NCBI
GRCm3811116,849,904 - 116,853,669 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003949365
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,740,730 - 116,744,511 (-)NCBI
GRCm3811116,849,904 - 116,853,675 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003949366
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,740,730 - 116,744,511 (-)NCBI
GRCm3811116,849,904 - 116,853,134 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035488   ⟸   NM_011358
- UniProtKB: Q542L3 (UniProtKB/Swiss-Prot),   Q60701 (UniProtKB/Swiss-Prot),   Q62093 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011247137   ⟸   XM_011248835
- Peptide Label: isoform X1
- UniProtKB: Q542L3 (UniProtKB/Swiss-Prot),   Q60701 (UniProtKB/Swiss-Prot),   Q62093 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030101584   ⟸   XM_030245724
- Peptide Label: isoform X1
- UniProtKB: Q62093 (UniProtKB/Swiss-Prot),   Q542L3 (UniProtKB/Swiss-Prot),   Q60701 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000090059   ⟸   ENSMUST00000092404
Ensembl Acc Id: ENSMUSP00000140016   ⟸   ENSMUST00000190993
Ensembl Acc Id: ENSMUSP00000134907   ⟸   ENSMUST00000176834
Ensembl Acc Id: ENSMUSP00000120086   ⟸   ENSMUST00000136914
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62093-F1-model_v2 AlphaFold Q62093 1-221 view protein structure

Promoters
RGD ID:6822108
Promoter ID:MM_KWN:10693
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000072341,   ENSMUST00000092403,   NM_011358,   OTTMUST00000008308,   UC007MMO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611116,712,221 - 116,714,387 (-)MPROMDB
RGD ID:8677490
Promoter ID:EPDNEW_M16776
Type:single initiation site
Name:Srsf2_2
Description:Mus musculus serine/arginine-rich splicing factor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16777  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811116,851,192 - 116,851,252EPDNEW
RGD ID:8677492
Promoter ID:EPDNEW_M16777
Type:multiple initiation site
Name:Srsf2_1
Description:Mus musculus serine/arginine-rich splicing factor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16776  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811116,853,090 - 116,853,150EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98284 AgrOrtholog
Ensembl Genes ENSMUSG00000034120 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000092404 ENTREZGENE
  ENSMUST00000092404.13 UniProtKB/Swiss-Prot
  ENSMUST00000136914.8 UniProtKB/Swiss-Prot
  ENSMUST00000176834.8 UniProtKB/TrEMBL
  ENSMUST00000190993.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBM UniProtKB/TrEMBL
  RNA-bind/splicing_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20382 UniProtKB/Swiss-Prot
MGD MGI:98284 ENTREZGENE
NCBI Gene 20382 ENTREZGENE
PANTHER GLYCINE-RICH RNA-BINDING PROTEIN RZ1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SC35-LIKE SPLICING FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE_ARGININE-RICH SPLICING FACTOR 2 UniProtKB/TrEMBL
  TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Srsf2 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BJA4_MOUSE UniProtKB/TrEMBL
  Q06477_MOUSE UniProtKB/TrEMBL
  Q542L3 ENTREZGENE
  Q60701 ENTREZGENE
  Q62093 ENTREZGENE
  Q8C671_MOUSE UniProtKB/TrEMBL
  Q99MY4_MOUSE UniProtKB/TrEMBL
  Q99MY5_MOUSE UniProtKB/TrEMBL
  SRSF2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q542L3 UniProtKB/Swiss-Prot
  Q60701 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-16 Srsf2  serine and arginine-rich splicing factor 2  Srsf2  serine/arginine-rich splicing factor 2  Symbol and/or name change 5135510 APPROVED
2011-07-27 Srsf2  serine/arginine-rich splicing factor 2  Sfrs2  splicing factor, arginine/serine-rich 2 (SC-35)  Symbol and/or name change 5135510 APPROVED